UniProtKB - O14718 (OPSX_HUMAN)
Protein
Visual pigment-like receptor peropsin
Gene
RRH
Organism
Homo sapiens (Human)
Status
Functioni
May play a role in rpe physiology either by detecting light directly or by monitoring the concentration of retinoids or other photoreceptor-derived compounds.
GO - Molecular functioni
- G protein-coupled photoreceptor activity Source: GO_Central
- G protein-coupled receptor activity Source: ProtInc
GO - Biological processi
- cellular response to light stimulus Source: GO_Central
- G protein-coupled receptor signaling pathway Source: GO_Central
- phototransduction Source: GO_Central
- protein-chromophore linkage Source: UniProtKB-KW
- visual perception Source: ProtInc
Keywordsi
Molecular function | G-protein coupled receptor, Photoreceptor protein, Receptor, Retinal protein, Transducer |
Biological process | |
Ligand | Chromophore |
Enzyme and pathway databases
Reactomei | R-HSA-418594 G alpha (i) signalling events R-HSA-419771 Opsins |
Names & Taxonomyi
Protein namesi | Recommended name: Visual pigment-like receptor peropsin |
Gene namesi | Name:RRH |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000180245.4 |
HGNCi | HGNC:10450 RRH |
MIMi | 605224 gene |
neXtProti | NX_O14718 |
Subcellular locationi
Other locations
- Membrane By similarity; Multi-pass membrane protein By similarity
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Other locations
- photoreceptor outer segment Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 26 | ExtracellularAdd BLAST | 26 | |
Transmembranei | 27 – 49 | Helical; Name=1Sequence analysisAdd BLAST | 23 | |
Topological domaini | 50 – 61 | CytoplasmicAdd BLAST | 12 | |
Transmembranei | 62 – 87 | Helical; Name=2Sequence analysisAdd BLAST | 26 | |
Topological domaini | 88 – 101 | ExtracellularAdd BLAST | 14 | |
Transmembranei | 102 – 121 | Helical; Name=3Sequence analysisAdd BLAST | 20 | |
Topological domaini | 122 – 140 | CytoplasmicAdd BLAST | 19 | |
Transmembranei | 141 – 164 | Helical; Name=4Sequence analysisAdd BLAST | 24 | |
Topological domaini | 165 – 188 | ExtracellularAdd BLAST | 24 | |
Transmembranei | 189 – 212 | Helical; Name=5Sequence analysisAdd BLAST | 24 | |
Topological domaini | 213 – 240 | CytoplasmicAdd BLAST | 28 | |
Transmembranei | 241 – 264 | Helical; Name=6Sequence analysisAdd BLAST | 24 | |
Topological domaini | 265 – 272 | Extracellular | 8 | |
Transmembranei | 273 – 297 | Helical; Name=7Sequence analysisAdd BLAST | 25 | |
Topological domaini | 298 – 337 | CytoplasmicAdd BLAST | 40 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 10692 |
OpenTargetsi | ENSG00000180245 |
PharmGKBi | PA34865 |
Polymorphism and mutation databases
BioMutai | RRH |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000197819 | 1 – 337 | Visual pigment-like receptor peropsinAdd BLAST | 337 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 8 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 98 ↔ 175 | PROSITE-ProRule annotation | ||
Modified residuei | 284 | N6-(retinylidene)lysine | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | O14718 |
PeptideAtlasi | O14718 |
PRIDEi | O14718 |
ProteomicsDBi | 48181 |
PTM databases
PhosphoSitePlusi | O14718 |
Expressioni
Tissue specificityi
Found only in the eye, where it is localized to the retinal pigment epithelium (RPE). In the RPE, it is localized to the microvilli that surround the photoreceptor outer segments.
Gene expression databases
Bgeei | ENSG00000180245 Expressed in 57 organ(s), highest expression level in pigmented layer of retina |
Genevisiblei | O14718 HS |
Interactioni
Protein-protein interaction databases
IntActi | O14718, 1 interactor |
STRINGi | 9606.ENSP00000314992 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656 Eukaryota ENOG410XRW9 LUCA |
GeneTreei | ENSGT00940000153478 |
HOGENOMi | HOG000115897 |
HOVERGENi | HBG098035 |
InParanoidi | O14718 |
KOi | K04253 |
OMAi | AGCQIYA |
OrthoDBi | 704940at2759 |
PhylomeDBi | O14718 |
TreeFami | TF324998 |
Family and domain databases
CDDi | cd15073 7tmA_Peropsin, 1 hit |
InterProi | View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR002962 Peropsin IPR027430 Retinal_BS IPR032972 RRH |
PANTHERi | PTHR24240:SF77 PTHR24240:SF77, 1 hit |
Pfami | View protein in Pfam PF00001 7tm_1, 1 hit |
PRINTSi | PR00237 GPCRRHODOPSN PR01244 PEROPSIN |
SMARTi | View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit PS00238 OPSIN, 1 hit |
i Sequence
Sequence statusi: Complete.
