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UniProtKB - O14776 (TCRG1_HUMAN)

Entry version 187 (02 Jun 2021)
Sequence version 2 (24 Jul 2007)
Previous versions | rss
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Protein

Transcription elongation regulator 1

Gene

TCERG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target promoters. Regulates transcription elongation in a TATA box-dependent manner. Necessary for TAT-dependent activation of the human immunodeficiency virus type 1 (HIV-1) promoter.

2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O14776

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		O14776

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcription elongation regulator 1
Alternative name(s):
TATA box-binding protein-associated factor 2S
Transcription factor CA150
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TCERG1
Synonyms:CA150, TAF2S
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:15630, TCERG1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		605409, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O14776

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000113649.11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi148 – 150YYY → AAA: Reduces repression of transcription by 35%. Reduces repression of transcription by 63%; when associated with 446-AAA-448. 1 Publication3
Mutagenesisi446 – 448YYY → AAA: Loss of interaction with SF1. Reduces repression of transcription by 35%. Reduces repression of transcription by 63%; when associated with 148-AAA-150. 1 Publication3
Mutagenesisi545 – 547FFY → AAA: No effect. 1 Publication3

Organism-specific databases

DisGeNET

More...DisGeNETi		10915

Open Targets

More...OpenTargetsi		ENSG00000113649

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA38007

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O14776, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TCERG1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000760631 – 1098Transcription elongation regulator 1Add BLAST1098

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei11PhosphoserineCombined sources1
Modified residuei20Omega-N-methylarginineCombined sources1
Modified residuei28Asymmetric dimethylarginineCombined sources1
Modified residuei30Asymmetric dimethylarginineCombined sources1
Modified residuei41Asymmetric dimethylarginineCombined sources1
Modified residuei48Asymmetric dimethylarginineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki503Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki507Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki608Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei638PhosphoserineCombined sources1
Modified residuei834PhosphoserineCombined sources1
Modified residuei933PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O14776

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O14776

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O14776

MaxQB - The MaxQuant DataBase

More...MaxQBi		O14776

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O14776

PeptideAtlas

More...PeptideAtlasi		O14776

PRoteomics IDEntifications database

More...PRIDEi		O14776

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		48229 [O14776-1]
48230 [O14776-2]

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		O14776

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O14776

MetOSite database of methionine sulfoxide sites

More...MetOSitei		O14776

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O14776

SwissPalm database of S-palmitoylation events

More...SwissPalmi		O14776

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in brain neurons.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated in brain tissue from patients with Huntington disease.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000113649, Expressed in intestine and 186 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O14776, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O14776, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000113649, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds formin (By similarity).

Interacts (via the second WW domain) with TREX1 (via proline-rich region) (By similarity). Binds RNA polymerase II, HD and SF1.

By similarity5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		116120, 117 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		O14776

Database of interacting proteins

More...DIPi		DIP-32504N

Protein interaction database and analysis system

More...IntActi		O14776, 33 interactors

Molecular INTeraction database

More...MINTi		O14776

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000296702

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O14776, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11098
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O14776

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		O14776

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini131 – 164WW 1PROSITE-ProRule annotationAdd BLAST34
Domaini429 – 462WW 2PROSITE-ProRule annotationAdd BLAST34
Domaini528 – 561WW 3PROSITE-ProRule annotationAdd BLAST34
Domaini659 – 712FF 1Add BLAST54
Domaini725 – 779FF 2Add BLAST55
Domaini791 – 846FF 3Add BLAST56
Domaini896 – 952FF 4Add BLAST57
Domaini954 – 1010FF 5Add BLAST57
Domaini1012 – 1077FF 6Add BLAST66

