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Protein

Visual pigment-like receptor peropsin

Gene

RRH

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in rpe physiology either by detecting light directly or by monitoring the concentration of retinoids or other photoreceptor-derived compounds.

GO - Molecular functioni

  • G protein-coupled photoreceptor activity Source: GO_Central
  • G protein-coupled receptor activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Photoreceptor protein, Receptor, Retinal protein, Transducer
Biological process
LigandChromophore

Enzyme and pathway databases

ReactomeiR-HSA-418594 G alpha (i) signalling events
R-HSA-419771 Opsins

Names & Taxonomyi

Protein namesi
Recommended name:
Visual pigment-like receptor peropsin
Gene namesi
Name:RRH
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000180245.4
HGNCiHGNC:10450 RRH
MIMi605224 gene
neXtProtiNX_O14718

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26ExtracellularAdd BLAST26
Transmembranei27 – 49Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini50 – 61CytoplasmicAdd BLAST12
Transmembranei62 – 87Helical; Name=2Sequence analysisAdd BLAST26
Topological domaini88 – 101ExtracellularAdd BLAST14
Transmembranei102 – 121Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini122 – 140CytoplasmicAdd BLAST19
Transmembranei141 – 164Helical; Name=4Sequence analysisAdd BLAST24
Topological domaini165 – 188ExtracellularAdd BLAST24
Transmembranei189 – 212Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini213 – 240CytoplasmicAdd BLAST28
Transmembranei241 – 264Helical; Name=6Sequence analysisAdd BLAST24
Topological domaini265 – 272Extracellular8
Transmembranei273 – 297Helical; Name=7Sequence analysisAdd BLAST25
Topological domaini298 – 337CytoplasmicAdd BLAST40

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10692
OpenTargetsiENSG00000180245
PharmGKBiPA34865

Polymorphism and mutation databases

BioMutaiRRH

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001978191 – 337Visual pigment-like receptor peropsinAdd BLAST337

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi8N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi98 ↔ 175PROSITE-ProRule annotation
Modified residuei284N6-(retinylidene)lysine1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO14718
PeptideAtlasiO14718
PRIDEiO14718
ProteomicsDBi48181

PTM databases

PhosphoSitePlusiO14718

Expressioni

Tissue specificityi

Found only in the eye, where it is localized to the retinal pigment epithelium (RPE). In the RPE, it is localized to the microvilli that surround the photoreceptor outer segments.

Gene expression databases

BgeeiENSG00000180245 Expressed in 57 organ(s), highest expression level in pigmented layer of retina
CleanExiHS_RRH
GenevisibleiO14718 HS

Interactioni

Protein-protein interaction databases

IntActiO14718, 1 interactor
STRINGi9606.ENSP00000314992

Structurei

3D structure databases

ProteinModelPortaliO14718
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118977
HOGENOMiHOG000115897
HOVERGENiHBG098035
InParanoidiO14718
KOiK04253
OMAiAGCQIYA
OrthoDBiEOG091G0ALC
PhylomeDBiO14718
TreeFamiTF324998

Family and domain databases

CDDicd15073 7tmA_Peropsin, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR002962 Peropsin
IPR027430 Retinal_BS
IPR032972 RRH
PANTHERiPTHR24240:SF77 PTHR24240:SF77, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01244 PEROPSIN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
PS00238 OPSIN, 1 hit

Sequencei

Sequence statusi: Complete.

O14718-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRNNLGNSS DSKNEDGSVF SQTEHNIVAT YLIMAGMISI ISNIIVLGIF
60 70 80 90 100
IKYKELRTPT NAIIINLAVT DIGVSSIGYP MSAASDLYGS WKFGYAGCQV
110 120 130 140 150
YAGLNIFFGM ASIGLLTVVA VDRYLTICLP DVGRRMTTNT YIGLILGAWI
160 170 180 190 200
NGLFWALMPI IGWASYAPDP TGATCTINWR KNDRSFVSYT MTVIAINFIV
210 220 230 240 250
PLTVMFYCYY HVTLSIKHHT TSDCTESLNR DWSDQIDVTK MSVIMICMFL
260 270 280 290 300
VAWSPYSIVC LWASFGDPKK IPPPMAIIAP LFAKSSTFYN PCIYVVANKK
310 320 330
FRRAMLAMFK CQTHQTMPVT SILPMDVSQN PLASGRI
Length:337
Mass (Da):37,423
Last modified:January 1, 1998 - v1
Checksum:i9DFD8847F07A28EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF012270 mRNA Translation: AAC51757.1
CH471057 Genomic DNA Translation: EAX06255.1
BC128120 mRNA Translation: AAI28121.1
BC128121 mRNA Translation: AAI28122.1
BC128401 mRNA Translation: AAI28402.1
BK000958 Genomic DNA Translation: DAA00976.1
CCDSiCCDS3687.1
RefSeqiNP_006574.1, NM_006583.2
UniGeneiHs.658310

Genome annotation databases

EnsembliENST00000317735; ENSP00000314992; ENSG00000180245
GeneIDi10692
KEGGihsa:10692
UCSCiuc003hzv.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF012270 mRNA Translation: AAC51757.1
CH471057 Genomic DNA Translation: EAX06255.1
BC128120 mRNA Translation: AAI28121.1
BC128121 mRNA Translation: AAI28122.1
BC128401 mRNA Translation: AAI28402.1
BK000958 Genomic DNA Translation: DAA00976.1
CCDSiCCDS3687.1
RefSeqiNP_006574.1, NM_006583.2
UniGeneiHs.658310

3D structure databases

ProteinModelPortaliO14718
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO14718, 1 interactor
STRINGi9606.ENSP00000314992

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiO14718

Polymorphism and mutation databases

BioMutaiRRH

Proteomic databases

PaxDbiO14718
PeptideAtlasiO14718
PRIDEiO14718
ProteomicsDBi48181

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317735; ENSP00000314992; ENSG00000180245
GeneIDi10692
KEGGihsa:10692
UCSCiuc003hzv.4 human

Organism-specific databases

CTDi10692
DisGeNETi10692
EuPathDBiHostDB:ENSG00000180245.4
GeneCardsiRRH
HGNCiHGNC:10450 RRH
MIMi605224 gene
neXtProtiNX_O14718
OpenTargetsiENSG00000180245
PharmGKBiPA34865
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118977
HOGENOMiHOG000115897
HOVERGENiHBG098035
InParanoidiO14718
KOiK04253
OMAiAGCQIYA
OrthoDBiEOG091G0ALC
PhylomeDBiO14718
TreeFamiTF324998

Enzyme and pathway databases

ReactomeiR-HSA-418594 G alpha (i) signalling events
R-HSA-419771 Opsins

Miscellaneous databases

GeneWikiiRRH
GenomeRNAii10692
PROiPR:O14718
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000180245 Expressed in 57 organ(s), highest expression level in pigmented layer of retina
CleanExiHS_RRH
GenevisibleiO14718 HS

Family and domain databases

CDDicd15073 7tmA_Peropsin, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR002962 Peropsin
IPR027430 Retinal_BS
IPR032972 RRH
PANTHERiPTHR24240:SF77 PTHR24240:SF77, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01244 PEROPSIN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
PS00238 OPSIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOPSX_HUMAN
AccessioniPrimary (citable) accession number: O14718
Secondary accession number(s): A1A4V2, Q7RTS4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: November 7, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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Main funding by: National Institutes of Health

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