O14718-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLRNNLGNSS DSKNEDGSVF SQTEHNIVAT YLIMAGMISI ISNIIVLGIF
60 70 80 90 100
IKYKELRTPT NAIIINLAVT DIGVSSIGYP MSAASDLYGS WKFGYAGCQV
110 120 130 140 150
YAGLNIFFGM ASIGLLTVVA VDRYLTICLP DVGRRMTTNT YIGLILGAWI
160 170 180 190 200
NGLFWALMPI IGWASYAPDP TGATCTINWR KNDRSFVSYT MTVIAINFIV
210 220 230 240 250
PLTVMFYCYY HVTLSIKHHT TSDCTESLNR DWSDQIDVTK MSVIMICMFL
260 270 280 290 300
VAWSPYSIVC LWASFGDPKK IPPPMAIIAP LFAKSSTFYN PCIYVVANKK
310 320 330
FRRAMLAMFK CQTHQTMPVT SILPMDVSQN PLASGRI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF012270 mRNA Translation: AAC51757.1 CH471057 Genomic DNA Translation: EAX06255.1 BC128120 mRNA Translation: AAI28121.1 BC128121 mRNA Translation: AAI28122.1 BC128401 mRNA Translation: AAI28402.1 BK000958 Genomic DNA Translation: DAA00976.1 |
CCDSi | CCDS3687.1 |
RefSeqi | NP_006574.1, NM_006583.2 |
UniGenei | Hs.658310 |
Genome annotation databases
Ensembli | ENST00000317735; ENSP00000314992; ENSG00000180245 |
GeneIDi | 10692 |
KEGGi | hsa:10692 |
UCSCi | uc003hzv.4 human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF012270 mRNA Translation: AAC51757.1 CH471057 Genomic DNA Translation: EAX06255.1 BC128120 mRNA Translation: AAI28121.1 BC128121 mRNA Translation: AAI28122.1 BC128401 mRNA Translation: AAI28402.1 BK000958 Genomic DNA Translation: DAA00976.1 |
CCDSi | CCDS3687.1 |
RefSeqi | NP_006574.1, NM_006583.2 |
UniGenei | Hs.658310 |
3D structure databases
ProteinModelPortali | O14718 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
IntActi | O14718, 1 interactor |
STRINGi | 9606.ENSP00000314992 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
PhosphoSitePlusi | O14718 |
Polymorphism and mutation databases
BioMutai | RRH |
Proteomic databases
PaxDbi | O14718 |
PeptideAtlasi | O14718 |
PRIDEi | O14718 |
ProteomicsDBi | 48181 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENST00000317735; ENSP00000314992; ENSG00000180245 |
GeneIDi | 10692 |
KEGGi | hsa:10692 |
UCSCi | uc003hzv.4 human |
Organism-specific databases
CTDi | 10692 |
DisGeNETi | 10692 |
EuPathDBi | HostDB:ENSG00000180245.4 |
GeneCardsi | RRH |
HGNCi | HGNC:10450 RRH |
MIMi | 605224 gene |
neXtProti | NX_O14718 |
OpenTargetsi | ENSG00000180245 |
PharmGKBi | PA34865 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3656 Eukaryota ENOG410XRW9 LUCA |
GeneTreei | ENSGT00940000153478 |
HOGENOMi | HOG000115897 |
HOVERGENi | HBG098035 |
InParanoidi | O14718 |
KOi | K04253 |
OMAi | AGCQIYA |
OrthoDBi | 704940at2759 |
PhylomeDBi | O14718 |
TreeFami | TF324998 |
Enzyme and pathway databases
Reactomei | R-HSA-418594 G alpha (i) signalling events R-HSA-419771 Opsins |
Miscellaneous databases
GeneWikii | RRH |
GenomeRNAii | 10692 |
PROi | PR:O14718 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000180245 Expressed in 57 organ(s), highest expression level in pigmented layer of retina |
Genevisiblei | O14718 HS |
Family and domain databases
CDDi | cd15073 7tmA_Peropsin, 1 hit |
InterProi | View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR002962 Peropsin IPR027430 Retinal_BS IPR032972 RRH |
PANTHERi | PTHR24240:SF77 PTHR24240:SF77, 1 hit |
Pfami | View protein in Pfam PF00001 7tm_1, 1 hit |
PRINTSi | PR00237 GPCRRHODOPSN PR01244 PEROPSIN |
SMARTi | View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit PS00238 OPSIN, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | OPSX_HUMAN | |
Accessioni | O14718Primary (citable) accession number: O14718 Secondary accession number(s): A1A4V2, Q7RTS4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | January 1, 1998 | |
Last modified: | February 13, 2019 | |
This is version 146 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries