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Protein

Integrin beta-1-binding protein 1

Gene

ITGB1BP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Key regulator of the integrin-mediated cell-matrix interaction signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha-5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1. Plays a role in cell proliferation, differentiation, spreading, adhesion and migration in the context of mineralization and bone development and angiogenesis. Stimulates cellular proliferation in a fibronectin-dependent manner. Involved in the regulation of beta-1 integrin-containing focal adhesion (FA) site dynamics by controlling its assembly rate during cell adhesion; inhibits beta-1 integrin clustering within FA by directly competing with talin TLN1, and hence stimulates osteoblast spreading and migration in a fibronectin-and/or collagen-dependent manner. Acts as a guanine nucleotide dissociation inhibitor (GDI) by regulating Rho family GTPases during integrin-mediated cell matrix adhesion; reduces the level of active GTP-bound form of both CDC42 and RAC1 GTPases upon cell adhesion to fibronectin. Stimulates the release of active CDC42 from the membranes to maintain it in an inactive cytoplasmic pool. Participates in the translocation of the Rho-associated protein kinase ROCK1 to membrane ruffles at cell leading edges of the cell membrane, leading to an increase of myoblast cell migration on laminin. Plays a role in bone mineralization at a late stage of osteoblast differentiation; modulates the dynamic formation of focal adhesions into fibrillar adhesions, which are adhesive structures responsible for fibronectin deposition and fibrillogenesis. Plays a role in blood vessel development; acts as a negative regulator of angiogenesis by attenuating endothelial cell proliferation and migration, lumen formation and sprouting angiogenesis by promoting AKT phosphorylation and inhibiting ERK1/2 phosphorylation through activation of the Notch signaling pathway. Promotes transcriptional activity of the MYC promoter.9 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMitogen
Biological processAngiogenesis, Biomineralization, Cell adhesion, Differentiation, Notch signaling pathway, Transcription, Transcription regulation

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

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SIGNORi
O14713

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Integrin beta-1-binding protein 1
Alternative name(s):
Integrin cytoplasmic domain-associated protein 1
Short name:
ICAP-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ITGB1BP1
Synonyms:ICAP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000119185.12

Human Gene Nomenclature Database

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HGNCi
HGNC:23927 ITGB1BP1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
607153 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_O14713

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi6 – 7KK → AA: Abolishes nuclear import and transcriptional activity. 1 Publication2
Mutagenesisi38T → A: Stimulates cell spreading on fibronectin to a similar extent as inhibition of CaMKII. 2 Publications1
Mutagenesisi38T → D: Changes in cell spreading. 2 Publications1
Mutagenesisi38T → D: Strong defect in cell spreading. 2 Publications1
Mutagenesisi82L → A: Reduces ITGB1 binding. 1 Publication1
Mutagenesisi82L → Q: No effect on ITGB1 binding. 1 Publication1
Mutagenesisi86L → Q: No effect on ITGB1 binding. 1 Publication1
Mutagenesisi89I → R: Reduces KRIT1 binding. No effect on ITGB1 binding. 1 Publication1
Mutagenesisi93D → A: Abolishes KRIT1 binding; when associated with A-96. 1 Publication1
Mutagenesisi96Q → A: Abolishes KRIT1 binding; when associated with A-93. 1 Publication1
Mutagenesisi135 – 139LYLII → AYAA: Reduces KRIT1 and ITGB1 binding. 1 Publication5
Mutagenesisi135L → A: Abolishes ITGB1 binding. 1 Publication1
Mutagenesisi138I → A: Abolishes ITGB1 binding. 2 Publications1
Mutagenesisi139I → A: Abolishes ITGB1 binding. 1 Publication1
Mutagenesisi144Y → T: Abolishes ITGB1 binding. 1 Publication1
Mutagenesisi184C → D: Reduces KRIT1 and ITGB1 binding. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
9270

Open Targets

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OpenTargetsi
ENSG00000119185

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA134913590

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ITGB1BP1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000842641 – 200Integrin beta-1-binding protein 1Add BLAST200

