Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Neuropilin-1

Gene

NRP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF165 isoform of VEGFA and VEGFB. Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulate VEGF-induced angiogenesis. Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity).By similarity
The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi195CalciumCombined sources1 Publication1
Metal bindingi209CalciumCombined sources1 Publication1
Metal bindingi250CalciumCombined sources1 Publication1

GO - Molecular functioni

  • coreceptor activity Source: BHF-UCL
  • cytokine binding Source: BHF-UCL
  • growth factor binding Source: UniProtKB
  • GTPase activator activity Source: BHF-UCL
  • heparin binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW
  • protein kinase binding Source: Ensembl
  • semaphorin receptor activity Source: BHF-UCL
  • vascular endothelial growth factor-activated receptor activity Source: BHF-UCL
  • vascular endothelial growth factor binding Source: BHF-UCL

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Heparin-binding, Receptor
Biological processAngiogenesis, Differentiation, Neurogenesis
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-194306 Neurophilin interactions with VEGF and VEGFR
R-HSA-376176 Signaling by ROBO receptors
R-HSA-399954 Sema3A PAK dependent Axon repulsion
R-HSA-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
R-HSA-399956 CRMPs in Sema3A signaling
R-HSA-445144 Signal transduction by L1
R-HSA-447041 CHL1 interactions
SIGNORiO14786

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropilin-1
Alternative name(s):
Vascular endothelial cell growth factor 165 receptor
CD_antigen: CD304
Gene namesi
Name:NRP1
Synonyms:NRP, VEGF165R
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000099250.17
HGNCiHGNC:8004 NRP1
MIMi602069 gene
neXtProtiNX_O14786

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 856ExtracellularSequence analysisAdd BLAST835
Transmembranei857 – 879HelicalSequence analysisAdd BLAST23
Topological domaini880 – 923CytoplasmicSequence analysisAdd BLAST44

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi8829
OpenTargetsiENSG00000099250
PharmGKBiPA31783

Chemistry databases

ChEMBLiCHEMBL5174
DrugBankiDB00039 Palifermin
DB04895 Pegaptanib
GuidetoPHARMACOLOGYi2998

Polymorphism and mutation databases

BioMutaiNRP1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 212 PublicationsAdd BLAST21
ChainiPRO_000002185922 – 923Neuropilin-1Add BLAST902

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi27 ↔ 541 Publication
Disulfide bondi82 ↔ 1041 Publication
Disulfide bondi147 ↔ 1731 Publication
Glycosylationi150N-linked (GlcNAc...) asparagine3 Publications1
Disulfide bondi206 ↔ 2281 Publication
Glycosylationi261N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi275 ↔ 4241 Publication
Glycosylationi300N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi431 ↔ 5831 Publication
Glycosylationi522N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi612O-linked (Xyl...) (chondroitin sulfate) serine; alternate1 Publication1
Glycosylationi612O-linked (Xyl...) (heparan sulfate) serine; alternate1 Publication1
Glycosylationi842N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei894PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Heparan sulfate, Phosphoprotein, Proteoglycan

Proteomic databases

EPDiO14786
MaxQBiO14786
PaxDbiO14786
PeptideAtlasiO14786
PRIDEiO14786
ProteomicsDBi48233
48234 [O14786-2]

PTM databases

GlyConnecti1557
iPTMnetiO14786
PhosphoSitePlusiO14786
SwissPalmiO14786

Expressioni

Tissue specificityi

The expression of isoforms 1 and 2 does not seem to overlap. Isoform 1 is expressed by the blood vessels of different tissues. In the developing embryo it is found predominantly in the nervous system. In adult tissues, it is highly expressed in heart and placenta; moderately in lung, liver, skeletal muscle, kidney and pancreas; and low in adult brain. Isoform 2 is found in liver hepatocytes, kidney distal and proximal tubules.

