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UniProtKB - O14744 (ANM5_HUMAN)

Entry version 195 (02 Jun 2021)
Sequence version 4 (23 Jan 2007)
Previous versions | rss
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Protein

Protein arginine N-methyltransferase 5

Gene

PRMT5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA (PubMed:10531356, PubMed:11152681, PubMed:11747828, PubMed:12411503, PubMed:15737618, PubMed:17709427, PubMed:20159986, PubMed:20810653, PubMed:21258366, PubMed:21917714, PubMed:22269951, PubMed:21081503).

Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles (PubMed:12411503, PubMed:11747828, PubMed:17709427).

Methylates SUPT5H and may regulate its transcriptional elongation properties (PubMed:12718890).

Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. Methylates histone H2A and H4 'Arg-3' during germ cell development (By similarity).

Methylates histone H3 'Arg-8', which may repress transcription (By similarity).

Methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage (By similarity).

Methylates RPS10. Attenuates EGF signaling through the MAPK1/MAPK3 pathway acting at 2 levels. First, monomethylates EGFR; this enhances EGFR 'Tyr-1197' phosphorylation and PTPN6 recruitment, eventually leading to reduced SOS1 phosphorylation (PubMed:21917714, PubMed:21258366).

Second, methylates RAF1 and probably BRAF, hence destabilizing these 2 signaling proteins and reducing their catalytic activity (PubMed:21917714).

Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation. Methylates HOXA9 (PubMed:22269951).

Methylates and regulates SRGAP2 which is involved in cell migration and differentiation (PubMed:20810653).

Acts as a transcriptional corepressor in CRY1-mediated repression of the core circadian component PER1 by regulating the H4R3 dimethylation at the PER1 promoter (By similarity).

Methylates GM130/GOLGA2, regulating Golgi ribbon formation (PubMed:20421892).

Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner (PubMed:25284789).

Symmetrically methylates POLR2A, a modification that allows the recruitment to POLR2A of proteins including SMN1/SMN2 and SETX. This is required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination (PubMed:26700805).

Along with LYAR, binds the promoter of gamma-globin HBG1/HBG2 and represses its expression (PubMed:25092918).

Symmetrically methylates NCL (PubMed:21081503).

Methylates TP53; methylation might possibly affect TP53 target gene specificity (PubMed:19011621).

Involved in spliceosome maturation and mRNA splicing in prophase I spermatocytes through the catalysis of the symmetrical arginine dimethylation of SNRPB (small nuclear ribonucleoprotein-associated protein) and the interaction with tudor domain-containing protein TDRD6 (By similarity).

By similarity18 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activity is increased by EGF, HGF, FGF1 or FGF2 treatments, and slightly decreased by NGF treatment.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei304Peptide substrate1 Publication1
Binding sitei307Peptide substrate1 Publication1
Binding sitei324S-adenosyl-L-methionine1 Publication1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei327Critical for specifying symmetric addition of methyl groupsBy similarity1
Binding sitei392S-adenosyl-L-methionine1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei435Proton donor/acceptor1 Publication1
Active sitei444Proton donor/acceptor1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, Methyltransferase, Repressor, Transferase
Biological processBiological rhythms, Transcription, Transcription regulation
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:HS02092-MONOMER

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.1.1.320, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O14744

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-191859, snRNP Assembly
R-HSA-3214858, RMTs methylate histone arginines
R-HSA-6804760, Regulation of TP53 Activity through Methylation

SIGNOR Signaling Network Open Resource

More...SIGNORi		O14744

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein arginine N-methyltransferase 5 (EC:2.1.1.3203 Publications)
Short name:
PRMT5
Alternative name(s):
72 kDa ICln-binding protein
Histone-arginine N-methyltransferase PRMT5
Jak-binding protein 1
Shk1 kinase-binding protein 1 homolog
Short name:
SKB1 homolog
Short name:
SKB1Hs
Cleaved into the following chain:
Protein arginine N-methyltransferase 5, N-terminally processed
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PRMT5
Synonyms:HRMT1L5, IBP72, JBP1, SKB1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:10894, PRMT5

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604045, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O14744

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000100462.15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Chromosome, Cytoplasm, Golgi apparatus, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi365 – 369Missing : Increased MAPK1/MAPK3 phosphorylation in response to EGF. 1 Publication5
Mutagenesisi367 – 368GR → AA: Abolishes enzymatic activity. 1 Publication2