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei38Phosphothreonine; by CaMK21 Publication1
Modified residuei41PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation at Thr-38 seems to enhance integrin alpha5beta1-mediated cell adhesion. The degree of phosphorylation is regulated by integrin-dependent cell-matrix interaction.3 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O14713

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O14713

MaxQB - The MaxQuant DataBase

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MaxQBi
O14713

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O14713

PeptideAtlas

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PeptideAtlasi
O14713

PRoteomics IDEntifications database

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PRIDEi
O14713

ProteomicsDB human proteome resource

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ProteomicsDBi
48172
48173 [O14713-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O14713

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O14713

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in endothelial cells and fibroblasts (at protein level). Ubiquitously expressed. Expressed in intestine, colon, testis, ovary, thymus, spleen and prostate.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000119185 Expressed in 237 organ(s), highest expression level in caudate nucleus

CleanEx database of gene expression profiles

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CleanExi
HS_ITGB1BP1

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O14713 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O14713 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA067348
HPA071538

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via N-terminus and PTB domain) with ROCK1 (By similarity). Found in a complex, at least composed of ITGB1BP1, KRIT1 and RAP1A. Interacts (via C-terminal region) with ITGB1 (via C-terminal cytoplasmic tail); the interaction prevents talin TLN1 binding to ITGB1 and KRIT1 and ITGB1 compete for the same binding site. Interacts with KRIT1 (via N-terminal NPXY motif); the interaction induces the opening conformation of KRIT1 and KRIT1 and ITGB1 compete for the same binding site. Isoform 2 does not interact with ITGB1. Interacts with CDC42 (GTP- or GDP-bound form); the interaction is increased with the CDC42-membrane bound forms and prevents both CDC42 activation and cell spreading. Interacts (via C-terminal domain region) with NME2. Interacts with FERMT2 and RAC1.By similarity11 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
114689, 16 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
O14713

Protein interaction database and analysis system

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IntActi
O14713, 12 interactors

Molecular INTeraction database

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MINTi
O14713

STRING: functional protein association networks

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STRINGi
9606.ENSP00000347504

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1200
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K11model-A58-196[»]
4DX8X-ray2.54A/B/D/E49-200[»]
4DX9X-ray2.990/1/2/3/4/5/A/C/E/G/I/K/M/O/Q/S/U/W/Y/a/c/e/g/i/k/m/o/q/s/u49-200[»]
4JIFX-ray1.70A49-200[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O14713

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O14713

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini58 – 200PIDAdd BLAST143

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni136 – 139Interaction with KRIT14
Regioni139 – 141Interaction with ITGB13

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi6 – 7Nuclear localization signal2

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi10 – 57Ser/Thr-richAdd BLAST48

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IFN6 Eukaryota
ENOG4111GWT LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000003990

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000015089

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG052155

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O14713

KEGG Orthology (KO)

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KOi
K20058

Identification of Orthologs from Complete Genome Data

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OMAi
RMLCYDD

Database of Orthologous Groups

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OrthoDBi
1409828at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O14713

TreeFam database of animal gene trees

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TreeFami
TF105393

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR019517 Integrin-bd_ICAP-1
IPR011993 PH-like_dom_sf
IPR006020 PTB/PI_dom

The PANTHER Classification System

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PANTHERi
PTHR32055 PTHR32055, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF10480 ICAP-1_inte_bdg, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00462 PTB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O14713-1) [UniParc]FASTAAdd to basket
Also known as: ICAP1-alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFRKGKKRHS SSSSQSSEIS TKSKSVDSSL GGLSRSSTVA SLDTDSTKSS
60 70 80 90 100
GQSNNNSDTC AEFRIKYVGA IEKLKLSEGK GLEGPLDLIN YIDVAQQDGK
110 120 130 140 150
LPFVPPEEEF IMGVSKYGIK VSTSDQYDVL HRHALYLIIR MVCYDDGLGA
160 170 180 190 200
GKSLLALKTT DASNEEYSLW VYQCNSLEQA QAICKVLSTA FDSVLTSEKP
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Length:200
Mass (Da):21,782
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0F041238E68FBE23
GO
Isoform 2 (identifier: O14713-2) [UniParc]FASTAAdd to basket
Also known as: ICAP1-beta

