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UniProtKB - O14770 (MEIS2_HUMAN)

Entry version 189 (25 May 2022)
Sequence version 2 (21 Feb 2001)
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Protein

Homeobox protein Meis2

Gene

MEIS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex. Isoform 3 is required for the activity of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element; MEIS2 is not involved in complex DNA-binding. Probably in complex with PBX1, is involved in transcriptional regulation by KLF4. Isoform 3 and isoform 4 can bind to a EPHA8 promoter sequence containing the DNA motif 5'-CGGTCA-3'; in cooperation with a PBX protein (such as PBX2) is proposed to be involved in the transcriptional activation of EPHA8 in the developing midbrain. May be involved in regulation of myeloid differentiation. Can bind to the DNA sequence 5'-TGACAG-3'in the activator ACT sequence of the D(1A) dopamine receptor (DRD1) promoter and activate DRD1 transcription; isoform 5 cannot activate DRD1 transcription.

3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi276 – 338Homeobox; TALE-typePROSITE-ProRule annotationAdd BLAST63

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O14770

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		O14770

SIGNOR Signaling Network Open Resource

More...SIGNORi		O14770

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Homeobox protein Meis2
Alternative name(s):
Meis1-related protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MEIS2
Synonyms:MRG1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:7001, MEIS2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		601740, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O14770

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000134138

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Cleft palate, cardiac defects, and mental retardation (CPCMR)3 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant disease characterized by multiple congenital malformations, mild-to-severe intellectual disability with poor speech, and delayed psychomotor development. Congenital malformations include heart defects, cleft lip/palate, distally-placed thumbs and toes, and cutaneous syndactyly between the second and third toes.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_078978204 – 477Missing in CPCMR. 1 PublicationAdd BLAST274
Natural variantiVAR_078979333Missing in CPCMR. 1 Publication1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi85L → A: Impairs interaction with PBX1; when associated with A-88. 1 Publication1
Mutagenesisi88L → A: Impairs interaction with PBX1; when associated with A-85. HELIX 285 297. 1 Publication1
Mutagenesisi94 – 97EKCE → NNGT: Impairs interaction with PBX1. 1 Publication4
Mutagenesisi151I → A: Impairs interaction with PBX1; when associated with A-154. 1 Publication1
Mutagenesisi154L → A: Impairs interaction with PBX1; when associated with A-151. 1 Publication1
Mutagenesisi158 – 159LL → AA: Impairs interaction with PBX1; when associated with A-161. 1 Publication2
Mutagenesisi161L → A: Impairs interaction with PBX1; when associated with 158-A-A-159. 1 Publication1
Mutagenesisi332R → M: Impairs DNA binding and PBX1-dependent transcriptional activation. No effect on interaction with PBX1. 2 Publications1

Keywords - Diseasei

Disease variant, Mental retardation

Organism-specific databases

DisGeNET

More...DisGeNETi		4212

MalaCards human disease database

More...MalaCardsi		MEIS2
MIMi600987, phenotype

Open Targets

More...OpenTargetsi		ENSG00000134138

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		261190, 15q14 microdeletion syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30741

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O14770, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MEIS2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000491081 – 477Homeobox protein Meis2Add BLAST477

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O14770

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O14770

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O14770

MaxQB - The MaxQuant DataBase

More...MaxQBi		O14770

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O14770

PeptideAtlas

More...PeptideAtlasi		O14770

PRoteomics IDEntifications database

More...PRIDEi		O14770

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		48214 [O14770-1]
48215 [O14770-2]
48216 [O14770-3]
48217 [O14770-4]
48218 [O14770-5]
48219 [O14770-6]
48220 [O14770-7]
48221 [O14770-8]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		O14770, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O14770

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O14770

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in various tissues. Expressed at high level in the lymphoid organs of hematopoietic tissues. Also expressed in some regions of the brain, such as the putamen.

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in the proliferative zones of the fetal neocortex. Expressed at a very high level in the developing ganglionic eminence and at a more moderate level in the cortical plate.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000134138, Expressed in forebrain and 234 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O14770, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O14770, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000134138, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer and homodimer (PubMed:26550823). Heterodimer with HOXB13 (Ref. 16).

