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Protein

17-beta-hydroxysteroid dehydrogenase type 6

Gene

HSD17B6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3-alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is first oxidized to 5-alpha-androstane-3,17-dione and then reduced to epi-andosterone. Can act on both C-19 and C-21 3-alpha-hydroxysteroids.3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

The kinetic parameters were determined using microsomes from transfected cells.
  1. KM=0.19 µM for NAD2 Publications
  2. KM=0.18 µM for NADH2 Publications
  3. KM=54 µM for NADPH2 Publications
  4. KM=940 µM for NADP2 Publications
  5. KM=3.2 µM for all-trans-retinol2 Publications
  6. KM=0.24 µM for allopregnanolone2 Publications
  7. KM=0.13 µM for 3-alpha-androstanediol2 Publications
  8. KM=0.23 µM for androsterone2 Publications
  9. KM=0.13 µM for dehydroepiandrosterone2 Publications
  1. Vmax=1.2 nmol/min/mg enzyme with all-trans-retinol2 Publications
  2. Vmax=14.7 nmol/min/mg enzyme with allopregnanolone2 Publications
  3. Vmax=16.5 nmol/min/mg enzyme with 3-alpha-androstanediol2 Publications
  4. Vmax=35 nmol/min/mg enzyme with androsterone2 Publications
  5. Vmax=0.90 nmol/min/mg enzyme with dehydroepiandrosterone2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei164SubstrateSequence analysis1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei176Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi33 – 57NADBy similarityAdd BLAST25

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • catalytic activity Source: ProtInc
  • electron transfer activity Source: UniProtKB
  • estradiol 17-beta-dehydrogenase activity Source: UniProtKB-EC
  • oxidoreductase activity Source: UniProtKB
  • retinol dehydrogenase activity Source: UniProtKB-EC
  • testosterone dehydrogenase (NAD+) activity Source: UniProtKB-EC

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Biological processLipid metabolism, Steroid metabolism
LigandNAD

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.1.1.62 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2453902 The canonical retinoid cycle in rods (twilight vision)

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
O14756

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000000807

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
17-beta-hydroxysteroid dehydrogenase type 6 (EC:1.1.1.105, EC:1.1.1.239, EC:1.1.1.62)
Short name:
17-beta-HSD 6
Short name:
17-beta-HSD6
Alternative name(s):
3-alpha->beta-hydroxysteroid epimerase
Short name:
3-alpha->beta-HSE
Oxidative 3-alpha hydroxysteroid dehydrogenase
Short chain dehydrogenase/reductase family 9C member 6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HSD17B6
Synonyms:RODH, SDR9C6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000025423.11

Human Gene Nomenclature Database

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HGNCi
HGNC:23316 HSD17B6

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606623 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O14756

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Endosome, Membrane, Microsome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
8630

Open Targets

More...
OpenTargetsi
ENSG00000025423

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142671671

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB00139 Succinic acid

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 17Sequence analysisAdd BLAST17
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000030321118 – 31717-beta-hydroxysteroid dehydrogenase type 6Add BLAST300

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi161N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi215N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi256N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O14756

PeptideAtlas

More...
PeptideAtlasi
O14756

PRoteomics IDEntifications database

More...
PRIDEi
O14756

ProteomicsDB human proteome resource

More...
ProteomicsDBi
48207

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O14756

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O14756

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in liver and prostate (at protein level). Detected in adult liver, lung, brain, placenta, prostate, adrenal gland, testis, mammary gland, spleen, spinal cord and uterus. Detected in caudate nucleus, and at lower levels in amygdala, corpus callosum, hippocampus, substantia nigra and thalamus. Detected in fetal lung, liver and brain.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000025423 Expressed in 164 organ(s), highest expression level in liver

CleanEx database of gene expression profiles

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CleanExi
HS_HSD17B6

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O14756 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O14756 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA059141

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114183, 13 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000318631

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O14756

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1610 Eukaryota
ENOG410Y7FK LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162028

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG005482

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O14756

KEGG Orthology (KO)

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KOi
K13369

Identification of Orthologs from Complete Genome Data

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OMAi
DVTKMES

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0LMI

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O14756

TreeFam database of animal gene trees

More...
TreeFami
TF325617

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00106 adh_short, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00081 GDHRDH
PR00080 SDRFAMILY

