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Protein

Inositol monophosphatase 2

Gene

IMPA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Can use myo-inositol monophosphates, scylloinositol 1,4-diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. Has been implicated as the pharmacological target for lithium Li+ action in brain.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+1 Publication

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by high Li+ and restricted Mg2+ concentrations.2 Publications

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=5 mM for myo-inositol 1-monophosphate1 Publication

    pH dependencei

    Optimum pH is 7.5-8.0.1 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: myo-inositol biosynthesis

    This protein is involved in step 2 of the subpathway that synthesizes myo-inositol from D-glucose 6-phosphate.
    Proteins known to be involved in the 2 steps of the subpathway in this organism are:
    1. Inositol-3-phosphate synthase 1 (ISYNA1)
    2. Inositol-1-monophosphatase (IMPA1), Inositol-1-monophosphatase (IMPA1), Inositol-1-monophosphatase (IMPA1), Inositol-1-monophosphatase, Inositol-1-monophosphatase (suhB), Inositol-1-monophosphatase (IMPA1), Inositol monophosphatase 3 (IMPAD1), Inositol monophosphatase 1 (IMPA1), Inositol monophosphatase 2 (IMPA2)
    This subpathway is part of the pathway myo-inositol biosynthesis, which is itself part of Polyol metabolism.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes myo-inositol from D-glucose 6-phosphate, the pathway myo-inositol biosynthesis and in Polyol metabolism.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi81Magnesium 1By similarity1
    <p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei81Substrate1 Publication1
    Metal bindingi101Magnesium 1By similarity1
    Metal bindingi101Magnesium 2By similarity1
    Metal bindingi103Magnesium 1; via carbonyl oxygenBy similarity1
    Metal bindingi104Magnesium 2By similarity1
    Binding sitei224Substrate1 Publication1
    Metal bindingi231Magnesium 2By similarity1
    Binding sitei231SubstrateBy similarity1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionHydrolase
    LigandMagnesium, Metal-binding

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    MetaCyc:HS06822-MONOMER

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-1855183 Synthesis of IP2, IP, and Ins in the cytosol

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...
    UniPathwayi
    UPA00823;UER00788

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Inositol monophosphatase 2 (EC:3.1.3.25)
    Short name:
    IMP 2
    Short name:
    IMPase 2
    Alternative name(s):
    Inositol-1(or 4)-monophosphatase 2
    Myo-inositol monophosphatase A2
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:IMPA2
    Synonyms:IMP.18P
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    HostDB:ENSG00000141401.11

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:6051 IMPA2

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    605922 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_O14732

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi104D → N: Loss of activity. 1 Publication1

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    3613

    Open Targets

    More...
    OpenTargetsi
    ENSG00000141401

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA29861

    Chemistry databases

    Drug and drug target database

    More...
    DrugBanki
    DB01356 Lithium

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    IMPA2

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001425201 – 288Inositol monophosphatase 2Add BLAST288

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    O14732

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    O14732

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    O14732

    PeptideAtlas

    More...
    PeptideAtlasi
    O14732

    PRoteomics IDEntifications database

    More...
    PRIDEi
    O14732

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    48190
    48191 [O14732-2]

    Consortium for Top Down Proteomics

    More...
    TopDownProteomicsi
    O14732-2 [O14732-2]

    PTM databases

    DEPOD human dephosphorylation database

    More...
    DEPODi
    O14732

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    O14732

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    O14732

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

    Repressed by Li+.

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000141401 Expressed in 195 organ(s), highest expression level in body of pancreas

    CleanEx database of gene expression profiles

    More...
    CleanExi
    HS_IMPA2

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    O14732 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    O14732 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    HPA029561

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homodimer.1 Publication

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    GO - Molecular functioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    109826, 39 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    O14732, 7 interactors

    Molecular INTeraction database

    More...
    MINTi
    O14732

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000269159

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1288
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

    More...
    ProteinModelPortali
    O14732

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    O14732

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...
    EvolutionaryTracei
    O14732

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni103 – 106Substrate binding4
    Regioni205 – 207Substrate binding3

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG2951 Eukaryota
    COG0483 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000160536

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000282238

    The HOVERGEN Database of Homologous Vertebrate Genes

    More...
    HOVERGENi
    HBG052123

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    O14732

    KEGG Orthology (KO)

