RRH

Functionⁱ

May play a role in rpe physiology either by detecting light directly or by monitoring the concentration of retinoids or other photoreceptor-derived compounds.

GO - Molecular functionⁱ

G protein-coupled photoreceptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
G protein-coupled receptor activity
Source: ProtInc
Traceable author statementⁱ
- 9275222

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to light stimulus
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
G protein-coupled receptor signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
phototransduction
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein-chromophore linkage Source: UniProtKB-KW
visual perception
Source: ProtInc
Traceable author statementⁱ
- 9275222

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Photoreceptor protein, Receptor, Retinal protein, Transducer
Biological process
Ligand	Chromophore

Enzyme and pathway databases

Reactomeⁱ	R-HSA-418594 G alpha (i) signalling events R-HSA-419771 Opsins

Reactomeⁱ

R-HSA-418594 G alpha (i) signalling events
R-HSA-419771 Opsins

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Visual pigment-like receptor peropsin
Gene namesⁱ	Name:RRH
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 4

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000180245.4
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10450 RRH
MIMⁱ	605224 gene
neXtProtⁱ	NX_O14718

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 26	ExtracellularAdd BLAST	26
Transmembraneⁱ	27 – 49	Helical; Name=1Sequence analysisAdd BLAST	23
Topological domainⁱ	50 – 61	CytoplasmicAdd BLAST	12
Transmembraneⁱ	62 – 87	Helical; Name=2Sequence analysisAdd BLAST	26
Topological domainⁱ	88 – 101	ExtracellularAdd BLAST	14
Transmembraneⁱ	102 – 121	Helical; Name=3Sequence analysisAdd BLAST	20
Topological domainⁱ	122 – 140	CytoplasmicAdd BLAST	19
Transmembraneⁱ	141 – 164	Helical; Name=4Sequence analysisAdd BLAST	24
Topological domainⁱ	165 – 188	ExtracellularAdd BLAST	24
Transmembraneⁱ	189 – 212	Helical; Name=5Sequence analysisAdd BLAST	24
Topological domainⁱ	213 – 240	CytoplasmicAdd BLAST	28
Transmembraneⁱ	241 – 264	Helical; Name=6Sequence analysisAdd BLAST	24
Topological domainⁱ	265 – 272	Extracellular	8
Transmembraneⁱ	273 – 297	Helical; Name=7Sequence analysisAdd BLAST	25
Topological domainⁱ	298 – 337	CytoplasmicAdd BLAST	40

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	10692
Open Targets More...OpenTargetsⁱ	ENSG00000180245
PharmGKBⁱ	PA34865

Polymorphism and mutation databases

BioMutaⁱ	RRH

BioMutaⁱ

RRH

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000197819	1 – 337	Visual pigment-like receptor peropsinAdd BLAST		337

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	8	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	98 ↔ 175	PROSITE-ProRule annotation
Modified residueⁱ	284	N6-(retinylidene)lysine	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	O14718
PeptideAtlas More...PeptideAtlasⁱ	O14718
PRIDEⁱ	O14718
ProteomicsDBⁱ	48181

PTM databases

PhosphoSitePlusⁱ	O14718

PhosphoSitePlusⁱ

O14718

Expressionⁱ

Tissue specificityⁱ

Found only in the eye, where it is localized to the retinal pigment epithelium (RPE). In the RPE, it is localized to the microvilli that surround the photoreceptor outer segments.

Gene expression databases

Bgeeⁱ	ENSG00000180245 Expressed in 57 organ(s), highest expression level in pigmented layer of retina
CleanExⁱ	HS_RRH
Genevisibleⁱ	O14718 HS

Interactionⁱ

Protein-protein interaction databases

IntActⁱ	O14718, 1 interactor
STRINGⁱ	9606.ENSP00000314992

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O14718
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118977
HOGENOMⁱ	HOG000115897
HOVERGENⁱ	HBG098035
InParanoidⁱ	O14718
KEGG Orthology (KO) More...KOⁱ	K04253
OMAⁱ	AGCQIYA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0ALC
PhylomeDBⁱ	O14718
TreeFamⁱ	TF324998

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd15073 7tmA_Peropsin, 1 hit
InterProⁱ	View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR002962 Peropsin IPR027430 Retinal_BS IPR032972 RRH
PANTHERⁱ	PTHR24240:SF77 PTHR24240:SF77, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN PR01244 PEROPSIN
SMARTⁱ	View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit PS00238 OPSIN, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

O14718-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLRNNLGNSS DSKNEDGSVF SQTEHNIVAT YLIMAGMISI ISNIIVLGIF 
        60         70         80         90        100
IKYKELRTPT NAIIINLAVT DIGVSSIGYP MSAASDLYGS WKFGYAGCQV 
       110        120        130        140        150
YAGLNIFFGM ASIGLLTVVA VDRYLTICLP DVGRRMTTNT YIGLILGAWI 
       160        170        180        190        200
NGLFWALMPI IGWASYAPDP TGATCTINWR KNDRSFVSYT MTVIAINFIV 
       210        220        230        240        250
PLTVMFYCYY HVTLSIKHHT TSDCTESLNR DWSDQIDVTK MSVIMICMFL 
       260        270        280        290        300
VAWSPYSIVC LWASFGDPKK IPPPMAIIAP LFAKSSTFYN PCIYVVANKK 
       310        320        330 
FRRAMLAMFK CQTHQTMPVT SILPMDVSQN PLASGRI