Gene expression databases

BgeeiENSG00000099250 Expressed in 225 organ(s), highest expression level in caput epididymis
CleanExiHS_NRP1
ExpressionAtlasiO14786 baseline and differential
GenevisibleiO14786 HS

Organism-specific databases

HPAiCAB004511
HPA030278

Interactioni

Subunit structurei

Homodimer, and heterodimer with NRP2. Interacts with FER (By similarity). Binds PLXNB1. Interacts with VEGFA (PubMed:26503042).By similarity3 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114356, 48 interactors
CORUMiO14786
DIPiDIP-5743N
IntActiO14786, 10 interactors
MINTiO14786
STRINGi9606.ENSP00000265371

Chemistry databases

BindingDBiO14786

Structurei

Secondary structure

1923
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO14786
SMRiO14786
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO14786

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 141CUB 1PROSITE-ProRule annotationAdd BLAST115
Domaini147 – 265CUB 2PROSITE-ProRule annotationAdd BLAST119
Domaini275 – 424F5/8 type C 1PROSITE-ProRule annotationAdd BLAST150
Domaini431 – 583F5/8 type C 2PROSITE-ProRule annotationAdd BLAST153
Domaini645 – 811MAMPROSITE-ProRule annotationAdd BLAST167

Domaini

The tandem CUB domains mediate binding to semaphorin, while the tandem F5/8 domains are responsible for heparin and VEGF binding.

Sequence similaritiesi

Belongs to the neuropilin family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE8T Eukaryota
ENOG410YRBE LUCA
GeneTreeiENSGT00910000143988
HOGENOMiHOG000039978
HOVERGENiHBG000502
InParanoidiO14786
KOiK06724
OMAiLYCACWH
OrthoDBiEOG091G017M
PhylomeDBiO14786
TreeFamiTF316506

Family and domain databases

CDDicd00041 CUB, 2 hits
cd00057 FA58C, 2 hits
cd06263 MAM, 1 hit
Gene3Di2.60.120.260, 2 hits
2.60.120.290, 2 hits
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR000859 CUB_dom
IPR000421 FA58C
IPR008979 Galactose-bd-like_sf
IPR000998 MAM_dom
IPR014648 Neuropilin
IPR022579 Neuropilin_C
IPR027146 NRP1
IPR035914 Sperma_CUB_dom_sf
PANTHERiPTHR44185 PTHR44185, 1 hit
PTHR44185:SF1 PTHR44185:SF1, 1 hit
PfamiView protein in Pfam
PF00431 CUB, 2 hits
PF11980 DUF3481, 1 hit
PF00754 F5_F8_type_C, 2 hits
PF00629 MAM, 1 hit
PIRSFiPIRSF036960 Neuropilin, 1 hit
PRINTSiPR00020 MAMDOMAIN
SMARTiView protein in SMART
SM00042 CUB, 2 hits
SM00231 FA58C, 2 hits
SM00137 MAM, 1 hit
SUPFAMiSSF49785 SSF49785, 2 hits
SSF49854 SSF49854, 2 hits
SSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS01180 CUB, 2 hits
PS01285 FA58C_1, 2 hits
PS01286 FA58C_2, 2 hits
PS50022 FA58C_3, 2 hits
PS00740 MAM_1, 1 hit
PS50060 MAM_2, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O14786-1) [UniParc]FASTAAdd to basket
Also known as: Membrane-bound