Isoform 2 interacts with TLX1.

Isoform 3 interacts with HOXA13 and PBX1 isoform PBX1b.

Isoform 4 interacts with SP1, SP3 and KLF4. Isoform 4 and isoform 5 interact with PBX1 isoform PBX1a; the interaction partially relieves MEIS2 autoinhibition. Isoform 3 also known as MEIS2b is part of a PDX1:PBX1b:Meis2B complex; Meis2B is recruited by PBX1b and can be replaced by isoform 4 in a small fraction of complexes. Can form trimeric complexes including HOXB8 and PBX2 or PBX3.

5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
O14770
With#Exp.IntAct
ANXA1 [Q5TZZ9]3EBI-2804934,EBI-10181435
C1orf94 [Q6P1W5]3EBI-2804934,EBI-946029
CCDC196 [A0A1B0GWI1]3EBI-2804934,EBI-10181422
OSGIN1 [Q9UJX0]4EBI-2804934,EBI-9057006
gag-pro-pol [P03363] from Human T-cell leukemia virus 2.3EBI-2804934,EBI-9676133
Isoform 2 [O14770-2]
With#Exp.IntAct
TLX1 [P31314]4EBI-6390216,EBI-2820655
Isoform 4 [O14770-4]
With#Exp.IntAct
ADRA2C [P18825]3EBI-8025850,EBI-12015266
ANTKMT [Q9BQD7]3EBI-8025850,EBI-713602
BPIFA1 [Q9NP55]3EBI-8025850,EBI-953896
CARTPT [Q16568]3EBI-8025850,EBI-4314526
CCDC196 [A0A1B0GWI1]3EBI-8025850,EBI-10181422
CTAG1B [P78358]3EBI-8025850,EBI-1188472
FAM136A [Q96C01]3EBI-8025850,EBI-373319
FAM168A - isoform 2 [Q92567-2]3EBI-8025850,EBI-11978259
IGFBP6 [P24592]3EBI-8025850,EBI-947015
ITGB3BP [Q13352]3EBI-8025850,EBI-712105
KRTAP10-8 [P60410]3EBI-8025850,EBI-10171774
KRTAP11-1 [Q8IUC1]3EBI-8025850,EBI-1052037
KRTAP19-2 [Q3LHN2]5EBI-8025850,EBI-12196745
KRTAP19-6 [Q3LI70]3EBI-8025850,EBI-12805508
KRTAP6-1 [Q3LI64]3EBI-8025850,EBI-12111050
KRTAP6-2 [Q3LI66]5EBI-8025850,EBI-11962084
MCCD1 [P59942]3EBI-8025850,EBI-11987923
NDUFB7 [P17568]3EBI-8025850,EBI-1246238
NOTO [A8MTQ0]3EBI-8025850,EBI-17490746
NUP58 [Q9BVL2]3EBI-8025850,EBI-2811583
OIP5 [O43482]3EBI-8025850,EBI-536879
PBX1 [P40424]9EBI-8025850,EBI-301611
PBX4 [Q9BYU1]6EBI-8025850,EBI-10302990
POU2AF1 [Q16633]3EBI-8025850,EBI-943588
POU6F2 [P78424]3EBI-8025850,EBI-12029004
PTK6 [Q13882]3EBI-8025850,EBI-1383632
RUSC1 [Q9BVN2]3EBI-8025850,EBI-6257312
SCT [P09683]3EBI-8025850,EBI-12844598
SMRP1 [Q8NCR6]3EBI-8025850,EBI-10269322
TBX2 [Q13207]3EBI-8025850,EBI-2853051
TIMM10B [Q9Y5J6]3EBI-8025850,EBI-1200382
TRIM42 [Q8IWZ5]3EBI-8025850,EBI-5235829
VGLL1 [Q99990]3EBI-8025850,EBI-11983165
Isoform 7 [O14770-7]
With#Exp.IntAct
PMP22 [D3DTS7]3EBI-25848073,EBI-25882629

