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Protein

RANBP2-like and GRIP domain-containing protein 8

Gene

RGPD8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

One of the 8 copies of RANBP2 clustered close to the chromosome 2 centromere.

GO - Molecular functioni

  • Ran GTPase binding Source: UniProtKB

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
RANBP2-like and GRIP domain-containing protein 8
Alternative name(s):
Ran-binding protein 2-like 3
Short name:
RanBP2-like 3
Short name:
RanBP2L3
Gene namesi
Name:RGPD8
Synonyms:RANBP2ALPHA, RANBP2L1, RANBP2L3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000169629.11
HGNCiHGNC:9849 RGPD8
MIMi602752 gene
neXtProtiNX_O14715

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000169629
PharmGKBiPA34210

Polymorphism and mutation databases

BioMutaiRGPD8

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002049171 – 1765RANBP2-like and GRIP domain-containing protein 8Add BLAST1765

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19PhosphothreonineCombined sources1
Modified residuei21PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO14715
MaxQBiO14715
PaxDbiO14715
PeptideAtlasiO14715
PRIDEiO14715
ProteomicsDBi48174

PTM databases

iPTMnetiO14715
PhosphoSitePlusiO14715

Expressioni

Gene expression databases

BgeeiENSG00000169629
CleanExiHS_RGPD8
ExpressionAtlasiO14715 baseline and differential
GenevisibleiO14715 HS

Organism-specific databases

HPAiHPA049497
HPA051675
HPA067564

Interactioni

Subunit structurei

Interacts with GTP-bound ARL1.1 Publication

GO - Molecular functioni

  • Ran GTPase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi608294, 33 interactors
IntActiO14715, 9 interactors
STRINGi9606.ENSP00000306637

Structurei

3D structure databases

ProteinModelPortaliO14715
SMRiO14715
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati26 – 59TPR 1Add BLAST34
Repeati60 – 93TPR 2Add BLAST34
Repeati648 – 681TPR 3Add BLAST34
Domaini1036 – 1172RanBD1 1PROSITE-ProRule annotationAdd BLAST137
Domaini1333 – 1469RanBD1 2PROSITE-ProRule annotationAdd BLAST137
Domaini1702 – 1752GRIPPROSITE-ProRule annotationAdd BLAST51

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1261 – 1266Poly-Ser6

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG0864 Eukaryota
COG5171 LUCA
GeneTreeiENSGT00760000119119
HOGENOMiHOG000089994
HOVERGENiHBG108404
InParanoidiO14715
KOiK12172
OrthoDBiEOG091G0BGL
PhylomeDBiO14715
TreeFamiTF314797

Family and domain databases

Gene3Di1.25.40.10, 1 hit
2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR032023 GCC2_Rab_bind
IPR000237 GRIP_dom
IPR011993 PH-like_dom_sf
IPR000156 Ran_bind_dom
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF01465 GRIP, 1 hit
PF16704 Rab_bind, 1 hit
PF00638 Ran_BP1, 2 hits
SMARTiView protein in SMART
SM00755 Grip, 1 hit
SM00160 RanBD, 2 hits
SM00028 TPR, 1 hit
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50913 GRIP, 1 hit
PS50196 RANBD1, 2 hits
PS50005 TPR, 1 hit
PS50293 TPR_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

