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Protein

Zinc finger protein 197

Gene

ZNF197

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri370 – 392C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri398 – 420C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri426 – 448C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri454 – 476C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri482 – 504C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri510 – 532C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri538 – 560C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri566 – 588C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri594 – 616C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri622 – 644C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri650 – 672C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri678 – 700C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri706 – 728C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri734 – 756C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri762 – 784C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri790 – 812C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri818 – 840C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri846 – 868C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri874 – 896C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri902 – 924C2H2-type 20PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri930 – 952C2H2-type 21PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri958 – 980C2H2-type 22PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • DNA binding Source: GO_Central
  • DNA-binding transcription factor activity Source: ProtInc
  • DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
  • metal ion binding Source: UniProtKB-KW

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-212436 Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 197
Alternative name(s):
Zinc finger protein with KRAB and SCAN domains 9
ZnF20
pVHL-associated KRAB domain-containing protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF197
Synonyms:ZKSCAN9, ZNF166
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000186448.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:12988 ZNF197

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O14709

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
10168

Open Targets

More...
OpenTargetsi
ENSG00000186448

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37568

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF197

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000474481 – 1029Zinc finger protein 197Add BLAST1029

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O14709

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O14709

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O14709

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O14709

PeptideAtlas

More...
PeptideAtlasi
O14709

PRoteomics IDEntifications database

More...
PRIDEi
O14709

ProteomicsDB human proteome resource

More...
ProteomicsDBi
48170
48171 [O14709-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O14709

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O14709

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000186448 Expressed in 193 organ(s), highest expression level in kidney

CleanEx database of gene expression profiles

More...
CleanExi
HS_ZNF197

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O14709 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O14709 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA054567

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
115470, 13 interactors

Protein interaction database and analysis system

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IntActi
O14709, 5 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000345809

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O14709

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O14709

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini42 – 124SCAN boxPROSITE-ProRule annotationAdd BLAST83
Domaini217 – 289KRABPROSITE-ProRule annotationAdd BLAST73

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri370 – 392C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri398 – 420C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri426 – 448C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri454 – 476C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri482 – 504C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri510 – 532C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri538 – 560C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri566 – 588C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri594 – 616C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri622 – 644C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri650 – 672C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri678 – 700C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri706 – 728C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri734 – 756C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri762 – 784C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri790 – 812C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri818 – 840C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri846 – 868C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri874 – 896C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri902 – 924C2H2-type 20PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri930 – 952C2H2-type 21PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri958 – 980C2H2-type 22PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162801

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234617

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG067525

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O14709

KEGG Orthology (KO)

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KOi
K09229

Identification of Orthologs from Complete Genome Data

More...
OMAi
HTVEEFS

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O14709

TreeFam database of animal gene trees

More...
TreeFami
TF350837

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765 KRAB_A-box, 1 hit
cd07936 SCAN, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.4020.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352 KRAB, 1 hit
PF02023 SCAN, 1 hit
PF00096 zf-C2H2, 20 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349 KRAB, 1 hit
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 22 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 12 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805 KRAB, 1 hit
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 22 hits
PS50157 ZINC_FINGER_C2H2_2, 22 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O14709-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTRENVAHNA LRQEGLVKGK DDTWKWGTSF QGSSSSVWET SHLHFRQLRY
60 70 80 90 100
HETSGPQEAL SRLRELCRRW LRPEARTKAQ ILELLVLEQF LSILPGEIRT
110 120 130 140 150
WVQLHHPGSG EEAVALVEEL QKDLDGPAIQ VPVLVKDQDT LQKVVSAPGT
160 170 180 190 200
TLPPVLPGSH IAAEICPHPP TDLVAFNLQD PQHDSPAPEA SALSQEENPR
210 220 230 240 250
NQLMALMLLT AQPQELVMFE EVSVCFTSEE WACLGPIQRA LYWDVMLENY
260 270 280 290 300
GNVTSLEWET MTENEEVTSK PSSSQRADSH KGTSKRLQGS VPQVLDFEEE
310 320 330 340 350
CEWQVLASQW GNETDERADT VKKVSLCERD KKKRTPPEKQ GQKWKELGDS
360 370 380 390 400
LTFGSAISES LIGTEGKKFY KCDMCCKHFN KISHLINHRR IHTGEKPHKC
410 420 430 440 450
KECGKGFIQR SSLLMHLRNH SGEKPYKCNE CGKAFSQSAY LLNHQRIHTG
460 470 480 490 500
EKPYKCKECG KGFYRHSGLI IHLRRHSGER PYKCNECGKV FSQNAYLIDH
510 520 530 540 550
QRLHKGEEPY KCNKCQKAFI LKKSLILHQR IHSGEKPYKC DECGKTFAQT
560 570 580 590 600
TYLIDHQRLH SAENPYKCKE CGKVFIRSKS LLLHQRVHTE KKTFGCKKCG
610 620 630 640 650
KIFSSKSNFI DHKRMHSREK PYKCTECGKA FTQSAYLFDH QRLHNGEKPY
660 670 680 690 700
ECNECGKVFI LKKSLILHQR FHTGENLYEC KDCGKVFGSN RNLIDHERLH
710 720 730 740 750
NGEKPYECRE CGKTFIMSKS FMVHQKLHTQ EKAYKCEDCG KAFSYNSSLL
760 770 780 790 800
VHRRIHTGEK PFECSECGRA FSSNRNLIEH KRIHSGEKPY ECDECGKCFI
810 820 830 840 850
LKKSLIGHQR IHTREKSYKC NDCGKVFSYR SNLIAHQRIH TGEKPYACSE
860 870 880 890 900
CGKGFTYNRN LIEHQRIHSG EKTYECHVCR KVLTSSRNLM VHQRIHTGEK
910 920 930 940 950
PYKCNECGKD FSQNKNLVVH QRMHTGEKPY ECDKCRKSFT SKRNLVGHQR
960 970 980 990 1000
IHTGEKPYGC NDCSKVFRQR KNLTVHQKIH TDEKPCECDV SEKEFSQTSN
1010 1020
LHLQQKIHTI EEFSWLQNTN ESKIEIQKI
Length:1,029
Mass (Da):118,847
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i95DB6F65A170F76B
GO
Isoform 2 (identifier: O14709-2) [UniParc]FASTAAdd to basket
Also known as: VHLaK

The sequence of this isoform differs from the canonical sequence as follows:
     257-267: EWETMTENEEV → GYRKYRRQRNK
     268-1029: Missing.