The sequence of this isoform differs from the canonical sequence as follows:
     128-177: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:150
Mass (Da):16,140
Checksum:iFC6E3D387878DB81
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8MPU2A8MPU2_HUMAN
Integrin beta 1 binding protein 1, ...
ITGB1BP1 hCG_1686416
184Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JBU8C9JBU8_HUMAN
Integrin beta-1-binding protein 1
ITGB1BP1
136Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J5T5C9J5T5_HUMAN
Integrin beta-1-binding protein 1
ITGB1BP1
114Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JZ07C9JZ07_HUMAN
Integrin beta-1-binding protein 1
ITGB1BP1
96Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J6Y2C9J6Y2_HUMAN
Integrin beta-1-binding protein 1
ITGB1BP1
84Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J0J6C9J0J6_HUMAN
Integrin beta-1-binding protein 1
ITGB1BP1
86Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9IZZ8C9IZZ8_HUMAN
Integrin beta-1-binding protein 1
ITGB1BP1
65Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V1A3G3V1A3_HUMAN
Integrin beta 1 binding protein 1, ...
ITGB1BP1 hCG_1686416
107Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WF20F8WF20_HUMAN
Integrin beta-1-binding protein 1
ITGB1BP1
38Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti150A → V in AAH12264 (Ref. 4) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_003898128 – 177Missing in isoform 2. 1 PublicationAdd BLAST50

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF012023 mRNA Translation: AAB88671.1
AF012024 mRNA Translation: AAB88672.1
CH471053 Genomic DNA Translation: EAX00992.1
CH471053 Genomic DNA Translation: EAX00995.1
CH471053 Genomic DNA Translation: EAX01000.1
CH471053 Genomic DNA Translation: EAX01001.1
AC080162 Genomic DNA Translation: AAY14857.1
CH471053 Genomic DNA Translation: EAX00993.1
CH471053 Genomic DNA Translation: EAX00997.1
BC012264 mRNA Translation: AAH12264.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1662.1 [O14713-1]
CCDS1663.1 [O14713-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001305995.1, NM_001319066.1 [O14713-1]
NP_001305996.1, NM_001319067.1 [O14713-1]
NP_001305997.1, NM_001319068.1 [O14713-1]
NP_004754.1, NM_004763.4 [O14713-1]
NP_071729.1, NM_022334.4 [O14713-2]
XP_005246240.1, XM_005246183.4 [O14713-1]
XP_005246241.1, XM_005246184.4 [O14713-1]
XP_005246242.1, XM_005246185.4 [O14713-1]
XP_005246246.1, XM_005246189.4 [O14713-2]
XP_006711966.1, XM_006711903.3 [O14713-1]
XP_011508718.1, XM_011510416.2 [O14713-1]
XP_016860756.1, XM_017005267.1 [O14713-1]
XP_016860757.1, XM_017005268.1 [O14713-1]
XP_016860758.1, XM_017005269.1 [O14713-2]
XP_016860759.1, XM_017005270.1 [O14713-2]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.467662

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000238091; ENSP00000238091; ENSG00000119185 [O14713-2]
ENST00000355346; ENSP00000347504; ENSG00000119185 [O14713-1]
ENST00000360635; ENSP00000353850; ENSG00000119185 [O14713-1]
ENST00000488451; ENSP00000419524; ENSG00000119185 [O14713-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
9270

