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Protein

Inositol monophosphatase 2

Gene

IMPA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Can use myo-inositol monophosphates, scylloinositol 1,4-diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. Has been implicated as the pharmacological target for lithium Li+ action in brain.1 Publication

Catalytic activityi

Myo-inositol phosphate + H2O = myo-inositol + phosphate.

Cofactori

Mg2+1 Publication

Activity regulationi

Inhibited by high Li+ and restricted Mg2+ concentrations.2 Publications

Kineticsi

  1. KM=5 mM for myo-inositol 1-monophosphate1 Publication

    pH dependencei

    Optimum pH is 7.5-8.0.1 Publication

    Pathwayi: myo-inositol biosynthesis

    This protein is involved in step 2 of the subpathway that synthesizes myo-inositol from D-glucose 6-phosphate.
    Proteins known to be involved in the 2 steps of the subpathway in this organism are:
    1. Inositol-3-phosphate synthase 1 (ISYNA1)
    2. Inositol monophosphatase 1 (IMPA1), Inositol monophosphatase 2 (IMPA2), Inositol monophosphatase 3 (IMPAD1), Inositol-1-monophosphatase (IMPA1), Inositol-1-monophosphatase (IMPA1), Inositol-1-monophosphatase (suhB), Inositol-1-monophosphatase (IMPA1), Inositol-1-monophosphatase (IMPA1), Inositol-1-monophosphatase
    This subpathway is part of the pathway myo-inositol biosynthesis, which is itself part of Polyol metabolism.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes myo-inositol from D-glucose 6-phosphate, the pathway myo-inositol biosynthesis and in Polyol metabolism.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Metal bindingi81Magnesium 1By similarity1
    Binding sitei81Substrate1 Publication1
    Metal bindingi101Magnesium 1By similarity1
    Metal bindingi101Magnesium 2By similarity1
    Metal bindingi103Magnesium 1; via carbonyl oxygenBy similarity1
    Metal bindingi104Magnesium 2By similarity1
    Binding sitei224Substrate1 Publication1
    Metal bindingi231Magnesium 2By similarity1
    Binding sitei231SubstrateBy similarity1

    GO - Molecular functioni

    GO - Biological processi

    Keywordsi

    Molecular functionHydrolase
    LigandMagnesium, Metal-binding

    Enzyme and pathway databases

    BioCyciMetaCyc:HS06822-MONOMER
    ReactomeiR-HSA-1855183 Synthesis of IP2, IP, and Ins in the cytosol
    UniPathwayi
    UPA00823;UER00788

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inositol monophosphatase 2 (EC:3.1.3.25)
    Short name:
    IMP 2
    Short name:
    IMPase 2
    Alternative name(s):
    Inositol-1(or 4)-monophosphatase 2
    Myo-inositol monophosphatase A2
    Gene namesi
    Name:IMPA2
    Synonyms:IMP.18P
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    Proteomesi
    • UP000005640 Componenti: Chromosome 18

    Organism-specific databases

    EuPathDBiHostDB:ENSG00000141401.11
    HGNCiHGNC:6051 IMPA2
    MIMi605922 gene
    neXtProtiNX_O14732

    Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Mutagenesisi104D → N: Loss of activity. 1 Publication1

    Organism-specific databases

    DisGeNETi3613
    OpenTargetsiENSG00000141401
    PharmGKBiPA29861

    Chemistry databases

    DrugBankiDB01356 Lithium

    Polymorphism and mutation databases

    BioMutaiIMPA2

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00001425201 – 288Inositol monophosphatase 2Add BLAST288

    Proteomic databases

    EPDiO14732
    MaxQBiO14732
    PaxDbiO14732
    PeptideAtlasiO14732
    PRIDEiO14732
    ProteomicsDBi48190
    48191 [O14732-2]
    TopDownProteomicsiO14732-2 [O14732-2]

    PTM databases

    DEPODiO14732
    iPTMnetiO14732
    PhosphoSitePlusiO14732

    Expressioni

    Inductioni

    Repressed by Li+.

