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UniProtKB - O14753 (OVOL1_HUMAN)
Protein
Putative transcription factor Ovo-like 1
Gene
OVOL1
Organism
Homo sapiens (Human)
Status
Functioni
Putative transcription factor. Involved in hair formation and spermatogenesis. May function in the differentiation and/or maintenance of the urogenital system (By similarity).
By similarityRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 118 – 140 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 146 – 168 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 174 – 197 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 213 – 235 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: Ensembl
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- epidermal cell differentiation Source: GO_Central
- germline cell cycle switching, mitotic to meiotic cell cycle Source: Ensembl
- kidney development Source: Ensembl
- mesoderm development Source: Ensembl
- negative regulation of meiotic cell cycle phase transition Source: Ensembl
- negative regulation of stem cell proliferation Source: Ensembl
- regulation of transcription by RNA polymerase II Source: GO_Central
- skin development Source: Ensembl
- spermatogenesis Source: Ensembl
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | O14753 |
SignaLinki | O14753 |
Names & Taxonomyi
Protein namesi | Recommended name: Putative transcription factor Ovo-like 1Short name: hOvo1 |
Gene namesi | Name:OVOL1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:8525, OVOL1 |
MIMi | 602313, gene |
neXtProti | NX_O14753 |
VEuPathDBi | HostDB:ENSG00000172818 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 5017 |
OpenTargetsi | ENSG00000172818 |
PharmGKBi | PA32853 |
Miscellaneous databases
Pharosi | O14753, Tbio |
Genetic variation databases
BioMutai | OVOL1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047011 | 1 – 267 | Putative transcription factor Ovo-like 1Add BLAST | 267 |
Proteomic databases
jPOSTi | O14753 |
MassIVEi | O14753 |
MaxQBi | O14753 |
PaxDbi | O14753 |
PeptideAtlasi | O14753 |
PRIDEi | O14753 |
ProteomicsDBi | 48206 |
PTM databases
iPTMneti | O14753 |
PhosphoSitePlusi | O14753 |
Expressioni
Tissue specificityi
Expressed in fetal kidney, and also in adult pancreas and placenta. Not expressed in intestine, peripheral blood lymphocytes and ovary.
Gene expression databases
Bgeei | ENSG00000172818, Expressed in ectocervix and 132 other tissues |
ExpressionAtlasi | O14753, baseline and differential |
Genevisiblei | O14753, HS |
Organism-specific databases
HPAi | ENSG00000172818, Tissue enhanced (esophagus, skin, testis) |
Interactioni
Binary interactionsi
Protein-protein interaction databases
BioGRIDi | 111057, 9 interactors |
IntActi | O14753, 4 interactors |
STRINGi | 9606.ENSP00000337862 |
Miscellaneous databases
RNActi | O14753, protein |
Family & Domainsi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 118 – 140 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 146 – 168 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 174 – 197 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 213 – 235 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG3576, Eukaryota |
GeneTreei | ENSGT00940000161363 |
HOGENOMi | CLU_087964_0_0_1 |
InParanoidi | O14753 |
OMAi | PLCLTKH |
OrthoDBi | 1419156at2759 |
PhylomeDBi | O14753 |
TreeFami | TF337552 |
Family and domain databases
InterProi | View protein in InterPro IPR027756, Ovo-like IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR10032, PTHR10032, 1 hit |
Pfami | View protein in Pfam PF00096, zf-C2H2, 1 hit |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 4 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
