PRMT5

Functionⁱ

Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA (PubMed:10531356, PubMed:11152681, PubMed:11747828, PubMed:12411503, PubMed:15737618, PubMed:17709427, PubMed:20159986, PubMed:20810653, PubMed:21258366, PubMed:21917714, PubMed:22269951, PubMed:21081503). Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles (PubMed:12411503, PubMed:11747828, PubMed:17709427). Methylates SUPT5H and may regulate its transcriptional elongation properties (PubMed:12718890). Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. Methylates histone H2A and H4 'Arg-3' during germ cell development. Methylates histone H3 'Arg-8', which may repress transcription. Methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage (By similarity). Methylates RPS10. Attenuates EGF signaling through the MAPK1/MAPK3 pathway acting at 2 levels. First, monomethylates EGFR; this enhances EGFR 'Tyr-1197' phosphorylation and PTPN6 recruitment, eventually leading to reduced SOS1 phosphorylation (PubMed:21917714, PubMed:21258366). Second, methylates RAF1 and probably BRAF, hence destabilizing these 2 signaling proteins and reducing their catalytic activity (PubMed:21917714). Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation. Methylates HOXA9 (PubMed:22269951). Methylates and regulates SRGAP2 which is involved in cell migration and differentiation (PubMed:20810653). Acts as a transcriptional corepressor in CRY1-mediated repression of the core circadian component PER1 by regulating the H4R3 dimethylation at the PER1 promoter (By similarity). Methylates GM130/GOLGA2, regulating Golgi ribbon formation (PubMed:20421892). Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner (PubMed:25284789). Symmetrically methylates POLR2A, a modification that allows the recruitment to POLR2A of proteins including SMN1/SMN2 and SETX. This is required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination (PubMed:26700805). Along with LYAR, binds the promoter of gamma-globin HBG1/HBG2 and represses its expression (PubMed:25092918). Symmetrically methylates NCL (PubMed:21081503).By similarity17 Publications

Catalytic activityⁱ

2 S-adenosyl-L-methionine + [protein]-L-arginine = 2 S-adenosyl-L-homocysteine + [protein]-N(omega),N(omega')-dimethyl-L-arginine.2 Publications

Activity regulationⁱ

Activity is increased by EGF, HGF, FGF1 or FGF2 treatments, and slightly decreased by NGF treatment.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	304	Peptide substrate1 Publication	1
Binding siteⁱ	307	Peptide substrate1 Publication	1
Binding siteⁱ	324	S-adenosyl-L-methionine1 Publication	1
Siteⁱ	327	Critical for specifying symmetric addition of methyl groupsBy similarity	1
Binding siteⁱ	392	S-adenosyl-L-methionine1 Publication	1
Active siteⁱ	435	Proton donor/acceptor1 Publication	1
Active siteⁱ	444	Proton donor/acceptor1 Publication	1

GO - Molecular functionⁱ

E-box binding Source: UniProtKB
histone-arginine N-methyltransferase activity Source: Reactome
histone methyltransferase activity (H4-R3 specific)
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 25284789
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
methyl-CpG binding
Source: UniProtKB
Inferred from direct assayⁱ
- 25284789
methyltransferase activity
Source: MGI
Inferred from direct assayⁱ
- 15369763
protein-arginine N-methyltransferase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 20421892
protein-arginine omega-N symmetric methyltransferase activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17709427
protein heterodimerization activity
Source: MGI
Inferred from direct assayⁱ
- 18495660
ribonucleoprotein complex binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 17709427
transcription corepressor activity Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell proliferation
Source: ProtInc
Traceable author statementⁱ
- 9843966
circadian regulation of gene expression Source: UniProtKB
DNA-templated transcription, termination
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 26700805
endothelial cell activation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 22269951
Golgi ribbon formation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20421892
histone H4-R3 methylation Source: UniProtKB
liver regeneration Source: Ensembl
negative regulation of cell differentiation Source: Ensembl
peptidyl-arginine methylation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17709427
peptidyl-arginine N-methylation
Source: WormBase
Inferred from direct assayⁱ
- 26554819
positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway
Source: WormBase
Inferred from genetic interactionⁱ
- 26554819
positive regulation of oligodendrocyte differentiation Source: Ensembl
regulation of DNA methylation Source: Ensembl
regulation of ERK1 and ERK2 cascade Source: Ensembl
regulation of mitotic nuclear division
Source: ProtInc
Traceable author statementⁱ
- 9843966
regulation of signal transduction by p53 class mediator Source: Reactome
regulation of transcription, DNA-templated Source: GO_Central
spliceosomal snRNP assembly
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17709427

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Chromatin regulator, Methyltransferase, Repressor, Transferase
Biological process	Biological rhythms, Transcription, Transcription regulation
Ligand	S-adenosyl-L-methionine

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS02092-MONOMER
BRENDAⁱ	2.1.1.125 2681
Reactomeⁱ	R-HSA-191859 snRNP Assembly R-HSA-3214858 RMTs methylate histone arginines R-HSA-6804760 Regulation of TP53 Activity through Methylation
SIGNORⁱ	O14744

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein arginine N-methyltransferase 5 (EC:2.1.1.3202 Publications) Alternative name(s): 72 kDa ICln-binding protein Histone-arginine N-methyltransferase PRMT5 Jak-binding protein 1 Shk1 kinase-binding protein 1 homolog Short name: SKB1 homolog Short name: SKB1Hs Cleaved into the following chain: Protein arginine N-methyltransferase 5, N-terminally processed
Gene namesⁱ	Name:PRMT5 Synonyms:HRMT1L5, IBP72, JBP1, SKB1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 14