    Gene expression databases

    BgeeiENSG00000141401 Expressed in 195 organ(s), highest expression level in body of pancreas
    CleanExiHS_IMPA2
    ExpressionAtlasiO14732 baseline and differential
    GenevisibleiO14732 HS

    Organism-specific databases

    HPAiHPA029561

    Interactioni

    Subunit structurei

    Homodimer.1 Publication

    Binary interactionsi

    GO - Molecular functioni

    Protein-protein interaction databases

    BioGridi109826, 39 interactors
    IntActiO14732, 7 interactors
    MINTiO14732
    STRINGi9606.ENSP00000269159

    Structurei

    Secondary structure

    1288
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    ProteinModelPortaliO14732
    SMRiO14732
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO14732

    Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Regioni103 – 106Substrate binding4
    Regioni205 – 207Substrate binding3

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiKOG2951 Eukaryota
    COG0483 LUCA
    GeneTreeiENSGT00390000014699
    HOGENOMiHOG000282238
    HOVERGENiHBG052123
    InParanoidiO14732
    KOiK01092
    OMAiYLWAIDP
    OrthoDBiEOG091G0D21
    PhylomeDBiO14732
    TreeFamiTF313194

    Family and domain databases

    CDDicd01639 IMPase, 1 hit
    InterProiView protein in InterPro
    IPR033942 IMPase
    IPR020583 Inositol_monoP_metal-BS
    IPR020552 Inositol_monoPase_Li-sen
    IPR000760 Inositol_monophosphatase-like
    IPR020550 Inositol_monophosphatase_CS
    PfamiView protein in Pfam
    PF00459 Inositol_P, 1 hit
    PRINTSiPR00377 IMPHPHTASES
    PR00378 LIIMPHPHTASE
    PROSITEiView protein in PROSITE
    PS00629 IMP_1, 1 hit
    PS00630 IMP_2, 1 hit

    Sequences (2+)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: O14732-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MKPSGEDQAA LAAGPWEECF QAAVQLALRA GQIIRKALTE EKRVSTKTSA
    60 70 80 90 100
    ADLVTETDHL VEDLIISELR ERFPSHRFIA EEAAASGAKC VLTHSPTWII
    110 120 130 140 150
    DPIDGTCNFV HRFPTVAVSI GFAVRQELEF GVIYHCTEER LYTGRRGRGA
    160 170 180 190 200
    FCNGQRLRVS GETDLSKALV LTEIGPKRDP ATLKLFLSNM ERLLHAKAHG
    210 220 230 240 250
    VRVIGSSTLA LCHLASGAAD AYYQFGLHCW DLAAATVIIR EAGGIVIDTS
    260 270 280
    GGPLDLMACR VVAASTREMA MLIAQALQTI NYGRDDEK
    Length:288
    Mass (Da):31,321
    Last modified:January 1, 1998 - v1
    Checksum:i30D83FA339AC69B4
    GO
    Isoform 2 (identifier: O14732-2) [UniParc]FASTAAdd to basket
    Also known as: A2b

    The sequence of this isoform differs from the canonical sequence as follows:
         6-34: EDQAALAAGPWEECFQAAVQLALRAGQII → QD

    Show »
    Length:261
    Mass (Da):28,512
    Checksum:iA9D2BC0A05D0DF2F
    GO

    Computationally mapped potential isoform sequencesi

    There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    K7EL65K7EL65_HUMAN
    Inositol monophosphatase 2
    IMPA2
    116Annotation score:
    K7ELF8K7ELF8_HUMAN
    Inositol monophosphatase 2
    IMPA2
    163Annotation score:
    K7EIH6K7EIH6_HUMAN
    Inositol monophosphatase 2
    IMPA2
    126Annotation score:
    K7EII9K7EII9_HUMAN
    Inositol monophosphatase 2
    IMPA2
    99Annotation score:
    Q6PIP6Q6PIP6_HUMAN
    IMPA2 protein
    IMPA2
    85Annotation score:

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_04960188A → T. Corresponds to variant dbSNP:rs16976948Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Alternative sequenceiVSP_0136746 – 34EDQAA…AGQII → QD in isoform 2. 1 PublicationAdd BLAST29

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF014398 mRNA Translation: AAB70915.1
    AF157102
    , AF157096, AF157097, AF157098, AF157099, AF157100, AF157101 Genomic DNA Translation: AAD40683.1
    AF200432 mRNA Translation: AAF07824.1
    BT007061 mRNA Translation: AAP35710.1
    EF444990 Genomic DNA Translation: ACA06007.1
    CH471113 Genomic DNA Translation: EAX01559.1
    BC017176 mRNA Translation: AAH17176.1
    CCDSiCCDS11855.1 [O14732-1]
    RefSeqiNP_055029.1, NM_014214.2 [O14732-1]
    UniGeneiHs.743311

    Genome annotation databases

    EnsembliENST00000269159; ENSP00000269159; ENSG00000141401 [O14732-1]
    GeneIDi3613
    KEGGihsa:3613
    UCSCiuc002kqp.3 human [O14732-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Similar proteinsi

