UniProtKB - O14744 (ANM5_HUMAN)
Protein arginine N-methyltransferase 5
PRMT5
Functioni
Catalytic activityi
- L-arginyl-[protein] + 2 S-adenosyl-L-methionine = 2 H+ + Nω,Nω'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine3 PublicationsEC:2.1.1.3203 Publications
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 304 | Peptide substrate1 Publication | 1 | |
Binding sitei | 307 | Peptide substrate1 Publication | 1 | |
Binding sitei | 324 | S-adenosyl-L-methionine1 Publication | 1 | |
Sitei | 327 | Critical for specifying symmetric addition of methyl groupsBy similarity | 1 | |
Binding sitei | 392 | S-adenosyl-L-methionine1 Publication | 1 | |
Active sitei | 435 | Proton donor/acceptor1 Publication | 1 | |
Active sitei | 444 | Proton donor/acceptor1 Publication | 1 |
GO - Molecular functioni
- E-box binding Source: UniProtKB
- histone-arginine N-methyltransferase activity Source: GO_Central
- histone methyltransferase activity (H4-R3 specific) Source: UniProtKB
- identical protein binding Source: IntAct
- methyl-CpG binding Source: UniProtKB
- methyltransferase activity Source: UniProtKB
- p53 binding Source: UniProtKB
- protein-arginine N-methyltransferase activity Source: UniProtKB
- protein-arginine omega-N symmetric methyltransferase activity Source: UniProtKB
- protein heterodimerization activity Source: MGI
- ribonucleoprotein complex binding Source: UniProtKB
- transcription corepressor activity Source: UniProtKB
GO - Biological processi
- circadian regulation of gene expression Source: UniProtKB
- DNA-templated transcription, termination Source: UniProtKB
- endothelial cell activation Source: UniProtKB
- Golgi ribbon formation Source: UniProtKB
- histone arginine methylation Source: GO_Central
- histone H4-R3 methylation Source: UniProtKB
- liver regeneration Source: Ensembl
- negative regulation of cell differentiation Source: Ensembl
- peptidyl-arginine methylation Source: UniProtKB
- peptidyl-arginine N-methylation Source: WormBase
- positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway Source: WormBase
- positive regulation of oligodendrocyte differentiation Source: Ensembl
- regulation of DNA methylation Source: Ensembl
- regulation of ERK1 and ERK2 cascade Source: Ensembl
- regulation of mitotic nuclear division Source: ProtInc
- regulation of signal transduction by p53 class mediator Source: Reactome
- regulation of transcription, DNA-templated Source: GO_Central
- spliceosomal snRNP assembly Source: UniProtKB
Keywordsi
Molecular function | Chromatin regulator, Methyltransferase, Repressor, Transferase |
Biological process | Biological rhythms, Transcription, Transcription regulation |
Ligand | S-adenosyl-L-methionine |
Enzyme and pathway databases
BioCyci | MetaCyc:HS02092-MONOMER |
BRENDAi | 2.1.1.125, 2681 |
PathwayCommonsi | O14744 |
Reactomei | R-HSA-191859, snRNP Assembly R-HSA-3214858, RMTs methylate histone arginines R-HSA-6804760, Regulation of TP53 Activity through Methylation |
SIGNORi | O14744 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein arginine N-methyltransferase 5 (EC:2.1.1.3203 Publications)Short name: PRMT5 Alternative name(s): 72 kDa ICln-binding protein Histone-arginine N-methyltransferase PRMT5 Jak-binding protein 1 Shk1 kinase-binding protein 1 homolog Short name: SKB1 homolog Short name: SKB1Hs Cleaved into the following chain: |
Gene namesi | Name:PRMT5 Synonyms:HRMT1L5, IBP72, JBP1, SKB1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10894, PRMT5 |
MIMi | 604045, gene |
neXtProti | NX_O14744 |
VEuPathDBi | HostDB:ENSG00000100462.15 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 3 Publications
Nucleus
- Nucleus 4 Publications
Golgi apparatus
- Golgi apparatus 1 Publication
Other locations
