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Protein

Zinc finger protein 213

Gene

ZNF213

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri317 – 339C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri345 – 367C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri373 – 395C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri401 – 423C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri429 – 451C2H2-type 5PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 213
Alternative name(s):
Putative transcription factor CR53
Zinc finger protein with KRAB and SCAN domains 21
Gene namesi
Name:ZNF213
Synonyms:ZKSCAN21
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000085644.13
HGNCiHGNC:13005 ZNF213
MIMi608387 gene
neXtProtiNX_O14771

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000085644
PharmGKBiPA37584

Polymorphism and mutation databases

BioMutaiZNF213

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474571 – 459Zinc finger protein 213Add BLAST459

Proteomic databases

EPDiO14771
PaxDbiO14771
PeptideAtlasiO14771
PRIDEiO14771
ProteomicsDBi48222

PTM databases

iPTMnetiO14771
PhosphoSitePlusiO14771

Expressioni

Tissue specificityi

Widely expressed with highest levels in testis.1 Publication

Gene expression databases

BgeeiENSG00000085644 Expressed in 193 organ(s), highest expression level in sperm
CleanExiHS_ZNF213
ExpressionAtlasiO14771 baseline and differential
GenevisibleiO14771 HS

Organism-specific databases

HPAiHPA035000
HPA056750

Interactioni

Protein-protein interaction databases

BioGridi113543, 18 interactors
IntActiO14771, 7 interactors
STRINGi9606.ENSP00000380087

Structurei

3D structure databases

ProteinModelPortaliO14771
SMRiO14771
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini45 – 126SCAN boxPROSITE-ProRule annotationAdd BLAST82
Domaini202 – 292KRABPROSITE-ProRule annotationAdd BLAST91

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri317 – 339C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri345 – 367C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri373 – 395C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri401 – 423C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri429 – 451C2H2-type 5PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144000
HOGENOMiHOG000234619
HOVERGENiHBG018163
InParanoidiO14771
KOiK09229
OMAiWESENRP
OrthoDBiEOG091G09O3
PhylomeDBiO14771
TreeFamiTF350828

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
cd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF02023 SCAN, 1 hit
PF00096 zf-C2H2, 5 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O14771-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAPLEAQDQ APGEGEGLLI VKVEDSSWEQ ESAQHEDGRD SEACRQRFRQ
60 70 80 90 100
FCYGDVHGPH EAFSQLWELC CRWLRPELRT KEQILELLVL EQFLTVLPGE
110 120 130 140 150
IQGWVREQHP GSGEEAVALV EDLQKQPVKA WRQDVPSEEA EPEAAGRGSQ
160 170 180 190 200
ATGPPPTVGA RRRPSVPQEQ HSHSAQPPAL LKEGRPGETT DTCFVSGVHG
210 220 230 240 250
PVALGDIPFY FSREEWGTLD PAQRDLFWDI KRENSRNTTL GFGLKGQSEK
260 270 280 290 300
SLLQEMVPVV PGQTGSDVTV SWSPEEAEAW ESENRPRAAL GPVVGARRGR
310 320 330 340 350
PPTRRRQFRD LAAEKPHSCG QCGKRFRWGS DLARHQRTHT GEKPHKCPEC
360 370 380 390 400
DKSFRSSSDL VRHQGVHTGE KPFSCSECGK SFSRSAYLAD HQRIHTGEKP
410 420 430 440 450
FGCSDCGKSF SLRSYLLDHR RVHTGERPFG CGECDKSFKQ RAHLIAHQSL

HAKMAQPVG
Length:459
Mass (Da):51,263
Last modified:April 30, 2003 - v2
Checksum:i062F64A205533541
GO
Isoform 2 (identifier: O14771-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-41: MAAPLEAQDQ...SAQHEDGRDS → MCPRRRRNPR...LFPRSSTAIA
     42-199: Missing.