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000100462.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10894 PRMT5
MIMⁱ	604045 gene
neXtProtⁱ	NX_O14744

Keywords - Cellular componentⁱ

Cytoplasm, Golgi apparatus, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	365 – 369	Missing : Increased MAPK1/MAPK3 phosphorylation in response to EGF. 1 Publication		5
Mutagenesisⁱ	367 – 368	GR → AA: Abolishes enzymatic activity. 1 Publication		2

Organism-specific databases

DisGeNET More...DisGeNETⁱ	10419
Open Targets More...OpenTargetsⁱ	ENSG00000100462
PharmGKBⁱ	PA35794

Chemistry databases

ChEMBLⁱ	CHEMBL1795116
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	1256

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
ChainⁱPRO_0000212342	1 – 637	Protein arginine N-methyltransferase 5Add BLAST	637
Initiator methionineⁱ		Removed; alternateCombined sources2 Publications
ChainⁱPRO_0000417602	2 – 637	Protein arginine N-methyltransferase 5, N-terminally processedAdd BLAST	636

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	2	N-acetylalanine; in Protein arginine N-methyltransferase 5, N-terminally processedCombined sources1 Publication		1

Keywords - PTMⁱ

Acetylation

Proteomic databases

EPDⁱ	O14744
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O14744
PaxDbⁱ	O14744
PeptideAtlas More...PeptideAtlasⁱ	O14744
PRIDEⁱ	O14744
ProteomicsDBⁱ	48200 48201 [O14744-2]

PTM databases

iPTMnetⁱ	O14744
PhosphoSitePlusⁱ	O14744
SwissPalmⁱ	O14744

Expressionⁱ

Tissue specificityⁱ

Ubiquitous.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000100462 Expressed in 215 organ(s), highest expression level in testis
CleanExⁱ	HS_PRMT5
ExpressionAtlasⁱ	O14744 baseline and differential
Genevisibleⁱ	O14744 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB012459 HPA005525 HPA064708

HPAⁱ

CAB012459
HPA005525
HPA064708

Interactionⁱ

Subunit structureⁱ

Forms, at least, homodimers and homotetramers. Component of the methylosome complex, composed of PRMT5, WDR77 and CLNS1A (PubMed:21081503). Found in a complex composed of PRMT5, WDR77 and RIOK1 (PubMed:21081503). RIOK1 and CLNS1A associate with PRMT5 in a mutually exclusive fashion, which allows the recruitment of distinct methylation substrates, such as nucleolin/NCL and Sm proteins, respectively (PubMed:21081503). Interacts with PRDM1 (By similarity). Identified in a complex composed of methylosome and PRMT1 and ERH (PubMed:25284789). Interacts with EGFR; methylates EGFR and stimulates EGFR-mediated ERK activation. Interacts with HOXA9. Interacts with SRGAP2. Found in a complex with COPRS, RUNX1 AND CBFB. Interacts with CHTOP; the interaction symmetrically methylates CHTOP, but seems to require the presence of PRMT1 (PubMed:25284789). Interacts with EPB41L3; this modulates methylation of target proteins. Component of a high molecular weight E2F-pocket protein complex, CERC (cyclin E1 repressor complex). Associates with SWI/SNF remodeling complexes containing SMARCA2 and SMARCA4. Interacts with JAK2, SSTR1, SUPT5H, BRAF and with active RAF1. Interacts with LSM11, PRMT7 and SNRPD3 (PubMed:17709427, PubMed:16087681). Interacts with COPRS; promoting its recruitment on histone H4. Interacts with CLNS1A/pICln (PubMed:21081503, PubMed:9556550). Identified in a complex with CLNS1A/pICln and Sm proteins. Interacts with RPS10 (PubMed:20159986). Interacts with WDR77. Interacts with IWS1. Interacts with CRY1. Interacts with POLR2A (PubMed:26700805). Interacts with SMN1/SMN2 (PubMed:26700805). Interacts with LYAR; this interaction is direct (PubMed:25092918).By similarity23 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
itself		3	EBI-351098,EBI-351098
Ajuba	Q91XC0	4	EBI-351098,EBI-1565930	From Mus musculus.
CDYL2	Q8N8U2	2	EBI-351098,EBI-8467076
CLNS1A	P54105	8	EBI-351098,EBI-724693
COPRS	Q9NQ92	6	EBI-351098,EBI-1642558
DNMT3A	Q9Y6K1	4	EBI-351098,EBI-923653
E2F1	Q01094	8	EBI-351098,EBI-448924
GRHL3	Q8TE85	2	EBI-351098,EBI-8469396
GTPBP2	Q9BX10	2	EBI-351098,EBI-6115579
HIST2H4B	P62805	6	EBI-351098,EBI-302023
HOXA9	P31269	4	EBI-351098,EBI-742314
N	P03418	2	EBI-351098,EBI-6930799	From Human respiratory syncytial virus A (strain A2).
NFE4	Q86UQ8-1	2	EBI-351098,EBI-15759783
NUDCD2	Q8WVJ2	2	EBI-351098,EBI-1052153
POLR2A	P24928	6	EBI-351098,EBI-295301
RBM23	Q86U06	3	EBI-351098,EBI-780319
RIOK1	Q9BRS2	4	EBI-351098,EBI-7307838
SRGAP2	O75044	4	EBI-351098,EBI-1051034
TRIB3	Q96RU7	2	EBI-351098,EBI-492476
WDR77	Q9BQA1	16	EBI-351098,EBI-1237307
YWHAZ	P63104	2	EBI-351098,EBI-347088