- Chromosome 1 Publication
Note: Localizes to promoter regions of target genes on chromosomes.1 Publication
Cytosol
- cytosol Source: UniProtKB
Golgi apparatus
- Golgi apparatus Source: UniProtKB
Nucleus
- histone methyltransferase complex Source: ParkinsonsUK-UCL
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- chromatin Source: UniProtKB
- cytoplasm Source: CACAO
- methylosome Source: UniProtKB
Keywords - Cellular componenti
Chromosome, Cytoplasm, Golgi apparatus, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 365 – 369 | Missing : Increased MAPK1/MAPK3 phosphorylation in response to EGF. 1 Publication | 5 | |
Mutagenesisi | 367 – 368 | GR → AA: Abolishes enzymatic activity. 1 Publication | 2 |
Organism-specific databases
DisGeNETi | 10419 |
OpenTargetsi | ENSG00000100462 |
PharmGKBi | PA35794 |
Miscellaneous databases
Pharosi | O14744, Tchem |
Chemistry databases
ChEMBLi | CHEMBL1795116 |
GuidetoPHARMACOLOGYi | 1256 |
Genetic variation databases
BioMutai | PRMT5 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000212342 | 1 – 637 | Protein arginine N-methyltransferase 5Add BLAST | 637 | |
Initiator methioninei | Removed; alternateCombined sources2 Publications | |||
ChainiPRO_0000417602 | 2 – 637 | Protein arginine N-methyltransferase 5, N-terminally processedAdd BLAST | 636 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanine; in Protein arginine N-methyltransferase 5, N-terminally processedCombined sources1 Publication | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | O14744 |
jPOSTi | O14744 |
MassIVEi | O14744 |
MaxQBi | O14744 |
PaxDbi | O14744 |
PeptideAtlasi | O14744 |
PRIDEi | O14744 |
ProteomicsDBi | 2039 48200 [O14744-1] 48201 [O14744-2] 5410 |
PTM databases
iPTMneti | O14744 |
MetOSitei | O14744 |
PhosphoSitePlusi | O14744 |
SwissPalmi | O14744 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000100462, Expressed in testis and 227 other tissues |
ExpressionAtlasi | O14744, baseline and differential |
Genevisiblei | O14744, HS |
Organism-specific databases
HPAi | ENSG00000100462, Low tissue specificity |
Interactioni
Subunit structurei
Forms, at least, homodimers and homotetramers (PubMed:11152681).
Component of the methylosome complex, composed of PRMT5, WDR77 and CLNS1A (PubMed:21081503, PubMed:23071334, PubMed:33376131).
Found in a complex composed of PRMT5, WDR77 and RIOK1 (PubMed:21081503). RIOK1 and CLNS1A associate with PRMT5 in a mutually exclusive fashion, which allows the recruitment of distinct methylation substrates, such as nucleolin/NCL and Sm proteins, respectively (PubMed:21081503).
Interacts with PRDM1 (By similarity).
Identified in a complex composed of methylosome and PRMT1 and ERH (PubMed:25284789).
Interacts with EGFR; methylates EGFR and stimulates EGFR-mediated ERK activation.
Interacts with HOXA9.
Interacts with SRGAP2.
Found in a complex with COPRS, RUNX1 and CBFB.
Interacts with CHTOP; the interaction symmetrically methylates CHTOP, but seems to require the presence of PRMT1 (PubMed:25284789).
Interacts with EPB41L3; this modulates methylation of target proteins.
Component of a high molecular weight E2F-pocket protein complex, CERC (cyclin E1 repressor complex). Associates with SWI/SNF remodeling complexes containing SMARCA2 and SMARCA4.
Interacts with JAK2, SSTR1, SUPT5H, BRAF and with active RAF1.
Interacts with LSM11, PRMT7 and SNRPD3 (PubMed:17709427, PubMed:16087681).
Interacts with COPRS; promoting its recruitment on histone H4.
Interacts with CLNS1A/pICln (PubMed:21081503, PubMed:9556550).
Identified in a complex with CLNS1A/pICln and Sm proteins.
Interacts with RPS10 (PubMed:20159986).
Interacts with WDR77.
Interacts with IWS1.
Interacts with CRY1.
Interacts with POLR2A (PubMed:26700805).
