UniProtKB - O14776 (TCRG1_HUMAN)

BLAST

>sp|O14776|TCRG1_HUMAN Transcription elongation regulator 1 OS=Homo sapiens OX=9606 GN=TCERG1 PE=1 SV=2
MAERGGDGGESERFNPGELRMAQQQALRFRGPAPPPNAVMRGPPPLMRPPPPFGMMRGPP
PPPRPPFGRPPFDPNMPPMPPPGGIPPPMGPPHLQRPPFMPPPMSSMPPPPGMMFPPGMP
PVTAPGTPALPPTEEIWVENKTPDGKVYYYNARTRESAWTKPDGVKVIQQSELTPMLAAQ
AQVQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQ
AQVQAQVQAQVQAQAVGASTPTTSSPAPAVSTSTSSSTPSSTTSTTTTATSVAQTVSTPT
TQDQTPSSAVSVATPTVSVSTPAPTATPVQTVPQPHPQTLPPAVPHSVPQPTTAIPAFPP
VMVPPFRVPLPGMPIPLPGVAMMQIVSCPYVKTVATTKTGVLPGMAPPIVPMIHPQVAIA
ASPATLAGATAVSEWTEYKTADGKTYYYNNRTLESTWEKPQELKEKEKLEEKIKEPIKEP
SEEPLPMETEEEDPKEEPIKEIKEEPKEEEMTEEEKAAQKAKPVATAPIPGTPWCVVWTG
DERVFFYNPTTRLSMWDRPDDLIGRADVDKIIQEPPHKKGMEELKKLRHPTPTMLSIQKW
QFSMSAIKEEQELMEEINEDEPVKAKKRKRDDNKDIDSEKEAAMEAEIKAARERAIVPLE
ARMKQFKDMLLERGVSAFSTWEKELHKIVFDPRYLLLNPKERKQVFDQYVKTRAEEERRE
KKNKIMQAKEDFKKMMEEAKFNPRATFSEFAAKHAKDSRFKAIEKMKDREALFNEFVAAA
RKKEKEDSKTRGEKIKSDFFELLSNHHLDSQSRWSKVKDKVESDPRYKAVDSSSMREDLF
KQYIEKIAKNLDSEKEKELERQARIEASLREREREVQKARSEQTKEIDREREQHKREEAI
QNFKALLSDMVRSSDVSWSDTRRTLRKDHRWESGSLLEREEKEKLFNEHIEALTKKKREH
FRQLLDETSAITLTSTWKEVKKIIKEDPRCIKFSSSDRKKQREFEEYIRDKYITAKADFR
TLLKETKFITYRSKKLIQESDQHLKDVEKILQNDKRYLVLDCVPEERRKLIVAYVDDLDR
RGPPPPPTASEPTRRSTK

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History
Entry version 169 (07 Nov 2018)
Sequence version 2 (24 Jul 2007)
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Protein

Transcription elongation regulator 1

Gene

TCERG1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target promoters. Regulates transcription elongation in a TATA box-dependent manner. Necessary for TAT-dependent activation of the human immunodeficiency virus type 1 (HIV-1) promoter.2 Publications

GO - Molecular functionⁱ

identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 17060612
proline-rich region binding Source: Ensembl
RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22658674
- 22681889
RNA polymerase binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
RNA polymerase II repressing transcription factor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 20956529
transcription coactivator activity
Source: ProtInc
Traceable author statementⁱ
- 9315662
transcription corepressor activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 20956529

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

negative regulation of transcription by RNA polymerase II
Source: BHF-UCL
Inferred from direct assayⁱ
- 20956529
transcription by RNA polymerase II
Source: ProtInc
Traceable author statementⁱ
- 9315662

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, Repressor
Biological process	Transcription, Transcription regulation

Enzyme and pathway databases

SignaLinkⁱ	O14776

SignaLinkⁱ

O14776

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transcription elongation regulator 1 Alternative name(s): TATA box-binding protein-associated factor 2S Transcription factor CA150
Gene namesⁱ	Name:TCERG1 Synonyms:CA150, TAF2S
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000113649.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:15630 TCERG1
MIMⁱ	605409 gene
neXtProtⁱ	NX_O14776