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:9270

UCSC genome browser

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UCSCi
uc002qzj.4 human [O14713-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF012023 mRNA Translation: AAB88671.1
AF012024 mRNA Translation: AAB88672.1
CH471053 Genomic DNA Translation: EAX00992.1
CH471053 Genomic DNA Translation: EAX00995.1
CH471053 Genomic DNA Translation: EAX01000.1
CH471053 Genomic DNA Translation: EAX01001.1
AC080162 Genomic DNA Translation: AAY14857.1
CH471053 Genomic DNA Translation: EAX00993.1
CH471053 Genomic DNA Translation: EAX00997.1
BC012264 mRNA Translation: AAH12264.1
CCDSiCCDS1662.1 [O14713-1]
CCDS1663.1 [O14713-2]
RefSeqiNP_001305995.1, NM_001319066.1 [O14713-1]
NP_001305996.1, NM_001319067.1 [O14713-1]
NP_001305997.1, NM_001319068.1 [O14713-1]
NP_004754.1, NM_004763.4 [O14713-1]
NP_071729.1, NM_022334.4 [O14713-2]
XP_005246240.1, XM_005246183.4 [O14713-1]
XP_005246241.1, XM_005246184.4 [O14713-1]
XP_005246242.1, XM_005246185.4 [O14713-1]
XP_005246246.1, XM_005246189.4 [O14713-2]
XP_006711966.1, XM_006711903.3 [O14713-1]
XP_011508718.1, XM_011510416.2 [O14713-1]
XP_016860756.1, XM_017005267.1 [O14713-1]
XP_016860757.1, XM_017005268.1 [O14713-1]
XP_016860758.1, XM_017005269.1 [O14713-2]
XP_016860759.1, XM_017005270.1 [O14713-2]
UniGeneiHs.467662

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K11model-A58-196[»]
4DX8X-ray2.54A/B/D/E49-200[»]
4DX9X-ray2.990/1/2/3/4/5/A/C/E/G/I/K/M/O/Q/S/U/W/Y/a/c/e/g/i/k/m/o/q/s/u49-200[»]
4JIFX-ray1.70A49-200[»]
ProteinModelPortaliO14713
SMRiO14713
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114689, 16 interactors
CORUMiO14713
IntActiO14713, 12 interactors
MINTiO14713
STRINGi9606.ENSP00000347504

PTM databases

iPTMnetiO14713
PhosphoSitePlusiO14713

Polymorphism and mutation databases

BioMutaiITGB1BP1

Proteomic databases

EPDiO14713
jPOSTiO14713
MaxQBiO14713
PaxDbiO14713
PeptideAtlasiO14713
PRIDEiO14713
ProteomicsDBi48172
48173 [O14713-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
9270
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000238091; ENSP00000238091; ENSG00000119185 [O14713-2]
ENST00000355346; ENSP00000347504; ENSG00000119185 [O14713-1]
ENST00000360635; ENSP00000353850; ENSG00000119185 [O14713-1]
ENST00000488451; ENSP00000419524; ENSG00000119185 [O14713-2]
GeneIDi9270
KEGGihsa:9270
UCSCiuc002qzj.4 human [O14713-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9270
DisGeNETi9270
EuPathDBiHostDB:ENSG00000119185.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ITGB1BP1
HGNCiHGNC:23927 ITGB1BP1
HPAiHPA067348
HPA071538
MIMi607153 gene
neXtProtiNX_O14713
OpenTargetsiENSG00000119185
PharmGKBiPA134913590

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IFN6 Eukaryota
ENOG4111GWT LUCA
GeneTreeiENSGT00390000003990
HOGENOMiHOG000015089
HOVERGENiHBG052155
InParanoidiO14713
KOiK20058
OMAiRMLCYDD
OrthoDBi1409828at2759
PhylomeDBiO14713
TreeFamiTF105393

Enzyme and pathway databases

SIGNORiO14713

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ITGB1BP1 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
ITGB1BP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9270

Protein Ontology

More...
PROi
PR:O14713

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000119185 Expressed in 237 organ(s), highest expression level in caudate nucleus
CleanExiHS_ITGB1BP1
ExpressionAtlasiO14713 baseline and differential
GenevisibleiO14713 HS

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR019517 Integrin-bd_ICAP-1
IPR011993 PH-like_dom_sf
IPR006020 PTB/PI_dom
PANTHERiPTHR32055 PTHR32055, 1 hit
PfamiView protein in Pfam
PF10480 ICAP-1_inte_bdg, 1 hit
SMARTiView protein in SMART
SM00462 PTB, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiITBP1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O14713
Secondary accession number(s): D6W4Y9, O14714, Q53RS0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: January 1, 1998
Last modified: January 16, 2019
This is version 161 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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