GO - Molecular functionⁱ

identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
protein heterodimerization activity
Source: MGI
Inferred from direct assayⁱ
- 18495660

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	115688, 190 interactors
ComplexPortalⁱ	CPX-696 Methylosome
CORUMⁱ	O14744
Database of interacting proteins More...DIPⁱ	DIP-33172N
IntActⁱ	O14744, 102 interactors
Molecular INTeraction database More...MINTⁱ	O14744
STRINGⁱ	9606.ENSP00000319169

Chemistry databases

BindingDBⁱ

O14744

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	16 – 19	Combined sources	4
Helixⁱ	26 – 35	Combined sources	10
Beta strandⁱ	39 – 46	Combined sources	8
Beta strandⁱ	54 – 56	Combined sources	3
Helixⁱ	59 – 61	Combined sources	3
Helixⁱ	70 – 72	Combined sources	3
Helixⁱ	75 – 81	Combined sources	7
Beta strandⁱ	82 – 85	Combined sources	4
Helixⁱ	97 – 117	Combined sources	21
Beta strandⁱ	120 – 125	Combined sources	6
Helixⁱ	132 – 142	Combined sources	11
Beta strandⁱ	144 – 146	Combined sources	3
Beta strandⁱ	150 – 158	Combined sources	9
Helixⁱ	160 – 163	Combined sources	4
Helixⁱ	181 – 183	Combined sources	3
Helixⁱ	184 – 195	Combined sources	12
Turnⁱ	196 – 198	Combined sources	3
Beta strandⁱ	202 – 207	Combined sources	6
Helixⁱ	215 – 219	Combined sources	5
Turnⁱ	220 – 223	Combined sources	4
Beta strandⁱ	226 – 232	Combined sources	7
Helixⁱ	233 – 235	Combined sources	3
Helixⁱ	248 – 259	Combined sources	12
Beta strandⁱ	263 – 268	Combined sources	6
Helixⁱ	273 – 275	Combined sources	3
Helixⁱ	279 – 289	Combined sources	11
Helixⁱ	296 – 300	Combined sources	5
Helixⁱ	302 – 304	Combined sources	3
Beta strandⁱ	309 – 311	Combined sources	3
Turnⁱ	314 – 316	Combined sources	3
Helixⁱ	321 – 327	Combined sources	7
Helixⁱ	331 – 348	Combined sources	18
Helixⁱ	351 – 353	Combined sources	3
Turnⁱ	354 – 356	Combined sources	3
Beta strandⁱ	358 – 365	Combined sources	8
Turnⁱ	367 – 369	Combined sources	3
Helixⁱ	370 – 381	Combined sources	12
Beta strandⁱ	385 – 393	Combined sources	9
Helixⁱ	395 – 407	Combined sources	13
Helixⁱ	410 – 412	Combined sources	3
Beta strandⁱ	413 – 418	Combined sources	6
Turnⁱ	420 – 422	Combined sources	3
Beta strandⁱ	429 – 433	Combined sources	5
Helixⁱ	442 – 444	Combined sources	3
Helixⁱ	446 – 453	Combined sources	8
Helixⁱ	454 – 456	Combined sources	3
Beta strandⁱ	457 – 465	Combined sources	9
Beta strandⁱ	467 – 476	Combined sources	10
Helixⁱ	478 – 485	Combined sources	8
Helixⁱ	496 – 499	Combined sources	4
Beta strandⁱ	502 – 505	Combined sources	4
Beta strandⁱ	516 – 524	Combined sources	9
Beta strandⁱ	527 – 529	Combined sources	3
Beta strandⁱ	534 – 541	Combined sources	8
Beta strandⁱ	546 – 560	Combined sources	15
Beta strandⁱ	563 – 566	Combined sources	4
Helixⁱ	569 – 571	Combined sources	3
Beta strandⁱ	582 – 592	Combined sources	11
Beta strandⁱ	597 – 606	Combined sources	10
Beta strandⁱ	608 – 621	Combined sources	14
Helixⁱ	628 – 630	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	O14744
SMRⁱ	O14744
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	308 – 615	SAM-dependent MTase PRMT-typePROSITE-ProRule annotationAdd BLAST		308

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	13 – 292	TIM barrel1 PublicationAdd BLAST	280
Regionⁱ	333 – 334	S-adenosyl-L-methionine binding1 Publication	2
Regionⁱ	419 – 420	S-adenosyl-L-methionine binding1 Publication	2
Regionⁱ	465 – 637	Beta barrel1 PublicationAdd BLAST	173
Regionⁱ	488 – 494	Dimerization1 Publication	7

Sequence similaritiesⁱ

Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGⁱ	KOG0822 Eukaryota ENOG410XNZM LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000001141
HOGENOMⁱ	HOG000175933
HOVERGENⁱ	HBG057083
InParanoidⁱ	O14744
KEGG Orthology (KO) More...KOⁱ	K02516
OMAⁱ	FPMFFPT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G03PD
PhylomeDBⁱ	O14744
TreeFamⁱ	TF300626