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF014398 mRNA Translation: AAB70915.1
    AF157102
    , AF157096, AF157097, AF157098, AF157099, AF157100, AF157101 Genomic DNA Translation: AAD40683.1
    AF200432 mRNA Translation: AAF07824.1
    BT007061 mRNA Translation: AAP35710.1
    EF444990 Genomic DNA Translation: ACA06007.1
    CH471113 Genomic DNA Translation: EAX01559.1
    BC017176 mRNA Translation: AAH17176.1
    CCDSiCCDS11855.1 [O14732-1]
    RefSeqiNP_055029.1, NM_014214.2 [O14732-1]
    UniGeneiHs.743311

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    2CZHX-ray2.70A/B1-288[»]
    2CZIX-ray3.00A1-288[»]
    2CZKX-ray2.90A1-288[»]
    2DDKX-ray2.70A/B1-288[»]
    2FVZX-ray2.40A/B/C/D16-288[»]
    ProteinModelPortaliO14732
    SMRiO14732
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi109826, 39 interactors
    IntActiO14732, 7 interactors
    MINTiO14732
    STRINGi9606.ENSP00000269159

    Chemistry databases

    DrugBankiDB01356 Lithium

    PTM databases

    DEPODiO14732
    iPTMnetiO14732
    PhosphoSitePlusiO14732

    Polymorphism and mutation databases

    BioMutaiIMPA2

    Proteomic databases

    EPDiO14732
    MaxQBiO14732
    PaxDbiO14732
    PeptideAtlasiO14732
    PRIDEiO14732
    ProteomicsDBi48190
    48191 [O14732-2]
    TopDownProteomicsiO14732-2 [O14732-2]

    Protocols and materials databases

    DNASUi3613
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000269159; ENSP00000269159; ENSG00000141401 [O14732-1]
    GeneIDi3613
    KEGGihsa:3613
    UCSCiuc002kqp.3 human [O14732-1]

    Organism-specific databases

    CTDi3613
    DisGeNETi3613
    EuPathDBiHostDB:ENSG00000141401.11
    GeneCardsiIMPA2
    HGNCiHGNC:6051 IMPA2
    HPAiHPA029561
    MIMi605922 gene
    neXtProtiNX_O14732
    OpenTargetsiENSG00000141401
    PharmGKBiPA29861
    GenAtlasiSearch...

    Phylogenomic databases

    eggNOGiKOG2951 Eukaryota
    COG0483 LUCA
    GeneTreeiENSGT00390000014699
    HOGENOMiHOG000282238
    HOVERGENiHBG052123
    InParanoidiO14732
    KOiK01092
    OMAiYLWAIDP
    OrthoDBiEOG091G0D21
    PhylomeDBiO14732
    TreeFamiTF313194

    Enzyme and pathway databases

    UniPathwayi
    UPA00823;UER00788

    BioCyciMetaCyc:HS06822-MONOMER
    ReactomeiR-HSA-1855183 Synthesis of IP2, IP, and Ins in the cytosol

    Miscellaneous databases

    ChiTaRSiIMPA2 human
    EvolutionaryTraceiO14732
    GeneWikiiIMPA2
    GenomeRNAii3613
    PROiPR:O14732
    SOURCEiSearch...

    Gene expression databases

    BgeeiENSG00000141401 Expressed in 195 organ(s), highest expression level in body of pancreas
    CleanExiHS_IMPA2
    ExpressionAtlasiO14732 baseline and differential
    GenevisibleiO14732 HS

    Family and domain databases

    CDDicd01639 IMPase, 1 hit
    InterProiView protein in InterPro
    IPR033942 IMPase
    IPR020583 Inositol_monoP_metal-BS
    IPR020552 Inositol_monoPase_Li-sen
    IPR000760 Inositol_monophosphatase-like
    IPR020550 Inositol_monophosphatase_CS
    PfamiView protein in Pfam
    PF00459 Inositol_P, 1 hit
    PRINTSiPR00377 IMPHPHTASES
    PR00378 LIIMPHPHTASE
    PROSITEiView protein in PROSITE
    PS00629 IMP_1, 1 hit
    PS00630 IMP_2, 1 hit
    ProtoNetiSearch...

    Entry informationi

    Entry nameiIMPA2_HUMAN
    AccessioniPrimary (citable) accession number: O14732
    Secondary accession number(s): B0YJ29, Q9UJT3
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: January 1, 1998
    Last modified: November 7, 2018
    This is version 163 of the entry and version 1 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. Human chromosome 18
      Human chromosome 18: entries, gene names and cross-references to MIM
    7. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
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