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Protein

tRNA (cytosine(38)-C(5))-methyltransferase

Gene

TRDMT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp).1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei34S-adenosyl-L-methionineCombined sources1 Publication1
Binding sitei76S-adenosyl-L-methionineCombined sources1 Publication1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei79PROSITE-ProRule annotation1
Binding sitei376S-adenosyl-L-methionineCombined sources1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, RNA-binding, Transferase
Biological processtRNA processing
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS03011-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.1.1.204 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6782315 tRNA modification in the nucleus and cytosol

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
tRNA (cytosine(38)-C(5))-methyltransferase (EC:2.1.1.204)
Alternative name(s):
DNA (cytosine-5)-methyltransferase-like protein 2
Short name:
Dnmt2
DNA methyltransferase homolog HsaIIP
Short name:
DNA MTase homolog HsaIIP
Short name:
M.HsaIIP
PuMet
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRDMT1
Synonyms:DNMT2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000107614.21

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2977 TRDMT1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602478 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O14717

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
1787

Open Targets

More...
OpenTargetsi
ENSG00000107614

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162406922

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB04077 Glycerol
DB00738 Pentamidine
DB01752 S-Adenosyl-L-Homocysteine

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TRDMT1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000880401 – 391tRNA (cytosine(38)-C(5))-methyltransferaseAdd BLAST391

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O14717

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O14717

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O14717

PeptideAtlas

More...
PeptideAtlasi
O14717

PRoteomics IDEntifications database

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PRIDEi
O14717

ProteomicsDB human proteome resource

More...
ProteomicsDBi
48175
48176 [O14717-2]
48177 [O14717-3]
48178 [O14717-4]
48179 [O14717-5]
48180 [O14717-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O14717

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O14717

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. Higher expression in testis, ovary and thymus and at much lower levels in spleen, prostate, colon, small intestine, and peripheral blood leukocytes.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000107614 Expressed in 158 organ(s), highest expression level in caput epididymis

CleanEx database of gene expression profiles

More...
CleanExi
HS_TRDMT1

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O14717 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O14717 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB009468
HPA036945
HPA036946

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
108124, 16 interactors

Protein interaction database and analysis system

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IntActi
O14717, 15 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000367030

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1391
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1G55X-ray1.80A2-391[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O14717

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O14717

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
O14717

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4 – 391SAM-dependent MTase C5-typePROSITE-ProRule annotationAdd BLAST388

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni13 – 15S-adenosyl-L-methionine bindingCombined sources1 Publication3
Regioni57 – 58S-adenosyl-L-methionine bindingCombined sources1 Publication2

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0919 Eukaryota
COG0270 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000016416

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG051385

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O14717

KEGG Orthology (KO)

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KOi
K15336

Identification of Orthologs from Complete Genome Data

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OMAi
RLMSFPE

Database of Orthologous Groups

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OrthoDBi
1519639at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O14717

TreeFam database of animal gene trees

More...
TreeFami
TF300024

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001525 C5_MeTfrase
IPR031303 C5_meth_CS
IPR029063 SAM-dependent_MTases

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00145 DNA_methylase, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00105 C5METTRFRASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53335 SSF53335, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00675 dcm, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00095 C5_MTASE_2, 1 hit
PS51679 SAM_MT_C5, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 6 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform A (identifier: O14717-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEPLRVLELY SGVGGMHHAL RESCIPAQVV AAIDVNTVAN EVYKYNFPHT
60 70 80 90 100
QLLAKTIEGI TLEEFDRLSF DMILMSPPCQ PFTRIGRQGD MTDSRTNSFL
110 120 130 140 150
HILDILPRLQ KLPKYILLEN VKGFEVSSTR DLLIQTIENC GFQYQEFLLS
160 170 180 190 200
PTSLGIPNSR LRYFLIAKLQ SEPLPFQAPG QVLMEFPKIE SVHPQKYAMD
210 220 230 240 250
VENKIQEKNV EPNISFDGSI QCSGKDAILF KLETAEEIHR KNQQDSDLSV
260 270 280 290 300
KMLKDFLEDD TDVNQYLLPP KSLLRYALLL DIVQPTCRRS VCFTKGYGSY
310 320 330 340 350
IEGTGSVLQT AEDVQVENIY KSLTNLSQEE QITKLLILKL RYFTPKEIAN
360 370 380 390
LLGFPPEFGF PEKITVKQRY RLLGNSLNVH VVAKLIKILY E
Length:391
Mass (Da):44,597
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBCA549E4EB2E6950
GO
Isoform B (identifier: O14717-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     84-107: Missing.

