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Protein

Prostaglandin E synthase

Gene

PTGES

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2).1 Publication

Catalytic activityi

(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate.1 Publication

Cofactori

glutathione1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei117Glutathione1
Binding sitei126Glutathione1
Binding sitei130Glutathione1
Binding sitei134Glutathione1

GO - Molecular functioni

  • glutathione binding Source: UniProtKB
  • prostaglandin-E synthase activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Prostaglandin biosynthesis, Prostaglandin metabolism

Enzyme and pathway databases

BioCyciMetaCyc:HS07518-MONOMER
BRENDAi5.3.99.3 2681
ReactomeiR-HSA-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
SABIO-RKiO14684
SIGNORiO14684

Chemistry databases

SwissLipidsiSLP:000001631

Names & Taxonomyi

Protein namesi
Recommended name:
Prostaglandin E synthase (EC:5.3.99.3)
Alternative name(s):
Microsomal glutathione S-transferase 1-like 1
Short name:
MGST1-L1
Microsomal prostaglandin E synthase 1
Short name:
MPGES-1
p53-induced gene 12 protein
Gene namesi
Name:PTGES
Synonyms:MGST1L1, MPGES1, PGES, PIG12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000148344.10
HGNCiHGNC:9599 PTGES
MIMi605172 gene
neXtProtiNX_O14684

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 12LumenalAdd BLAST12
Transmembranei13 – 41HelicalAdd BLAST29
Topological domaini42 – 60CytoplasmicAdd BLAST19
Transmembranei61 – 90HelicalAdd BLAST30
Topological domaini91 – 95Lumenal5
Transmembranei96 – 119HelicalAdd BLAST24
Topological domaini120 – 123Cytoplasmic4
Transmembranei124 – 152HelicalAdd BLAST29

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi66E → A: Reduces enzyme activity by 50%. 1 Publication1
Mutagenesisi67R → A: Loss of enzyme activity. 1 Publication1
Mutagenesisi70R → A: Slightly reduced enzyme activity. 1 Publication1
Mutagenesisi72H → A: Reduces enzyme activity by 70%. 1 Publication1
Mutagenesisi110R → A or S: Loss of enzyme activity. 1 Publication1
Mutagenesisi117Y → A: Loss of enzyme activity. 1 Publication1
Mutagenesisi117Y → F: No effect on enzyme activity. 1 Publication1

Organism-specific databases

DisGeNETi9536
OpenTargetsiENSG00000148344
PharmGKBiPA33948

Chemistry databases

ChEMBLiCHEMBL5658
GuidetoPHARMACOLOGYi1377

Polymorphism and mutation databases

BioMutaiPTGES

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002177451 – 152Prostaglandin E synthaseAdd BLAST152

Proteomic databases

EPDiO14684
MaxQBiO14684
PaxDbiO14684
PeptideAtlasiO14684
PRIDEiO14684
ProteomicsDBi48167
TopDownProteomicsiO14684

PTM databases

PhosphoSitePlusiO14684
SwissPalmiO14684

Expressioni

Inductioni

By p53/TP53.1 Publication

Gene expression databases

BgeeiENSG00000148344
CleanExiHS_PTGES
GenevisibleiO14684 HS

Organism-specific databases

HPAiHPA045064

Interactioni

Subunit structurei

Homotrimer.1 Publication

Protein-protein interaction databases

BioGridi114912, 2 interactors
IntActiO14684, 10 interactors
STRINGi9606.ENSP00000342385

Chemistry databases

BindingDBiO14684

Structurei

Secondary structure

1152
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 9Combined sources4
Helixi13 – 41Combined sources29
Beta strandi44 – 46Combined sources3
Helixi47 – 52Combined sources6
Helixi56 – 58Combined sources3
Helixi63 – 90Combined sources28
Helixi96 – 118Combined sources23
Helixi125 – 150Combined sources26

3D structure databases

ProteinModelPortaliO14684
SMRiO14684
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO14684

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni28 – 38Glutathione bindingAdd BLAST11
Regioni70 – 77Glutathione binding8
Regioni110 – 113Glutathione binding4

Sequence similaritiesi

Belongs to the MAPEG family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IY81 Eukaryota
ENOG4111VJG LUCA
GeneTreeiENSGT00390000011980
HOGENOMiHOG000231759
HOVERGENiHBG052470
InParanoidiO14684
KOiK15729
OMAiCFSMALQ
OrthoDBiEOG091G14I4
PhylomeDBiO14684
TreeFamiTF105327

Family and domain databases

Gene3Di1.20.120.550, 1 hit
InterProiView protein in InterPro
IPR023352 MAPEG-like_dom_sf
IPR001129 Membr-assoc_MAPEG
PfamiView protein in Pfam
PF01124 MAPEG, 1 hit
SUPFAMiSSF161084 SSF161084, 1 hit

Sequencei

Sequence statusi: Complete.

O14684-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAHSLVMSS PALPAFLLCS TLLVIKMYVV AIITGQVRLR KKAFANPEDA
60 70 80 90 100
LRHGGPQYCR SDPDVERCLR AHRNDMETIY PFLFLGFVYS FLGPNPFVAW
110 120 130 140 150
MHFLVFLVGR VAHTVAYLGK LRAPIRSVTY TLAQLPCASM ALQILWEAAR

HL
Length:152
Mass (Da):17,102
Last modified:May 30, 2000 - v2
Checksum:iBF9B9ED81CA67A3D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti55G → GG in AAC39534 (PubMed:9305847).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF010316 mRNA Translation: AAC39534.1
AF027740 mRNA Translation: AAB82299.1
AJ271802, AJ271803, AJ271804 Genomic DNA Translation: CAB72099.1
AK311947 mRNA Translation: BAG34888.1
EF543149 Genomic DNA Translation: ABQ01233.1
AL590369 Genomic DNA No translation available.
AL592219 Genomic DNA No translation available.
BC008280 mRNA Translation: AAH08280.1
CCDSiCCDS6927.1
RefSeqiNP_004869.1, NM_004878.4
UniGeneiHs.146688

Genome annotation databases

EnsembliENST00000340607; ENSP00000342385; ENSG00000148344
GeneIDi9536
KEGGihsa:9536
UCSCiuc004byi.4 human

Similar proteinsi

Entry informationi

Entry nameiPTGES_HUMAN
AccessioniPrimary (citable) accession number: O14684
Secondary accession number(s): O14900, Q5SZC0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: July 18, 2018
This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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