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MERGLPLLCA VLALVLAPAG AFRNDKCGDT IKIESPGYLT SPGYPHSYHP
60 70 80 90 100
SEKCEWLIQA PDPYQRIMIN FNPHFDLEDR DCKYDYVEVF DGENENGHFR
110 120 130 140 150
GKFCGKIAPP PVVSSGPFLF IKFVSDYETH GAGFSIRYEI FKRGPECSQN
160 170 180 190 200
YTTPSGVIKS PGFPEKYPNS LECTYIVFVP KMSEIILEFE SFDLEPDSNP
210 220 230 240 250
PGGMFCRYDR LEIWDGFPDV GPHIGRYCGQ KTPGRIRSSS GILSMVFYTD
260 270 280 290 300
SAIAKEGFSA NYSVLQSSVS EDFKCMEALG MESGEIHSDQ ITASSQYSTN
310 320 330 340 350
WSAERSRLNY PENGWTPGED SYREWIQVDL GLLRFVTAVG TQGAISKETK
360 370 380 390 400
KKYYVKTYKI DVSSNGEDWI TIKEGNKPVL FQGNTNPTDV VVAVFPKPLI
410 420 430 440 450
TRFVRIKPAT WETGISMRFE VYGCKITDYP CSGMLGMVSG LISDSQITSS
460 470 480 490 500
NQGDRNWMPE NIRLVTSRSG WALPPAPHSY INEWLQIDLG EEKIVRGIII
510 520 530 540 550
QGGKHRENKV FMRKFKIGYS NNGSDWKMIM DDSKRKAKSF EGNNNYDTPE
560 570 580 590 600
LRTFPALSTR FIRIYPERAT HGGLGLRMEL LGCEVEAPTA GPTTPNGNLV
610 620 630 640 650
DECDDDQANC HSGTGDDFQL TGGTTVLATE KPTVIDSTIQ SEFPTYGFNC
660 670 680 690 700
EFGWGSHKTF CHWEHDNHVQ LKWSVLTSKT GPIQDHTGDG NFIYSQADEN
710 720 730 740 750
QKGKVARLVS PVVYSQNSAH CMTFWYHMSG SHVGTLRVKL RYQKPEEYDQ
760 770 780 790 800
LVWMAIGHQG DHWKEGRVLL HKSLKLYQVI FEGEIGKGNL GGIAVDDISI
810 820 830 840 850
NNHISQEDCA KPADLDKKNP EIKIDETGST PGYEGEGEGD KNISRKPGNV
860 870 880 890 900
LKTLDPILIT IIAMSALGVL LGAVCGVVLY CACWHNGMSE RNLSALENYN
910 920
FELVDGVKLK KDKLNTQSTY SEA
Length:923
Mass (Da):103,134
Last modified:September 23, 2008 - v3
Checksum:i1EAC2FA6C8FD6A0B
GO
Isoform 2 (identifier: O14786-2) [UniParc]FASTAAdd to basket
Also known as: Soluble, SNRP1

The sequence of this isoform differs from the canonical sequence as follows:
     642-644: EFP → GIK
     645-923: Missing.

Show »
Length:644
Mass (Da):71,935
Checksum:i1F055D9E6DD9BE70
GO
Isoform 3 (identifier: O14786-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     587-621: Missing.
     642-644: EFP → GIK
     645-923: Missing.

Note: No experimental confirmation available.
Show »
Length:609
Mass (Da):68,376
Checksum:i5CE3CEAE3CAD8CB8
GO

Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PEP6E9PEP6_HUMAN
Neuropilin
NRP1
906Annotation score:
Q5T7F0Q5T7F0_HUMAN
Neuropilin
NRP1
704Annotation score:
Q5JWQ6Q5JWQ6_HUMAN
Neuropilin
NRP1
735Annotation score:
E7EX60E7EX60_HUMAN
Neuropilin-1
NRP1
641Annotation score:
Q5JWQ4Q5JWQ4_HUMAN
Neuropilin-1
NRP1
597Annotation score:
Q5JWQ2Q5JWQ2_HUMAN
Neuropilin-1
NRP1
105Annotation score:
H0Y4A0H0Y4A0_HUMAN
Neuropilin-1
NRP1
170Annotation score:
V9GYL7V9GYL7_HUMAN
Neuropilin-1
NRP1
60Annotation score:
H0Y4N6H0Y4N6_HUMAN
Neuropilin-1
NRP1
100Annotation score:
H0Y7Z2H0Y7Z2_HUMAN
Neuropilin-1
NRP1
77Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26K → E in AAC51759 (PubMed:9288753).Curated1
Sequence conflicti219D → G in CAD91133 (PubMed:17974005).Curated1
Sequence conflicti749D → H in AAC12921 (PubMed:9529250).Curated1
Sequence conflicti855D → E in AAC51759 (PubMed:9288753).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_046536179V → A8 PublicationsCorresponds to variant dbSNP:rs7079053Ensembl.1
Natural variantiVAR_046537561F → L. Corresponds to variant dbSNP:rs2228637Ensembl.1
Natural variantiVAR_056957733V → I. Corresponds to variant dbSNP:rs2228638Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_053498587 – 621Missing in isoform 3. 1 PublicationAdd BLAST35
Alternative sequenceiVSP_004339642 – 644EFP → GIK in isoform 2 and isoform 3. 3 Publications3
Alternative sequenceiVSP_004340645 – 923Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST279