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		110376, 84 interactors

Database of interacting proteins

More...DIPi		DIP-61027N

Protein interaction database and analysis system

More...IntActi		O14770, 63 interactors

Molecular INTeraction database

More...MINTi		O14770

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000453793

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O14770, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1477
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		O14770

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O14770

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		O14770

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni71 – 191Required for interaction with PBX1By similarityAdd BLAST121
Regioni193 – 283DisorderedSequence analysisAdd BLAST91
Regioni299 – 333Interaction with DNA2 PublicationsAdd BLAST35
Regioni340 – 477Transcriptional activation domainAdd BLAST138

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi227 – 258Polar residuesSequence analysisAdd BLAST32

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TALE/MEIS homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0773, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155643

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_023139_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O14770

Identification of Orthologs from Complete Genome Data

More...OMAi		QIMDIHA

Database for complete collections of gene phylogenies

More...PhylomeDBi		O14770

TreeFam database of animal gene trees

More...TreeFami		TF318093

Family and domain databases

Conserved Domains Database

More...CDDi		cd00086, homeodomain, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR009057, Homeobox-like_sf
IPR001356, Homeobox_dom
IPR008422, Homeobox_KN_domain
IPR032453, PKNOX/Meis_N

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05920, Homeobox_KN, 1 hit
PF16493, Meis_PKNOX_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00389, HOX, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46689, SSF46689, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50071, HOMEOBOX_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (8+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 8 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 8 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O14770-1) [UniParc]FASTAAdd to basket
Also known as: Meis2C

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAQRYDELPH YGGMDGVGVP ASMYGDPHAP RPIPPVHHLN HGPPLHATQH 
        60         70         80         90        100
YGAHAPHPNV MPASMGSAVN DALKRDKDAI YGHPLFPLLA LVFEKCELAT 
       110        120        130        140        150
CTPREPGVAG GDVCSSDSFN EDIAVFAKQV RAEKPLFSSN PELDNLMIQA 
       160        170        180        190        200
IQVLRFHLLE LEKVHELCDN FCHRYISCLK GKMPIDLVID ERDGSSKSDH 
       210        220        230        240        250
EELSGSSTNL ADHNPSSWRD HDDATSTHSA GTPGPSSGGH ASQSGDNSSE 
       260        270        280        290        300
QGDGLDNSVA SPGTGDDDDP DKDKKRQKKR GIFPKVATNI MRAWLFQHLT 
       310        320        330        340        350
HPYPSEEQKK QLAQDTGLTI LQVNNWFINA RRRIVQPMID QSNRAGFLLD 
       360        370        380        390        400
PSVSQGAAYS PEGQPMGSFV LDGQQHMGIR PAGLQSMPGD YVSQGGPMGM 
       410        420        430        440        450
SMAQPSYTPP QMTPHPTQLR HGPPMHSYLP SHPHHPAMMM HGGPPTHPGM 
       460        470 
TMSAQSPTML NSVDPNVGGQ VMDIHAQ
Length:477
Mass (Da):51,790
Last modified:February 21, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i94EBD0801A312B24
GO
Isoform 2 (identifier: O14770-2) [UniParc]FASTAAdd to basket
Also known as: Meis2A

The sequence of this isoform differs from the canonical sequence as follows:
     384-401: LQSMPGDYVSQGGPMGMS → PMSGMGMNMGMDGQWHYM
     402-477: Missing.

Show »
Length:401
Mass (Da):43,791
Checksum:i0682C0E92326516D
GO
Isoform 3 (identifier: O14770-3) [UniParc]FASTAAdd to basket
Also known as: Meis2B

The sequence of this isoform differs from the canonical sequence as follows:
     346-352: Missing.
     384-401: LQSMPGDYVSQGGPMGMS → PMSGMGMNMGMDGQWHYM
     402-477: Missing.

Show »
Length:394
Mass (Da):43,061
Checksum:i6BCC0382F0C55296
GO
Isoform 4 (identifier: O14770-4) [UniParc]FASTAAdd to basket
Also known as: Meis2D

The sequence of this isoform differs from the canonical sequence as follows:
     346-352: Missing.

