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Protein

Fucose-1-phosphate guanylyltransferase

Gene

FPGT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the formation of GDP-L-fucose from GTP and L-fucose-1-phosphate. Functions as a salvage pathway to reutilize L-fucose arising from the turnover of glycoproteins and glycolipids.

Catalytic activityi

GTP + beta-L-fucose 1-phosphate = diphosphate + GDP-L-fucose.

GO - Molecular functioni

  • catalytic activity Source: ProtInc
  • fucose-1-phosphate guanylyltransferase activity Source: Reactome
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.7.30 2681
ReactomeiR-HSA-6787639 GDP-fucose biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Fucose-1-phosphate guanylyltransferase (EC:2.7.7.30)
Alternative name(s):
GDP-L-fucose diphosphorylase
GDP-L-fucose pyrophosphorylase
Gene namesi
Name:FPGT
Synonyms:GFPP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000254685.6
HGNCiHGNC:3825 FPGT
MIMi603609 gene
neXtProtiNX_O14772

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi8790
OpenTargetsiENSG00000254685
PharmGKBiPA28243

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000873271 – 607Fucose-1-phosphate guanylyltransferaseAdd BLAST607

Proteomic databases

EPDiO14772
PaxDbiO14772
PeptideAtlasiO14772
PRIDEiO14772
ProteomicsDBi48223

PTM databases

iPTMnetiO14772
PhosphoSitePlusiO14772

Expressioni

Tissue specificityi

Expressed in many tissues.

Gene expression databases

BgeeiENSG00000254685 Expressed in 197 organ(s), highest expression level in sigmoid colon
CleanExiHS_FPGT
ExpressionAtlasiO14772 baseline and differential
GenevisibleiO14772 HS

Organism-specific databases

HPAiHPA072331

Interactioni

Protein-protein interaction databases

BioGridi114318, 1 interactor
STRINGi9606.ENSP00000359935

Structurei

3D structure databases

ProteinModelPortaliO14772
SMRiO14772
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IE28 Eukaryota
ENOG410XT7S LUCA
GeneTreeiENSGT00780000122095
HOGENOMiHOG000067964
HOVERGENiHBG025123
InParanoidiO14772
KOiK00976
OMAiDMIAYRE
PhylomeDBiO14772
TreeFamiTF328750

Family and domain databases

InterProiView protein in InterPro
IPR012887 Fucokinase
IPR012120 Fucose-1-phosphate_GuaTrfase
IPR011004 Trimer_LpxA-like_sf
PfamiView protein in Pfam
PF07959 Fucokinase, 1 hit
PIRSFiPIRSF036640 FPGT, 1 hit
SUPFAMiSSF51161 SSF51161, 1 hit

Sequences (6+)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 2 (identifier: O14772-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRAVRRGLRE GGAMAAARDP PEVSLREATQ RKLRRFSELR GKLVARGEFW
60 70 80 90 100
DIVAITAADE KQELAYNQQL SEKLKRKELP LGVQYHVFVD PAGAKIGNGG
110 120 130 140 150
STLCALQCLE KLYGDKWNSF TILLIHSGGY SQRLPNASAL GKIFTALPLG
160 170 180 190 200
NPIYQMLELK LAMYIDFPLN MNPGILVTCA DDIELYSIGE FEFIRFDKPG
210 220 230 240 250
FTALAHPSSL TIGTTHGVFV LDPFDDLKHR DLEYRSCHRF LHKPSIEKMY
260 270 280 290 300
QFNAVCRPGN FCQQDFAGGD IADLKLDSDY VYTDSLFYMD HKSAKMLLAF
310 320 330 340 350
YEKIGTLSCE IDAYGDFLQA LGPGATVEYT RNTSNVIKEE SELVEMRQRI
360 370 380 390 400
FHLLKGTSLN VVVLNNSKFY HIGTTEEYLF YFTSDNSLKS ELGLQSITFS
410 420 430 440 450
IFPDIPECSG KTSCIIQSIL DSRCSVAPGS VVEYSRLGPD VSVGENCIIS
460 470 480 490 500
GSYILTKAAL PAHSFVCSLS LKMNRCLKYA TMAFGVQDNL KKSVKTLSDI
510 520 530 540 550
KLLQFFGVCF LSCLDVWNLK VTEELFSGNK TCLSLWTARI FPVCSSLSDS
560 570 580 590 600
VITSLKMLNA VKNKSAFSLN SYKLLSIEEM LIYKDVEDMI TYREQIFLEI

SLKSSLM
Length:607
Mass (Da):68,010
Last modified:April 25, 2018 - v3
Checksum:i5175BB73A69255F1
GO
Isoform 1 (identifier: Q59H18-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q59H18.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Based on a naturally occurring readthrough transcript which produces a FPGT-TNNI3K fusion protein.
Length:936
Mass (Da):104,179
GO
Isoform 3 (identifier: Q59H18-3) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q59H18.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Based on a naturally occurring readthrough transcript which produces a FPGT-TNNI3K fusion protein.
Length:697
Mass (Da):77,957
GO
Isoform 4 (identifier: Q59H18-4) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q59H18.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Based on a naturally occurring readthrough transcript which produces a FPGT-TNNI3K fusion protein.
Length:843
Mass (Da):94,517
GO
Isoform 5 (identifier: O14772-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: Missing.
     150-403: Missing.