Show »
Length:367
Mass (Da):41,858
Checksum:i3801D5651DBC2614
GO
Isoform C (identifier: O14717-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     84-129: Missing.

Show »
Length:345
Mass (Da):39,313
Checksum:i65939D1BE01D958B
GO
Isoform D (identifier: O14717-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     59-63: GITLE → DWPAG
     64-391: Missing.

Show »
Length:63
Mass (Da):6,965
Checksum:i3DBEA06674461233
GO
Isoform E (identifier: O14717-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     59-71: GITLEEFDRLSFD → ITKITKVYSFGKC
     72-391: Missing.

Show »
Length:71
Mass (Da):7,908
Checksum:i862BC392F37BFA8C
GO
Isoform F (identifier: O14717-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     59-107: GITLEEFDRL...SFLHILDILP → RPLDTNNRKL...SVRAITLSSP
     108-391: Missing.

Show »
Length:107
Mass (Da):12,087
Checksum:iBDD5DD4DC6D6BD3E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q7Z3E4Q7Z3E4_HUMAN
tRNA (cytosine(38)-C(5))-methyltran...
TRDMT1 DKFZp686N1286
69Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B7Z8H2B7Z8H2_HUMAN
cDNA FLJ52038, highly similar to DN...
TRDMT1
254Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y2T8H0Y2T8_HUMAN
tRNA (cytosine(38)-C(5))-methyltran...
TRDMT1
227Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4J214A0A0B4J214_HUMAN
tRNA (cytosine(38)-C(5))-methyltran...
TRDMT1
136Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DG18A0A0C4DG18_HUMAN
tRNA (cytosine(38)-C(5))-methyltran...
TRDMT1
53Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y4A2H0Y4A2_HUMAN
tRNA (cytosine(38)-C(5))-methyltran...
TRDMT1
86Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti148L → I in AAC39764 (PubMed:9592134).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051961101H → Y1 PublicationCorresponds to variant dbSNP:rs11254413Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00563459 – 107GITLE…LDILP → RPLDTNNRKLWLSVPRVYII SNLSWHSKFKATIFSYCKAS VRAITLSSP in isoform F. 1 PublicationAdd BLAST49
Alternative sequenceiVSP_00563259 – 71GITLE…RLSFD → ITKITKVYSFGKC in isoform E. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_00563059 – 63GITLE → DWPAG in isoform D. 1 Publication5
Alternative sequenceiVSP_00563164 – 391Missing in isoform D. 1 PublicationAdd BLAST328
Alternative sequenceiVSP_00563372 – 391Missing in isoform E. 1 PublicationAdd BLAST320
Alternative sequenceiVSP_00562984 – 129Missing in isoform C. 1 PublicationAdd BLAST46
Alternative sequenceiVSP_00562884 – 107Missing in isoform B. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_005635108 – 391Missing in isoform F. 1 PublicationAdd BLAST284

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF012128 mRNA Translation: AAC51939.1
AJ223333 mRNA Translation: CAA11272.1
AF045888 mRNA Translation: AAC39764.1
EF444974 Genomic DNA Translation: ACA05980.1
EF444974 Genomic DNA Translation: ACA05984.1
EF444974 Genomic DNA Translation: ACA05985.1
EF444974 Genomic DNA Translation: ACA05986.1
AC067747 Genomic DNA No translation available.
AL133415 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86218.1
CH471072 Genomic DNA Translation: EAW86219.1
BC047733 mRNA Translation: AAH47733.1
AF329940 mRNA Translation: AAK68034.1
AF329941 mRNA Translation: AAK68035.1
AF329942 mRNA Translation: AAK68036.1
AF329943 mRNA Translation: AAK68037.1
AF329944 mRNA Translation: AAK68033.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS7114.1 [O14717-1]

NCBI Reference Sequences

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RefSeqi
NP_001307935.1, NM_001321006.1
NP_001307936.1, NM_001321007.1
NP_004403.1, NM_004412.6 [O14717-1]
XP_005252432.1, XM_005252375.4 [O14717-3]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.351665
Hs.564140
Hs.733857

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000377799; ENSP00000367030; ENSG00000107614 [O14717-1]
ENST00000495022; ENSP00000417594; ENSG00000107614 [O14717-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
1787