Show »
Length:470
Mass (Da):51,060
Checksum:iC15C82B9F0098CB9
GO
Isoform 5 (identifier: O14770-5) [UniParc]FASTAAdd to basket
Also known as: Meis2E

The sequence of this isoform differs from the canonical sequence as follows:
     301-302: HP → VY
     303-477: Missing.

Show »
Length:302
Mass (Da):32,837
Checksum:i059D4D332A95FE5F
GO
Isoform 6 (identifier: O14770-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-89: MAQRYDELPH...IYGHPLFPLL → M
     346-352: Missing.
     384-401: LQSMPGDYVSQGGPMGMS → PMSGMGMNMGMDGQWHYM
     402-477: Missing.

Show »
Length:306
Mass (Da):33,598
Checksum:i4DF1350FB0F28AF1
GO
Isoform 7 (identifier: O14770-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: Missing.
     346-352: Missing.
     384-401: LQSMPGDYVSQGGPMGMS → PMSGMGMNMGMDGQWHYM
     402-477: Missing.

Show »
Length:381
Mass (Da):41,542
Checksum:i4F6D947B1EDA0528
GO
Isoform 8 (identifier: O14770-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: Missing.
     384-401: LQSMPGDYVSQGGPMGMS → PMSGMGMNMGMDGQWHYM
     402-477: Missing.

Show »
Length:388
Mass (Da):42,272
Checksum:iE9F5455311C5BC69
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
U3KQI2U3KQI2_HUMAN
Homeobox protein Meis2
MEIS2
235Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YKN2H0YKN2_HUMAN
Homeobox protein Meis2
MEIS2
105Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YMX5H0YMX5_HUMAN
Homeobox protein Meis2
MEIS2
157Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
U3KQ95U3KQ95_HUMAN
Homeobox protein Meis2
MEIS2
139Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YKE5H0YKE5_HUMAN
Homeobox protein Meis2
MEIS2
94Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YM65H0YM65_HUMAN
Homeobox protein Meis2
MEIS2
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_078978204 – 477Missing in CPCMR. 1 PublicationAdd BLAST274
Natural variantiVAR_078979333Missing in CPCMR. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0432191 – 89MAQRY…LFPLL → M in isoform 6. 1 PublicationAdd BLAST89
Alternative sequenceiVSP_0434941 – 13Missing in isoform 7 and isoform 8. 2 PublicationsAdd BLAST13
Alternative sequenceiVSP_002243301 – 302HP → VY in isoform 5. 1 Publication2
Alternative sequenceiVSP_002244303 – 477Missing in isoform 5. 1 PublicationAdd BLAST175
Alternative sequenceiVSP_002242346 – 352Missing in isoform 3, isoform 4, isoform 6 and isoform 7. 4 Publications7
Alternative sequenceiVSP_002245384 – 401LQSMP…PMGMS → PMSGMGMNMGMDGQWHYM in isoform 2, isoform 3, isoform 6, isoform 7 and isoform 8. 4 PublicationsAdd BLAST18
Alternative sequenceiVSP_002246402 – 477Missing in isoform 2, isoform 3, isoform 6, isoform 7 and isoform 8. 4 PublicationsAdd BLAST76

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF178948 mRNA Translation: AAF81638.1
AF179896 mRNA Translation: AAF81639.1
AF179897 mRNA Translation: AAF81640.1
AF179898 mRNA Translation: AAF81641.1
AF179899 mRNA Translation: AAF81642.1
AK056038 mRNA Translation: BAG51610.1
AK056620 mRNA Translation: BAG51768.1
AC018563 Genomic DNA No translation available.
AC069483 Genomic DNA No translation available.
AC078909 Genomic DNA No translation available.
CH471125 Genomic DNA Translation: EAW92353.1
CH471125 Genomic DNA Translation: EAW92354.1
CH471125 Genomic DNA Translation: EAW92356.1
BC001516 mRNA Translation: AAH01516.1
BC001844 mRNA Translation: AAH01844.3
BC007202 mRNA Translation: AAH07202.1
BC050431 mRNA Translation: AAH50431.1
AF017418 mRNA Translation: AAB70270.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS10044.1 [O14770-1]
CCDS10045.1 [O14770-4]
CCDS42014.1 [O14770-7]
CCDS45217.1 [O14770-2]
CCDS45218.1 [O14770-3]
CCDS45219.1 [O14770-8]
CCDS45220.1 [O14770-6]