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51735 SSF51735, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00061 ADH_SHORT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O14756-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWLYLAAFVG LYYLLHWYRE RQVVSHLQDK YVFITGCDSG FGNLLARQLD
60 70 80 90 100
ARGLRVLAAC LTEKGAEQLR GQTSDRLETV TLDVTKMESI AAATQWVKEH
110 120 130 140 150
VGDRGLWGLV NNAGILTPIT LCEWLNTEDS MNMLKVNLIG VIQVTLSMLP
160 170 180 190 200
LVRRARGRIV NVSSILGRVA FFVGGYCVSK YGVEAFSDIL RREIQHFGVK
210 220 230 240 250
ISIVEPGYFR TGMTNMTQSL ERMKQSWKEA PKHIKETYGQ QYFDALYNIM
260 270 280 290 300
KEGLLNCSTN LNLVTDCMEH ALTSVHPRTR YSAGWDAKFF FIPLSYLPTS
310
LADYILTRSW PKPAQAV
Length:317
Mass (Da):35,966
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i46F1E940605CBEE9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V3Y9G3V3Y9_HUMAN
17-beta-hydroxysteroid dehydrogenas...
HSD17B6
88Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V508G3V508_HUMAN
17-beta-hydroxysteroid dehydrogenas...
HSD17B6
75Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB88252 differs from that shown. Reason: Frameshift at positions 158 and 174.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti63E → D in AAB88252 (PubMed:9188497).Curated1
Sequence conflicti105G → R in AAB88252 (PubMed:9188497).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U89281 mRNA Translation: AAB88252.1 Frameshift.
AF016509 mRNA Translation: AAB67236.1
AF223225 mRNA Translation: AAF81017.1
BC020710 mRNA Translation: AAH20710.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS8925.1

NCBI Reference Sequences

More...
RefSeqi
NP_003716.2, NM_003725.3
XP_005269264.1, XM_005269207.1
XP_005269265.1, XM_005269208.1
XP_005269266.1, XM_005269209.1
XP_006719735.1, XM_006719672.1
XP_011537227.1, XM_011538925.1
XP_011537228.1, XM_011538926.1
XP_011537229.1, XM_011538927.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.524513

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000322165; ENSP00000318631; ENSG00000025423
ENST00000554150; ENSP00000452273; ENSG00000025423
ENST00000554643; ENSP00000451406; ENSG00000025423
ENST00000555159; ENSP00000450698; ENSG00000025423
ENST00000555805; ENSP00000451753; ENSG00000025423

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8630

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:8630

UCSC genome browser

More...
UCSCi
uc001smg.3 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U89281 mRNA Translation: AAB88252.1 Frameshift.
AF016509 mRNA Translation: AAB67236.1
AF223225 mRNA Translation: AAF81017.1
BC020710 mRNA Translation: AAH20710.1
CCDSiCCDS8925.1
RefSeqiNP_003716.2, NM_003725.3
XP_005269264.1, XM_005269207.1
XP_005269265.1, XM_005269208.1
XP_005269266.1, XM_005269209.1
XP_006719735.1, XM_006719672.1
XP_011537227.1, XM_011538925.1
XP_011537228.1, XM_011538926.1
XP_011537229.1, XM_011538927.1
UniGeneiHs.524513

3D structure databases

ProteinModelPortaliO14756
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114183, 13 interactors
STRINGi9606.ENSP00000318631

Chemistry databases

DrugBankiDB00139 Succinic acid
SwissLipidsiSLP:000000807

PTM databases

iPTMnetiO14756
PhosphoSitePlusiO14756

Proteomic databases

PaxDbiO14756
PeptideAtlasiO14756
PRIDEiO14756
ProteomicsDBi48207

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
8630
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000322165; ENSP00000318631; ENSG00000025423
ENST00000554150; ENSP00000452273; ENSG00000025423
ENST00000554643; ENSP00000451406; ENSG00000025423
ENST00000555159; ENSP00000450698; ENSG00000025423
ENST00000555805; ENSP00000451753; ENSG00000025423
GeneIDi8630
KEGGihsa:8630
UCSCiuc001smg.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8630
DisGeNETi8630
EuPathDBiHostDB:ENSG00000025423.11

GeneCards: human genes, protein and diseases

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GeneCardsi
HSD17B6
HGNCiHGNC:23316 HSD17B6
HPAiHPA059141
MIMi606623 gene
neXtProtiNX_O14756
OpenTargetsiENSG00000025423
PharmGKBiPA142671671

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1610 Eukaryota
ENOG410Y7FK LUCA
GeneTreeiENSGT00940000162028
HOVERGENiHBG005482
InParanoidiO14756
KOiK13369
OMAiDVTKMES
OrthoDBiEOG091G0LMI
PhylomeDBiO14756
TreeFamiTF325617

Enzyme and pathway databases

BRENDAi1.1.1.62 2681
ReactomeiR-HSA-2453902 The canonical retinoid cycle in rods (twilight vision)
SABIO-RKiO14756

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
HSD17B6 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
HSD17B6

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
8630

Protein Ontology

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PROi
PR:O14756

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000025423 Expressed in 164 organ(s), highest expression level in liver
CleanExiHS_HSD17B6
ExpressionAtlasiO14756 baseline and differential
GenevisibleiO14756 HS

Family and domain databases

InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH17B6_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O14756
Secondary accession number(s): O43275
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: January 1, 1998
Last modified: December 5, 2018
This is version 163 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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