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Protein

Putative transcription factor Ovo-like 1

Gene

OVOL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Putative transcription factor. Involved in hair formation and spermatogenesis. May function in the differentiation and/or maintenance of the urogenital system (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri118 – 140C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri146 – 168C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri174 – 197C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri213 – 235C2H2-type 4PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Putative transcription factor Ovo-like 1
Short name:
hOvo1
Gene namesi
Name:OVOL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000172818.9
HGNCiHGNC:8525 OVOL1
MIMi602313 gene
neXtProtiNX_O14753

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi5017
OpenTargetsiENSG00000172818
PharmGKBiPA32853

Polymorphism and mutation databases

BioMutaiOVOL1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000470111 – 267Putative transcription factor Ovo-like 1Add BLAST267

Proteomic databases

EPDiO14753
MaxQBiO14753
PaxDbiO14753
PeptideAtlasiO14753
PRIDEiO14753
ProteomicsDBi48206

PTM databases

iPTMnetiO14753
PhosphoSitePlusiO14753

Expressioni

Tissue specificityi

Expressed in fetal kidney, and also in adult pancreas and placenta. Not expressed in intestine, peripheral blood lymphocytes and ovary.

Gene expression databases

BgeeiENSG00000172818 Expressed in 112 organ(s), highest expression level in ectocervix
CleanExiHS_OVOL1
ExpressionAtlasiO14753 baseline and differential
GenevisibleiO14753 HS

Organism-specific databases

HPAiHPA003984

Interactioni

Protein-protein interaction databases

BioGridi111057, 5 interactors
IntActiO14753, 3 interactors
STRINGi9606.ENSP00000337862

Structurei

3D structure databases

ProteinModelPortaliO14753
SMRiO14753
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri118 – 140C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri146 – 168C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri174 – 197C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri213 – 235C2H2-type 4PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG3576 Eukaryota
ENOG4111H28 LUCA
GeneTreeiENSGT00920000149010
HOGENOMiHOG000231694
HOVERGENiHBG053384
InParanoidiO14753
KOiK09216
OMAiQPYQEPE
OrthoDBiEOG091G0LB1
PhylomeDBiO14753
TreeFamiTF337552

Family and domain databases

InterProiView protein in InterPro
IPR027756 Ovo-like
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR10032 PTHR10032, 1 hit
PfamiView protein in Pfam
PF00096 zf-C2H2, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 4 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O14753-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPRAFLVKKP CVSTCKRNWS ELPDEERGEI YVPVSLGFCP PQPYREPEPS
60 70 80 90 100
VAEPPSCPLA LNMSLRDSSY SMAPGPCVVA QLPSEDMGHL TDPQSRDHGF
110 120 130 140 150
LRTKMKVTLG DSPSGDLFTC RVCQKAFTYQ RMLNRHMKCH NDVKRHLCTY
160 170 180 190 200
CGKGFNDTFD LKRHVRTHTG VRPYKCSLCD KAFTQRCSLE SHLKKIHGVQ
210 220 230 240 250
QKYAYKERRA KLYVCEECGC TSESQEGHVL HLKEHHPDSP LLRKTSKKVA
260
VALQNTVTSL LQGSPHL
Length:267
Mass (Da):30,259
Last modified:November 23, 2004 - v3
Checksum:i57C67CD8A060A9B8
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V1B0G3V1B0_HUMAN
Ovo-like 1(Drosophila)
OVOL1 hCG_1775310
205Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti150Y → G in AAB72084 (PubMed:9383297).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX648725 mRNA Translation: CAH56127.1
BC059408 mRNA Translation: AAH59408.1
AF016045 mRNA Translation: AAB72084.1
CCDSiCCDS8112.1
RefSeqiNP_004552.2, NM_004561.3
UniGeneiHs.134434

Genome annotation databases

EnsembliENST00000335987; ENSP00000337862; ENSG00000172818
GeneIDi5017
KEGGihsa:5017
UCSCiuc001ofp.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX648725 mRNA Translation: CAH56127.1
BC059408 mRNA Translation: AAH59408.1
AF016045 mRNA Translation: AAB72084.1
CCDSiCCDS8112.1
RefSeqiNP_004552.2, NM_004561.3
UniGeneiHs.134434

3D structure databases

ProteinModelPortaliO14753
SMRiO14753
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111057, 5 interactors
IntActiO14753, 3 interactors
STRINGi9606.ENSP00000337862

PTM databases

iPTMnetiO14753
PhosphoSitePlusiO14753

Polymorphism and mutation databases

BioMutaiOVOL1

Proteomic databases

EPDiO14753
MaxQBiO14753
PaxDbiO14753
PeptideAtlasiO14753
PRIDEiO14753
ProteomicsDBi48206

Protocols and materials databases

DNASUi5017
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000335987; ENSP00000337862; ENSG00000172818
GeneIDi5017
KEGGihsa:5017
UCSCiuc001ofp.4 human

Organism-specific databases

CTDi5017
DisGeNETi5017
EuPathDBiHostDB:ENSG00000172818.9
GeneCardsiOVOL1
HGNCiHGNC:8525 OVOL1
HPAiHPA003984
MIMi602313 gene
neXtProtiNX_O14753
OpenTargetsiENSG00000172818
PharmGKBiPA32853
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3576 Eukaryota
ENOG4111H28 LUCA
GeneTreeiENSGT00920000149010
HOGENOMiHOG000231694
HOVERGENiHBG053384
InParanoidiO14753
KOiK09216
OMAiQPYQEPE
OrthoDBiEOG091G0LB1
PhylomeDBiO14753
TreeFamiTF337552

Miscellaneous databases

GenomeRNAii5017
PROiPR:O14753
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000172818 Expressed in 112 organ(s), highest expression level in ectocervix
CleanExiHS_OVOL1
ExpressionAtlasiO14753 baseline and differential
GenevisibleiO14753 HS

Family and domain databases

InterProiView protein in InterPro
IPR027756 Ovo-like
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR10032 PTHR10032, 1 hit
PfamiView protein in Pfam
PF00096 zf-C2H2, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 4 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiOVOL1_HUMAN
AccessioniPrimary (citable) accession number: O14753
Secondary accession number(s): Q6PCB1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 23, 2004
Last modified: November 7, 2018
This is version 155 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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