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	148 – 150	YYY → AAA: Reduces repression of transcription by 35%. Reduces repression of transcription by 63%; when associated with 446-AAA-448. 1 Publication	3
Mutagenesisⁱ	446 – 448	YYY → AAA: Loss of interaction with SF1. Reduces repression of transcription by 35%. Reduces repression of transcription by 63%; when associated with 148-AAA-150. 1 Publication	3
Mutagenesisⁱ	545 – 547	FFY → AAA: No effect. 1 Publication	3

Organism-specific databases

DisGeNET More...DisGeNETⁱ	10915
Open Targets More...OpenTargetsⁱ	ENSG00000113649
PharmGKBⁱ	PA38007

Polymorphism and mutation databases

BioMutaⁱ	TCERG1

BioMutaⁱ

TCERG1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000076063	1 – 1098	Transcription elongation regulator 1Add BLAST		1098

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	11	PhosphoserineCombined sources	1
Modified residueⁱ	20	Omega-N-methylarginineCombined sources	1
Modified residueⁱ	28	Asymmetric dimethylarginineCombined sources	1
Modified residueⁱ	30	Asymmetric dimethylarginineCombined sources	1
Modified residueⁱ	41	Asymmetric dimethylarginineCombined sources	1
Modified residueⁱ	48	Asymmetric dimethylarginineCombined sources	1
Cross-linkⁱ	503	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	507	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	608	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	638	PhosphoserineCombined sources	1
Modified residueⁱ	834	PhosphoserineCombined sources	1
Modified residueⁱ	933	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	O14776
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O14776
PaxDbⁱ	O14776
PeptideAtlas More...PeptideAtlasⁱ	O14776
PRIDEⁱ	O14776
ProteomicsDBⁱ	48229 48230 [O14776-2]

PTM databases

CarbonylDBⁱ	O14776
iPTMnetⁱ	O14776
PhosphoSitePlusⁱ	O14776
SwissPalmⁱ	O14776

Expressionⁱ

Tissue specificityⁱ

Detected in brain neurons.1 Publication

Inductionⁱ

Up-regulated in brain tissue from patients with Huntington disease.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000113649 Expressed in 171 organ(s), highest expression level in intestine
CleanExⁱ	HS_TCERG1
ExpressionAtlasⁱ	O14776 baseline and differential
Genevisibleⁱ	O14776 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA064854 HPA069752 HPA069808

HPAⁱ

HPA064854
HPA069752
HPA069808

Interactionⁱ

Subunit structureⁱ

Binds formin (By similarity). Interacts (via the second WW domain) with TREX1 (via proline-rich region) (By similarity). Binds RNA polymerase II, HD and SF1.By similarity5 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
itself		4	EBI-473271,EBI-473271
BARD1	Q99728	2	EBI-473271,EBI-473181
HTT	P42858	9	EBI-473271,EBI-466029

GO - Molecular functionⁱ

identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 17060612
proline-rich region binding Source: Ensembl
RNA polymerase binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
RNA polymerase II repressing transcription factor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 20956529

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	116120, 84 interactors
CORUMⁱ	O14776
Database of interacting proteins More...DIPⁱ	DIP-32504N
IntActⁱ	O14776, 19 interactors
Molecular INTeraction database More...MINTⁱ	O14776
STRINGⁱ	9606.ENSP00000296702

