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Protein

Zinc finger protein 197

Gene

ZNF197

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri370 – 392C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri398 – 420C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri426 – 448C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri454 – 476C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri482 – 504C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri510 – 532C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri538 – 560C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri566 – 588C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri594 – 616C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri622 – 644C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri650 – 672C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri678 – 700C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri706 – 728C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri734 – 756C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri762 – 784C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri790 – 812C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri818 – 840C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri846 – 868C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri874 – 896C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri902 – 924C2H2-type 20PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri930 – 952C2H2-type 21PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri958 – 980C2H2-type 22PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • DNA binding Source: GO_Central
  • DNA-binding transcription factor activity Source: ProtInc
  • DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
  • metal ion binding Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 197
Alternative name(s):
Zinc finger protein with KRAB and SCAN domains 9
ZnF20
pVHL-associated KRAB domain-containing protein
Gene namesi
Name:ZNF197
Synonyms:ZKSCAN9, ZNF166
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000186448.14
HGNCiHGNC:12988 ZNF197
neXtProtiNX_O14709

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi10168
OpenTargetsiENSG00000186448
PharmGKBiPA37568

Polymorphism and mutation databases

BioMutaiZNF197

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474481 – 1029Zinc finger protein 197Add BLAST1029

Proteomic databases

EPDiO14709
MaxQBiO14709
PaxDbiO14709
PeptideAtlasiO14709
PRIDEiO14709
ProteomicsDBi48170
48171 [O14709-2]

PTM databases

iPTMnetiO14709
PhosphoSitePlusiO14709

Expressioni

Gene expression databases

BgeeiENSG00000186448 Expressed in 193 organ(s), highest expression level in kidney
CleanExiHS_ZNF197
ExpressionAtlasiO14709 baseline and differential
GenevisibleiO14709 HS

Organism-specific databases

HPAiHPA054567

Interactioni

Protein-protein interaction databases

BioGridi115470, 13 interactors
IntActiO14709, 5 interactors
STRINGi9606.ENSP00000345809

Structurei

3D structure databases

ProteinModelPortaliO14709
SMRiO14709
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 124SCAN boxPROSITE-ProRule annotationAdd BLAST83
Domaini217 – 289KRABPROSITE-ProRule annotationAdd BLAST73

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri370 – 392C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri398 – 420C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri426 – 448C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri454 – 476C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri482 – 504C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri510 – 532C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri538 – 560C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri566 – 588C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri594 – 616C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri622 – 644C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri650 – 672C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri678 – 700C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri706 – 728C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri734 – 756C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri762 – 784C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri790 – 812C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri818 – 840C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri846 – 868C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri874 – 896C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri902 – 924C2H2-type 20PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri930 – 952C2H2-type 21PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri958 – 980C2H2-type 22PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000150816
HOGENOMiHOG000234617
HOVERGENiHBG067525
InParanoidiO14709
KOiK09229
OMAiHTVEEFS
OrthoDBiEOG091G02KC
PhylomeDBiO14709
TreeFamiTF350837

