OVOL1

Functionⁱ

Putative transcription factor. Involved in hair formation and spermatogenesis. May function in the differentiation and/or maintenance of the urogenital system (By similarity).By similarity

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	118 – 140	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	146 – 168	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	174 – 197	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	24
Zinc fingerⁱ	213 – 235	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23

GO - Molecular functionⁱ

DNA-binding transcription activator activity, RNA polymerase II-specific
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
metal ion binding Source: UniProtKB-KW
proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
RNA polymerase II proximal promoter sequence-specific DNA binding Source: Ensembl
sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

epidermal cell differentiation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
germline cell cycle switching, mitotic to meiotic cell cycle Source: Ensembl
kidney development Source: Ensembl
mesoderm development Source: Ensembl
negative regulation of meiotic cell cycle phase transition Source: Ensembl
negative regulation of stem cell proliferation Source: Ensembl
negative regulation of transcription, DNA-templated
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
skin development Source: Ensembl
spermatogenesis Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Putative transcription factor Ovo-like 1 Short name: hOvo1
Gene namesⁱ	Name:OVOL1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000172818.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:8525 OVOL1
MIMⁱ	602313 gene
neXtProtⁱ	NX_O14753

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5017
Open Targets More...OpenTargetsⁱ	ENSG00000172818
PharmGKBⁱ	PA32853

Polymorphism and mutation databases

BioMutaⁱ	OVOL1

BioMutaⁱ

OVOL1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000047011	1 – 267	Putative transcription factor Ovo-like 1Add BLAST		267

Proteomic databases

EPDⁱ	O14753
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O14753
PaxDbⁱ	O14753
PeptideAtlas More...PeptideAtlasⁱ	O14753
PRIDEⁱ	O14753
ProteomicsDBⁱ	48206

PTM databases

iPTMnetⁱ	O14753
PhosphoSitePlusⁱ	O14753

Expressionⁱ

Tissue specificityⁱ

Expressed in fetal kidney, and also in adult pancreas and placenta. Not expressed in intestine, peripheral blood lymphocytes and ovary.

Gene expression databases

Bgeeⁱ	ENSG00000172818 Expressed in 112 organ(s), highest expression level in ectocervix
CleanExⁱ	HS_OVOL1
ExpressionAtlasⁱ	O14753 baseline and differential
Genevisibleⁱ	O14753 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA003984

HPAⁱ

HPA003984

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	111057, 5 interactors
IntActⁱ	O14753, 3 interactors
STRINGⁱ	9606.ENSP00000337862

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O14753
SMRⁱ	O14753
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	118 – 140	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	146 – 168	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	174 – 197	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	24
Zinc fingerⁱ	213 – 235	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG3576 Eukaryota ENOG4111H28 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00920000149010
HOGENOMⁱ	HOG000231694
HOVERGENⁱ	HBG053384
InParanoidⁱ	O14753
KEGG Orthology (KO) More...KOⁱ	K09216
OMAⁱ	QPYQEPE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0LB1
PhylomeDBⁱ	O14753
TreeFamⁱ	TF337552

Family and domain databases

InterProⁱ	View protein in InterPro IPR027756 Ovo-like IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
PANTHERⁱ	PTHR10032 PTHR10032, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 1 hit
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 4 hits
SUPFAMⁱ	SSF57667 SSF57667, 2 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 3 hits PS50157 ZINC_FINGER_C2H2_2, 4 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

O14753-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPRAFLVKKP CVSTCKRNWS ELPDEERGEI YVPVSLGFCP PQPYREPEPS 
        60         70         80         90        100
VAEPPSCPLA LNMSLRDSSY SMAPGPCVVA QLPSEDMGHL TDPQSRDHGF 
       110        120        130        140        150
LRTKMKVTLG DSPSGDLFTC RVCQKAFTYQ RMLNRHMKCH NDVKRHLCTY 
       160        170        180        190        200
CGKGFNDTFD LKRHVRTHTG VRPYKCSLCD KAFTQRCSLE SHLKKIHGVQ 
       210        220        230        240        250
QKYAYKERRA KLYVCEECGC TSESQEGHVL HLKEHHPDSP LLRKTSKKVA 
       260 
VALQNTVTSL LQGSPHL

Length:267

Mass (Da):30,259

Last modified:November 23, 2004 - v3

Checksum:ⁱ57C67CD8A060A9B8

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	G3V1B0	G3V1B0_HUMAN		Ovo-like 1(Drosophila) Ovo-like 1(Drosophila) (Putative transcription factor Ovo-like 1)	OVOL1 hCG_1775310	205	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	150	Y → G in AAB72084 (PubMed:9383297).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BX648725 mRNA Translation: CAH56127.1 BC059408 mRNA Translation: AAH59408.1 AF016045 mRNA Translation: AAB72084.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8112.1
NCBI Reference Sequences More...RefSeqⁱ	NP_004552.2, NM_004561.3
UniGeneⁱ	Hs.134434