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	103 – 105	Combined sources	3
Beta strandⁱ	435 – 440	Combined sources	6
Turnⁱ	441 – 443	Combined sources	3
Beta strandⁱ	444 – 449	Combined sources	6
Turnⁱ	450 – 453	Combined sources	4
Beta strandⁱ	454 – 458	Combined sources	5
Turnⁱ	461 – 463	Combined sources	3
Beta strandⁱ	523 – 528	Combined sources	6
Beta strandⁱ	530 – 533	Combined sources	4
Beta strandⁱ	535 – 542	Combined sources	8
Beta strandⁱ	544 – 548	Combined sources	5
Turnⁱ	549 – 552	Combined sources	4
Turnⁱ	560 – 564	Combined sources	5
Helixⁱ	567 – 573	Combined sources	7
Turnⁱ	576 – 578	Combined sources	3
Beta strandⁱ	652 – 656	Combined sources	5
Turnⁱ	661 – 663	Combined sources	3
Helixⁱ	669 – 672	Combined sources	4
Beta strandⁱ	677 – 679	Combined sources	3
Helixⁱ	681 – 689	Combined sources	9
Helixⁱ	692 – 696	Combined sources	5
Helixⁱ	705 – 710	Combined sources	6
Helixⁱ	713 – 720	Combined sources	8
Beta strandⁱ	721 – 723	Combined sources	3
Turnⁱ	726 – 728	Combined sources	3
Helixⁱ	747 – 752	Combined sources	6
Helixⁱ	758 – 762	Combined sources	5
Helixⁱ	773 – 780	Combined sources	8
Beta strandⁱ	783 – 786	Combined sources	4
Helixⁱ	798 – 804	Combined sources	7
Helixⁱ	814 – 821	Combined sources	8
Turnⁱ	825 – 827	Combined sources	3
Helixⁱ	833 – 840	Combined sources	8
Beta strandⁱ	888 – 890	Combined sources	3
Helixⁱ	895 – 910	Combined sources	16
Helixⁱ	918 – 925	Combined sources	8
Helixⁱ	929 – 934	Combined sources	6
Helixⁱ	939 – 966	Combined sources	28
Helixⁱ	977 – 984	Combined sources	8
Helixⁱ	988 – 991	Combined sources	4
Helixⁱ	997 – 1025	Combined sources	29
Helixⁱ	1033 – 1039	Combined sources	7
Helixⁱ	1042 – 1051	Combined sources	10
Helixⁱ	1055 – 1058	Combined sources	4
Turnⁱ	1059 – 1062	Combined sources	4
Helixⁱ	1064 – 1076	Combined sources	13

Show more details

3D structure databases

ProteinModelPortalⁱ	O14776
SMRⁱ	O14776
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	O14776

EvolutionaryTraceⁱ

O14776

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	131 – 164	WW 1PROSITE-ProRule annotationAdd BLAST	34
Domainⁱ	429 – 462	WW 2PROSITE-ProRule annotationAdd BLAST	34
Domainⁱ	528 – 561	WW 3PROSITE-ProRule annotationAdd BLAST	34
Domainⁱ	659 – 712	FF 1Add BLAST	54
Domainⁱ	725 – 779	FF 2Add BLAST	55
Domainⁱ	791 – 846	FF 3Add BLAST	56
Domainⁱ	896 – 952	FF 4Add BLAST	57
Domainⁱ	954 – 1010	FF 5Add BLAST	57
Domainⁱ	1012 – 1077	FF 6Add BLAST	66

Coiled coil

Feature key	Position(s)	DescriptionActions	Length
Coiled coilⁱ	184 – 244	Sequence analysisAdd BLAST	61
Coiled coilⁱ	606 – 655	Sequence analysisAdd BLAST	50
Coiled coilⁱ	844 – 906	Sequence analysisAdd BLAST	63

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	626 – 630	Nuclear localization signalSequence analysis		5

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	32 – 132	Pro-richAdd BLAST	101
Compositional biasⁱ	169 – 258	Ala/Gln-richAdd BLAST	90
Compositional biasⁱ	260 – 331	Thr-richAdd BLAST	72
Compositional biasⁱ	328 – 378	Pro-richAdd BLAST	51
Compositional biasⁱ	454 – 515	Glu-richAdd BLAST	62
Compositional biasⁱ	1083 – 1087	Poly-Pro	5

Domainⁱ

The FF domains bind the phosphorylated C-terminus of the largest subunit of RNA polymerase II, probably mediate interaction with HTATSF1 and preferentially bind peptides with the consensus sequence [DE]_2-5-[FWY]-[DE]_2-5.

The WW domains bind Pro-rich domains.