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
cd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF02023 SCAN, 1 hit
PF00096 zf-C2H2, 20 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 22 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 12 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 22 hits
PS50157 ZINC_FINGER_C2H2_2, 22 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O14709-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTRENVAHNA LRQEGLVKGK DDTWKWGTSF QGSSSSVWET SHLHFRQLRY
60 70 80 90 100
HETSGPQEAL SRLRELCRRW LRPEARTKAQ ILELLVLEQF LSILPGEIRT
110 120 130 140 150
WVQLHHPGSG EEAVALVEEL QKDLDGPAIQ VPVLVKDQDT LQKVVSAPGT
160 170 180 190 200
TLPPVLPGSH IAAEICPHPP TDLVAFNLQD PQHDSPAPEA SALSQEENPR
210 220 230 240 250
NQLMALMLLT AQPQELVMFE EVSVCFTSEE WACLGPIQRA LYWDVMLENY
260 270 280 290 300
GNVTSLEWET MTENEEVTSK PSSSQRADSH KGTSKRLQGS VPQVLDFEEE
310 320 330 340 350
CEWQVLASQW GNETDERADT VKKVSLCERD KKKRTPPEKQ GQKWKELGDS
360 370 380 390 400
LTFGSAISES LIGTEGKKFY KCDMCCKHFN KISHLINHRR IHTGEKPHKC
410 420 430 440 450
KECGKGFIQR SSLLMHLRNH SGEKPYKCNE CGKAFSQSAY LLNHQRIHTG
460 470 480 490 500
EKPYKCKECG KGFYRHSGLI IHLRRHSGER PYKCNECGKV FSQNAYLIDH
510 520 530 540 550
QRLHKGEEPY KCNKCQKAFI LKKSLILHQR IHSGEKPYKC DECGKTFAQT
560 570 580 590 600
TYLIDHQRLH SAENPYKCKE CGKVFIRSKS LLLHQRVHTE KKTFGCKKCG
610 620 630 640 650
KIFSSKSNFI DHKRMHSREK PYKCTECGKA FTQSAYLFDH QRLHNGEKPY
660 670 680 690 700
ECNECGKVFI LKKSLILHQR FHTGENLYEC KDCGKVFGSN RNLIDHERLH
710 720 730 740 750
NGEKPYECRE CGKTFIMSKS FMVHQKLHTQ EKAYKCEDCG KAFSYNSSLL
760 770 780 790 800
VHRRIHTGEK PFECSECGRA FSSNRNLIEH KRIHSGEKPY ECDECGKCFI
810 820 830 840 850
LKKSLIGHQR IHTREKSYKC NDCGKVFSYR SNLIAHQRIH TGEKPYACSE
860 870 880 890 900
CGKGFTYNRN LIEHQRIHSG EKTYECHVCR KVLTSSRNLM VHQRIHTGEK
910 920 930 940 950
PYKCNECGKD FSQNKNLVVH QRMHTGEKPY ECDKCRKSFT SKRNLVGHQR
960 970 980 990 1000
IHTGEKPYGC NDCSKVFRQR KNLTVHQKIH TDEKPCECDV SEKEFSQTSN
1010 1020
LHLQQKIHTI EEFSWLQNTN ESKIEIQKI
Length:1,029
Mass (Da):118,847
Last modified:January 1, 1998 - v1
Checksum:i95DB6F65A170F76B
GO
Isoform 2 (identifier: O14709-2) [UniParc]FASTAAdd to basket
Also known as: VHLaK

The sequence of this isoform differs from the canonical sequence as follows:
     257-267: EWETMTENEEV → GYRKYRRQRNK
     268-1029: Missing.

Note: Negative regulator of HIF1A transactivation.
Show »
Length:267
Mass (Da):30,229
Checksum:iE93D82A22B930CE3
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JQH5C9JQH5_HUMAN
Zinc finger protein 197
ZNF197
78Annotation score:
F8WEU5F8WEU5_HUMAN
Zinc finger protein 197
ZNF197
173Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_043021257 – 267EWETMTENEEV → GYRKYRRQRNK in isoform 2. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_043022268 – 1029Missing in isoform 2. 1 PublicationAdd BLAST762

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF011573 mRNA Translation: AAB84385.1
AY074878 mRNA Translation: AAL79677.1
AK314196 mRNA Translation: BAG36875.1
AC099669 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW64714.1
CCDSiCCDS2717.1 [O14709-1]
CCDS33743.1 [O14709-2]
RefSeqiNP_001020026.1, NM_001024855.2 [O14709-2]
NP_001310222.1, NM_001323293.1 [O14709-1]
NP_001310223.1, NM_001323294.1 [O14709-2]
NP_008922.1, NM_006991.4 [O14709-1]
UniGeneiHs.157035