Interacts with SMN1/SMN2 (PubMed:26700805).
Interacts with LYAR; this interaction is direct (PubMed:25092918).
Interacts with STRAP (PubMed:19011621).
Interacts with TP53 in response to DNA damage; the interaction is STRAP dependent (PubMed:19011621).
Interacts with FAM47E; the interaction is direct, promotes PRMT5 localization to chromatin, and does not disrupt its association with WDR77 or STUB1 (PubMed:33376131).
Interacts with TDRD6 (By similarity).
Interacts with STUB1 (PubMed:33376131).
By similarity25 PublicationsBinary interactionsi
Hide detailsO14744
GO - Molecular functioni
- identical protein binding Source: IntAct
- p53 binding Source: UniProtKB
- protein heterodimerization activity Source: MGI
Protein-protein interaction databases
BioGRIDi | 115688, 317 interactors |
ComplexPortali | CPX-696, PRMT5 methylosome complex |
CORUMi | O14744 |
DIPi | DIP-33172N |
IntActi | O14744, 141 interactors |
MINTi | O14744 |
STRINGi | 9606.ENSP00000319169 |
Chemistry databases
BindingDBi | O14744 |
Miscellaneous databases
RNActi | O14744, protein |
Structurei
Secondary structure
3D structure databases
SMRi | O14744 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 308 – 615 | SAM-dependent MTase PRMT-typePROSITE-ProRule annotationAdd BLAST | 308 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 13 – 292 | TIM barrel1 PublicationAdd BLAST | 280 | |
Regioni | 333 – 334 | S-adenosyl-L-methionine binding1 Publication | 2 | |
Regioni | 419 – 420 | S-adenosyl-L-methionine binding1 Publication | 2 | |
Regioni | 465 – 637 | Beta barrel1 PublicationAdd BLAST | 173 | |
Regioni | 488 – 494 | Dimerization1 Publication | 7 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0822, Eukaryota |
GeneTreei | ENSGT00390000001141 |
HOGENOMi | CLU_010247_3_0_1 |
InParanoidi | O14744 |
OMAi | FPMFFPT |
OrthoDBi | 475852at2759 |
PhylomeDBi | O14744 |
TreeFami | TF300626 |
Family and domain databases
IDEALi | IID00405 |
InterProi | View protein in InterPro IPR025799, Arg_MeTrfase IPR007857, Arg_MeTrfase_PRMT5 IPR035075, PRMT5 IPR035248, PRMT5_C IPR035247, PRMT5_TIM IPR029063, SAM-dependent_MTases |
PANTHERi | PTHR10738, PTHR10738, 1 hit |
Pfami | View protein in Pfam PF05185, PRMT5, 1 hit PF17286, PRMT5_C, 1 hit PF17285, PRMT5_TIM, 1 hit |
PIRSFi | PIRSF015894, Skb1_MeTrfase, 1 hit |
SUPFAMi | SSF53335, SSF53335, 1 hit |
PROSITEi | View protein in PROSITE PS51678, SAM_MT_PRMT, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 14 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAAMAVGGAG GSRVSSGRDL NCVPEIADTL GAVAKQGFDF LCMPVFHPRF
60 70 80 90 100
KREFIQEPAK NRPGPQTRSD LLLSGRDWNT LIVGKLSPWI RPDSKVEKIR
110 120 130 140 150
RNSEAAMLQE LNFGAYLGLP AFLLPLNQED NTNLARVLTN HIHTGHHSSM
160 170 180 190 200
FWMRVPLVAP EDLRDDIIEN APTTHTEEYS GEEKTWMWWH NFRTLCDYSK
210 220 230 240 250
RIAVALEIGA DLPSNHVIDR WLGEPIKAAI LPTSIFLTNK KGFPVLSKMH
260 270 280 290 300
QRLIFRLLKL EVQFIITGTN HHSEKEFCSY LQYLEYLSQN RPPPNAYELF
310 320 330 340 350
AKGYEDYLQS PLQPLMDNLE SQTYEVFEKD PIKYSQYQQA IYKCLLDRVP
360 370 380 390 400