Note: No experimental confirmation available.
Show »
Length:301
Mass (Da):33,828
Checksum:i5E242674FE09451A
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L473I3L473_HUMAN
Zinc finger protein 213, isoform CR...
ZNF213 hCG_2039168
145Annotation score:
I3L1Z4I3L1Z4_HUMAN
Zinc finger protein 213
ZNF213
182Annotation score:
I3L216I3L216_HUMAN
Zinc finger protein 213
ZNF213
270Annotation score:
I3L2V8I3L2V8_HUMAN
Zinc finger protein 213
ZNF213
51Annotation score:

Sequence cautioni

The sequence AAB70531 differs from that shown. Reason: Frameshift at positions 400, 405 and 457.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti407G → A in AAB70531 (PubMed:10023065).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0559421 – 41MAAPL…DGRDS → MCPRRRRNPRLQAGDPRPRG LPRRWGHGGGRLFPRSSTAI A in isoform 2. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_05594342 – 199Missing in isoform 2. 1 PublicationAdd BLAST158

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017433 mRNA Translation: AAB70531.1 Frameshift.
AK289834 mRNA Translation: BAF82523.1
AK291789 mRNA Translation: BAF84478.1
AK297454 mRNA Translation: BAG59878.1
AC108134 Genomic DNA No translation available.
CH471112 Genomic DNA Translation: EAW85394.1
BC007287 mRNA Translation: AAH07287.1
CCDSiCCDS10495.1 [O14771-1]
RefSeqiNP_001128127.1, NM_001134655.1 [O14771-1]
NP_004211.1, NM_004220.2 [O14771-1]
UniGeneiHs.115284

Genome annotation databases

EnsembliENST00000396878; ENSP00000380087; ENSG00000085644 [O14771-1]
ENST00000416391; ENSP00000403892; ENSG00000085644 [O14771-1]
ENST00000574902; ENSP00000460157; ENSG00000085644 [O14771-1]
ENST00000576416; ENSP00000459177; ENSG00000085644 [O14771-1]
GeneIDi7760
KEGGihsa:7760
UCSCiuc010bth.4 human [O14771-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017433 mRNA Translation: AAB70531.1 Frameshift.
AK289834 mRNA Translation: BAF82523.1
AK291789 mRNA Translation: BAF84478.1
AK297454 mRNA Translation: BAG59878.1
AC108134 Genomic DNA No translation available.
CH471112 Genomic DNA Translation: EAW85394.1
BC007287 mRNA Translation: AAH07287.1
CCDSiCCDS10495.1 [O14771-1]
RefSeqiNP_001128127.1, NM_001134655.1 [O14771-1]
NP_004211.1, NM_004220.2 [O14771-1]
UniGeneiHs.115284

3D structure databases

ProteinModelPortaliO14771
SMRiO14771
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113543, 18 interactors
IntActiO14771, 7 interactors
STRINGi9606.ENSP00000380087

PTM databases

iPTMnetiO14771
PhosphoSitePlusiO14771

Polymorphism and mutation databases

BioMutaiZNF213

Proteomic databases

EPDiO14771
PaxDbiO14771
PeptideAtlasiO14771
PRIDEiO14771
ProteomicsDBi48222

Protocols and materials databases

DNASUi7760
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000396878; ENSP00000380087; ENSG00000085644 [O14771-1]
ENST00000416391; ENSP00000403892; ENSG00000085644 [O14771-1]
ENST00000574902; ENSP00000460157; ENSG00000085644 [O14771-1]
ENST00000576416; ENSP00000459177; ENSG00000085644 [O14771-1]
GeneIDi7760
KEGGihsa:7760
UCSCiuc010bth.4 human [O14771-1]

Organism-specific databases

CTDi7760
EuPathDBiHostDB:ENSG00000085644.13
GeneCardsiZNF213
HGNCiHGNC:13005 ZNF213
HPAiHPA035000
HPA056750
MIMi608387 gene
neXtProtiNX_O14771
OpenTargetsiENSG00000085644
PharmGKBiPA37584
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144000
HOGENOMiHOG000234619
HOVERGENiHBG018163
InParanoidiO14771
KOiK09229
OMAiWESENRP
OrthoDBiEOG091G09O3
PhylomeDBiO14771
TreeFamiTF350828

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

GenomeRNAii7760
PROiPR:O14771
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000085644 Expressed in 193 organ(s), highest expression level in sperm
CleanExiHS_ZNF213
ExpressionAtlasiO14771 baseline and differential
GenevisibleiO14771 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
cd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF02023 SCAN, 1 hit
PF00096 zf-C2H2, 5 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN213_HUMAN
AccessioniPrimary (citable) accession number: O14771
Secondary accession number(s): A8K1B9, B4DMG6, Q96IS1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: April 30, 2003
Last modified: October 10, 2018
This is version 165 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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