NCBI Reference Sequences

More...RefSeqi		NP_001207411.1, NM_001220482.1 [O14770-4]
NP_002390.1, NM_002399.3 [O14770-7]
NP_733774.1, NM_170674.4 [O14770-3]
NP_733775.1, NM_170675.4 [O14770-1]
NP_733776.1, NM_170676.4 [O14770-4]
NP_733777.1, NM_170677.4 [O14770-2]
NP_758526.1, NM_172315.2 [O14770-8]
NP_758527.1, NM_172316.2 [O14770-6]
XP_016877694.1, XM_017022205.1 [O14770-6]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000314177.12; ENSP00000326296.8; ENSG00000134138.20 [O14770-5]
ENST00000338564.9; ENSP00000341400.4; ENSG00000134138.20 [O14770-4]
ENST00000340545.9; ENSP00000339549.5; ENSG00000134138.20 [O14770-7]
ENST00000397620.6; ENSP00000380745.2; ENSG00000134138.20 [O14770-6]
ENST00000397624.7; ENSP00000380749.3; ENSG00000134138.20 [O14770-6]
ENST00000424352.6; ENSP00000404185.2; ENSG00000134138.20 [O14770-2]
ENST00000557796.6; ENSP00000452693.2; ENSG00000134138.20 [O14770-7]
ENST00000559085.5; ENSP00000453390.1; ENSG00000134138.20 [O14770-8]
ENST00000559561.5; ENSP00000453497.1; ENSG00000134138.20 [O14770-3]
ENST00000561208.6; ENSP00000453793.1; ENSG00000134138.20

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4212

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:4212

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000561208.6; ENSP00000453793.1; NM_170675.5; NP_733775.1

UCSC genome browser

More...UCSCi		uc001zjl.4, human [O14770-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF178948 mRNA Translation: AAF81638.1
AF179896 mRNA Translation: AAF81639.1
AF179897 mRNA Translation: AAF81640.1
AF179898 mRNA Translation: AAF81641.1
AF179899 mRNA Translation: AAF81642.1
AK056038 mRNA Translation: BAG51610.1
AK056620 mRNA Translation: BAG51768.1
AC018563 Genomic DNA No translation available.
AC069483 Genomic DNA No translation available.
AC078909 Genomic DNA No translation available.
CH471125 Genomic DNA Translation: EAW92353.1
CH471125 Genomic DNA Translation: EAW92354.1
CH471125 Genomic DNA Translation: EAW92356.1
BC001516 mRNA Translation: AAH01516.1
BC001844 mRNA Translation: AAH01844.3
BC007202 mRNA Translation: AAH07202.1
BC050431 mRNA Translation: AAH50431.1
AF017418 mRNA Translation: AAB70270.1
CCDSiCCDS10044.1 [O14770-1]
CCDS10045.1 [O14770-4]
CCDS42014.1 [O14770-7]
CCDS45217.1 [O14770-2]
CCDS45218.1 [O14770-3]
CCDS45219.1 [O14770-8]
CCDS45220.1 [O14770-6]
RefSeqiNP_001207411.1, NM_001220482.1 [O14770-4]
NP_002390.1, NM_002399.3 [O14770-7]
NP_733774.1, NM_170674.4 [O14770-3]
NP_733775.1, NM_170675.4 [O14770-1]
NP_733776.1, NM_170676.4 [O14770-4]
NP_733777.1, NM_170677.4 [O14770-2]
NP_758526.1, NM_172315.2 [O14770-8]
NP_758527.1, NM_172316.2 [O14770-6]
XP_016877694.1, XM_017022205.1 [O14770-6]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3K2AX-ray1.95A/B281-345[»]
4XRMX-ray1.60A/B281-342[»]
5BNGX-ray3.50A/B283-342[»]
5EG0X-ray3.10A284-338[»]
AlphaFoldDBiO14770
SMRiO14770
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi110376, 84 interactors
DIPiDIP-61027N
IntActiO14770, 63 interactors
MINTiO14770
STRINGi9606.ENSP00000453793

