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Protein

CDP-diacylglycerol--inositol 3-phosphatidyltransferase

Gene

CDIPT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns:inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content. The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme.1 Publication

Catalytic activityi

CDP-diacylglycerol + myo-inositol = CMP + phosphatidyl-1D-myo-inositol.1 Publication

Cofactori

Mn2+1 Publication, Mg2+1 PublicationNote: Divalent metal cations; Mn2+ or Mg2+.1 Publication

Activity regulationi

Inhibited by PtdIns (product inhibition), phosphatidylinositol phosphate, and nucleoside di- and tri-phosphates.

pH dependencei

Optimum pH is 9.0.1 Publication

Temperature dependencei

Optimum temperature is 50 degrees Celsius.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism
LigandMagnesium, Manganese

Enzyme and pathway databases

BioCyciMetaCyc:HS02513-MONOMER
BRENDAi2.7.8.11 2681
ReactomeiR-HSA-1483226 Synthesis of PI

Chemistry databases

SwissLipidsiSLP:000000533

Names & Taxonomyi

Protein namesi
Recommended name:
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (EC:2.7.8.11)
Alternative name(s):
Phosphatidylinositol synthase
Short name:
PI synthase
Short name:
PtdIns synthase
Gene namesi
Name:CDIPT
Synonyms:PIS, PIS1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000103502.13
HGNCiHGNC:1769 CDIPT
MIMi605893 gene
neXtProtiNX_O14735

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 26HelicalSequence analysisAdd BLAST21
Transmembranei29 – 49HelicalSequence analysisAdd BLAST21
Transmembranei76 – 96HelicalSequence analysisAdd BLAST21
Transmembranei140 – 160HelicalSequence analysisAdd BLAST21
Transmembranei175 – 195HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10423
OpenTargetsiENSG00000103502
PharmGKBiPA26306

Chemistry databases

DrugBankiDB03106 Myo-Inositol

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000568021 – 213CDP-diacylglycerol--inositol 3-phosphatidyltransferaseAdd BLAST213

Proteomic databases

EPDiO14735
MaxQBiO14735
PaxDbiO14735
PeptideAtlasiO14735
PRIDEiO14735
ProteomicsDBi48197
48198 [O14735-2]

PTM databases

iPTMnetiO14735
PhosphoSitePlusiO14735

Expressioni

Tissue specificityi

Detected in placenta (at protein level). Widely expressed. Higher expression in adult liver and skeletal muscle, slightly lower levels seen in pancreas, kidney, lung, placenta, brain, heart, leukocyte, colon, small intestine, ovary, testis, prostate, thymus and spleen. In fetus, expressed in kidney, liver, lung and brain.1 Publication

Gene expression databases

BgeeiENSG00000103502 Expressed in 241 organ(s), highest expression level in parotid gland
CleanExiHS_CDIPT
ExpressionAtlasiO14735 baseline and differential
GenevisibleiO14735 HS

Organism-specific databases

HPAiHPA056597

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi115692, 28 interactors
DIPiDIP-54492N
IntActiO14735, 84 interactors
MINTiO14735
STRINGi9606.ENSP00000219789

Structurei

3D structure databases

ProteinModelPortaliO14735
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3240 Eukaryota
COG0558 LUCA
GeneTreeiENSGT00390000017279
HOGENOMiHOG000204051
HOVERGENiHBG050862
InParanoidiO14735
KOiK00999
OMAiLWITAPI
PhylomeDBiO14735
TreeFamiTF314603

Family and domain databases

InterProiView protein in InterPro
IPR000462 CDP-OH_P_trans
IPR014387 CDP_diag_ino_3_P_euk
PfamiView protein in Pfam
PF01066 CDP-OH_P_transf, 1 hit
PIRSFiPIRSF000848 CDP_diag_ino_3_P, 1 hit
PROSITEiView protein in PROSITE
PS00379 CDP_ALCOHOL_P_TRANSF, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O14735-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPDENIFLFV PNLIGYARIV FAIISFYFMP CCPLTASSFY LLSGLLDAFD
60 70 80 90 100
GHAARALNQG TRFGAMLDML TDRCSTMCLL VNLALLYPGA TLFFQISMSL
110 120 130 140 150
DVASHWLHLH SSVVRGSESH KMIDLSGNPV LRIYYTSRPA LFTLCAGNEL
160 170 180 190 200
FYCLLYLFHF SEGPLVGSVG LFRMGLWVTA PIALLKSLIS VIHLITAARN
210
MAALDAADRA KKK
Length:213
Mass (Da):23,539
Last modified:January 1, 1998 - v1
Checksum:i7885B72EF2A88093
GO
Isoform 2 (identifier: O14735-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: MPDENIFLFVPNLI → MLPTAAGFSI...PALSPRVPFQ
     111-129: SSVVRGSESHKMIDLSGNP → RSAAILGAWATWRHYSGVG
     130-213: Missing.

Show »
Length:182
Mass (Da):19,455
Checksum:i390F56D184377985
GO
Isoform 3 (identifier: O14735-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     15-59: Missing.

Show »
Length:168
Mass (Da):18,624
Checksum:i7941BB498981C00C
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B3KY94B3KY94_HUMAN
CDP-diacylglycerol--inositol 3-phos...
CDIPT
237Annotation score:
H3BUR9H3BUR9_HUMAN
CDP-diacylglycerol--inositol 3-phos...
CDIPT
157Annotation score:
H3BTJ7H3BTJ7_HUMAN
CDP-diacylglycerol--inositol 3-phos...
CDIPT
41Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti75S → P in BAG62462 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048734199R → C. Corresponds to variant dbSNP:rs1802002Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0136181 – 14MPDEN…VPNLI → MLPTAAGFSIWGQVGAAREA PRCQTKISSCSCPTSSVSAA HGPGPNERARGLGGLPDPAL SPRVPFQ in isoform 2. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_05476715 – 59Missing in isoform 3. 1 PublicationAdd BLAST45
Alternative sequenceiVSP_013619111 – 129SSVVR…LSGNP → RSAAILGAWATWRHYSGVG in isoform 2. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_013620130 – 213Missing in isoform 2. 1 PublicationAdd BLAST84

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF014807 mRNA Translation: AAB94860.1
BT007301 mRNA Translation: AAP35965.1
AK131349 mRNA Translation: BAD18505.1
AK300805 mRNA Translation: BAG62462.1
CR542016 mRNA Translation: CAG46813.1
AC120114 Genomic DNA No translation available.
BC001444 mRNA Translation: AAH01444.1
CCDSiCCDS10657.1 [O14735-1]
CCDS67002.1 [O14735-3]
RefSeqiNP_001273514.1, NM_001286585.1 [O14735-3]
NP_006310.1, NM_006319.4 [O14735-1]
UniGeneiHs.121549

Genome annotation databases

EnsembliENST00000219789; ENSP00000219789; ENSG00000103502 [O14735-1]
ENST00000566113; ENSP00000457340; ENSG00000103502 [O14735-3]
ENST00000569956; ENSP00000457339; ENSG00000103502 [O14735-1]
ENST00000570016; ENSP00000454453; ENSG00000103502 [O14735-1]
GeneIDi10423
KEGGihsa:10423
UCSCiuc002dum.5 human [O14735-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF014807 mRNA Translation: AAB94860.1
BT007301 mRNA Translation: AAP35965.1
AK131349 mRNA Translation: BAD18505.1
AK300805 mRNA Translation: BAG62462.1
CR542016 mRNA Translation: CAG46813.1
AC120114 Genomic DNA No translation available.
BC001444 mRNA Translation: AAH01444.1
CCDSiCCDS10657.1 [O14735-1]
CCDS67002.1 [O14735-3]
RefSeqiNP_001273514.1, NM_001286585.1 [O14735-3]
NP_006310.1, NM_006319.4 [O14735-1]
UniGeneiHs.121549

3D structure databases

ProteinModelPortaliO14735
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115692, 28 interactors
DIPiDIP-54492N
IntActiO14735, 84 interactors
MINTiO14735
STRINGi9606.ENSP00000219789

Chemistry databases

DrugBankiDB03106 Myo-Inositol
SwissLipidsiSLP:000000533

PTM databases

iPTMnetiO14735
PhosphoSitePlusiO14735

Proteomic databases

EPDiO14735
MaxQBiO14735
PaxDbiO14735
PeptideAtlasiO14735
PRIDEiO14735
ProteomicsDBi48197
48198 [O14735-2]

Protocols and materials databases

DNASUi10423
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000219789; ENSP00000219789; ENSG00000103502 [O14735-1]
ENST00000566113; ENSP00000457340; ENSG00000103502 [O14735-3]
ENST00000569956; ENSP00000457339; ENSG00000103502 [O14735-1]
ENST00000570016; ENSP00000454453; ENSG00000103502 [O14735-1]
GeneIDi10423
KEGGihsa:10423
UCSCiuc002dum.5 human [O14735-1]

Organism-specific databases

CTDi10423
DisGeNETi10423
EuPathDBiHostDB:ENSG00000103502.13
GeneCardsiCDIPT
HGNCiHGNC:1769 CDIPT
HPAiHPA056597
MIMi605893 gene
neXtProtiNX_O14735
OpenTargetsiENSG00000103502
PharmGKBiPA26306
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3240 Eukaryota
COG0558 LUCA
GeneTreeiENSGT00390000017279
HOGENOMiHOG000204051
HOVERGENiHBG050862
InParanoidiO14735
KOiK00999
OMAiLWITAPI
PhylomeDBiO14735
TreeFamiTF314603

Enzyme and pathway databases

BioCyciMetaCyc:HS02513-MONOMER
BRENDAi2.7.8.11 2681
ReactomeiR-HSA-1483226 Synthesis of PI

Miscellaneous databases

ChiTaRSiCDIPT human
GeneWikiiCDIPT
GenomeRNAii10423
PROiPR:O14735
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000103502 Expressed in 241 organ(s), highest expression level in parotid gland
CleanExiHS_CDIPT
ExpressionAtlasiO14735 baseline and differential
GenevisibleiO14735 HS

Family and domain databases

InterProiView protein in InterPro
IPR000462 CDP-OH_P_trans
IPR014387 CDP_diag_ino_3_P_euk
PfamiView protein in Pfam
PF01066 CDP-OH_P_transf, 1 hit
PIRSFiPIRSF000848 CDP_diag_ino_3_P, 1 hit
PROSITEiView protein in PROSITE
PS00379 CDP_ALCOHOL_P_TRANSF, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCDIPT_HUMAN
AccessioniPrimary (citable) accession number: O14735
Secondary accession number(s): B4DUV0
, H3BTV1, Q6FGU1, Q6ZN70
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: September 12, 2018
This is version 163 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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Main funding by: National Institutes of Health

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