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 105DisorderedSequence analysisAdd BLAST105
Regioni259 – 348DisorderedSequence analysisAdd BLAST90
Regioni469 – 526DisorderedSequence analysisAdd BLAST58
Regioni615 – 640DisorderedSequence analysisAdd BLAST26
Regioni870 – 895DisorderedSequence analysisAdd BLAST26
Regioni1076 – 1098DisorderedSequence analysisAdd BLAST23

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili184 – 244Sequence analysisAdd BLAST61
Coiled coili606 – 655Sequence analysisAdd BLAST50
Coiled coili844 – 906Sequence analysisAdd BLAST63

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi626 – 630Nuclear localization signalSequence analysis5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi36 – 105Pro residuesSequence analysisAdd BLAST70
Compositional biasi259 – 327Polar residuesSequence analysisAdd BLAST69
Compositional biasi328 – 348Pro residuesSequence analysisAdd BLAST21
Compositional biasi469 – 484Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi496 – 520Basic and acidic residuesSequence analysisAdd BLAST25
Compositional biasi618 – 640Basic and acidic residuesSequence analysisAdd BLAST23

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The FF domains bind the phosphorylated C-terminus of the largest subunit of RNA polymerase II, probably mediate interaction with HTATSF1 and preferentially bind peptides with the consensus sequence [DE]2-5-[FWY]-[DE]2-5.
The WW domains bind Pro-rich domains.

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0155, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157770

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_008684_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O14776

Identification of Orthologs from Complete Genome Data

More...OMAi		MMNGPIG

Database of Orthologous Groups

More...OrthoDBi		1388955at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O14776

TreeFam database of animal gene trees

More...TreeFami		TF317748

Family and domain databases

Conserved Domains Database

More...CDDi		cd00201, WW, 3 hits

Database of protein disorder

More...DisProti		DP01893

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.10.440, 6 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002713, FF_domain
IPR036517, FF_domain_sf
IPR001202, WW_dom
IPR036020, WW_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01846, FF, 6 hits
PF00397, WW, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00441, FF, 6 hits
SM00456, WW, 3 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF51045, SSF51045, 3 hits
SSF81698, SSF81698, 5 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51676, FF, 6 hits
PS01159, WW_DOMAIN_1, 1 hit
PS50020, WW_DOMAIN_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O14776-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAERGGDGGE SERFNPGELR MAQQQALRFR GPAPPPNAVM RGPPPLMRPP 
        60         70         80         90        100
PPFGMMRGPP PPPRPPFGRP PFDPNMPPMP PPGGIPPPMG PPHLQRPPFM 
       110        120        130        140        150
PPPMSSMPPP PGMMFPPGMP PVTAPGTPAL PPTEEIWVEN KTPDGKVYYY 
       160        170        180        190        200
NARTRESAWT KPDGVKVIQQ SELTPMLAAQ AQVQAQAQAQ AQAQAQAQAQ 
       210        220        230        240        250
AQAQAQAQAQ AQAQAQAQAQ AQAQAQAQAQ AQAQAQAQAQ AQVQAQVQAQ 
       260        270        280        290        300
VQAQAVGAST PTTSSPAPAV STSTSSSTPS STTSTTTTAT SVAQTVSTPT 
       310        320        330        340        350
TQDQTPSSAV SVATPTVSVS TPAPTATPVQ TVPQPHPQTL PPAVPHSVPQ 
       360        370        380        390        400
PTTAIPAFPP VMVPPFRVPL PGMPIPLPGV AMMQIVSCPY VKTVATTKTG 
       410        420        430        440        450
VLPGMAPPIV PMIHPQVAIA ASPATLAGAT AVSEWTEYKT ADGKTYYYNN 
       460        470        480        490        500
RTLESTWEKP QELKEKEKLE EKIKEPIKEP SEEPLPMETE EEDPKEEPIK 
       510        520        530        540        550
EIKEEPKEEE MTEEEKAAQK AKPVATAPIP GTPWCVVWTG DERVFFYNPT 
       560        570        580        590        600
TRLSMWDRPD DLIGRADVDK IIQEPPHKKG MEELKKLRHP TPTMLSIQKW 
       610        620        630        640        650
QFSMSAIKEE QELMEEINED EPVKAKKRKR DDNKDIDSEK EAAMEAEIKA 
       660        670        680        690        700
ARERAIVPLE ARMKQFKDML LERGVSAFST WEKELHKIVF DPRYLLLNPK 
       710        720        730        740        750
ERKQVFDQYV KTRAEEERRE KKNKIMQAKE DFKKMMEEAK FNPRATFSEF 
       760        770        780        790        800
AAKHAKDSRF KAIEKMKDRE ALFNEFVAAA RKKEKEDSKT RGEKIKSDFF 
       810        820        830        840        850
ELLSNHHLDS QSRWSKVKDK VESDPRYKAV DSSSMREDLF KQYIEKIAKN 
       860        870        880        890        900
LDSEKEKELE RQARIEASLR EREREVQKAR SEQTKEIDRE REQHKREEAI 
       910        920        930        940        950
QNFKALLSDM VRSSDVSWSD TRRTLRKDHR WESGSLLERE EKEKLFNEHI 
       960        970        980        990       1000
EALTKKKREH FRQLLDETSA ITLTSTWKEV KKIIKEDPRC IKFSSSDRKK 
      1010       1020       1030       1040       1050
QREFEEYIRD KYITAKADFR TLLKETKFIT YRSKKLIQES DQHLKDVEKI 
      1060       1070       1080       1090 
LQNDKRYLVL DCVPEERRKL IVAYVDDLDR RGPPPPPTAS EPTRRSTK
Length:1,098
Mass (Da):123,901
Last modified:July 24, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5F0A0C3A07EBF00F
GO
Isoform 2 (identifier: O14776-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     379-399: Missing.