Keywords - Domainⁱ

Coiled coil, Repeat

Phylogenomic databases

eggNOGⁱ	KOG0155 Eukaryota ENOG410XPZW LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150983
HOGENOMⁱ	HOG000008544
HOVERGENⁱ	HBG062908
InParanoidⁱ	O14776
KEGG Orthology (KO) More...KOⁱ	K12824
OMAⁱ	NPRTTFS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0I5O
PhylomeDBⁱ	O14776
TreeFamⁱ	TF317748

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00201 WW, 3 hits
Gene3Dⁱ	1.10.10.440, 6 hits
InterProⁱ	View protein in InterPro IPR002713 FF_domain IPR036517 FF_domain_sf IPR001202 WW_dom IPR036020 WW_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01846 FF, 6 hits PF00397 WW, 2 hits
SMARTⁱ	View protein in SMART SM00441 FF, 6 hits SM00456 WW, 3 hits
SUPFAMⁱ	SSF51045 SSF51045, 3 hits SSF81698 SSF81698, 5 hits
PROSITEⁱ	View protein in PROSITE PS51676 FF, 6 hits PS01159 WW_DOMAIN_1, 1 hit PS50020 WW_DOMAIN_2, 3 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: O14776-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAERGGDGGE SERFNPGELR MAQQQALRFR GPAPPPNAVM RGPPPLMRPP 
        60         70         80         90        100
PPFGMMRGPP PPPRPPFGRP PFDPNMPPMP PPGGIPPPMG PPHLQRPPFM 
       110        120        130        140        150
PPPMSSMPPP PGMMFPPGMP PVTAPGTPAL PPTEEIWVEN KTPDGKVYYY 
       160        170        180        190        200
NARTRESAWT KPDGVKVIQQ SELTPMLAAQ AQVQAQAQAQ AQAQAQAQAQ 
       210        220        230        240        250
AQAQAQAQAQ AQAQAQAQAQ AQAQAQAQAQ AQAQAQAQAQ AQVQAQVQAQ 
       260        270        280        290        300
VQAQAVGAST PTTSSPAPAV STSTSSSTPS STTSTTTTAT SVAQTVSTPT 
       310        320        330        340        350
TQDQTPSSAV SVATPTVSVS TPAPTATPVQ TVPQPHPQTL PPAVPHSVPQ 
       360        370        380        390        400
PTTAIPAFPP VMVPPFRVPL PGMPIPLPGV AMMQIVSCPY VKTVATTKTG 
       410        420        430        440        450
VLPGMAPPIV PMIHPQVAIA ASPATLAGAT AVSEWTEYKT ADGKTYYYNN 
       460        470        480        490        500
RTLESTWEKP QELKEKEKLE EKIKEPIKEP SEEPLPMETE EEDPKEEPIK 
       510        520        530        540        550
EIKEEPKEEE MTEEEKAAQK AKPVATAPIP GTPWCVVWTG DERVFFYNPT 
       560        570        580        590        600
TRLSMWDRPD DLIGRADVDK IIQEPPHKKG MEELKKLRHP TPTMLSIQKW 
       610        620        630        640        650
QFSMSAIKEE QELMEEINED EPVKAKKRKR DDNKDIDSEK EAAMEAEIKA 
       660        670        680        690        700
ARERAIVPLE ARMKQFKDML LERGVSAFST WEKELHKIVF DPRYLLLNPK 
       710        720        730        740        750
ERKQVFDQYV KTRAEEERRE KKNKIMQAKE DFKKMMEEAK FNPRATFSEF 
       760        770        780        790        800
AAKHAKDSRF KAIEKMKDRE ALFNEFVAAA RKKEKEDSKT RGEKIKSDFF 
       810        820        830        840        850
ELLSNHHLDS QSRWSKVKDK VESDPRYKAV DSSSMREDLF KQYIEKIAKN 
       860        870        880        890        900
LDSEKEKELE RQARIEASLR EREREVQKAR SEQTKEIDRE REQHKREEAI 
       910        920        930        940        950
QNFKALLSDM VRSSDVSWSD TRRTLRKDHR WESGSLLERE EKEKLFNEHI 
       960        970        980        990       1000
EALTKKKREH FRQLLDETSA ITLTSTWKEV KKIIKEDPRC IKFSSSDRKK 
      1010       1020       1030       1040       1050
QREFEEYIRD KYITAKADFR TLLKETKFIT YRSKKLIQES DQHLKDVEKI 
      1060       1070       1080       1090 
LQNDKRYLVL DCVPEERRKL IVAYVDDLDR RGPPPPPTAS EPTRRSTK

Length:1,098

Mass (Da):123,901

Last modified:July 24, 2007 - v2

Checksum:ⁱ5F0A0C3A07EBF00F

Isoform 2 (identifier: O14776-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
379-399: Missing.