O14753-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPRAFLVKKP CVSTCKRNWS ELPDEERGEI YVPVSLGFCP PQPYREPEPS
60 70 80 90 100
VAEPPSCPLA LNMSLRDSSY SMAPGPCVVA QLPSEDMGHL TDPQSRDHGF
110 120 130 140 150
LRTKMKVTLG DSPSGDLFTC RVCQKAFTYQ RMLNRHMKCH NDVKRHLCTY
160 170 180 190 200
CGKGFNDTFD LKRHVRTHTG VRPYKCSLCD KAFTQRCSLE SHLKKIHGVQ
210 220 230 240 250
QKYAYKERRA KLYVCEECGC TSESQEGHVL HLKEHHPDSP LLRKTSKKVA
260
VALQNTVTSL LQGSPHL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketG3V1B0 | G3V1B0_HUMAN | Ovo-like 1(Drosophila) | OVOL1 hCG_1775310 | 205 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 150 | Y → G in AAB72084 (PubMed:9383297).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX648725 mRNA Translation: CAH56127.1 BC059408 mRNA Translation: AAH59408.1 AF016045 mRNA Translation: AAB72084.1 |
CCDSi | CCDS8112.1 |
RefSeqi | NP_004552.2, NM_004561.3 |
Genome annotation databases
Ensembli | ENST00000335987; ENSP00000337862; ENSG00000172818 |
GeneIDi | 5017 |
KEGGi | hsa:5017 |
MANE-Selecti | ENST00000335987.8; ENSP00000337862.3; NM_004561.4; NP_004552.2 |
UCSCi | uc001ofp.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX648725 mRNA Translation: CAH56127.1 BC059408 mRNA Translation: AAH59408.1 AF016045 mRNA Translation: AAB72084.1 |
CCDSi | CCDS8112.1 |
RefSeqi | NP_004552.2, NM_004561.3 |
3D structure databases
SMRi | O14753 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 111057, 9 interactors |
IntActi | O14753, 4 interactors |
STRINGi | 9606.ENSP00000337862 |
PTM databases
iPTMneti | O14753 |
PhosphoSitePlusi | O14753 |
Genetic variation databases
BioMutai | OVOL1 |
Proteomic databases
jPOSTi | O14753 |
MassIVEi | O14753 |
MaxQBi | O14753 |
PaxDbi | O14753 |
PeptideAtlasi | O14753 |
PRIDEi | O14753 |
ProteomicsDBi | 48206 |
Protocols and materials databases
Antibodypediai | 1312, 244 antibodies from 28 providers |
DNASUi | 5017 |
Genome annotation databases
Ensembli | ENST00000335987; ENSP00000337862; ENSG00000172818 |
GeneIDi | 5017 |
KEGGi | hsa:5017 |
MANE-Selecti | ENST00000335987.8; ENSP00000337862.3; NM_004561.4; NP_004552.2 |
UCSCi | uc001ofp.4, human |
Organism-specific databases
CTDi | 5017 |
DisGeNETi | 5017 |
GeneCardsi | OVOL1 |
HGNCi | HGNC:8525, OVOL1 |
HPAi | ENSG00000172818, Tissue enhanced (esophagus, skin, testis) |
MIMi | 602313, gene |
neXtProti | NX_O14753 |
OpenTargetsi | ENSG00000172818 |
PharmGKBi | PA32853 |
VEuPathDBi | HostDB:ENSG00000172818 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3576, Eukaryota |
GeneTreei | ENSGT00940000161363 |
HOGENOMi | CLU_087964_0_0_1 |
InParanoidi | O14753 |
OMAi | PLCLTKH |
OrthoDBi | 1419156at2759 |
PhylomeDBi | O14753 |
TreeFami | TF337552 |
Enzyme and pathway databases
PathwayCommonsi | O14753 |
SignaLinki | O14753 |
Miscellaneous databases
BioGRID-ORCSi | 5017, 6 hits in 1063 CRISPR screens |
GenomeRNAii | 5017 |
Pharosi | O14753, Tbio |
PROi | PR:O14753 |
RNActi | O14753, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000172818, Expressed in ectocervix and 132 other tissues |
ExpressionAtlasi | O14753, baseline and differential |
Genevisiblei | O14753, HS |
Family and domain databases
InterProi | View protein in InterPro IPR027756, Ovo-like IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR10032, PTHR10032, 1 hit |
Pfami | View protein in Pfam PF00096, zf-C2H2, 1 hit |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 4 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | OVOL1_HUMAN | |
Accessioni | O14753Primary (citable) accession number: O14753 Secondary accession number(s): Q6PCB1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | November 23, 2004 | |
Last modified: | February 23, 2022 | |
This is version 175 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot