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Protein

Transcription elongation regulator 1

Gene

TCERG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target promoters. Regulates transcription elongation in a TATA box-dependent manner. Necessary for TAT-dependent activation of the human immunodeficiency virus type 1 (HIV-1) promoter.2 Publications

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • proline-rich region binding Source: Ensembl
  • RNA binding Source: UniProtKB
  • RNA polymerase II repressing transcription factor binding Source: BHF-UCL
  • transcription coactivator activity Source: ProtInc
  • transcription corepressor activity Source: BHF-UCL

GO - Biological processi

Keywordsi

Molecular functionActivator, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SignaLinkiO14776

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription elongation regulator 1
Alternative name(s):
TATA box-binding protein-associated factor 2S
Transcription factor CA150
Gene namesi
Name:TCERG1
Synonyms:CA150, TAF2S
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000113649.11
HGNCiHGNC:15630 TCERG1
MIMi605409 gene
neXtProtiNX_O14776

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi148 – 150YYY → AAA: Reduces repression of transcription by 35%. Reduces repression of transcription by 63%; when associated with 446-AAA-448. 1 Publication3
Mutagenesisi446 – 448YYY → AAA: Loss of interaction with SF1. Reduces repression of transcription by 35%. Reduces repression of transcription by 63%; when associated with 148-AAA-150. 1 Publication3
Mutagenesisi545 – 547FFY → AAA: No effect. 1 Publication3

Organism-specific databases

DisGeNETi10915
OpenTargetsiENSG00000113649
PharmGKBiPA38007

Polymorphism and mutation databases

BioMutaiTCERG1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000760631 – 1098Transcription elongation regulator 1Add BLAST1098

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei11PhosphoserineCombined sources1
Modified residuei20Omega-N-methylarginineCombined sources1
Modified residuei28Asymmetric dimethylarginineCombined sources1
Modified residuei30Asymmetric dimethylarginineCombined sources1
Modified residuei41Asymmetric dimethylarginineCombined sources1
Modified residuei48Asymmetric dimethylarginineCombined sources1
Cross-linki503Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki507Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki608Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei638PhosphoserineCombined sources1
Modified residuei834PhosphoserineCombined sources1
Modified residuei933PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO14776
MaxQBiO14776
PaxDbiO14776
PeptideAtlasiO14776
PRIDEiO14776
ProteomicsDBi48229
48230 [O14776-2]

PTM databases

CarbonylDBiO14776
iPTMnetiO14776
PhosphoSitePlusiO14776
SwissPalmiO14776

Expressioni

Tissue specificityi

Detected in brain neurons.1 Publication

Inductioni

Up-regulated in brain tissue from patients with Huntington disease.1 Publication

Gene expression databases

BgeeiENSG00000113649 Expressed in 171 organ(s), highest expression level in intestine
CleanExiHS_TCERG1
ExpressionAtlasiO14776 baseline and differential
GenevisibleiO14776 HS

Organism-specific databases

HPAiHPA064854
HPA069752
HPA069808

Interactioni

Subunit structurei

Binds formin (By similarity). Interacts (via the second WW domain) with TREX1 (via proline-rich region) (By similarity). Binds RNA polymerase II, HD and SF1.By similarity5 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116120, 84 interactors
CORUMiO14776
DIPiDIP-32504N
IntActiO14776, 19 interactors
MINTiO14776
STRINGi9606.ENSP00000296702

Structurei

Secondary structure

11098
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO14776
SMRiO14776
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO14776

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini131 – 164WW 1PROSITE-ProRule annotationAdd BLAST34
Domaini429 – 462WW 2PROSITE-ProRule annotationAdd BLAST34
Domaini528 – 561WW 3PROSITE-ProRule annotationAdd BLAST34
Domaini659 – 712FF 1Add BLAST54
Domaini725 – 779FF 2Add BLAST55
Domaini791 – 846FF 3Add BLAST56
Domaini896 – 952FF 4Add BLAST57
Domaini954 – 1010FF 5Add BLAST57
Domaini1012 – 1077FF 6Add BLAST66

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili184 – 244Sequence analysisAdd BLAST61
Coiled coili606 – 655Sequence analysisAdd BLAST50
Coiled coili844 – 906Sequence analysisAdd BLAST63

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi626 – 630Nuclear localization signalSequence analysis5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi32 – 132Pro-richAdd BLAST101
Compositional biasi169 – 258Ala/Gln-richAdd BLAST90
Compositional biasi260 – 331Thr-richAdd BLAST72
Compositional biasi328 – 378Pro-richAdd BLAST51
Compositional biasi454 – 515Glu-richAdd BLAST62
Compositional biasi1083 – 1087Poly-Pro5

Domaini

The FF domains bind the phosphorylated C-terminus of the largest subunit of RNA polymerase II, probably mediate interaction with HTATSF1 and preferentially bind peptides with the consensus sequence [DE]2-5-[FWY]-[DE]2-5.
The WW domains bind Pro-rich domains.