EEEKDTNVQV LMVLGAGRGP LVNASLRAAK QADRRIKLYA VEKNPNAVVT
410 420 430 440 450
LENWQFEEWG SQVTVVSSDM REWVAPEKAD IIVSELLGSF ADNELSPECL
460 470 480 490 500
DGAQHFLKDD GVSIPGEYTS FLAPISSSKL YNEVRACREK DRDPEAQFEM
510 520 530 540 550
PYVVRLHNFH QLSAPQPCFT FSHPNRDPMI DNNRYCTLEF PVEVNTVLHG
560 570 580 590 600
FAGYFETVLY QDITLSIRPE THSPGMFSWF PILFPIKQPI TVREGQTICV
610 620 630
RFWRCSNSKK VWYEWAVTAP VCSAIHNPTG RSYTIGL
Computationally mapped potential isoform sequencesi
There are 14 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YJD3 | H0YJD3_HUMAN | Histone-arginine N-methyltransferas... | PRMT5 | 177 | Annotation score: | ||
H7BZ44 | H7BZ44_HUMAN | Histone-arginine N-methyltransferas... | PRMT5 | 179 | Annotation score: | ||
C9JSX3 | C9JSX3_HUMAN | Protein arginine N-methyltransferas... | PRMT5 | 186 | Annotation score: | ||
G3V2X6 | G3V2X6_HUMAN | Protein arginine N-methyltransferas... | PRMT5 | 185 | Annotation score: | ||
H0YJY6 | H0YJY6_HUMAN | Protein arginine N-methyltransferas... | PRMT5 | 61 | Annotation score: | ||
G3V2L6 | G3V2L6_HUMAN | Protein arginine N-methyltransferas... | PRMT5 | 183 | Annotation score: | ||
G3V580 | G3V580_HUMAN | Protein arginine N-methyltransferas... | PRMT5 | 180 | Annotation score: | ||
G3V5T6 | G3V5T6_HUMAN | Protein arginine N-methyltransferas... | PRMT5 | 104 | Annotation score: | ||
H0YJ77 | H0YJ77_HUMAN | Protein arginine N-methyltransferas... | PRMT5 | 138 | Annotation score: | ||
H0YJX6 | H0YJX6_HUMAN | Protein arginine N-methyltransferas... | PRMT5 | 279 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 183 | E → K in BAG63592 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 247 | S → F in AAB66581 (PubMed:9843966).Curated | 1 | |
Sequence conflicti | 420 | M → T in BAG63592 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 553 | G → V in AAB66581 (PubMed:9843966).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_043382 | 1 – 34 | MAAMA…LGAVA → MRGPNSGTEKGRLVIPE in isoform 2, isoform 3 and isoform 4. 2 PublicationsAdd BLAST | 34 | |
Alternative sequenceiVSP_054685 | 77 – 120 | Missing in isoform 3 and isoform 5. 1 PublicationAdd BLAST | 44 | |
Alternative sequenceiVSP_054768 | 106 – 259 | Missing in isoform 4. 1 PublicationAdd BLAST | 154 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF015913 mRNA Translation: AAB66581.1 AF167572 mRNA Translation: AAF04502.1 AK075251 mRNA Translation: BAG52095.1 AK301812 mRNA Translation: BAG63261.1 AK302240 mRNA Translation: BAG63592.1 CR456741 mRNA Translation: CAG33022.1 AB451246 mRNA Translation: BAG70060.1 AB451370 mRNA Translation: BAG70184.1 AL132780 Genomic DNA No translation available. CH471078 Genomic DNA Translation: EAW66218.1 CH471078 Genomic DNA Translation: EAW66219.1 CH471078 Genomic DNA Translation: EAW66220.1 CH471078 Genomic DNA Translation: EAW66221.1 BC005820 mRNA No translation available. BC025979 mRNA Translation: AAH25979.1 |
CCDSi | CCDS41922.1 [O14744-2] CCDS61394.1 [O14744-3] CCDS61395.1 [O14744-4] CCDS61396.1 [O14744-5] CCDS9579.1 [O14744-1] |