Organism-specific databases

DisGeNET

More...DisGeNETi		10419

Open Targets

More...OpenTargetsi		ENSG00000100462

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA35794

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O14744, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL1795116

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		1256

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PRMT5

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002123421 – 637Protein arginine N-methyltransferase 5Add BLAST637
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved; alternateCombined sources2 Publications
ChainiPRO_00004176022 – 637Protein arginine N-methyltransferase 5, N-terminally processedAdd BLAST636

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanine; in Protein arginine N-methyltransferase 5, N-terminally processedCombined sources1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O14744

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O14744

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O14744

MaxQB - The MaxQuant DataBase

More...MaxQBi		O14744

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O14744

PeptideAtlas

More...PeptideAtlasi		O14744

PRoteomics IDEntifications database

More...PRIDEi		O14744

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		2039
48200 [O14744-1]
48201 [O14744-2]
5410

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O14744

MetOSite database of methionine sulfoxide sites

More...MetOSitei		O14744

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O14744

SwissPalm database of S-palmitoylation events

More...SwissPalmi		O14744

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000100462, Expressed in testis and 228 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O14744, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O14744, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000100462, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms, at least, homodimers and homotetramers (PubMed:11152681).

Component of the methylosome complex, composed of PRMT5, WDR77 and CLNS1A (PubMed:21081503, PubMed:23071334, PubMed:33376131).

Found in a complex composed of PRMT5, WDR77 and RIOK1 (PubMed:21081503). RIOK1 and CLNS1A associate with PRMT5 in a mutually exclusive fashion, which allows the recruitment of distinct methylation substrates, such as nucleolin/NCL and Sm proteins, respectively (PubMed:21081503).

Interacts with PRDM1 (By similarity).

Identified in a complex composed of methylosome and PRMT1 and ERH (PubMed:25284789).

Interacts with EGFR; methylates EGFR and stimulates EGFR-mediated ERK activation.

Interacts with HOXA9.

Interacts with SRGAP2.

Found in a complex with COPRS, RUNX1 and CBFB.

Interacts with CHTOP; the interaction symmetrically methylates CHTOP, but seems to require the presence of PRMT1 (PubMed:25284789).

Interacts with EPB41L3; this modulates methylation of target proteins.

Component of a high molecular weight E2F-pocket protein complex, CERC (cyclin E1 repressor complex). Associates with SWI/SNF remodeling complexes containing SMARCA2 and SMARCA4.

Interacts with JAK2, SSTR1, SUPT5H, BRAF and with active RAF1.

Interacts with LSM11, PRMT7 and SNRPD3 (PubMed:17709427, PubMed:16087681).

Interacts with COPRS; promoting its recruitment on histone H4.

Interacts with CLNS1A/pICln (PubMed:21081503, PubMed:9556550).

Identified in a complex with CLNS1A/pICln and Sm proteins.

Interacts with RPS10 (PubMed:20159986).

Interacts with WDR77.

Interacts with IWS1.

Interacts with CRY1.

Interacts with POLR2A (PubMed:26700805).

Interacts with SMN1/SMN2 (PubMed:26700805).

Interacts with LYAR; this interaction is direct (PubMed:25092918).

Interacts with STRAP (PubMed:19011621).

Interacts with TP53 in response to DNA damage; the interaction is STRAP dependent (PubMed:19011621).

Interacts with FAM47E; the interaction is direct, promotes PRMT5 localization to chromatin, and does not disrupt its association with WDR77 or STUB1 (PubMed:33376131).

Interacts with TDRD6 (By similarity).

Interacts with STUB1 (PubMed:33376131).