Note: Negative regulator of HIF1A transactivation.
Show »
Length:267
Mass (Da):30,229
Checksum:iE93D82A22B930CE3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WEU5F8WEU5_HUMAN
Zinc finger protein 197
ZNF197
173Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JQH5C9JQH5_HUMAN
Zinc finger protein 197
ZNF197
78Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_043021257 – 267EWETMTENEEV → GYRKYRRQRNK in isoform 2. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_043022268 – 1029Missing in isoform 2. 1 PublicationAdd BLAST762

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF011573 mRNA Translation: AAB84385.1
AY074878 mRNA Translation: AAL79677.1
AK314196 mRNA Translation: BAG36875.1
AC099669 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW64714.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS2717.1 [O14709-1]
CCDS33743.1 [O14709-2]

NCBI Reference Sequences

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RefSeqi
NP_001020026.1, NM_001024855.2 [O14709-2]
NP_001310222.1, NM_001323293.1 [O14709-1]
NP_001310223.1, NM_001323294.1 [O14709-2]
NP_008922.1, NM_006991.4 [O14709-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.157035

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000344387; ENSP00000345809; ENSG00000186448 [O14709-1]
ENST00000383744; ENSP00000373250; ENSG00000186448 [O14709-2]
ENST00000383745; ENSP00000373251; ENSG00000186448 [O14709-2]
ENST00000396058; ENSP00000379370; ENSG00000186448 [O14709-1]
ENST00000627517; ENSP00000487305; ENSG00000281709 [O14709-2]
ENST00000627752; ENSP00000486777; ENSG00000281709 [O14709-2]
ENST00000627845; ENSP00000486739; ENSG00000281709 [O14709-1]
ENST00000628172; ENSP00000485709; ENSG00000281709 [O14709-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
10168

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:10168

UCSC genome browser

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UCSCi
uc003cnm.4 human [O14709-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF011573 mRNA Translation: AAB84385.1
AY074878 mRNA Translation: AAL79677.1
AK314196 mRNA Translation: BAG36875.1
AC099669 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW64714.1
CCDSiCCDS2717.1 [O14709-1]
CCDS33743.1 [O14709-2]
RefSeqiNP_001020026.1, NM_001024855.2 [O14709-2]
NP_001310222.1, NM_001323293.1 [O14709-1]
NP_001310223.1, NM_001323294.1 [O14709-2]
NP_008922.1, NM_006991.4 [O14709-1]
UniGeneiHs.157035

3D structure databases

ProteinModelPortaliO14709
SMRiO14709
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115470, 13 interactors
IntActiO14709, 5 interactors
STRINGi9606.ENSP00000345809

PTM databases

iPTMnetiO14709
PhosphoSitePlusiO14709

Polymorphism and mutation databases

BioMutaiZNF197

Proteomic databases

EPDiO14709
jPOSTiO14709
MaxQBiO14709
PaxDbiO14709
PeptideAtlasiO14709
PRIDEiO14709
ProteomicsDBi48170
48171 [O14709-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
10168
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344387; ENSP00000345809; ENSG00000186448 [O14709-1]
ENST00000383744; ENSP00000373250; ENSG00000186448 [O14709-2]
ENST00000383745; ENSP00000373251; ENSG00000186448 [O14709-2]
ENST00000396058; ENSP00000379370; ENSG00000186448 [O14709-1]
ENST00000627517; ENSP00000487305; ENSG00000281709 [O14709-2]
ENST00000627752; ENSP00000486777; ENSG00000281709 [O14709-2]
ENST00000627845; ENSP00000486739; ENSG00000281709 [O14709-1]
ENST00000628172; ENSP00000485709; ENSG00000281709 [O14709-1]
GeneIDi10168
KEGGihsa:10168
UCSCiuc003cnm.4 human [O14709-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
10168
DisGeNETi10168
EuPathDBiHostDB:ENSG00000186448.14

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF197
HGNCiHGNC:12988 ZNF197
HPAiHPA054567
neXtProtiNX_O14709
OpenTargetsiENSG00000186448
PharmGKBiPA37568

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000162801
HOGENOMiHOG000234617
HOVERGENiHBG067525
InParanoidiO14709
KOiK09229
OMAiHTVEEFS
OrthoDBi1318335at2759
PhylomeDBiO14709
TreeFamiTF350837

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZNF197 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
10168

Protein Ontology

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PROi
PR:O14709

Gene expression databases

BgeeiENSG00000186448 Expressed in 193 organ(s), highest expression level in kidney
CleanExiHS_ZNF197
ExpressionAtlasiO14709 baseline and differential
GenevisibleiO14709 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
cd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF02023 SCAN, 1 hit
PF00096 zf-C2H2, 20 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 22 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 12 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 22 hits
PS50157 ZINC_FINGER_C2H2_2, 22 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN197_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O14709
Secondary accession number(s): B2RAH8, Q86VG0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 1, 1998
Last modified: January 16, 2019
This is version 174 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
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