Show »
Length:1,077
Mass (Da):121,690
Checksum:iD02B6E70E31F1551
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V220G3V220_HUMAN
Transcription elongation regulator ...
TCERG1 hCG_38116
1,032Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7P0T8N8A0A7P0T8N8_HUMAN
Transcription elongation regulator ...
TCERG1
1,115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD93147 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti324P → R in AAB80727 (PubMed:9315662).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_026933379 – 399Missing in isoform 2. 2 PublicationsAdd BLAST21

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF017789 mRNA Translation: AAB80727.1
AB209910 mRNA Translation: BAD93147.1 Different initiation.
BC111727 mRNA Translation: AAI11728.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS4282.1 [O14776-1]
CCDS43379.1 [O14776-2]

Protein sequence database of the Protein Information Resource

More...PIRi		T08599

NCBI Reference Sequences

More...RefSeqi		NP_001035095.1, NM_001040006.1 [O14776-2]
NP_006697.2, NM_006706.3 [O14776-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000296702; ENSP00000296702; ENSG00000113649 [O14776-1]
ENST00000394421; ENSP00000377943; ENSG00000113649 [O14776-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		10915

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:10915

UCSC genome browser

More...UCSCi		uc003lob.4, human [O14776-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017789 mRNA Translation: AAB80727.1
AB209910 mRNA Translation: BAD93147.1 Different initiation.
BC111727 mRNA Translation: AAI11728.1
CCDSiCCDS4282.1 [O14776-1]
CCDS43379.1 [O14776-2]
PIRiT08599
RefSeqiNP_001035095.1, NM_001040006.1 [O14776-2]
NP_006697.2, NM_006706.3 [O14776-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DK7NMR-A520-579[»]
2DODNMR-A651-719[»]
2DOENMR-A784-853[»]
2DOFNMR-A888-959[»]
2E71NMR-A717-786[»]
2KIQNMR-A724-782[»]
2KISNMR-A659-724[»]
2MW9NMR-A428-464[»]
2MWANMR-A428-464[»]
2MWBNMR-A428-464[»]
2MWDNMR-A433-460[»]
2MWENMR-A433-460[»]
2MWFNMR-A433-464[»]
2N4RNMR-A428-464[»]
2N4SNMR-A428-464[»]
2N4TNMR-A428-464[»]
2N4UNMR-A428-464[»]
2N4VNMR-A428-464[»]
2N4WNMR-A428-464[»]
2NNTNMR-A/B/C/D428-464[»]
3HFHX-ray2.70A/B661-845[»]
3Q1IX-ray1.40E99-107[»]
4FQGX-ray2.00A/B895-1081[»]
7ABFelectron microscopy3.90A41-1098[»]
7ABGelectron microscopy7.80A41-1098[»]
SMRiO14776
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi116120, 117 interactors
CORUMiO14776
DIPiDIP-32504N
IntActiO14776, 33 interactors
MINTiO14776
STRINGi9606.ENSP00000296702