« Hide

        10         20         30         40         50
MAERGGDGGE SERFNPGELR MAQQQALRFR GPAPPPNAVM RGPPPLMRPP 
        60         70         80         90        100
PPFGMMRGPP PPPRPPFGRP PFDPNMPPMP PPGGIPPPMG PPHLQRPPFM 
       110        120        130        140        150
PPPMSSMPPP PGMMFPPGMP PVTAPGTPAL PPTEEIWVEN KTPDGKVYYY 
       160        170        180        190        200
NARTRESAWT KPDGVKVIQQ SELTPMLAAQ AQVQAQAQAQ AQAQAQAQAQ 
       210        220        230        240        250
AQAQAQAQAQ AQAQAQAQAQ AQAQAQAQAQ AQAQAQAQAQ AQVQAQVQAQ 
       260        270        280        290        300
VQAQAVGAST PTTSSPAPAV STSTSSSTPS STTSTTTTAT SVAQTVSTPT 
       310        320        330        340        350
TQDQTPSSAV SVATPTVSVS TPAPTATPVQ TVPQPHPQTL PPAVPHSVPQ 
       360        370        380        390        400
PTTAIPAFPP VMVPPFRVPL PGMPIPLPGV LPGMAPPIVP MIHPQVAIAA 
       410        420        430        440        450
SPATLAGATA VSEWTEYKTA DGKTYYYNNR TLESTWEKPQ ELKEKEKLEE 
       460        470        480        490        500
KIKEPIKEPS EEPLPMETEE EDPKEEPIKE IKEEPKEEEM TEEEKAAQKA 
       510        520        530        540        550
KPVATAPIPG TPWCVVWTGD ERVFFYNPTT RLSMWDRPDD LIGRADVDKI 
       560        570        580        590        600
IQEPPHKKGM EELKKLRHPT PTMLSIQKWQ FSMSAIKEEQ ELMEEINEDE 
       610        620        630        640        650
PVKAKKRKRD DNKDIDSEKE AAMEAEIKAA RERAIVPLEA RMKQFKDMLL 
       660        670        680        690        700
ERGVSAFSTW EKELHKIVFD PRYLLLNPKE RKQVFDQYVK TRAEEERREK 
       710        720        730        740        750
KNKIMQAKED FKKMMEEAKF NPRATFSEFA AKHAKDSRFK AIEKMKDREA 
       760        770        780        790        800
LFNEFVAAAR KKEKEDSKTR GEKIKSDFFE LLSNHHLDSQ SRWSKVKDKV 
       810        820        830        840        850
ESDPRYKAVD SSSMREDLFK QYIEKIAKNL DSEKEKELER QARIEASLRE 
       860        870        880        890        900
REREVQKARS EQTKEIDRER EQHKREEAIQ NFKALLSDMV RSSDVSWSDT 
       910        920        930        940        950
RRTLRKDHRW ESGSLLEREE KEKLFNEHIE ALTKKKREHF RQLLDETSAI 
       960        970        980        990       1000
TLTSTWKEVK KIIKEDPRCI KFSSSDRKKQ REFEEYIRDK YITAKADFRT 
      1010       1020       1030       1040       1050
LLKETKFITY RSKKLIQESD QHLKDVEKIL QNDKRYLVLD CVPEERRKLI 
      1060       1070 
VAYVDDLDRR GPPPPPTASE PTRRSTK

Show »

Length:1,077

Mass (Da):121,690

Checksum:ⁱD02B6E70E31F1551

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	G3V220	G3V220_HUMAN		Transcription elongation regulator ... Transcription elongation regulator 1 (Transcription elongation regulator 1, isoform CRA_c)	TCERG1 hCG_38116	1,032	Annotation score:

Sequence cautionⁱ

The sequence BAD93147 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	324	P → R in AAB80727 (PubMed:9315662).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_026933	379 – 399	Missing in isoform 2. 2 PublicationsAdd BLAST		21