Length:337

Mass (Da):37,423

Last modified:January 1, 1998 - v1

Checksum:ⁱ9DFD8847F07A28EA

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF012270 mRNA Translation: AAC51757.1 CH471057 Genomic DNA Translation: EAX06255.1 BC128120 mRNA Translation: AAI28121.1 BC128121 mRNA Translation: AAI28122.1 BC128401 mRNA Translation: AAI28402.1 BK000958 Genomic DNA Translation: DAA00976.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3687.1
NCBI Reference Sequences More...RefSeqⁱ	NP_006574.1, NM_006583.2
UniGeneⁱ	Hs.658310

Genome annotation databases

Ensemblⁱ	ENST00000317735; ENSP00000314992; ENSG00000180245
GeneIDⁱ	10692
KEGGⁱ	hsa:10692
UCSC genome browser More...UCSCⁱ	uc003hzv.4 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O14718	RRH isoform 1		PANTR		337	UniRef100_O14718
Uncharacterized protein		PANPA		337

Protein	Similar proteins		Species	Score	Length	Source
O14718	RRH isoform 1		PANTR		337	UniRef90_O14718
Uncharacterized protein		PANPA		337
Retinal pigment epithelium-derived rhodopsin homolog		CANLF		347
Retinal pigment epithelium-derived rhodopsin homolog		MACMU		337
Retinal pigment epithelium-derived rhodopsin homolog		MACFA		337
+33

Protein	Similar proteins		Species	Score	Length	Source
O14718	Visual pigment-like receptor peropsin		MOUSE		337	UniRef50_O14718
RRH isoform 1		PANTR		337
Uncharacterized protein		PANPA		337
Retinal pigment epithelium-derived rhodopsin homolog		CANLF		347
Retinal pigment epithelium-derived rhodopsin homolog		MACMU		337
+316

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF012270 mRNA Translation: AAC51757.1 CH471057 Genomic DNA Translation: EAX06255.1 BC128120 mRNA Translation: AAI28121.1 BC128121 mRNA Translation: AAI28122.1 BC128401 mRNA Translation: AAI28402.1 BK000958 Genomic DNA Translation: DAA00976.1
CCDSⁱ	CCDS3687.1
RefSeqⁱ	NP_006574.1, NM_006583.2
UniGeneⁱ	Hs.658310

3D structure databases

ProteinModelPortalⁱ	O14718
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	O14718, 1 interactor
STRINGⁱ	9606.ENSP00000314992

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

PTM databases

PhosphoSitePlusⁱ	O14718

PhosphoSitePlusⁱ

O14718

Polymorphism and mutation databases

BioMutaⁱ	RRH

BioMutaⁱ

RRH

Proteomic databases

PaxDbⁱ	O14718
PeptideAtlasⁱ	O14718
PRIDEⁱ	O14718
ProteomicsDBⁱ	48181

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000317735; ENSP00000314992; ENSG00000180245
GeneIDⁱ	10692
KEGGⁱ	hsa:10692
UCSCⁱ	uc003hzv.4 human

Organism-specific databases

CTDⁱ	10692
DisGeNETⁱ	10692
EuPathDBⁱ	HostDB:ENSG00000180245.4
GeneCardsⁱ	RRH
HGNCⁱ	HGNC:10450 RRH
MIMⁱ	605224 gene
neXtProtⁱ	NX_O14718
OpenTargetsⁱ	ENSG00000180245
PharmGKBⁱ	PA34865
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
GeneTreeⁱ	ENSGT00760000118977
HOGENOMⁱ	HOG000115897
HOVERGENⁱ	HBG098035
InParanoidⁱ	O14718
KOⁱ	K04253
OMAⁱ	AGCQIYA
OrthoDBⁱ	EOG091G0ALC
PhylomeDBⁱ	O14718
TreeFamⁱ	TF324998

Enzyme and pathway databases

Reactomeⁱ	R-HSA-418594 G alpha (i) signalling events R-HSA-419771 Opsins

Reactomeⁱ

R-HSA-418594 G alpha (i) signalling events
R-HSA-419771 Opsins

Miscellaneous databases

GeneWikiⁱ	RRH
GenomeRNAiⁱ	10692
Protein Ontology More...PROⁱ	PR:O14718
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000180245 Expressed in 57 organ(s), highest expression level in pigmented layer of retina
CleanExⁱ	HS_RRH
Genevisibleⁱ	O14718 HS

Family and domain databases

CDDⁱ	cd15073 7tmA_Peropsin, 1 hit
InterProⁱ	View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR002962 Peropsin IPR027430 Retinal_BS IPR032972 RRH
PANTHERⁱ	PTHR24240:SF77 PTHR24240:SF77, 1 hit
Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN PR01244 PEROPSIN
SMARTⁱ	View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit PS00238 OPSIN, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	OPSX_HUMAN
Accessionⁱ	O14718Primary (citable) accession number: O14718 Secondary accession number(s): A1A4V2, Q7RTS4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
	Last sequence update:	January 1, 1998
	Last modified:	November 7, 2018
	This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries

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UniProtKB - O14718 (OPSX_HUMAN)

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Visual pigment-like receptor peropsin

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