Note: No experimental confirmation available.
Show »
Length:340
Mass (Da):37,631
Checksum:i804504F161653FD2
GO
Isoform 6 (identifier: O14772-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: Missing.
     128-607: GGYSQRLPNA...LEISLKSSLM → VSFQIYQNAL...KTALLVVLTS

Note: No experimental confirmation available.
Show »
Length:169
Mass (Da):19,170
Checksum:iE8D68424A3C4D277
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YDF0H0YDF0_HUMAN
Fucose-1-phosphate guanylyltransfer...
FPGT
174Annotation score:
E9PK10E9PK10_HUMAN
Fucose-1-phosphate guanylyltransfer...
FPGT
101Annotation score:
E9PMK0E9PMK0_HUMAN
Fucose-1-phosphate guanylyltransfer...
FPGT
128Annotation score:
E9PMM4E9PMM4_HUMAN
Fucose-1-phosphate guanylyltransfer...
FPGT
137Annotation score:

Sequence cautioni

The sequence AAC73005 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAC82511 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAH32308 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAG65299 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti57A → T in BAG61434 (PubMed:14702039).Curated1
Sequence conflicti335N → H in AAC73005 (PubMed:9804772).Curated1
Sequence conflicti562K → R in BAG61434 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061650461P → L. Corresponds to variant dbSNP:rs55882158Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0595411 – 13Missing in isoform 5 and isoform 6. CuratedAdd BLAST13
Alternative sequenceiVSP_059542128 – 607GGYSQ…KSSLM → VSFQIYQNALAKHPVSFKAY WIQDVLWHLAQLWSIPDWGL MFQLGKTALLVVLTS in isoform 6. CuratedAdd BLAST480
Alternative sequenceiVSP_059543150 – 403Missing in isoform 5. CuratedAdd BLAST254

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017445 mRNA Translation: AAC73005.1 Different initiation.
AF017446 Genomic DNA Translation: AAC82511.1 Sequence problems.
AK299468 mRNA Translation: BAG61434.1
AK304490 mRNA Translation: BAG65299.1 Sequence problems.
AC098692 Genomic DNA No translation available.
BC032308 mRNA Translation: AAH32308.1 Different initiation.
CCDSiCCDS663.2 [O14772-1]
RefSeqiNP_001186257.2, NM_001199328.2
NP_001186258.2, NM_001199329.2
NP_003829.3, NM_003838.4 [O14772-1]
UniGeneiHs.480085

Genome annotation databases

EnsembliENST00000370894; ENSP00000359931; ENSG00000254685 [O14772-3]
ENST00000370898; ENSP00000359935; ENSG00000254685 [O14772-1]
ENST00000534056; ENSP00000432819; ENSG00000254685 [O14772-2]
GeneIDi8790
KEGGihsa:8790
UCSCiuc057hpq.1 human [O14772-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017445 mRNA Translation: AAC73005.1 Different initiation.
AF017446 Genomic DNA Translation: AAC82511.1 Sequence problems.
AK299468 mRNA Translation: BAG61434.1
AK304490 mRNA Translation: BAG65299.1 Sequence problems.
AC098692 Genomic DNA No translation available.
BC032308 mRNA Translation: AAH32308.1 Different initiation.
CCDSiCCDS663.2 [O14772-1]
RefSeqiNP_001186257.2, NM_001199328.2
NP_001186258.2, NM_001199329.2
NP_003829.3, NM_003838.4 [O14772-1]
UniGeneiHs.480085

3D structure databases

ProteinModelPortaliO14772
SMRiO14772
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114318, 1 interactor
STRINGi9606.ENSP00000359935

PTM databases

iPTMnetiO14772
PhosphoSitePlusiO14772

Proteomic databases

EPDiO14772
PaxDbiO14772
PeptideAtlasiO14772
PRIDEiO14772
ProteomicsDBi48223

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370894; ENSP00000359931; ENSG00000254685 [O14772-3]
ENST00000370898; ENSP00000359935; ENSG00000254685 [O14772-1]
ENST00000534056; ENSP00000432819; ENSG00000254685 [O14772-2]
GeneIDi8790
KEGGihsa:8790
UCSCiuc057hpq.1 human [O14772-1]

Organism-specific databases

CTDi8790
DisGeNETi8790
EuPathDBiHostDB:ENSG00000254685.6
GeneCardsiFPGT
HGNCiHGNC:3825 FPGT
HPAiHPA072331
MIMi603609 gene
neXtProtiNX_O14772
OpenTargetsiENSG00000254685
PharmGKBiPA28243
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE28 Eukaryota
ENOG410XT7S LUCA
GeneTreeiENSGT00780000122095
HOGENOMiHOG000067964
HOVERGENiHBG025123
InParanoidiO14772
KOiK00976
OMAiDMIAYRE
PhylomeDBiO14772
TreeFamiTF328750

Enzyme and pathway databases

BRENDAi2.7.7.30 2681
ReactomeiR-HSA-6787639 GDP-fucose biosynthesis

Miscellaneous databases

GeneWikiiFPGT
GenomeRNAii8790
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000254685 Expressed in 197 organ(s), highest expression level in sigmoid colon
CleanExiHS_FPGT
ExpressionAtlasiO14772 baseline and differential
GenevisibleiO14772 HS

Family and domain databases

InterProiView protein in InterPro
IPR012887 Fucokinase
IPR012120 Fucose-1-phosphate_GuaTrfase
IPR011004 Trimer_LpxA-like_sf
PfamiView protein in Pfam
PF07959 Fucokinase, 1 hit
PIRSFiPIRSF036640 FPGT, 1 hit
SUPFAMiSSF51161 SSF51161, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFPGT_HUMAN
AccessioniPrimary (citable) accession number: O14772
Secondary accession number(s): A0A0A0MRP2
, A6NMH3, B4DRX2, B4E2Y7, E9PNQ2, Q8N5J7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: April 25, 2018
Last modified: November 7, 2018
This is version 137 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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