By similarity25 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
O14744
With#Exp.IntAct
AGT [P01019]3EBI-351098,EBI-751728
BRK1 [Q8WUW1]3EBI-351098,EBI-2837444
C1orf109 [Q9NX04]3EBI-351098,EBI-8643161
CACNB2 [Q08289]3EBI-351098,EBI-2874501
CCT2 [P78371]3EBI-351098,EBI-357407
CDC37 [Q16543]3EBI-351098,EBI-295634
CDYL2 [Q8N8U2]2EBI-351098,EBI-8467076
CLNS1A [P54105]8EBI-351098,EBI-724693
COMT - isoform Soluble [P21964-2]3EBI-351098,EBI-10200977
COPRS [Q9NQ92]6EBI-351098,EBI-1642558
CRY1 [Q16526]3EBI-351098,EBI-741297
DNMT3A [Q9Y6K1]4EBI-351098,EBI-923653
E2F1 [Q01094]8EBI-351098,EBI-448924
EHHADH [Q08426]3EBI-351098,EBI-2339219
EIF4A3 [P38919]3EBI-351098,EBI-299104
ELOA [Q14241]3EBI-351098,EBI-742350
EPHB6 - isoform 2 [O15197-2]3EBI-351098,EBI-10182490
FAM47E [Q6ZV65]2EBI-351098,EBI-26583822
FOS [P01100]3EBI-351098,EBI-852851
GAS8 [O95995]3EBI-351098,EBI-1052570
GRB2 [P62993]4EBI-351098,EBI-401755
GRHL3 [Q8TE85]2EBI-351098,EBI-8469396
GTPBP2 [Q9BX10]2EBI-351098,EBI-6115579
H4C9 [P62805]6EBI-351098,EBI-302023
HOXA9 [P31269]4EBI-351098,EBI-742314
HSF1 [Q00613]3EBI-351098,EBI-719620
KANK2 [Q63ZY3]3EBI-351098,EBI-2556193
KLKB1 [P03952]3EBI-351098,EBI-10087153
LNX1 [Q8TBB1]3EBI-351098,EBI-739832
LPL [P06858]3EBI-351098,EBI-715909
NFE4 - isoform 1 [Q86UQ8-1]2EBI-351098,EBI-15759783
NTAQ1 [Q96HA8]3EBI-351098,EBI-741158
NUDCD2 [Q8WVJ2]2EBI-351098,EBI-1052153
POLR2A [P24928]6EBI-351098,EBI-295301
itself3EBI-351098,EBI-351098
RBM23 [Q86U06]3EBI-351098,EBI-780319
RIOK1 [Q9BRS2]4EBI-351098,EBI-7307838
SRGAP2 [O75044]4EBI-351098,EBI-1051034
TRIB3 [Q96RU7]2EBI-351098,EBI-492476
UQCRC1 [P31930]3EBI-351098,EBI-1052596
VHL - isoform 2 [P40337-2]3EBI-351098,EBI-12157263
WDR77 [Q9BQA1]17EBI-351098,EBI-1237307
YWHAZ [P63104]2EBI-351098,EBI-347088
ZMYND19 [Q96E35]3EBI-351098,EBI-746595
Ajuba [Q91XC0] from Mus musculus.4EBI-351098,EBI-1565930
N [P03418] from Human respiratory syncytial virus A (strain A2).2EBI-351098,EBI-6930799
Isoform 1 [O14744-1]
With#Exp.IntAct
FAM47E - isoform 2 [Q6ZV65-2]5EBI-26583938,EBI-26583549

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		115688, 319 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-696, PRMT5 methylosome complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		O14744

Database of interacting proteins

More...DIPi		DIP-33172N

Protein interaction database and analysis system

More...IntActi		O14744, 144 interactors

Molecular INTeraction database

More...MINTi		O14744

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000319169

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		O14744

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O14744, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1637
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O14744

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini308 – 615SAM-dependent MTase PRMT-typePROSITE-ProRule annotationAdd BLAST308

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni13 – 292TIM barrel1 PublicationAdd BLAST280
Regioni333 – 334S-adenosyl-L-methionine binding1 Publication2
Regioni419 – 420S-adenosyl-L-methionine binding1 Publication2
Regioni465 – 637Beta barrel1 PublicationAdd BLAST173
Regioni488 – 494Dimerization1 Publication7

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0822, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000001141

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_010247_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O14744

Identification of Orthologs from Complete Genome Data

More...OMAi		FPMFFPT

Database of Orthologous Groups

More...OrthoDBi		475852at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O14744

TreeFam database of animal gene trees

More...TreeFami		TF300626

Family and domain databases

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID00405

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR025799, Arg_MeTrfase
IPR007857, Arg_MeTrfase_PRMT5
IPR035075, PRMT5
IPR035248, PRMT5_C
IPR035247, PRMT5_TIM
IPR029063, SAM-dependent_MTases

The PANTHER Classification System

More...PANTHERi		PTHR10738, PTHR10738, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05185, PRMT5, 1 hit
PF17286, PRMT5_C, 1 hit
PF17285, PRMT5_TIM, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF015894, Skb1_MeTrfase, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53335, SSF53335, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51678, SAM_MT_PRMT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seems to exist. According to EST sequences.