Genome annotation databases

EnsembliENST00000344387; ENSP00000345809; ENSG00000186448 [O14709-1]
ENST00000383744; ENSP00000373250; ENSG00000186448 [O14709-2]
ENST00000383745; ENSP00000373251; ENSG00000186448 [O14709-2]
ENST00000396058; ENSP00000379370; ENSG00000186448 [O14709-1]
ENST00000627517; ENSP00000487305; ENSG00000281709 [O14709-2]
ENST00000627752; ENSP00000486777; ENSG00000281709 [O14709-2]
ENST00000627845; ENSP00000486739; ENSG00000281709 [O14709-1]
ENST00000628172; ENSP00000485709; ENSG00000281709 [O14709-1]
GeneIDi10168
KEGGihsa:10168
UCSCiuc003cnm.4 human [O14709-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF011573 mRNA Translation: AAB84385.1
AY074878 mRNA Translation: AAL79677.1
AK314196 mRNA Translation: BAG36875.1
AC099669 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW64714.1
CCDSiCCDS2717.1 [O14709-1]
CCDS33743.1 [O14709-2]
RefSeqiNP_001020026.1, NM_001024855.2 [O14709-2]
NP_001310222.1, NM_001323293.1 [O14709-1]
NP_001310223.1, NM_001323294.1 [O14709-2]
NP_008922.1, NM_006991.4 [O14709-1]
UniGeneiHs.157035

3D structure databases

ProteinModelPortaliO14709
SMRiO14709
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115470, 13 interactors
IntActiO14709, 5 interactors
STRINGi9606.ENSP00000345809

PTM databases

iPTMnetiO14709
PhosphoSitePlusiO14709

Polymorphism and mutation databases

BioMutaiZNF197

Proteomic databases

EPDiO14709
MaxQBiO14709
PaxDbiO14709
PeptideAtlasiO14709
PRIDEiO14709
ProteomicsDBi48170
48171 [O14709-2]

Protocols and materials databases

DNASUi10168
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344387; ENSP00000345809; ENSG00000186448 [O14709-1]
ENST00000383744; ENSP00000373250; ENSG00000186448 [O14709-2]
ENST00000383745; ENSP00000373251; ENSG00000186448 [O14709-2]
ENST00000396058; ENSP00000379370; ENSG00000186448 [O14709-1]
ENST00000627517; ENSP00000487305; ENSG00000281709 [O14709-2]
ENST00000627752; ENSP00000486777; ENSG00000281709 [O14709-2]
ENST00000627845; ENSP00000486739; ENSG00000281709 [O14709-1]
ENST00000628172; ENSP00000485709; ENSG00000281709 [O14709-1]
GeneIDi10168
KEGGihsa:10168
UCSCiuc003cnm.4 human [O14709-1]

Organism-specific databases

CTDi10168
DisGeNETi10168
EuPathDBiHostDB:ENSG00000186448.14
GeneCardsiZNF197
HGNCiHGNC:12988 ZNF197
HPAiHPA054567
neXtProtiNX_O14709
OpenTargetsiENSG00000186448
PharmGKBiPA37568
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000150816
HOGENOMiHOG000234617
HOVERGENiHBG067525
InParanoidiO14709
KOiK09229
OMAiHTVEEFS
OrthoDBiEOG091G02KC
PhylomeDBiO14709
TreeFamiTF350837

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

ChiTaRSiZNF197 human
GenomeRNAii10168
PROiPR:O14709

Gene expression databases

BgeeiENSG00000186448 Expressed in 193 organ(s), highest expression level in kidney
CleanExiHS_ZNF197
ExpressionAtlasiO14709 baseline and differential
GenevisibleiO14709 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
cd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF02023 SCAN, 1 hit
PF00096 zf-C2H2, 20 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 22 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 12 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 22 hits
PS50157 ZINC_FINGER_C2H2_2, 22 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN197_HUMAN
AccessioniPrimary (citable) accession number: O14709
Secondary accession number(s): B2RAH8, Q86VG0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 1, 1998
Last modified: November 7, 2018
This is version 172 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
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