    More...
    KOi
    K01092

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    YLWAIDP

    Database of Orthologous Groups

    More...
    OrthoDBi
    EOG091G0D21

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    O14732

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF313194

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd01639 IMPase, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR033942 IMPase
    IPR020583 Inositol_monoP_metal-BS
    IPR020552 Inositol_monoPase_Li-sen
    IPR000760 Inositol_monophosphatase-like
    IPR020550 Inositol_monophosphatase_CS

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00459 Inositol_P, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR00377 IMPHPHTASES
    PR00378 LIIMPHPHTASE

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00629 IMP_1, 1 hit
    PS00630 IMP_2, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: O14732-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MKPSGEDQAA LAAGPWEECF QAAVQLALRA GQIIRKALTE EKRVSTKTSA
    60 70 80 90 100
    ADLVTETDHL VEDLIISELR ERFPSHRFIA EEAAASGAKC VLTHSPTWII
    110 120 130 140 150
    DPIDGTCNFV HRFPTVAVSI GFAVRQELEF GVIYHCTEER LYTGRRGRGA
    160 170 180 190 200
    FCNGQRLRVS GETDLSKALV LTEIGPKRDP ATLKLFLSNM ERLLHAKAHG
    210 220 230 240 250
    VRVIGSSTLA LCHLASGAAD AYYQFGLHCW DLAAATVIIR EAGGIVIDTS
    260 270 280
    GGPLDLMACR VVAASTREMA MLIAQALQTI NYGRDDEK
    Length:288
    Mass (Da):31,321
    Last modified:January 1, 1998 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i30D83FA339AC69B4
    GO
    Isoform 2 (identifier: O14732-2) [UniParc]FASTAAdd to basket
    Also known as: A2b

    The sequence of this isoform differs from the canonical sequence as follows:
         6-34: EDQAALAAGPWEECFQAAVQLALRAGQII → QD

    Show »
    Length:261
    Mass (Da):28,512
    Checksum:iA9D2BC0A05D0DF2F
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    K7EL65K7EL65_HUMAN
    Inositol monophosphatase 2
    IMPA2
    116Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    K7ELF8K7ELF8_HUMAN
    Inositol monophosphatase 2
    IMPA2
    163Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    K7EIH6K7EIH6_HUMAN
    Inositol monophosphatase 2
    IMPA2
    126Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    K7EII9K7EII9_HUMAN
    Inositol monophosphatase 2
    IMPA2
    99Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    Q6PIP6Q6PIP6_HUMAN
    IMPA2 protein
    IMPA2
    85Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04960188A → T. Corresponds to variant dbSNP:rs16976948Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0136746 – 34EDQAA…AGQII → QD in isoform 2. 1 PublicationAdd BLAST29

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AF014398 mRNA Translation: AAB70915.1
    AF157102
    , AF157096, AF157097, AF157098, AF157099, AF157100, AF157101 Genomic DNA Translation: AAD40683.1
    AF200432 mRNA Translation: AAF07824.1
    BT007061 mRNA Translation: AAP35710.1
    EF444990 Genomic DNA Translation: ACA06007.1
    CH471113 Genomic DNA Translation: EAX01559.1
    BC017176 mRNA Translation: AAH17176.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS11855.1 [O14732-1]

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_055029.1, NM_014214.2 [O14732-1]

    UniGene gene-oriented nucleotide sequence clusters

    More...
    UniGenei
    Hs.743311

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

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    Ensembli
    ENST00000269159; ENSP00000269159; ENSG00000141401 [O14732-1]

    Database of genes from NCBI RefSeq genomes

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    GeneIDi
    3613

    KEGG: Kyoto Encyclopedia of Genes and Genomes

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    KEGGi
    hsa:3613

    UCSC genome browser

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    UCSCi
    uc002kqp.3 human [O14732-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF014398 mRNA Translation: AAB70915.1
    AF157102
    , AF157096, AF157097, AF157098, AF157099, AF157100, AF157101 Genomic DNA Translation: AAD40683.1
    AF200432 mRNA Translation: AAF07824.1
    BT007061 mRNA Translation: AAP35710.1
    EF444990 Genomic DNA Translation: ACA06007.1
    CH471113 Genomic DNA Translation: EAX01559.1
    BC017176 mRNA Translation: AAH17176.1
    CCDSiCCDS11855.1 [O14732-1]
    RefSeqiNP_055029.1, NM_014214.2 [O14732-1]
    UniGeneiHs.743311