PTM databases

CarbonylDBiO14776
iPTMnetiO14776
MetOSiteiO14776
PhosphoSitePlusiO14776
SwissPalmiO14776

Genetic variation databases

BioMutaiTCERG1

Proteomic databases

EPDiO14776
jPOSTiO14776
MassIVEiO14776
MaxQBiO14776
PaxDbiO14776
PeptideAtlasiO14776
PRIDEiO14776
ProteomicsDBi48229 [O14776-1]
48230 [O14776-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		15805, 182 antibodies

The DNASU plasmid repository

More...DNASUi		10915

Genome annotation databases

EnsembliENST00000296702; ENSP00000296702; ENSG00000113649 [O14776-1]
ENST00000394421; ENSP00000377943; ENSG00000113649 [O14776-2]
GeneIDi10915
KEGGihsa:10915
UCSCiuc003lob.4, human [O14776-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10915
DisGeNETi10915

GeneCards: human genes, protein and diseases

More...GeneCardsi		TCERG1
HGNCiHGNC:15630, TCERG1
HPAiENSG00000113649, Low tissue specificity
MIMi605409, gene
neXtProtiNX_O14776
OpenTargetsiENSG00000113649
PharmGKBiPA38007
VEuPathDBiHostDB:ENSG00000113649.11

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0155, Eukaryota
GeneTreeiENSGT00940000157770
HOGENOMiCLU_008684_0_0_1
InParanoidiO14776
OMAiMMNGPIG
OrthoDBi1388955at2759
PhylomeDBiO14776
TreeFamiTF317748

Enzyme and pathway databases

PathwayCommonsiO14776
SignaLinkiO14776

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		10915, 284 hits in 1009 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TCERG1, human
EvolutionaryTraceiO14776

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Transcription_elongation_regulator_1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		10915
PharosiO14776, Tbio

Protein Ontology

More...PROi		PR:O14776
RNActiO14776, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000113649, Expressed in intestine and 186 other tissues
ExpressionAtlasiO14776, baseline and differential
GenevisibleiO14776, HS

Family and domain databases

CDDicd00201, WW, 3 hits
DisProtiDP01893
Gene3Di1.10.10.440, 6 hits
InterProiView protein in InterPro
IPR002713, FF_domain
IPR036517, FF_domain_sf
IPR001202, WW_dom
IPR036020, WW_dom_sf
PfamiView protein in Pfam
PF01846, FF, 6 hits
PF00397, WW, 2 hits
SMARTiView protein in SMART
SM00441, FF, 6 hits
SM00456, WW, 3 hits
SUPFAMiSSF51045, SSF51045, 3 hits
SSF81698, SSF81698, 5 hits
PROSITEiView protein in PROSITE
PS51676, FF, 6 hits
PS01159, WW_DOMAIN_1, 1 hit
PS50020, WW_DOMAIN_2, 3 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTCRG1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O14776
Secondary accession number(s): Q2NKN2, Q59EA1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: July 24, 2007
Last modified: June 2, 2021
This is version 187 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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