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Protein

Programmed cell death protein 5

Gene

PDCD5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function in the process of apoptosis.

GO - Molecular functioni

  • acetyltransferase activator activity Source: UniProtKB
  • beta-tubulin binding Source: UniProtKB
  • DNA binding Source: InterPro
  • heparin binding Source: UniProtKB

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • cellular response to transforming growth factor beta stimulus Source: UniProtKB
  • negative regulation of cell proliferation Source: UniProtKB
  • negative regulation of chaperone-mediated protein folding Source: UniProtKB
  • positive regulation of apoptotic process Source: FlyBase
  • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
  • positive regulation of gene expression Source: UniProtKB
  • positive regulation of protein import into mitochondrial outer membrane Source: UniProtKB
  • positive regulation of release of cytochrome c from mitochondria Source: UniProtKB

Keywordsi

Biological processApoptosis

Enzyme and pathway databases

SIGNORiO14737

Names & Taxonomyi

Protein namesi
Recommended name:
Programmed cell death protein 5
Alternative name(s):
TF-1 cell apoptosis-related protein 19
Short name:
Protein TFAR19
Gene namesi
Name:PDCD5
Synonyms:TFAR19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000105185.11
HGNCiHGNC:8764 PDCD5
MIMi604583 gene
neXtProtiNX_O14737

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi9141
OpenTargetsiENSG00000105185
PharmGKBiPA33114

Polymorphism and mutation databases

BioMutaiPDCD5

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00001215452 – 125Programmed cell death protein 5Add BLAST124

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei51PhosphoserineCombined sources1
Modified residuei63N6-acetyllysineCombined sources1
Modified residuei119PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO14737
MaxQBiO14737
PaxDbiO14737
PeptideAtlasiO14737
PRIDEiO14737
ProteomicsDBi48199
TopDownProteomicsiO14737-1 [O14737-1]

PTM databases

iPTMnetiO14737
PhosphoSitePlusiO14737

Expressioni

Tissue specificityi

Widely expressed. Highest levels in heart, testis, kidney, pituitary gland, adrenal gland and placenta.

Developmental stagei

Expression in fetal tissues is significantly lower than in adult tissues.

Inductioni

Activated in cells undergoing apoptosis.

Gene expression databases

BgeeiENSG00000105185
CleanExiHS_PDCD5
ExpressionAtlasiO14737 baseline and differential
GenevisibleiO14737 HS

Organism-specific databases

HPAiHPA018471

Interactioni

GO - Molecular functioni

  • beta-tubulin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi114588, 29 interactors
DIPiDIP-50602N
IntActiO14737, 31 interactors
MINTiO14737
STRINGi9606.ENSP00000466214

Structurei

Secondary structure

1125
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2 – 19Combined sources18
Helixi26 – 47Combined sources22
Helixi50 – 62Combined sources13
Helixi64 – 80Combined sources17
Helixi89 – 99Combined sources11
Beta strandi100 – 102Combined sources3

3D structure databases

ProteinModelPortaliO14737
SMRiO14737
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO14737

Family & Domainsi

Sequence similaritiesi

Belongs to the PDCD5 family.Curated

Phylogenomic databases

eggNOGiKOG3431 Eukaryota
COG2118 LUCA
GeneTreeiENSGT00390000011085
HOGENOMiHOG000194121
HOVERGENiHBG053536
InParanoidiO14737
KOiK06875
OMAiRLNTVKM
OrthoDBiEOG091G0XYP
PhylomeDBiO14737

Family and domain databases

Gene3Di1.10.8.140, 1 hit
InterProiView protein in InterPro
IPR002836 PDCD5-like
IPR036883 PDCD5-like_sf
PANTHERiPTHR10840 PTHR10840, 1 hit
PfamiView protein in Pfam
PF01984 dsDNA_bind, 1 hit
PIRSFiPIRSF015730 TFAR19, 1 hit
SUPFAMiSSF46950 SSF46950, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O14737-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADEELEALR RQRLAELQAK HGDPGDAAQQ EAKHREAEMR NSILAQVLDQ
60 70 80 90 100
SARARLSNLA LVKPEKTKAV ENYLIQMARY GQLSEKVSEQ GLIEILKKVS
110 120
QQTEKTTTVK FNRRKVMDSD EDDDY
Length:125
Mass (Da):14,285
Last modified:January 23, 2007 - v3
Checksum:i9569E0679C3DC20D
GO
Isoform 2 (identifier: O14737-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     89-125: EQGLIEILKK...VMDSDEDDDY → LDSLEELYCY...LTLRRNCWRE

Note: No experimental confirmation available.
Show »
Length:129
Mass (Da):14,997
Checksum:i222EF19836188BA0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti104E → K in CAG33215 (Ref. 4) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05620389 – 125EQGLI…EDDDY → LDSLEELYCYLLYQNMASKG QLHLHWITEFLLTLRRNCWR E in isoform 2. 1 PublicationAdd BLAST37

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF014955 mRNA Translation: AAD11579.1
BT006694 mRNA Translation: AAP35340.1
AK293486 mRNA Translation: BAG56975.1
CR456934 mRNA Translation: CAG33215.1
AC008474 Genomic DNA No translation available.
BC015519 mRNA Translation: AAH15519.1
CCDSiCCDS12423.1 [O14737-1]
PIRiJG0192
RefSeqiNP_004699.1, NM_004708.3 [O14737-1]
XP_005259449.1, XM_005259392.4 [O14737-2]
UniGeneiHs.443831

Genome annotation databases

EnsembliENST00000419343; ENSP00000476525; ENSG00000105185 [O14737-2]
ENST00000590247; ENSP00000466214; ENSG00000105185 [O14737-1]
GeneIDi9141
KEGGihsa:9141
UCSCiuc002ntl.4 human [O14737-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPDCD5_HUMAN
AccessioniPrimary (citable) accession number: O14737
Secondary accession number(s): B4DE64, Q53YC9, Q6IB70
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: July 18, 2018
This is version 166 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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