This entry has 5 described isoforms and 14 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O14744-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAMAVGGAG GSRVSSGRDL NCVPEIADTL GAVAKQGFDF LCMPVFHPRF 
        60         70         80         90        100
KREFIQEPAK NRPGPQTRSD LLLSGRDWNT LIVGKLSPWI RPDSKVEKIR 
       110        120        130        140        150
RNSEAAMLQE LNFGAYLGLP AFLLPLNQED NTNLARVLTN HIHTGHHSSM 
       160        170        180        190        200
FWMRVPLVAP EDLRDDIIEN APTTHTEEYS GEEKTWMWWH NFRTLCDYSK 
       210        220        230        240        250
RIAVALEIGA DLPSNHVIDR WLGEPIKAAI LPTSIFLTNK KGFPVLSKMH 
       260        270        280        290        300
QRLIFRLLKL EVQFIITGTN HHSEKEFCSY LQYLEYLSQN RPPPNAYELF 
       310        320        330        340        350
AKGYEDYLQS PLQPLMDNLE SQTYEVFEKD PIKYSQYQQA IYKCLLDRVP 
       360        370        380        390        400
EEEKDTNVQV LMVLGAGRGP LVNASLRAAK QADRRIKLYA VEKNPNAVVT 
       410        420        430        440        450
LENWQFEEWG SQVTVVSSDM REWVAPEKAD IIVSELLGSF ADNELSPECL 
       460        470        480        490        500
DGAQHFLKDD GVSIPGEYTS FLAPISSSKL YNEVRACREK DRDPEAQFEM 
       510        520        530        540        550
PYVVRLHNFH QLSAPQPCFT FSHPNRDPMI DNNRYCTLEF PVEVNTVLHG 
       560        570        580        590        600
FAGYFETVLY QDITLSIRPE THSPGMFSWF PILFPIKQPI TVREGQTICV 
       610        620        630 
RFWRCSNSKK VWYEWAVTAP VCSAIHNPTG RSYTIGL
Length:637
Mass (Da):72,684
Last modified:January 23, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i522E255B384F25E7
GO
Isoform 2 (identifier: O14744-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-34: MAAMAVGGAGGSRVSSGRDLNCVPEIADTLGAVA → MRGPNSGTEKGRLVIPE

Show »
Length:620
Mass (Da):71,320
Checksum:i0E489272643DD83C
GO
Isoform 4 (identifier: O14744-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-34: MAAMAVGGAGGSRVSSGRDLNCVPEIADTLGAVA → MRGPNSGTEKGRLVIPE
     106-259: Missing.

Show »
Length:466
Mass (Da):53,580
Checksum:i62386C5B867CF619
GO
Isoform 5 (identifier: O14744-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     77-120: Missing.

Show »
Length:593
Mass (Da):67,674
Checksum:iD609BFECAFB7D108
GO
Isoform 3 (identifier: O14744-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-34: MAAMAVGGAGGSRVSSGRDLNCVPEIADTLGAVA → MRGPNSGTEKGRLVIPE
     77-120: Missing.

Show »
Length:576
Mass (Da):66,311
Checksum:i988C2D288FC214A1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 14 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YJD3H0YJD3_HUMAN
Histone-arginine N-methyltransferas...
PRMT5
177Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BZ44H7BZ44_HUMAN
Histone-arginine N-methyltransferas...
PRMT5
179Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JSX3C9JSX3_HUMAN
Protein arginine N-methyltransferas...
PRMT5
186Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V2X6G3V2X6_HUMAN
Protein arginine N-methyltransferas...
PRMT5
185Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJY6H0YJY6_HUMAN
Protein arginine N-methyltransferas...
PRMT5
61Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V2L6G3V2L6_HUMAN
Protein arginine N-methyltransferas...
PRMT5
183Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V580G3V580_HUMAN
Protein arginine N-methyltransferas...
PRMT5
180Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V5T6G3V5T6_HUMAN
Protein arginine N-methyltransferas...
PRMT5
104Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJ77H0YJ77_HUMAN
Protein arginine N-methyltransferas...
PRMT5
138Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJX6H0YJX6_HUMAN
Protein arginine N-methyltransferas...
PRMT5
279Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BC005820 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti183E → K in BAG63592 (PubMed:14702039).Curated1
Sequence conflicti247S → F in AAB66581 (PubMed:9843966).Curated1
Sequence conflicti420M → T in BAG63592 (PubMed:14702039).Curated1
Sequence conflicti553G → V in AAB66581 (PubMed:9843966).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0433821 – 34MAAMA…LGAVA → MRGPNSGTEKGRLVIPE in isoform 2, isoform 3 and isoform 4. 2 PublicationsAdd BLAST34
Alternative sequenceiVSP_05468577 – 120Missing in isoform 3 and isoform 5. 1 PublicationAdd BLAST44
Alternative sequenceiVSP_054768106 – 259Missing in isoform 4. 1 PublicationAdd BLAST154