Genome annotation databases

Ensemblⁱ	ENST00000335987; ENSP00000337862; ENSG00000172818
GeneIDⁱ	5017
KEGGⁱ	hsa:5017
UCSC genome browser More...UCSCⁱ	uc001ofp.4 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O14753	Ovo-like 1(Drosophila)		HUMAN		205	UniRef100_O14753

Protein	Similar proteins		Species	Score	Length	Source
O14753	Putative transcription factor Ovo-like 1		MOUSE		267	UniRef90_Q9WTJ2
Putative transcription factor Ovo-like 1		BOVIN		267
Ovo-like 1(Drosophila)		HUMAN		205
OVOL1 isoform 1		PANTR		267
Uncharacterized protein		NOMLE		267
+86

Protein	Similar proteins		Species	Score	Length	Source
O14753	Putative transcription factor Ovo-like 1		MOUSE		267	UniRef50_Q9WTJ2
Putative transcription factor Ovo-like 1		BOVIN		267
Uncharacterized protein		CALJA		267
Uncharacterized protein		AOTNA		267
Uncharacterized protein		CHLSB		267
+132

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BX648725 mRNA Translation: CAH56127.1 BC059408 mRNA Translation: AAH59408.1 AF016045 mRNA Translation: AAB72084.1
CCDSⁱ	CCDS8112.1
RefSeqⁱ	NP_004552.2, NM_004561.3
UniGeneⁱ	Hs.134434

3D structure databases

ProteinModelPortalⁱ	O14753
SMRⁱ	O14753
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111057, 5 interactors
IntActⁱ	O14753, 3 interactors
STRINGⁱ	9606.ENSP00000337862

PTM databases

iPTMnetⁱ	O14753
PhosphoSitePlusⁱ	O14753

Polymorphism and mutation databases

BioMutaⁱ	OVOL1

BioMutaⁱ

OVOL1

Proteomic databases

EPDⁱ	O14753
MaxQBⁱ	O14753
PaxDbⁱ	O14753
PeptideAtlasⁱ	O14753
PRIDEⁱ	O14753
ProteomicsDBⁱ	48206

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	5017
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000335987; ENSP00000337862; ENSG00000172818
GeneIDⁱ	5017
KEGGⁱ	hsa:5017
UCSCⁱ	uc001ofp.4 human

Organism-specific databases

CTDⁱ	5017
DisGeNETⁱ	5017
EuPathDBⁱ	HostDB:ENSG00000172818.9
GeneCardsⁱ	OVOL1
HGNCⁱ	HGNC:8525 OVOL1
HPAⁱ	HPA003984
MIMⁱ	602313 gene
neXtProtⁱ	NX_O14753
OpenTargetsⁱ	ENSG00000172818
PharmGKBⁱ	PA32853
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3576 Eukaryota ENOG4111H28 LUCA
GeneTreeⁱ	ENSGT00920000149010
HOGENOMⁱ	HOG000231694
HOVERGENⁱ	HBG053384
InParanoidⁱ	O14753
KOⁱ	K09216
OMAⁱ	QPYQEPE
OrthoDBⁱ	EOG091G0LB1
PhylomeDBⁱ	O14753
TreeFamⁱ	TF337552

Miscellaneous databases

GenomeRNAiⁱ	5017
Protein Ontology More...PROⁱ	PR:O14753
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000172818 Expressed in 112 organ(s), highest expression level in ectocervix
CleanExⁱ	HS_OVOL1
ExpressionAtlasⁱ	O14753 baseline and differential
Genevisibleⁱ	O14753 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR027756 Ovo-like IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
PANTHERⁱ	PTHR10032 PTHR10032, 1 hit
Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 1 hit
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 4 hits
SUPFAMⁱ	SSF57667 SSF57667, 2 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 3 hits PS50157 ZINC_FINGER_C2H2_2, 4 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	OVOL1_HUMAN
Accessionⁱ	O14753Primary (citable) accession number: O14753 Secondary accession number(s): Q6PCB1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
	Last sequence update:	November 23, 2004
	Last modified:	November 7, 2018
	This is version 155 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

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Annotation systems

Supporting data

UniProtKB - O14753 (OVOL1_HUMAN)

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Putative transcription factor Ovo-like 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