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG0155 Eukaryota
ENOG410XPZW LUCA
GeneTreeiENSGT00920000149021
HOGENOMiHOG000008544
HOVERGENiHBG062908
InParanoidiO14776
KOiK12824
OMAiPAEEIWV
OrthoDBiEOG091G0I5O
PhylomeDBiO14776
TreeFamiTF317748

Family and domain databases

CDDicd00201 WW, 3 hits
Gene3Di1.10.10.440, 6 hits
InterProiView protein in InterPro
IPR002713 FF_domain
IPR036517 FF_domain_sf
IPR001202 WW_dom
IPR036020 WW_dom_sf
PfamiView protein in Pfam
PF01846 FF, 6 hits
PF00397 WW, 2 hits
SMARTiView protein in SMART
SM00441 FF, 6 hits
SM00456 WW, 3 hits
SUPFAMiSSF51045 SSF51045, 3 hits
SSF81698 SSF81698, 5 hits
PROSITEiView protein in PROSITE
PS51676 FF, 6 hits
PS01159 WW_DOMAIN_1, 1 hit
PS50020 WW_DOMAIN_2, 3 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O14776-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAERGGDGGE SERFNPGELR MAQQQALRFR GPAPPPNAVM RGPPPLMRPP
60 70 80 90 100
PPFGMMRGPP PPPRPPFGRP PFDPNMPPMP PPGGIPPPMG PPHLQRPPFM
110 120 130 140 150
PPPMSSMPPP PGMMFPPGMP PVTAPGTPAL PPTEEIWVEN KTPDGKVYYY
160 170 180 190 200
NARTRESAWT KPDGVKVIQQ SELTPMLAAQ AQVQAQAQAQ AQAQAQAQAQ
210 220 230 240 250
AQAQAQAQAQ AQAQAQAQAQ AQAQAQAQAQ AQAQAQAQAQ AQVQAQVQAQ
260 270 280 290 300
VQAQAVGAST PTTSSPAPAV STSTSSSTPS STTSTTTTAT SVAQTVSTPT
310 320 330 340 350
TQDQTPSSAV SVATPTVSVS TPAPTATPVQ TVPQPHPQTL PPAVPHSVPQ
360 370 380 390 400
PTTAIPAFPP VMVPPFRVPL PGMPIPLPGV AMMQIVSCPY VKTVATTKTG
410 420 430 440 450
VLPGMAPPIV PMIHPQVAIA ASPATLAGAT AVSEWTEYKT ADGKTYYYNN
460 470 480 490 500
RTLESTWEKP QELKEKEKLE EKIKEPIKEP SEEPLPMETE EEDPKEEPIK
510 520 530 540 550
EIKEEPKEEE MTEEEKAAQK AKPVATAPIP GTPWCVVWTG DERVFFYNPT
560 570 580 590 600
TRLSMWDRPD DLIGRADVDK IIQEPPHKKG MEELKKLRHP TPTMLSIQKW
610 620 630 640 650
QFSMSAIKEE QELMEEINED EPVKAKKRKR DDNKDIDSEK EAAMEAEIKA
660 670 680 690 700
ARERAIVPLE ARMKQFKDML LERGVSAFST WEKELHKIVF DPRYLLLNPK
710 720 730 740 750
ERKQVFDQYV KTRAEEERRE KKNKIMQAKE DFKKMMEEAK FNPRATFSEF
760 770 780 790 800
AAKHAKDSRF KAIEKMKDRE ALFNEFVAAA RKKEKEDSKT RGEKIKSDFF
810 820 830 840 850
ELLSNHHLDS QSRWSKVKDK VESDPRYKAV DSSSMREDLF KQYIEKIAKN
860 870 880 890 900
LDSEKEKELE RQARIEASLR EREREVQKAR SEQTKEIDRE REQHKREEAI
910 920 930 940 950
QNFKALLSDM VRSSDVSWSD TRRTLRKDHR WESGSLLERE EKEKLFNEHI
960 970 980 990 1000
EALTKKKREH FRQLLDETSA ITLTSTWKEV KKIIKEDPRC IKFSSSDRKK
1010 1020 1030 1040 1050
QREFEEYIRD KYITAKADFR TLLKETKFIT YRSKKLIQES DQHLKDVEKI
1060 1070 1080 1090
LQNDKRYLVL DCVPEERRKL IVAYVDDLDR RGPPPPPTAS EPTRRSTK
Length:1,098
Mass (Da):123,901
Last modified:July 24, 2007 - v2
Checksum:i5F0A0C3A07EBF00F
GO
Isoform 2 (identifier: O14776-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     379-399: Missing.