Family and domain databases

InterProⁱ	View protein in InterPro IPR025799 Arg_MeTrfase IPR007857 Arg_MeTrfase_PRMT5 IPR035075 PRMT5 IPR035248 PRMT5_C IPR035247 PRMT5_TIM IPR029063 SAM-dependent_MTases
PANTHERⁱ	PTHR10738 PTHR10738, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05185 PRMT5, 1 hit PF17286 PRMT5_C, 1 hit PF17285 PRMT5_TIM, 1 hit
PIRSFⁱ	PIRSF015894 Skb1_MeTrfase, 1 hit
SUPFAMⁱ	SSF53335 SSF53335, 1 hit
PROSITEⁱ	View protein in PROSITE PS51678 SAM_MT_PRMT, 1 hit

Sequences (5+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsⁱ produced by alternative splicing. Align Add to basket

Note: Additional isoforms seems to exist. According to EST sequences.

This entry has 5 described isoforms and 14 potential isoforms that are computationally mapped.ⁱShow all

Isoform 1 (identifier: O14744-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAMAVGGAG GSRVSSGRDL NCVPEIADTL GAVAKQGFDF LCMPVFHPRF 
        60         70         80         90        100
KREFIQEPAK NRPGPQTRSD LLLSGRDWNT LIVGKLSPWI RPDSKVEKIR 
       110        120        130        140        150
RNSEAAMLQE LNFGAYLGLP AFLLPLNQED NTNLARVLTN HIHTGHHSSM 
       160        170        180        190        200
FWMRVPLVAP EDLRDDIIEN APTTHTEEYS GEEKTWMWWH NFRTLCDYSK 
       210        220        230        240        250
RIAVALEIGA DLPSNHVIDR WLGEPIKAAI LPTSIFLTNK KGFPVLSKMH 
       260        270        280        290        300
QRLIFRLLKL EVQFIITGTN HHSEKEFCSY LQYLEYLSQN RPPPNAYELF 
       310        320        330        340        350
AKGYEDYLQS PLQPLMDNLE SQTYEVFEKD PIKYSQYQQA IYKCLLDRVP 
       360        370        380        390        400
EEEKDTNVQV LMVLGAGRGP LVNASLRAAK QADRRIKLYA VEKNPNAVVT 
       410        420        430        440        450
LENWQFEEWG SQVTVVSSDM REWVAPEKAD IIVSELLGSF ADNELSPECL 
       460        470        480        490        500
DGAQHFLKDD GVSIPGEYTS FLAPISSSKL YNEVRACREK DRDPEAQFEM 
       510        520        530        540        550
PYVVRLHNFH QLSAPQPCFT FSHPNRDPMI DNNRYCTLEF PVEVNTVLHG 
       560        570        580        590        600
FAGYFETVLY QDITLSIRPE THSPGMFSWF PILFPIKQPI TVREGQTICV 
       610        620        630 
RFWRCSNSKK VWYEWAVTAP VCSAIHNPTG RSYTIGL

Length:637

Mass (Da):72,684

Last modified:January 23, 2007 - v4

Checksum:ⁱ522E255B384F25E7

GO

Isoform 2 (identifier: O14744-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-34: MAAMAVGGAGGSRVSSGRDLNCVPEIADTLGAVA → MRGPNSGTEKGRLVIPE

« Hide

        10         20         30         40         50
MRGPNSGTEK GRLVIPEKQG FDFLCMPVFH PRFKREFIQE PAKNRPGPQT 
        60         70         80         90        100
RSDLLLSGRD WNTLIVGKLS PWIRPDSKVE KIRRNSEAAM LQELNFGAYL 
       110        120        130        140        150
GLPAFLLPLN QEDNTNLARV LTNHIHTGHH SSMFWMRVPL VAPEDLRDDI 
       160        170        180        190        200
IENAPTTHTE EYSGEEKTWM WWHNFRTLCD YSKRIAVALE IGADLPSNHV 
       210        220        230        240        250
IDRWLGEPIK AAILPTSIFL TNKKGFPVLS KMHQRLIFRL LKLEVQFIIT 
       260        270        280        290        300
GTNHHSEKEF CSYLQYLEYL SQNRPPPNAY ELFAKGYEDY LQSPLQPLMD 
       310        320        330        340        350
NLESQTYEVF EKDPIKYSQY QQAIYKCLLD RVPEEEKDTN VQVLMVLGAG 
       360        370        380        390        400
RGPLVNASLR AAKQADRRIK LYAVEKNPNA VVTLENWQFE EWGSQVTVVS 
       410        420        430        440        450
SDMREWVAPE KADIIVSELL GSFADNELSP ECLDGAQHFL KDDGVSIPGE 
       460        470        480        490        500
YTSFLAPISS SKLYNEVRAC REKDRDPEAQ FEMPYVVRLH NFHQLSAPQP 
       510        520        530        540        550
CFTFSHPNRD PMIDNNRYCT LEFPVEVNTV LHGFAGYFET VLYQDITLSI 
       560        570        580        590        600
RPETHSPGMF SWFPILFPIK QPITVREGQT ICVRFWRCSN SKKVWYEWAV 
       610        620
TAPVCSAIHN PTGRSYTIGL

Note: No experimental confirmation available.

Show »

Length:620

Mass (Da):71,320

Checksum:ⁱ0E489272643DD83C

GO

Isoform 4 (identifier: O14744-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-34: MAAMAVGGAGGSRVSSGRDLNCVPEIADTLGAVA → MRGPNSGTEKGRLVIPE
106-259: Missing.