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF015913 mRNA Translation: AAB66581.1
AF167572 mRNA Translation: AAF04502.1
AK075251 mRNA Translation: BAG52095.1
AK301812 mRNA Translation: BAG63261.1
AK302240 mRNA Translation: BAG63592.1
CR456741 mRNA Translation: CAG33022.1
AB451246 mRNA Translation: BAG70060.1
AB451370 mRNA Translation: BAG70184.1
AL132780 Genomic DNA No translation available.
CH471078 Genomic DNA Translation: EAW66218.1
CH471078 Genomic DNA Translation: EAW66219.1
CH471078 Genomic DNA Translation: EAW66220.1
CH471078 Genomic DNA Translation: EAW66221.1
BC005820 mRNA No translation available.
BC025979 mRNA Translation: AAH25979.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS41922.1 [O14744-2]
CCDS61394.1 [O14744-3]
CCDS61395.1 [O14744-4]
CCDS61396.1 [O14744-5]
CCDS9579.1 [O14744-1]

Protein sequence database of the Protein Information Resource

More...PIRi		T03842

NCBI Reference Sequences

More...RefSeqi		NP_001034708.1, NM_001039619.2 [O14744-2]
NP_001269882.1, NM_001282953.1 [O14744-3]
NP_001269884.1, NM_001282955.1 [O14744-5]
NP_001269885.1, NM_001282956.1 [O14744-4]
NP_006100.2, NM_006109.4 [O14744-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000216350; ENSP00000216350; ENSG00000100462 [O14744-3]
ENST00000324366; ENSP00000319169; ENSG00000100462 [O14744-1]
ENST00000397440; ENSP00000380582; ENSG00000100462 [O14744-4]
ENST00000397441; ENSP00000380583; ENSG00000100462 [O14744-2]
ENST00000553897; ENSP00000452555; ENSG00000100462 [O14744-5]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		10419

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:10419

UCSC genome browser

More...UCSCi		uc001whl.3, human [O14744-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF015913 mRNA Translation: AAB66581.1
AF167572 mRNA Translation: AAF04502.1
AK075251 mRNA Translation: BAG52095.1
AK301812 mRNA Translation: BAG63261.1
AK302240 mRNA Translation: BAG63592.1
CR456741 mRNA Translation: CAG33022.1
AB451246 mRNA Translation: BAG70060.1
AB451370 mRNA Translation: BAG70184.1
AL132780 Genomic DNA No translation available.
CH471078 Genomic DNA Translation: EAW66218.1
CH471078 Genomic DNA Translation: EAW66219.1
CH471078 Genomic DNA Translation: EAW66220.1
CH471078 Genomic DNA Translation: EAW66221.1
BC005820 mRNA No translation available.
BC025979 mRNA Translation: AAH25979.1
CCDSiCCDS41922.1 [O14744-2]
CCDS61394.1 [O14744-3]
CCDS61395.1 [O14744-4]
CCDS61396.1 [O14744-5]
CCDS9579.1 [O14744-1]
PIRiT03842
RefSeqiNP_001034708.1, NM_001039619.2 [O14744-2]
NP_001269882.1, NM_001282953.1 [O14744-3]
NP_001269884.1, NM_001282955.1 [O14744-5]
NP_001269885.1, NM_001282956.1 [O14744-4]
NP_006100.2, NM_006109.4 [O14744-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4GQBX-ray2.06A1-637[»]
4X60X-ray2.35A2-637[»]
4X61X-ray2.85A2-637[»]
4X63X-ray3.05A2-637[»]
5C9ZX-ray2.36A2-637[»]
5EMJX-ray2.27A2-637[»]
5EMKX-ray2.52A2-637[»]
5EMLX-ray2.39A2-637[»]
5EMMX-ray2.37A2-637[»]
5FA5X-ray2.34A1-637[»]
6CKCX-ray2.80A1-637[»]
6K1SX-ray2.60A2-637[»]
6RLLX-ray2.22A2-637[»]
6RLQX-ray2.53A2-637[»]
6UGHelectron microscopy3.40A1-637[»]
6UXXX-ray2.69A2-637[»]
6UXYX-ray2.57A2-637[»]
6V0NX-ray2.11A1-637[»]
6V0OX-ray2.86A1-637[»]
6V0PX-ray1.88A1-637[»]
SMRiO14744
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi115688, 319 interactors
ComplexPortaliCPX-696, PRMT5 methylosome complex
CORUMiO14744
DIPiDIP-33172N
IntActiO14744, 144 interactors
MINTiO14744
STRINGi9606.ENSP00000319169