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF018956 mRNA Translation: AAC51759.1
AF016050 mRNA Translation: AAC12921.1
AF145712 mRNA Translation: AAF44344.1
BT006995 mRNA Translation: AAP35641.1
BX510902 mRNA Translation: CAD91133.1
EU332859 Genomic DNA Translation: ABY87548.1
AL353600 Genomic DNA No translation available.
AL121748 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW85942.1
CH471072 Genomic DNA Translation: EAW85944.1
BC007533 mRNA Translation: AAH07533.1
BC007737 mRNA Translation: AAH07737.1
CCDSiCCDS31179.1 [O14786-3]
CCDS31180.1 [O14786-2]
CCDS7177.1 [O14786-1]
RefSeqiNP_001019799.1, NM_001024628.2
NP_001019800.1, NM_001024629.2
NP_001316997.1, NM_001330068.1
NP_003864.4, NM_003873.5
UniGeneiHs.131704
Hs.653996

Genome annotation databases

EnsembliENST00000265371; ENSP00000265371; ENSG00000099250 [O14786-1]
ENST00000374821; ENSP00000363954; ENSG00000099250 [O14786-3]
ENST00000374822; ENSP00000363955; ENSG00000099250 [O14786-2]
ENST00000374867; ENSP00000364001; ENSG00000099250 [O14786-1]
GeneIDi8829
KEGGihsa:8829
UCSCiuc001iwx.5 human [O14786-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF018956 mRNA Translation: AAC51759.1
AF016050 mRNA Translation: AAC12921.1
AF145712 mRNA Translation: AAF44344.1
BT006995 mRNA Translation: AAP35641.1
BX510902 mRNA Translation: CAD91133.1
EU332859 Genomic DNA Translation: ABY87548.1
AL353600 Genomic DNA No translation available.
AL121748 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW85942.1
CH471072 Genomic DNA Translation: EAW85944.1
BC007533 mRNA Translation: AAH07533.1
BC007737 mRNA Translation: AAH07737.1
CCDSiCCDS31179.1 [O14786-3]
CCDS31180.1 [O14786-2]
CCDS7177.1 [O14786-1]
RefSeqiNP_001019799.1, NM_001024628.2
NP_001019800.1, NM_001024629.2
NP_001316997.1, NM_001330068.1
NP_003864.4, NM_003873.5
UniGeneiHs.131704
Hs.653996

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KEXX-ray1.90A273-427[»]
2QQIX-ray1.80A273-586[»]
2QQMX-ray2.00A141-586[»]
2QQNX-ray2.20A273-427[»]
3I97X-ray2.90A/B273-427[»]
4DEQX-ray2.65A/B274-429[»]
4RN5X-ray1.73A273-427[»]
5C7GX-ray1.45A273-427[»]
5IJRX-ray1.52A/B273-427[»]
5IYYX-ray1.60A/B273-427[»]
5J1XX-ray2.10A/B/C/D273-427[»]
5JGIX-ray1.38A/B273-427[»]
5JGQX-ray1.60A/B273-427[»]
5JHKX-ray1.80A/B273-427[»]
5L73X-ray2.24A/B628-813[»]
ProteinModelPortaliO14786
SMRiO14786
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114356, 48 interactors
CORUMiO14786
DIPiDIP-5743N
IntActiO14786, 10 interactors
MINTiO14786
STRINGi9606.ENSP00000265371

Chemistry databases

BindingDBiO14786
ChEMBLiCHEMBL5174
DrugBankiDB00039 Palifermin
DB04895 Pegaptanib
GuidetoPHARMACOLOGYi2998