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF017789 mRNA Translation: AAB80727.1 AB209910 mRNA Translation: BAD93147.1 Different initiation. BC111727 mRNA Translation: AAI11728.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4282.1 [O14776-1] CCDS43379.1 [O14776-2]
PIRⁱ	T08599
NCBI Reference Sequences More...RefSeqⁱ	NP_001035095.1, NM_001040006.1 [O14776-2] NP_006697.2, NM_006706.3 [O14776-1]
UniGeneⁱ	Hs.443465

Genome annotation databases

Ensemblⁱ	ENST00000296702; ENSP00000296702; ENSG00000113649 [O14776-1] ENST00000394421; ENSP00000377943; ENSG00000113649 [O14776-2]
GeneIDⁱ	10915
KEGGⁱ	hsa:10915
UCSC genome browser More...UCSCⁱ	uc003lob.4 human [O14776-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O14776	Transcription elongation regulator 1		PANTR		1098	UniRef100_O14776
Transcription elongation regulator 1		GORGO		1098
O14776-2	Transcription elongation regulator 1		GORGO		1077	UniRef100_G3S484

Protein	Similar proteins		Species	Score	Length	Source
O14776	Transcription elongation regulator 1	)	MOUSE		1100	UniRef90_O14776
Transcription elongation regulator 1		PANTR		1098
Transcription elongation regulator 1		GORGO		1098
transcription elongation regulator 1 isoform X1		PHYCD		1131
transcription elongation regulator 1 isoform X3		BALAS		1103
+57
O14776-2	TCERG1 isoform 3		PANTR		1083	UniRef90_A0A2I3RCI5
Transcription elongation regulator 1 isoform 2 (Fragment)		MACMU		846
transcription elongation regulator 1 isoform X5		DIPOR		1091
transcription elongation regulator 1 isoform X5		ERIEU		1089
transcription elongation regulator 1 isoform X4		BALAS		1082
+54

Protein	Similar proteins		Species	Score	Length	Source
O14776	Transcription elongation regulator 1	)	MOUSE		1100	UniRef50_O14776
Transcription elongation regulator 1		PANTR		1098
Transcription elongation regulator 1		GORGO		1098
transcription elongation regulator 1 isoform X1		PHYCD		1131
transcription elongation regulator 1 isoform X1		ODORO		1103
+339
O14776-2	Uncharacterized protein		CHICK		987	UniRef50_A0A1D5NTY1
Transcription elongation regulator 1 (Fragment)		OPHHA		1023
transcription elongation regulator 1 isoform X3		ALLSI		1022
Uncharacterized protein (Fragment)		MICCO		1012
Uncharacterized protein (Fragment)		Micrurus paraensis		897
+520

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF017789 mRNA Translation: AAB80727.1 AB209910 mRNA Translation: BAD93147.1 Different initiation. BC111727 mRNA Translation: AAI11728.1
CCDSⁱ	CCDS4282.1 [O14776-1] CCDS43379.1 [O14776-2]
PIRⁱ	T08599
RefSeqⁱ	NP_001035095.1, NM_001040006.1 [O14776-2] NP_006697.2, NM_006706.3 [O14776-1]
UniGeneⁱ	Hs.443465

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2DK7	NMR	-	A	520-579	[»]
	2DOD	NMR	-	A	651-719	[»]
	2DOE	NMR	-	A	784-853	[»]
	2DOF	NMR	-	A	888-959	[»]
	2E71	NMR	-	A	717-786	[»]
	2KIQ	NMR	-	A	724-782	[»]
	2KIS	NMR	-	A	659-724	[»]
	2MW9	NMR	-	A	428-464	[»]
	2MWA	NMR	-	A	428-464	[»]
	2MWB	NMR	-	A	428-464	[»]
	2MWD	NMR	-	A	433-460	[»]
	2MWE	NMR	-	A	433-460	[»]
	2MWF	NMR	-	A	433-464	[»]
	2N4R	NMR	-	A	428-464	[»]
	2N4S	NMR	-	A	428-464	[»]
	2N4T	NMR	-	A	428-464	[»]
	2N4U	NMR	-	A	428-464	[»]
	2N4V	NMR	-	A	428-464	[»]
	2N4W	NMR	-	A	428-464	[»]
	2NNT	NMR	-	A/B/C/D	428-464	[»]
	3HFH	X-ray	2.70	A/B	661-845	[»]
	3Q1I	X-ray	1.40	E	99-107	[»]
	4FQG	X-ray	2.00	A/B	895-1081	[»]
ProteinModelPortalⁱ	O14776
SMRⁱ	O14776
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	116120, 84 interactors
CORUMⁱ	O14776
DIPⁱ	DIP-32504N
IntActⁱ	O14776, 19 interactors
MINTⁱ	O14776
STRINGⁱ	9606.ENSP00000296702