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        10         20         30         40         50
MRGPNSGTEK GRLVIPEKQG FDFLCMPVFH PRFKREFIQE PAKNRPGPQT 
        60         70         80         90        100
RSDLLLSGRD WNTLIVGKLS PWIRPDSKVE KIRRNSEALE VQFIITGTNH 
       110        120        130        140        150
HSEKEFCSYL QYLEYLSQNR PPPNAYELFA KGYEDYLQSP LQPLMDNLES 
       160        170        180        190        200
QTYEVFEKDP IKYSQYQQAI YKCLLDRVPE EEKDTNVQVL MVLGAGRGPL 
       210        220        230        240        250
VNASLRAAKQ ADRRIKLYAV EKNPNAVVTL ENWQFEEWGS QVTVVSSDMR 
       260        270        280        290        300
EWVAPEKADI IVSELLGSFA DNELSPECLD GAQHFLKDDG VSIPGEYTSF 
       310        320        330        340        350
LAPISSSKLY NEVRACREKD RDPEAQFEMP YVVRLHNFHQ LSAPQPCFTF 
       360        370        380        390        400
SHPNRDPMID NNRYCTLEFP VEVNTVLHGF AGYFETVLYQ DITLSIRPET 
       410        420        430        440        450
HSPGMFSWFP ILFPIKQPIT VREGQTICVR FWRCSNSKKV WYEWAVTAPV 
       460 
CSAIHNPTGR SYTIGL

Note: No experimental confirmation available.

Show »

Length:466

Mass (Da):53,580

Checksum:ⁱ62386C5B867CF619

GO

Isoform 5 (identifier: O14744-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
77-120: Missing.

« Hide

        10         20         30         40         50
MAAMAVGGAG GSRVSSGRDL NCVPEIADTL GAVAKQGFDF LCMPVFHPRF 
        60         70         80         90        100
KREFIQEPAK NRPGPQTRSD LLLSGRAFLL PLNQEDNTNL ARVLTNHIHT 
       110        120        130        140        150
GHHSSMFWMR VPLVAPEDLR DDIIENAPTT HTEEYSGEEK TWMWWHNFRT 
       160        170        180        190        200
LCDYSKRIAV ALEIGADLPS NHVIDRWLGE PIKAAILPTS IFLTNKKGFP 
       210        220        230        240        250
VLSKMHQRLI FRLLKLEVQF IITGTNHHSE KEFCSYLQYL EYLSQNRPPP 
       260        270        280        290        300
NAYELFAKGY EDYLQSPLQP LMDNLESQTY EVFEKDPIKY SQYQQAIYKC 
       310        320        330        340        350
LLDRVPEEEK DTNVQVLMVL GAGRGPLVNA SLRAAKQADR RIKLYAVEKN 
       360        370        380        390        400
PNAVVTLENW QFEEWGSQVT VVSSDMREWV APEKADIIVS ELLGSFADNE 
       410        420        430        440        450
LSPECLDGAQ HFLKDDGVSI PGEYTSFLAP ISSSKLYNEV RACREKDRDP 
       460        470        480        490        500
EAQFEMPYVV RLHNFHQLSA PQPCFTFSHP NRDPMIDNNR YCTLEFPVEV 
       510        520        530        540        550
NTVLHGFAGY FETVLYQDIT LSIRPETHSP GMFSWFPILF PIKQPITVRE 
       560        570        580        590 
GQTICVRFWR CSNSKKVWYE WAVTAPVCSA IHNPTGRSYT IGL

Note: No experimental confirmation available.

Show »

Length:593

Mass (Da):67,674

Checksum:ⁱD609BFECAFB7D108

GO

Isoform 3 (identifier: O14744-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-34: MAAMAVGGAGGSRVSSGRDLNCVPEIADTLGAVA → MRGPNSGTEKGRLVIPE
77-120: Missing.

« Hide

        10         20         30         40         50
MRGPNSGTEK GRLVIPEKQG FDFLCMPVFH PRFKREFIQE PAKNRPGPQT 
        60         70         80         90        100
RSDLLLSGRA FLLPLNQEDN TNLARVLTNH IHTGHHSSMF WMRVPLVAPE 
       110        120        130        140        150
DLRDDIIENA PTTHTEEYSG EEKTWMWWHN FRTLCDYSKR IAVALEIGAD 
       160        170        180        190        200
LPSNHVIDRW LGEPIKAAIL PTSIFLTNKK GFPVLSKMHQ RLIFRLLKLE 
       210        220        230        240        250
VQFIITGTNH HSEKEFCSYL QYLEYLSQNR PPPNAYELFA KGYEDYLQSP 
       260        270        280        290        300
LQPLMDNLES QTYEVFEKDP IKYSQYQQAI YKCLLDRVPE EEKDTNVQVL 
       310        320        330        340        350
MVLGAGRGPL VNASLRAAKQ ADRRIKLYAV EKNPNAVVTL ENWQFEEWGS 
       360        370        380        390        400
QVTVVSSDMR EWVAPEKADI IVSELLGSFA DNELSPECLD GAQHFLKDDG 
       410        420        430        440        450
VSIPGEYTSF LAPISSSKLY NEVRACREKD RDPEAQFEMP YVVRLHNFHQ 
       460        470        480        490        500
LSAPQPCFTF SHPNRDPMID NNRYCTLEFP VEVNTVLHGF AGYFETVLYQ 
       510        520        530        540        550
DITLSIRPET HSPGMFSWFP ILFPIKQPIT VREGQTICVR FWRCSNSKKV 
       560        570 
WYEWAVTAPV CSAIHNPTGR SYTIGL

Note: No experimental confirmation available.