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

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    PDBei

    Protein Data Bank RCSB

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    RCSB PDBi

    Protein Data Bank Japan

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    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    2CZHX-ray2.70A/B1-288[»]
    2CZIX-ray3.00A1-288[»]
    2CZKX-ray2.90A1-288[»]
    2DDKX-ray2.70A/B1-288[»]
    2FVZX-ray2.40A/B/C/D16-288[»]
    ProteinModelPortaliO14732
    SMRiO14732
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi109826, 39 interactors
    IntActiO14732, 7 interactors
    MINTiO14732
    STRINGi9606.ENSP00000269159

    Chemistry databases

    DrugBankiDB01356 Lithium

    PTM databases

    DEPODiO14732
    iPTMnetiO14732
    PhosphoSitePlusiO14732

    Polymorphism and mutation databases

    BioMutaiIMPA2

    Proteomic databases

    EPDiO14732
    MaxQBiO14732
    PaxDbiO14732
    PeptideAtlasiO14732
    PRIDEiO14732
    ProteomicsDBi48190
    48191 [O14732-2]
    TopDownProteomicsiO14732-2 [O14732-2]

    Protocols and materials databases

    The DNASU plasmid repository

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    DNASUi
    3613
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000269159; ENSP00000269159; ENSG00000141401 [O14732-1]
    GeneIDi3613
    KEGGihsa:3613
    UCSCiuc002kqp.3 human [O14732-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

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    CTDi
    3613
    DisGeNETi3613
    EuPathDBiHostDB:ENSG00000141401.11

    GeneCards: human genes, protein and diseases

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    GeneCardsi
    IMPA2
    HGNCiHGNC:6051 IMPA2
    HPAiHPA029561
    MIMi605922 gene
    neXtProtiNX_O14732
    OpenTargetsiENSG00000141401
    PharmGKBiPA29861

    GenAtlas: human gene database

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    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG2951 Eukaryota
    COG0483 LUCA
    GeneTreeiENSGT00940000160536
    HOGENOMiHOG000282238
    HOVERGENiHBG052123
    InParanoidiO14732
    KOiK01092
    OMAiYLWAIDP
    OrthoDBiEOG091G0D21
    PhylomeDBiO14732
    TreeFamiTF313194

    Enzyme and pathway databases

    UniPathwayi
    UPA00823;UER00788

    BioCyciMetaCyc:HS06822-MONOMER
    ReactomeiR-HSA-1855183 Synthesis of IP2, IP, and Ins in the cytosol

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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    ChiTaRSi
    IMPA2 human
    EvolutionaryTraceiO14732

    The Gene Wiki collection of pages on human genes and proteins

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    GeneWikii
    IMPA2

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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    GenomeRNAii
    3613

    Protein Ontology

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    PROi
    PR:O14732

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000141401 Expressed in 195 organ(s), highest expression level in body of pancreas
    CleanExiHS_IMPA2
    ExpressionAtlasiO14732 baseline and differential
    GenevisibleiO14732 HS

    Family and domain databases

    CDDicd01639 IMPase, 1 hit
    InterProiView protein in InterPro
    IPR033942 IMPase
    IPR020583 Inositol_monoP_metal-BS
    IPR020552 Inositol_monoPase_Li-sen
    IPR000760 Inositol_monophosphatase-like
    IPR020550 Inositol_monophosphatase_CS
    PfamiView protein in Pfam
    PF00459 Inositol_P, 1 hit
    PRINTSiPR00377 IMPHPHTASES
    PR00378 LIIMPHPHTASE
    PROSITEiView protein in PROSITE
    PS00629 IMP_1, 1 hit
    PS00630 IMP_2, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

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    ProtoNeti
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIMPA2_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O14732
    Secondary accession number(s): B0YJ29, Q9UJT3
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: January 1, 1998
    Last modified: December 5, 2018
    This is version 164 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Human chromosome 18
      Human chromosome 18: entries, gene names and cross-references to MIM
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    7. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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