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:1787

UCSC genome browser

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UCSCi
uc057sar.1 human [O14717-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF012128 mRNA Translation: AAC51939.1
AJ223333 mRNA Translation: CAA11272.1
AF045888 mRNA Translation: AAC39764.1
EF444974 Genomic DNA Translation: ACA05980.1
EF444974 Genomic DNA Translation: ACA05984.1
EF444974 Genomic DNA Translation: ACA05985.1
EF444974 Genomic DNA Translation: ACA05986.1
AC067747 Genomic DNA No translation available.
AL133415 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86218.1
CH471072 Genomic DNA Translation: EAW86219.1
BC047733 mRNA Translation: AAH47733.1
AF329940 mRNA Translation: AAK68034.1
AF329941 mRNA Translation: AAK68035.1
AF329942 mRNA Translation: AAK68036.1
AF329943 mRNA Translation: AAK68037.1
AF329944 mRNA Translation: AAK68033.1
CCDSiCCDS7114.1 [O14717-1]
RefSeqiNP_001307935.1, NM_001321006.1
NP_001307936.1, NM_001321007.1
NP_004403.1, NM_004412.6 [O14717-1]
XP_005252432.1, XM_005252375.4 [O14717-3]
UniGeneiHs.351665
Hs.564140
Hs.733857

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1G55X-ray1.80A2-391[»]
ProteinModelPortaliO14717
SMRiO14717
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108124, 16 interactors
IntActiO14717, 15 interactors
STRINGi9606.ENSP00000367030

Chemistry databases

DrugBankiDB04077 Glycerol
DB00738 Pentamidine
DB01752 S-Adenosyl-L-Homocysteine

PTM databases

iPTMnetiO14717
PhosphoSitePlusiO14717

Polymorphism and mutation databases

BioMutaiTRDMT1

Proteomic databases

EPDiO14717
jPOSTiO14717
PaxDbiO14717
PeptideAtlasiO14717
PRIDEiO14717
ProteomicsDBi48175
48176 [O14717-2]
48177 [O14717-3]
48178 [O14717-4]
48179 [O14717-5]
48180 [O14717-6]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377799; ENSP00000367030; ENSG00000107614 [O14717-1]
ENST00000495022; ENSP00000417594; ENSG00000107614 [O14717-4]
GeneIDi1787
KEGGihsa:1787
UCSCiuc057sar.1 human [O14717-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
1787
DisGeNETi1787
EuPathDBiHostDB:ENSG00000107614.21

GeneCards: human genes, protein and diseases

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GeneCardsi
TRDMT1
HGNCiHGNC:2977 TRDMT1
HPAiCAB009468
HPA036945
HPA036946
MIMi602478 gene
neXtProtiNX_O14717
OpenTargetsiENSG00000107614
PharmGKBiPA162406922

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0919 Eukaryota
COG0270 LUCA
GeneTreeiENSGT00390000016416
HOVERGENiHBG051385
InParanoidiO14717
KOiK15336
OMAiRLMSFPE
OrthoDBi1519639at2759
PhylomeDBiO14717
TreeFamiTF300024

Enzyme and pathway databases

BioCyciMetaCyc:HS03011-MONOMER
BRENDAi2.1.1.204 2681
ReactomeiR-HSA-6782315 tRNA modification in the nucleus and cytosol

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TRDMT1 human
EvolutionaryTraceiO14717

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
TRDMT1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
1787

Protein Ontology

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PROi
PR:O14717

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000107614 Expressed in 158 organ(s), highest expression level in caput epididymis
CleanExiHS_TRDMT1
ExpressionAtlasiO14717 baseline and differential
GenevisibleiO14717 HS

Family and domain databases

InterProiView protein in InterPro
IPR001525 C5_MeTfrase
IPR031303 C5_meth_CS
IPR029063 SAM-dependent_MTases
PfamiView protein in Pfam
PF00145 DNA_methylase, 1 hit
PRINTSiPR00105 C5METTRFRASE
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00675 dcm, 1 hit
PROSITEiView protein in PROSITE
PS00095 C5_MTASE_2, 1 hit
PS51679 SAM_MT_C5, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRDMT_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O14717
Secondary accession number(s): B0YJ02
, B0YJ03, B0YJ07, B0YJ08, O43669, Q86WW6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: January 1, 1998
Last modified: January 16, 2019
This is version 162 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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