Show »

Length:576

Mass (Da):66,311

Checksum:ⁱ988C2D288FC214A1

GO

Computationally mapped potential isoform sequencesⁱ

There are 14 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name	Protein names	Gene names	Length	Annotation
	H0YJD3	H0YJD3_HUMAN	Protein arginine N-methyltransferas... Protein arginine N-methyltransferase 5	PRMT5	177	Annotation score:
	H7BZ44	H7BZ44_HUMAN	Protein arginine N-methyltransferas... Protein arginine N-methyltransferase 5	PRMT5	179	Annotation score:
	H0YJY6	H0YJY6_HUMAN	Protein arginine N-methyltransferas... Protein arginine N-methyltransferase 5	PRMT5	61	Annotation score:
	G3V2L6	G3V2L6_HUMAN	Protein arginine N-methyltransferas... Protein arginine N-methyltransferase 5	PRMT5	183	Annotation score:
	H0YJX6	H0YJX6_HUMAN	Protein arginine N-methyltransferas... Protein arginine N-methyltransferase 5	PRMT5	279	Annotation score:
	G3V5T6	G3V5T6_HUMAN	Protein arginine N-methyltransferas... Protein arginine N-methyltransferase 5	PRMT5	104	Annotation score:
	H0YJ77	H0YJ77_HUMAN	Protein arginine N-methyltransferas... Protein arginine N-methyltransferase 5	PRMT5	138	Annotation score:
	G3V2X6	G3V2X6_HUMAN	Protein arginine N-methyltransferas... Protein arginine N-methyltransferase 5	PRMT5	185	Annotation score:
	C9JSX3	C9JSX3_HUMAN	Protein arginine N-methyltransferas... Protein arginine N-methyltransferase 5	PRMT5	186	Annotation score:
	G3V580	G3V580_HUMAN	Protein arginine N-methyltransferas... Protein arginine N-methyltransferase 5	PRMT5	180	Annotation score:
There are more potential isoformsShow all

Sequence cautionⁱ

The sequence BC005820 differs from that shown. Reason: Frameshift at position 370.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	183	E → K in BAG63592 (PubMed:14702039).Curated	1
Sequence conflictⁱ	247	S → F in AAB66581 (PubMed:9843966).Curated	1
Sequence conflictⁱ	420	M → T in BAG63592 (PubMed:14702039).Curated	1
Sequence conflictⁱ	553	G → V in AAB66581 (PubMed:9843966).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_043382	1 – 34	MAAMA…LGAVA → MRGPNSGTEKGRLVIPE in isoform 2, isoform 3 and isoform 4. 2 PublicationsAdd BLAST	34
Alternative sequenceⁱVSP_054685	77 – 120	Missing in isoform 3 and isoform 5. 1 PublicationAdd BLAST	44
Alternative sequenceⁱVSP_054768	106 – 259	Missing in isoform 4. 1 PublicationAdd BLAST	154

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF015913 mRNA Translation: AAB66581.1 AF167572 mRNA Translation: AAF04502.1 AK075251 mRNA Translation: BAG52095.1 AK301812 mRNA Translation: BAG63261.1 AK302240 mRNA Translation: BAG63592.1 CR456741 mRNA Translation: CAG33022.1 AB451246 mRNA Translation: BAG70060.1 AB451370 mRNA Translation: BAG70184.1 AL132780 Genomic DNA No translation available. CH471078 Genomic DNA Translation: EAW66218.1 CH471078 Genomic DNA Translation: EAW66219.1 CH471078 Genomic DNA Translation: EAW66220.1 CH471078 Genomic DNA Translation: EAW66221.1 BC005820 mRNA No translation available. BC025979 mRNA Translation: AAH25979.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS41922.1 [O14744-2] CCDS61394.1 [O14744-3] CCDS61395.1 [O14744-4] CCDS61396.1 [O14744-5] CCDS9579.1 [O14744-1]
PIRⁱ	T03842
NCBI Reference Sequences More...RefSeqⁱ	NP_001034708.1, NM_001039619.2 [O14744-2] NP_001269882.1, NM_001282953.1 [O14744-3] NP_001269884.1, NM_001282955.1 [O14744-5] NP_001269885.1, NM_001282956.1 [O14744-4] NP_006100.2, NM_006109.4 [O14744-1]
UniGeneⁱ	Hs.367854