PTM databases

GlyGeniO14770, 1 site, 1 O-linked glycan (1 site)
iPTMnetiO14770
PhosphoSitePlusiO14770

Genetic variation databases

BioMutaiMEIS2

Proteomic databases

EPDiO14770
jPOSTiO14770
MassIVEiO14770
MaxQBiO14770
PaxDbiO14770
PeptideAtlasiO14770
PRIDEiO14770
ProteomicsDBi48214 [O14770-1]
48215 [O14770-2]
48216 [O14770-3]
48217 [O14770-4]
48218 [O14770-5]
48219 [O14770-6]
48220 [O14770-7]
48221 [O14770-8]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		918, 304 antibodies from 36 providers

The DNASU plasmid repository

More...DNASUi		4212

Genome annotation databases

EnsembliENST00000314177.12; ENSP00000326296.8; ENSG00000134138.20 [O14770-5]
ENST00000338564.9; ENSP00000341400.4; ENSG00000134138.20 [O14770-4]
ENST00000340545.9; ENSP00000339549.5; ENSG00000134138.20 [O14770-7]
ENST00000397620.6; ENSP00000380745.2; ENSG00000134138.20 [O14770-6]
ENST00000397624.7; ENSP00000380749.3; ENSG00000134138.20 [O14770-6]
ENST00000424352.6; ENSP00000404185.2; ENSG00000134138.20 [O14770-2]
ENST00000557796.6; ENSP00000452693.2; ENSG00000134138.20 [O14770-7]
ENST00000559085.5; ENSP00000453390.1; ENSG00000134138.20 [O14770-8]
ENST00000559561.5; ENSP00000453497.1; ENSG00000134138.20 [O14770-3]
ENST00000561208.6; ENSP00000453793.1; ENSG00000134138.20
GeneIDi4212
KEGGihsa:4212
MANE-SelectiENST00000561208.6; ENSP00000453793.1; NM_170675.5; NP_733775.1
UCSCiuc001zjl.4, human [O14770-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4212
DisGeNETi4212

GeneCards: human genes, protein and diseases

More...GeneCardsi		MEIS2
HGNCiHGNC:7001, MEIS2
HPAiENSG00000134138, Low tissue specificity
MalaCardsiMEIS2
MIMi600987, phenotype
601740, gene
neXtProtiNX_O14770
OpenTargetsiENSG00000134138
Orphaneti261190, 15q14 microdeletion syndrome
PharmGKBiPA30741
VEuPathDBiHostDB:ENSG00000134138

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0773, Eukaryota
GeneTreeiENSGT00940000155643
HOGENOMiCLU_023139_0_0_1
InParanoidiO14770
OMAiQIMDIHA
PhylomeDBiO14770
TreeFamiTF318093

Enzyme and pathway databases

PathwayCommonsiO14770
SignaLinkiO14770
SIGNORiO14770

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		4212, 28 hits in 1106 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MEIS2, human
EvolutionaryTraceiO14770

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		MEIS2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		4212
PharosiO14770, Tbio

Protein Ontology

More...PROi		PR:O14770
RNActiO14770, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000134138, Expressed in forebrain and 234 other tissues
ExpressionAtlasiO14770, baseline and differential
GenevisibleiO14770, HS

Family and domain databases

CDDicd00086, homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057, Homeobox-like_sf
IPR001356, Homeobox_dom
IPR008422, Homeobox_KN_domain
IPR032453, PKNOX/Meis_N
PfamiView protein in Pfam
PF05920, Homeobox_KN, 1 hit
PF16493, Meis_PKNOX_N, 1 hit
SMARTiView protein in SMART
SM00389, HOX, 1 hit
SUPFAMiSSF46689, SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS50071, HOMEOBOX_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMEIS2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O14770
Secondary accession number(s): A6NJI5
, A8MWD5, B3KP98, B3KPQ6, Q96DI2, Q96KI4, Q96KI5, Q9NRS1, Q9NRS2, Q9NRS3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 21, 2001
Last modified: May 25, 2022
This is version 189 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
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