PIRi | T03842 |
RefSeqi | NP_001034708.1, NM_001039619.2 [O14744-2] NP_001269882.1, NM_001282953.1 [O14744-3] NP_001269884.1, NM_001282955.1 [O14744-5] NP_001269885.1, NM_001282956.1 [O14744-4] NP_006100.2, NM_006109.4 [O14744-1] |
Genome annotation databases
Ensembli | ENST00000216350; ENSP00000216350; ENSG00000100462 [O14744-3] ENST00000324366; ENSP00000319169; ENSG00000100462 [O14744-1] ENST00000397440; ENSP00000380582; ENSG00000100462 [O14744-4] ENST00000397441; ENSP00000380583; ENSG00000100462 [O14744-2] ENST00000553897; ENSP00000452555; ENSG00000100462 [O14744-5] |
GeneIDi | 10419 |
KEGGi | hsa:10419 |
UCSCi | uc001whl.3, human [O14744-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF015913 mRNA Translation: AAB66581.1 AF167572 mRNA Translation: AAF04502.1 AK075251 mRNA Translation: BAG52095.1 AK301812 mRNA Translation: BAG63261.1 AK302240 mRNA Translation: BAG63592.1 CR456741 mRNA Translation: CAG33022.1 AB451246 mRNA Translation: BAG70060.1 AB451370 mRNA Translation: BAG70184.1 AL132780 Genomic DNA No translation available. CH471078 Genomic DNA Translation: EAW66218.1 CH471078 Genomic DNA Translation: EAW66219.1 CH471078 Genomic DNA Translation: EAW66220.1 CH471078 Genomic DNA Translation: EAW66221.1 BC005820 mRNA No translation available. BC025979 mRNA Translation: AAH25979.1 |
CCDSi | CCDS41922.1 [O14744-2] CCDS61394.1 [O14744-3] CCDS61395.1 [O14744-4] CCDS61396.1 [O14744-5] CCDS9579.1 [O14744-1] |
PIRi | T03842 |
RefSeqi | NP_001034708.1, NM_001039619.2 [O14744-2] NP_001269882.1, NM_001282953.1 [O14744-3] NP_001269884.1, NM_001282955.1 [O14744-5] NP_001269885.1, NM_001282956.1 [O14744-4] NP_006100.2, NM_006109.4 [O14744-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4GQB | X-ray | 2.06 | A | 1-637 | [»] | |
4X60 | X-ray | 2.35 | A | 2-637 | [»] | |
4X61 | X-ray | 2.85 | A | 2-637 | [»] | |
4X63 | X-ray | 3.05 | A | 2-637 | [»] | |
5C9Z | X-ray | 2.36 | A | 2-637 | [»] | |
5EMJ | X-ray | 2.27 | A | 2-637 | [»] | |
5EMK | X-ray | 2.52 | A | 2-637 | [»] | |
5EML | X-ray | 2.39 | A | 2-637 | [»] | |
5EMM | X-ray | 2.37 | A | 2-637 | [»] | |
5FA5 | X-ray | 2.34 | A | 1-637 | [»] | |
6CKC | X-ray | 2.80 | A | 1-637 | [»] | |
6K1S | X-ray | 2.60 | A | 2-637 | [»] | |
6RLL | X-ray | 2.22 | A | 2-637 | [»] | |
6RLQ | X-ray | 2.53 | A | 2-637 | [»] | |
6UGH | electron microscopy | 3.40 | A | 1-637 | [»] | |
6UXX | X-ray | 2.69 | A | 2-637 | [»] | |
6UXY | X-ray | 2.57 | A | 2-637 | [»] | |
6V0N | X-ray | 2.11 | A | 1-637 | [»] | |
6V0O | X-ray | 2.86 | A | 1-637 | [»] | |
6V0P | X-ray | 1.88 | A | 1-637 | [»] | |
SMRi | O14744 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 115688, 317 interactors |
ComplexPortali | CPX-696, PRMT5 methylosome complex |
CORUMi | O14744 |
DIPi | DIP-33172N |
IntActi | O14744, 141 interactors |
MINTi | O14744 |
STRINGi | 9606.ENSP00000319169 |
Chemistry databases
BindingDBi | O14744 |
ChEMBLi | CHEMBL1795116 |
GuidetoPHARMACOLOGYi | 1256 |
PTM databases
iPTMneti | O14744 |
MetOSitei | O14744 |
PhosphoSitePlusi | O14744 |