Genome annotation databases

Ensemblⁱ	ENST00000216350; ENSP00000216350; ENSG00000100462 [O14744-3] ENST00000324366; ENSP00000319169; ENSG00000100462 [O14744-1] ENST00000397440; ENSP00000380582; ENSG00000100462 [O14744-4] ENST00000397441; ENSP00000380583; ENSG00000100462 [O14744-2] ENST00000553897; ENSP00000452555; ENSG00000100462 [O14744-5]
GeneIDⁱ	10419
KEGGⁱ	hsa:10419
UCSC genome browser More...UCSCⁱ	uc001whl.3 human [O14744-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O14744	Protein arginine N-methyltransferase 5		PANTR		637	UniRef100_O14744
Protein arginine N-methyltransferase 5		MACMU		637
Protein arginine N-methyltransferase 5		TARSY		637
Protein arginine N-methyltransferase 5		RHIRO		637
Protein arginine N-methyltransferase 5		PAPAN		637
+14
O14744-2	Protein arginine N-methyltransferase 5		PANTR		620	UniRef100_K6ZQM6
Protein arginine N-methyltransferase 5		TARSY		620
Protein arginine N-methyltransferase 5		PANPA		620
Protein arginine N-methyltransferase 5		NOMLE		620
O14744-4	PRMT5 isoform 5		PANTR		466	UniRef100_A0A2I3T9Y7
PRMT5 isoform 16		PONAB		466
Protein arginine methyltransferase 5		PANPA		466
Protein arginine methyltransferase 5		NOMLE		466
O14744-5	Protein arginine N-methyltransferase 5		PANTR		593	UniRef100_A0A2I3TFP6
Protein arginine N-methyltransferase 5		MACMU		593
Protein arginine N-methyltransferase 5		RHIRO		593
Protein arginine N-methyltransferase 5		PAPAN		593
Protein arginine N-methyltransferase 5		GORGO		593
+3
O14744-3	Protein arginine N-methyltransferase 5		PANTR		576	UniRef100_A0A2J8QK01
Protein arginine N-methyltransferase 5		PANPA		576
Protein arginine N-methyltransferase 5		NOMLE		576

Protein	Similar proteins		Species	Score	Length	Source
O14744	Protein arginine N-methyltransferase 5		BOVIN		637	UniRef90_O14744
Protein arginine N-methyltransferase 5		MACFA		637
Protein arginine N-methyltransferase 5		MOUSE		637
Protein arginine N-methyltransferase 5		PONAB		637
Protein arginine N-methyltransferase 5		PANTR		637
+251
O14744-4	Protein arginine N-methyltransferase 5		MACMU		466	UniRef90_F6SB65
Protein arginine methyltransferase 5		CERAT		466
Protein arginine methyltransferase 5		PAPAN		466
Protein arginine methyltransferase 5		MANLE		466
Protein arginine N-methyltransferase 5		MACFA		466
+21
O14744-5	Protein arginine N-methyltransferase 5		PANTR		593	UniRef90_A0A2I3TFP6
Protein arginine N-methyltransferase 5		MACMU		593
Protein arginine N-methyltransferase 5		RHIRO		593
Protein arginine N-methyltransferase 5		PAPAN		593
Protein arginine N-methyltransferase 5		GORGO		593
+43
O14744-3	Protein arginine N-methyltransferase 5		PANTR		593	UniRef90_A0A2I3TFP6
Protein arginine N-methyltransferase 5		MACMU		593
Protein arginine N-methyltransferase 5		RHIRO		593
Protein arginine N-methyltransferase 5		PAPAN		593
Protein arginine N-methyltransferase 5		GORGO		593
+43

Protein	Similar proteins		Species	Score	Length	Source
O14744	Protein arginine N-methyltransferase 5		MOUSE		637	UniRef50_O14744
Protein arginine N-methyltransferase 5		PONAB		637
Protein arginine N-methyltransferase 5		BOVIN		637
Protein arginine N-methyltransferase 5		MACFA		637
Protein arginine N-methyltransferase 5		PANTR		637
+307
O14744-4	Protein arginine N-methyltransferase 5		MACMU		466	UniRef50_F6SB65
Protein arginine methyltransferase 5		CERAT		466
Protein arginine methyltransferase 5		PAPAN		466
Protein arginine methyltransferase 5		MANLE		466
Protein arginine N-methyltransferase 5		MACFA		466
+26
O14744-5	Protein arginine N-methyltransferase 5		DANRE		631	UniRef50_B0R026
Protein arginine N-methyltransferase 5		SALSA		633
Protein arginine N-methyltransferase 5		Asian bonytongue		632
Protein arginine N-methyltransferase 5		ASTMX		631
Protein arginine N-methyltransferase		Daphnia magna		644
+201
O14744-3	Protein arginine N-methyltransferase 5		DANRE		631	UniRef50_B0R026
Protein arginine N-methyltransferase 5		SALSA		633
Protein arginine N-methyltransferase 5		Asian bonytongue		632
Protein arginine N-methyltransferase 5		ASTMX		631
Protein arginine N-methyltransferase		Daphnia magna		644
+201

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF015913 mRNA Translation: AAB66581.1 AF167572 mRNA Translation: AAF04502.1 AK075251 mRNA Translation: BAG52095.1 AK301812 mRNA Translation: BAG63261.1 AK302240 mRNA Translation: BAG63592.1 CR456741 mRNA Translation: CAG33022.1 AB451246 mRNA Translation: BAG70060.1 AB451370 mRNA Translation: BAG70184.1 AL132780 Genomic DNA No translation available. CH471078 Genomic DNA Translation: EAW66218.1 CH471078 Genomic DNA Translation: EAW66219.1 CH471078 Genomic DNA Translation: EAW66220.1 CH471078 Genomic DNA Translation: EAW66221.1 BC005820 mRNA No translation available. BC025979 mRNA Translation: AAH25979.1
CCDSⁱ	CCDS41922.1 [O14744-2] CCDS61394.1 [O14744-3] CCDS61395.1 [O14744-4] CCDS61396.1 [O14744-5] CCDS9579.1 [O14744-1]
PIRⁱ	T03842
RefSeqⁱ	NP_001034708.1, NM_001039619.2 [O14744-2] NP_001269882.1, NM_001282953.1 [O14744-3] NP_001269884.1, NM_001282955.1 [O14744-5] NP_001269885.1, NM_001282956.1 [O14744-4] NP_006100.2, NM_006109.4 [O14744-1]
UniGeneⁱ	Hs.367854