O14715-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRSKADVER YVASVLGLTP SPRQKSMKGF YFAKLYYEAK EYDLAKKYIC
60 70 80 90 100
TYINVQERDP KAHRFLGLLY ELEENTEKAV ECYRRSVELN PTQKDLVLKI
110 120 130 140 150
AELLCKNDVT DGRAKYWVER AAKLFPGSPA IYKLKEQLLD CEGEDGWNKL
160 170 180 190 200
FDLIQSELYV RPDDVHVNIR LVELYRSTKR LKDAVAHCHE AERNIALRSS
210 220 230 240 250
LEWNSCVVQT LKEYLESLQC LESDKSDWRA TNTDLLLAYA NLMLLTLSTR
260 270 280 290 300
DVQENRELLE SFDSALQSAK SSLGGNDELS ATFLEMKGHF YMYAGSLLLK
310 320 330 340 350
MGQHGNNVQW RALSELAALC YLIAFQVPRP KIKLREGKAG QNLLEMMACD
360 370 380 390 400
RLSQSGHMLL SLSRGKQDFL KEVVETFANK IGQSALYDAL FSSQSPKDTS
410 420 430 440 450
FLGSDDIGKI DVQEPELEDL ARYDVGAIRA HNGSLQHLTW LGLQWNSLPA
460 470 480 490 500
LPGIRKWLKQ LFHRLPHETS RLETNAPESI CILDLEVFLL GVVYTSHLQL
510 520 530 540 550
KEKCNSHHSS YQPLCLPFPV CKQLCTERQK SWWDAVCTLI HRKAVPGNLA
560 570 580 590 600
KLRLLVQHEI NTLRAQEKHG LQPALLVHWA KYLQKTGSGL NSFYGQLEYI
610 620 630 640 650
GRSVHYWKKV LPLLKIIKKN SIPEPIDPLF KHFHSVDIQA SEIVEYEEDA
660 670 680 690 700
HITFAILDAV NGNIEDAVTA FESIKSVVSY WNLALIFHRK AEDIENDALS
710 720 730 740 750
PEEQEECRNY LTKTRDYLIK IIDDGDSNLS VVKKLPVPLE SVKQMLNSVM
760 770 780 790 800
QELEDYSEGG PLYKNGSLRN ADSEIKHSTP SPTKYSLSPS KSYKYSPETP
810 820 830 840 850
PRWTEDRNSL LNMICQQVEA IKKEMQELKL NSSKSASRHR WPTENYGPDS
860 870 880 890 900
VPDGYQGSQT FHGAPLTVAT TGPSVYYSQS PAYNSQYLLR PAANVTPTKG
910 920 930 940 950
SSNTEFKSTK EGFSIPVSAD GFKFGISEPG NQEKKREKPL ENDTGLQAQD
960 970 980 990 1000
IRGRKKGRGV IFGQTSSTFT FADVAKSTSG EGFQFGKKDL NFKGFSGAGE
1010 1020 1030 1040 1050
KLFSSRYGKM ANKANTSGDF EKDDDAYKTE DSDDIHFEPV VQMPEKVELV
1060 1070 1080 1090 1100
TGEEGEKVLY SQGVKLFRFD AEVRQWKERG LGNLKILKNE VNGKLRMLMR
1110 1120 1130 1140 1150
REQVLKVCAN HWITTTMNLK PLSGSDRAWM WSASDFSDGD AKLERLAAKF
1160 1170 1180 1190 1200
KTPELAEEFK QKFEECQRLL LDIPLQTPHK LVDTGRAAKL IQRAEEMKSG
1210 1220 1230 1240 1250
LKDFKTFLTN DQTKVTEEEN KGSGTGVAGA SDTTIKPNAE NTGPTLEWDN
1260 1270 1280 1290 1300
YDLREDALDD SVSSSSVHAS PLASSPVRKN LFRFDESTTG SNFSFKSALS
1310 1320 1330 1340 1350
LSKSPAKLNQ SGTSVGTDEE SVVTQEEERD GQYFEPVVPL PDLVEVSSGE
1360 1370 1380 1390 1400
ENEQVVFSHR AEIYRYDKDV GQWKERGIGD IKILQNYDNK QVRIVMRRDQ
1410 1420 1430 1440 1450
VLKLCANHRI TPDMSLQNMK GTERVWVWTA CDFADGERKV EHLAVRFKLQ
1460 1470 1480 1490 1500
DVADSFKKIF DEAKTAQEKD SLITPHVSRS STPRESPCGK IAVAVLEEIT
1510 1520 1530 1540 1550
RERTDVIQGD DVADAASEVE VSSTSETTTK AVVSPPKFVF VSESVKRIFS
1560 1570 1580 1590 1600
SEKSKPFAFG NSSATGSLFG FSFNAPLKSN NSETSSVAQS GSESKVEPKK
1610 1620 1630 1640 1650
CELSKNSDIE QSSDSKVKNL SASFPTEESS INYTFKTPEK EPPLWHAEFT
1660 1670 1680 1690 1700
KEELVQKLRS TTKSADHLNG LLREIEATNA VLMEQIKLLK SEIRRLERNQ
1710 1720 1730 1740 1750
EREKSAANLE YLKNVLLQFI FLKPGSERER LLPVINTMLQ LSPEEKGKLA
1760
AVAQDEEENP SRSSG
Length:1,765
Mass (Da):198,993
Last modified:April 20, 2010 - v2
Checksum:iE8B7462EE211D670
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1541V → G in AAC05596 (PubMed:9480752).Curated1
Sequence conflicti1640K → A in CAI56757 (PubMed:17974005).Curated1
Sequence conflicti1741L → P in CAI56757 (PubMed:17974005).Curated1
Sequence conflicti1760P → A in CAI56757 (PubMed:17974005).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF012086 mRNA Translation: AAC05596.1
CR936614 mRNA Translation: CAI56757.1
CCDSiCCDS46394.1
RefSeqiNP_001157935.1, NM_001164463.1
UniGeneiHs.469630
Hs.535589

Genome annotation databases

EnsembliENST00000302558; ENSP00000306637; ENSG00000169629
GeneIDi727851
KEGGihsa:727851
UCSCiuc002ths.3 human

Similar proteinsi

Entry informationi

Entry nameiRGPD8_HUMAN
AccessioniPrimary (citable) accession number: O14715
Secondary accession number(s): Q5CZA8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: April 20, 2010
Last modified: June 20, 2018
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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