Show »
Length:1,077
Mass (Da):121,690
Checksum:iD02B6E70E31F1551
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V220G3V220_HUMAN
Transcription elongation regulator ...
TCERG1 hCG_38116
1,032Annotation score:

Sequence cautioni

The sequence BAD93147 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti324P → R in AAB80727 (PubMed:9315662).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_026933379 – 399Missing in isoform 2. 2 PublicationsAdd BLAST21

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017789 mRNA Translation: AAB80727.1
AB209910 mRNA Translation: BAD93147.1 Different initiation.
BC111727 mRNA Translation: AAI11728.1
CCDSiCCDS4282.1 [O14776-1]
CCDS43379.1 [O14776-2]
PIRiT08599
RefSeqiNP_001035095.1, NM_001040006.1 [O14776-2]
NP_006697.2, NM_006706.3 [O14776-1]
UniGeneiHs.443465

Genome annotation databases

EnsembliENST00000296702; ENSP00000296702; ENSG00000113649 [O14776-1]
ENST00000394421; ENSP00000377943; ENSG00000113649 [O14776-2]
GeneIDi10915
KEGGihsa:10915
UCSCiuc003lob.4 human [O14776-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017789 mRNA Translation: AAB80727.1
AB209910 mRNA Translation: BAD93147.1 Different initiation.
BC111727 mRNA Translation: AAI11728.1
CCDSiCCDS4282.1 [O14776-1]
CCDS43379.1 [O14776-2]
PIRiT08599
RefSeqiNP_001035095.1, NM_001040006.1 [O14776-2]
NP_006697.2, NM_006706.3 [O14776-1]
UniGeneiHs.443465

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DK7NMR-A520-579[»]
2DODNMR-A651-719[»]
2DOENMR-A784-853[»]
2DOFNMR-A888-959[»]
2E71NMR-A717-786[»]
2KIQNMR-A724-782[»]
2KISNMR-A659-724[»]
2MW9NMR-A428-464[»]
2MWANMR-A428-464[»]
2MWBNMR-A428-464[»]
2MWDNMR-A433-460[»]
2MWENMR-A433-460[»]
2MWFNMR-A433-464[»]
2N4RNMR-A428-464[»]
2N4SNMR-A428-464[»]
2N4TNMR-A428-464[»]
2N4UNMR-A428-464[»]
2N4VNMR-A428-464[»]
2N4WNMR-A428-464[»]
2NNTNMR-A/B/C/D428-464[»]
3HFHX-ray2.70A/B661-845[»]
3Q1IX-ray1.40E99-107[»]
4FQGX-ray2.00A/B895-1081[»]
ProteinModelPortaliO14776
SMRiO14776
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116120, 84 interactors
CORUMiO14776
DIPiDIP-32504N
IntActiO14776, 19 interactors
MINTiO14776
STRINGi9606.ENSP00000296702

PTM databases

CarbonylDBiO14776
iPTMnetiO14776
PhosphoSitePlusiO14776
SwissPalmiO14776

Polymorphism and mutation databases

BioMutaiTCERG1

Proteomic databases

EPDiO14776
MaxQBiO14776
PaxDbiO14776
PeptideAtlasiO14776
PRIDEiO14776
ProteomicsDBi48229
48230 [O14776-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296702; ENSP00000296702; ENSG00000113649 [O14776-1]
ENST00000394421; ENSP00000377943; ENSG00000113649 [O14776-2]
GeneIDi10915
KEGGihsa:10915
UCSCiuc003lob.4 human [O14776-1]

Organism-specific databases

CTDi10915
DisGeNETi10915
EuPathDBiHostDB:ENSG00000113649.11
GeneCardsiTCERG1
HGNCiHGNC:15630 TCERG1
HPAiHPA064854
HPA069752
HPA069808
MIMi605409 gene
neXtProtiNX_O14776
OpenTargetsiENSG00000113649
PharmGKBiPA38007
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0155 Eukaryota
ENOG410XPZW LUCA
GeneTreeiENSGT00920000149021
HOGENOMiHOG000008544
HOVERGENiHBG062908
InParanoidiO14776
KOiK12824
OMAiPAEEIWV
OrthoDBiEOG091G0I5O
PhylomeDBiO14776
TreeFamiTF317748

Enzyme and pathway databases

SignaLinkiO14776

Miscellaneous databases

ChiTaRSiTCERG1 human
EvolutionaryTraceiO14776
GeneWikiiTranscription_elongation_regulator_1
GenomeRNAii10915
PROiPR:O14776
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000113649 Expressed in 171 organ(s), highest expression level in intestine
CleanExiHS_TCERG1
ExpressionAtlasiO14776 baseline and differential
GenevisibleiO14776 HS

Family and domain databases

CDDicd00201 WW, 3 hits
Gene3Di1.10.10.440, 6 hits
InterProiView protein in InterPro
IPR002713 FF_domain
IPR036517 FF_domain_sf
IPR001202 WW_dom
IPR036020 WW_dom_sf
PfamiView protein in Pfam
PF01846 FF, 6 hits
PF00397 WW, 2 hits
SMARTiView protein in SMART
SM00441 FF, 6 hits
SM00456 WW, 3 hits
SUPFAMiSSF51045 SSF51045, 3 hits
SSF81698 SSF81698, 5 hits
PROSITEiView protein in PROSITE
PS51676 FF, 6 hits
PS01159 WW_DOMAIN_1, 1 hit
PS50020 WW_DOMAIN_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiTCRG1_HUMAN
AccessioniPrimary (citable) accession number: O14776
Secondary accession number(s): Q2NKN2, Q59EA1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: July 24, 2007
Last modified: September 12, 2018
This is version 168 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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