PTM databases

CarbonylDBⁱ	O14776
iPTMnetⁱ	O14776
PhosphoSitePlusⁱ	O14776
SwissPalmⁱ	O14776

Polymorphism and mutation databases

BioMutaⁱ	TCERG1

BioMutaⁱ

TCERG1

Proteomic databases

EPDⁱ	O14776
MaxQBⁱ	O14776
PaxDbⁱ	O14776
PeptideAtlasⁱ	O14776
PRIDEⁱ	O14776
ProteomicsDBⁱ	48229 48230 [O14776-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000296702; ENSP00000296702; ENSG00000113649 [O14776-1] ENST00000394421; ENSP00000377943; ENSG00000113649 [O14776-2]
GeneIDⁱ	10915
KEGGⁱ	hsa:10915
UCSCⁱ	uc003lob.4 human [O14776-1]

Organism-specific databases

CTDⁱ	10915
DisGeNETⁱ	10915
EuPathDBⁱ	HostDB:ENSG00000113649.11
GeneCardsⁱ	TCERG1
HGNCⁱ	HGNC:15630 TCERG1
HPAⁱ	HPA064854 HPA069752 HPA069808
MIMⁱ	605409 gene
neXtProtⁱ	NX_O14776
OpenTargetsⁱ	ENSG00000113649
PharmGKBⁱ	PA38007
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0155 Eukaryota ENOG410XPZW LUCA
GeneTreeⁱ	ENSGT00930000150983
HOGENOMⁱ	HOG000008544
HOVERGENⁱ	HBG062908
InParanoidⁱ	O14776
KOⁱ	K12824
OMAⁱ	NPRTTFS
OrthoDBⁱ	EOG091G0I5O
PhylomeDBⁱ	O14776
TreeFamⁱ	TF317748

Enzyme and pathway databases

SignaLinkⁱ	O14776

SignaLinkⁱ

O14776

Miscellaneous databases

ChiTaRSⁱ	TCERG1 human
EvolutionaryTraceⁱ	O14776
GeneWikiⁱ	Transcription_elongation_regulator_1
GenomeRNAiⁱ	10915
Protein Ontology More...PROⁱ	PR:O14776
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000113649 Expressed in 171 organ(s), highest expression level in intestine
CleanExⁱ	HS_TCERG1
ExpressionAtlasⁱ	O14776 baseline and differential
Genevisibleⁱ	O14776 HS

Family and domain databases

CDDⁱ	cd00201 WW, 3 hits
Gene3Dⁱ	1.10.10.440, 6 hits
InterProⁱ	View protein in InterPro IPR002713 FF_domain IPR036517 FF_domain_sf IPR001202 WW_dom IPR036020 WW_dom_sf
Pfamⁱ	View protein in Pfam PF01846 FF, 6 hits PF00397 WW, 2 hits
SMARTⁱ	View protein in SMART SM00441 FF, 6 hits SM00456 WW, 3 hits
SUPFAMⁱ	SSF51045 SSF51045, 3 hits SSF81698 SSF81698, 5 hits
PROSITEⁱ	View protein in PROSITE PS51676 FF, 6 hits PS01159 WW_DOMAIN_1, 1 hit PS50020 WW_DOMAIN_2, 3 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TCRG1_HUMAN
Accessionⁱ	O14776Primary (citable) accession number: O14776 Secondary accession number(s): Q2NKN2, Q59EA1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 27, 2004
	Last sequence update:	July 24, 2007
	Last modified:	November 7, 2018
	This is version 169 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM

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UniProtKB - O14776 (TCRG1_HUMAN)

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Transcription elongation regulator 1

TCERG1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

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<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

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Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

Motif

Compositional bias

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

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Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