SwissPalmi | O14744 |
Genetic variation databases
BioMutai | PRMT5 |
Proteomic databases
EPDi | O14744 |
jPOSTi | O14744 |
MassIVEi | O14744 |
MaxQBi | O14744 |
PaxDbi | O14744 |
PeptideAtlasi | O14744 |
PRIDEi | O14744 |
ProteomicsDBi | 2039 48200 [O14744-1] 48201 [O14744-2] 5410 |
Protocols and materials databases
ABCDi | O14744, 6 sequenced antibodies |
Antibodypediai | 115, 628 antibodies |
DNASUi | 10419 |
Genome annotation databases
Ensembli | ENST00000216350; ENSP00000216350; ENSG00000100462 [O14744-3] ENST00000324366; ENSP00000319169; ENSG00000100462 [O14744-1] ENST00000397440; ENSP00000380582; ENSG00000100462 [O14744-4] ENST00000397441; ENSP00000380583; ENSG00000100462 [O14744-2] ENST00000553897; ENSP00000452555; ENSG00000100462 [O14744-5] |
GeneIDi | 10419 |
KEGGi | hsa:10419 |
UCSCi | uc001whl.3, human [O14744-1] |
Organism-specific databases
CTDi | 10419 |
DisGeNETi | 10419 |
GeneCardsi | PRMT5 |
HGNCi | HGNC:10894, PRMT5 |
HPAi | ENSG00000100462, Low tissue specificity |
MIMi | 604045, gene |
neXtProti | NX_O14744 |
OpenTargetsi | ENSG00000100462 |
PharmGKBi | PA35794 |
VEuPathDBi | HostDB:ENSG00000100462.15 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0822, Eukaryota |
GeneTreei | ENSGT00390000001141 |
HOGENOMi | CLU_010247_3_0_1 |
InParanoidi | O14744 |
OMAi | FPMFFPT |
OrthoDBi | 475852at2759 |
PhylomeDBi | O14744 |
TreeFami | TF300626 |
Enzyme and pathway databases
BioCyci | MetaCyc:HS02092-MONOMER |
BRENDAi | 2.1.1.125, 2681 |
PathwayCommonsi | O14744 |
Reactomei | R-HSA-191859, snRNP Assembly R-HSA-3214858, RMTs methylate histone arginines R-HSA-6804760, Regulation of TP53 Activity through Methylation |
SIGNORi | O14744 |
Miscellaneous databases
BioGRID-ORCSi | 10419, 683 hits in 1018 CRISPR screens |
ChiTaRSi | PRMT5, human |
GeneWikii | Protein_arginine_methyltransferase_5 |
GenomeRNAii | 10419 |
Pharosi | O14744, Tchem |
PROi | PR:O14744 |
RNActi | O14744, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000100462, Expressed in testis and 227 other tissues |
ExpressionAtlasi | O14744, baseline and differential |
Genevisiblei | O14744, HS |
Family and domain databases
IDEALi | IID00405 |
InterProi | View protein in InterPro IPR025799, Arg_MeTrfase IPR007857, Arg_MeTrfase_PRMT5 IPR035075, PRMT5 IPR035248, PRMT5_C IPR035247, PRMT5_TIM IPR029063, SAM-dependent_MTases |
PANTHERi | PTHR10738, PTHR10738, 1 hit |
Pfami | View protein in Pfam PF05185, PRMT5, 1 hit PF17286, PRMT5_C, 1 hit PF17285, PRMT5_TIM, 1 hit |
PIRSFi | PIRSF015894, Skb1_MeTrfase, 1 hit |
SUPFAMi | SSF53335, SSF53335, 1 hit |
PROSITEi | View protein in PROSITE PS51678, SAM_MT_PRMT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ANM5_HUMAN | |
Accessioni | O14744Primary (citable) accession number: O14744 Secondary accession number(s): A8MTP3 Q9UKH1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 20, 2003 |
Last sequence update: | January 23, 2007 | |
Last modified: | April 7, 2021 | |
This is version 194 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families