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4GQB	X-ray	2.06	A	1-637	[»]
	4X60	X-ray	2.35	A	2-637	[»]
	4X61	X-ray	2.85	A	2-637	[»]
	4X63	X-ray	3.05	A	2-637	[»]
	5C9Z	X-ray	2.36	A	2-637	[»]
	5EMJ	X-ray	2.27	A	2-637	[»]
	5EMK	X-ray	2.52	A	2-637	[»]
	5EML	X-ray	2.39	A	2-637	[»]
	5EMM	X-ray	2.37	A	2-637	[»]
	5FA5	X-ray	2.34	A	1-637	[»]
	6CKC	X-ray	2.80	A	1-637	[»]
ProteinModelPortalⁱ	O14744
SMRⁱ	O14744
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	115688, 190 interactors
ComplexPortalⁱ	CPX-696 Methylosome
CORUMⁱ	O14744
DIPⁱ	DIP-33172N
IntActⁱ	O14744, 102 interactors
MINTⁱ	O14744
STRINGⁱ	9606.ENSP00000319169

Chemistry databases

BindingDBⁱ	O14744
ChEMBLⁱ	CHEMBL1795116
GuidetoPHARMACOLOGYⁱ	1256

PTM databases

iPTMnetⁱ	O14744
PhosphoSitePlusⁱ	O14744
SwissPalmⁱ	O14744

Proteomic databases

EPDⁱ	O14744
MaxQBⁱ	O14744
PaxDbⁱ	O14744
PeptideAtlasⁱ	O14744
PRIDEⁱ	O14744
ProteomicsDBⁱ	48200 48201 [O14744-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	10419
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000216350; ENSP00000216350; ENSG00000100462 [O14744-3] ENST00000324366; ENSP00000319169; ENSG00000100462 [O14744-1] ENST00000397440; ENSP00000380582; ENSG00000100462 [O14744-4] ENST00000397441; ENSP00000380583; ENSG00000100462 [O14744-2] ENST00000553897; ENSP00000452555; ENSG00000100462 [O14744-5]
GeneIDⁱ	10419
KEGGⁱ	hsa:10419
UCSCⁱ	uc001whl.3 human [O14744-1]

Organism-specific databases

CTDⁱ	10419
DisGeNETⁱ	10419
EuPathDBⁱ	HostDB:ENSG00000100462.15
GeneCardsⁱ	PRMT5
H-InvDBⁱ	HIX0011525
HGNCⁱ	HGNC:10894 PRMT5
HPAⁱ	CAB012459 HPA005525 HPA064708
MIMⁱ	604045 gene
neXtProtⁱ	NX_O14744
OpenTargetsⁱ	ENSG00000100462
PharmGKBⁱ	PA35794
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0822 Eukaryota ENOG410XNZM LUCA
GeneTreeⁱ	ENSGT00390000001141
HOGENOMⁱ	HOG000175933
HOVERGENⁱ	HBG057083
InParanoidⁱ	O14744
KOⁱ	K02516
OMAⁱ	FPMFFPT
OrthoDBⁱ	EOG091G03PD
PhylomeDBⁱ	O14744
TreeFamⁱ	TF300626

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS02092-MONOMER
BRENDAⁱ	2.1.1.125 2681
Reactomeⁱ	R-HSA-191859 snRNP Assembly R-HSA-3214858 RMTs methylate histone arginines R-HSA-6804760 Regulation of TP53 Activity through Methylation
SIGNORⁱ	O14744

Miscellaneous databases

ChiTaRSⁱ	PRMT5 human
GeneWikiⁱ	Protein_arginine_methyltransferase_5
GenomeRNAiⁱ	10419
Protein Ontology More...PROⁱ	PR:O14744
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000100462 Expressed in 215 organ(s), highest expression level in testis
CleanExⁱ	HS_PRMT5
ExpressionAtlasⁱ	O14744 baseline and differential
Genevisibleⁱ	O14744 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR025799 Arg_MeTrfase IPR007857 Arg_MeTrfase_PRMT5 IPR035075 PRMT5 IPR035248 PRMT5_C IPR035247 PRMT5_TIM IPR029063 SAM-dependent_MTases
PANTHERⁱ	PTHR10738 PTHR10738, 1 hit
Pfamⁱ	View protein in Pfam PF05185 PRMT5, 1 hit PF17286 PRMT5_C, 1 hit PF17285 PRMT5_TIM, 1 hit
PIRSFⁱ	PIRSF015894 Skb1_MeTrfase, 1 hit
SUPFAMⁱ	SSF53335 SSF53335, 1 hit
PROSITEⁱ	View protein in PROSITE PS51678 SAM_MT_PRMT, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ANM5_HUMAN
Accessionⁱ	O14744Primary (citable) accession number: O14744 Secondary accession number(s): A8MTP3 Q9UKH1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 20, 2003
	Last sequence update:	January 23, 2007
	Last modified:	September 12, 2018
	This is version 173 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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UniProtKB - O14744 (ANM5_HUMAN)

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Protein arginine N-methyltransferase 5

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Golgi apparatus

Nucleus

Other locations

Cytosol

Golgi apparatus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Computationally mapped potential isoform sequencesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