PTM databases

GlyConnecti1557
iPTMnetiO14786
PhosphoSitePlusiO14786
SwissPalmiO14786

Polymorphism and mutation databases

BioMutaiNRP1

Proteomic databases

EPDiO14786
MaxQBiO14786
PaxDbiO14786
PeptideAtlasiO14786
PRIDEiO14786
ProteomicsDBi48233
48234 [O14786-2]

Protocols and materials databases

DNASUi8829
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265371; ENSP00000265371; ENSG00000099250 [O14786-1]
ENST00000374821; ENSP00000363954; ENSG00000099250 [O14786-3]
ENST00000374822; ENSP00000363955; ENSG00000099250 [O14786-2]
ENST00000374867; ENSP00000364001; ENSG00000099250 [O14786-1]
GeneIDi8829
KEGGihsa:8829
UCSCiuc001iwx.5 human [O14786-1]

Organism-specific databases

CTDi8829
DisGeNETi8829
EuPathDBiHostDB:ENSG00000099250.17
GeneCardsiNRP1
HGNCiHGNC:8004 NRP1
HPAiCAB004511
HPA030278
MIMi602069 gene
neXtProtiNX_O14786
OpenTargetsiENSG00000099250
PharmGKBiPA31783
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE8T Eukaryota
ENOG410YRBE LUCA
GeneTreeiENSGT00910000143988
HOGENOMiHOG000039978
HOVERGENiHBG000502
InParanoidiO14786
KOiK06724
OMAiLYCACWH
OrthoDBiEOG091G017M
PhylomeDBiO14786
TreeFamiTF316506

Enzyme and pathway databases

ReactomeiR-HSA-194306 Neurophilin interactions with VEGF and VEGFR
R-HSA-376176 Signaling by ROBO receptors
R-HSA-399954 Sema3A PAK dependent Axon repulsion
R-HSA-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
R-HSA-399956 CRMPs in Sema3A signaling
R-HSA-445144 Signal transduction by L1
R-HSA-447041 CHL1 interactions
SIGNORiO14786

Miscellaneous databases

ChiTaRSiNRP1 human
EvolutionaryTraceiO14786
GeneWikiiNeuropilin_1
GenomeRNAii8829
PROiPR:O14786
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000099250 Expressed in 225 organ(s), highest expression level in caput epididymis
CleanExiHS_NRP1
ExpressionAtlasiO14786 baseline and differential
GenevisibleiO14786 HS

Family and domain databases

CDDicd00041 CUB, 2 hits
cd00057 FA58C, 2 hits
cd06263 MAM, 1 hit
Gene3Di2.60.120.260, 2 hits
2.60.120.290, 2 hits
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR000859 CUB_dom
IPR000421 FA58C
IPR008979 Galactose-bd-like_sf
IPR000998 MAM_dom
IPR014648 Neuropilin
IPR022579 Neuropilin_C
IPR027146 NRP1
IPR035914 Sperma_CUB_dom_sf
PANTHERiPTHR44185 PTHR44185, 1 hit
PTHR44185:SF1 PTHR44185:SF1, 1 hit
PfamiView protein in Pfam
PF00431 CUB, 2 hits
PF11980 DUF3481, 1 hit
PF00754 F5_F8_type_C, 2 hits
PF00629 MAM, 1 hit
PIRSFiPIRSF036960 Neuropilin, 1 hit
PRINTSiPR00020 MAMDOMAIN
SMARTiView protein in SMART
SM00042 CUB, 2 hits
SM00231 FA58C, 2 hits
SM00137 MAM, 1 hit
SUPFAMiSSF49785 SSF49785, 2 hits
SSF49854 SSF49854, 2 hits
SSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS01180 CUB, 2 hits
PS01285 FA58C_1, 2 hits
PS01286 FA58C_2, 2 hits
PS50022 FA58C_3, 2 hits
PS00740 MAM_1, 1 hit
PS50060 MAM_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNRP1_HUMAN
AccessioniPrimary (citable) accession number: O14786
Secondary accession number(s): B0LPG9
, O60461, Q5T7F1, Q5T7F2, Q5T7F3, Q86T59, Q96I90, Q96IH5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: September 23, 2008
Last modified: October 10, 2018
This is version 199 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again