Chemistry databases

BindingDBiO14744
ChEMBLiCHEMBL1795116
GuidetoPHARMACOLOGYi1256

PTM databases

iPTMnetiO14744
MetOSiteiO14744
PhosphoSitePlusiO14744
SwissPalmiO14744

Genetic variation databases

BioMutaiPRMT5

Proteomic databases

EPDiO14744
jPOSTiO14744
MassIVEiO14744
MaxQBiO14744
PaxDbiO14744
PeptideAtlasiO14744
PRIDEiO14744
ProteomicsDBi2039
48200 [O14744-1]
48201 [O14744-2]
5410

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		O14744, 6 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		115, 630 antibodies

The DNASU plasmid repository

More...DNASUi		10419

Genome annotation databases

EnsembliENST00000216350; ENSP00000216350; ENSG00000100462 [O14744-3]
ENST00000324366; ENSP00000319169; ENSG00000100462 [O14744-1]
ENST00000397440; ENSP00000380582; ENSG00000100462 [O14744-4]
ENST00000397441; ENSP00000380583; ENSG00000100462 [O14744-2]
ENST00000553897; ENSP00000452555; ENSG00000100462 [O14744-5]
GeneIDi10419
KEGGihsa:10419
UCSCiuc001whl.3, human [O14744-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10419
DisGeNETi10419

GeneCards: human genes, protein and diseases

More...GeneCardsi		PRMT5
HGNCiHGNC:10894, PRMT5
HPAiENSG00000100462, Low tissue specificity
MIMi604045, gene
neXtProtiNX_O14744
OpenTargetsiENSG00000100462
PharmGKBiPA35794
VEuPathDBiHostDB:ENSG00000100462.15

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0822, Eukaryota
GeneTreeiENSGT00390000001141
HOGENOMiCLU_010247_3_0_1
InParanoidiO14744
OMAiFPMFFPT
OrthoDBi475852at2759
PhylomeDBiO14744
TreeFamiTF300626

Enzyme and pathway databases

BioCyciMetaCyc:HS02092-MONOMER
BRENDAi2.1.1.320, 2681
PathwayCommonsiO14744
ReactomeiR-HSA-191859, snRNP Assembly
R-HSA-3214858, RMTs methylate histone arginines
R-HSA-6804760, Regulation of TP53 Activity through Methylation
SIGNORiO14744

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		10419, 683 hits in 1018 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PRMT5, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Protein_arginine_methyltransferase_5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		10419
PharosiO14744, Tchem

Protein Ontology

More...PROi		PR:O14744
RNActiO14744, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000100462, Expressed in testis and 228 other tissues
ExpressionAtlasiO14744, baseline and differential
GenevisibleiO14744, HS

Family and domain databases

IDEALiIID00405
InterProiView protein in InterPro
IPR025799, Arg_MeTrfase
IPR007857, Arg_MeTrfase_PRMT5
IPR035075, PRMT5
IPR035248, PRMT5_C
IPR035247, PRMT5_TIM
IPR029063, SAM-dependent_MTases
PANTHERiPTHR10738, PTHR10738, 1 hit
PfamiView protein in Pfam
PF05185, PRMT5, 1 hit
PF17286, PRMT5_C, 1 hit
PF17285, PRMT5_TIM, 1 hit
PIRSFiPIRSF015894, Skb1_MeTrfase, 1 hit
SUPFAMiSSF53335, SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS51678, SAM_MT_PRMT, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiANM5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O14744
Secondary accession number(s): A8MTP3
, A8MZ91, B4DX49, B4DY30, B5BU10, D3DS33, E2QRE7, Q6IBR1, Q9UKH1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: January 23, 2007
Last modified: June 2, 2021
This is version 195 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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