PTGES

Functionⁱ

Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2).1 Publication

Catalytic activityⁱ

(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate.1 Publication

Cofactorⁱ

glutathione1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	117	Glutathione	1
Binding siteⁱ	126	Glutathione	1
Binding siteⁱ	130	Glutathione	1
Binding siteⁱ	134	Glutathione	1

GO - Molecular functionⁱ

glutathione binding
Source: UniProtKB
Inferred from direct assayⁱ
- 18682561
glutathione transferase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
prostaglandin-E synthase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 18682561

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

acute inflammatory response Source: Ensembl
chronic inflammatory response Source: Ensembl
cyclooxygenase pathway Source: Reactome
glutathione metabolic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
negative regulation of cell proliferation Source: Ensembl
oxidation-reduction process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
prostaglandin biosynthetic process
Source: UniProtKB
Inferred from direct assayⁱ
- 18682561
prostaglandin metabolic process
Source: ProtInc
Traceable author statementⁱ
- 10377395
response to calcium ion Source: Ensembl
response to cytokine Source: Ensembl
response to lipopolysaccharide Source: Ensembl
response to organic cyclic compound Source: Ensembl
response to retinoic acid Source: Ensembl
signal transduction
Source: ProtInc
Non-traceable author statementⁱ
- 10377395

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Isomerase
Biological process	Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Prostaglandin biosynthesis, Prostaglandin metabolism

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS07518-MONOMER
BRENDAⁱ	5.3.99.3 2681
Reactomeⁱ	R-HSA-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
SABIO-RKⁱ	O14684
SIGNORⁱ	O14684

Chemistry databases

SwissLipidsⁱ	SLP:000001631

SwissLipidsⁱ

SLP:000001631

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Prostaglandin E synthase (EC:5.3.99.3) Alternative name(s): Microsomal glutathione S-transferase 1-like 1 Short name: MGST1-L1 Microsomal prostaglandin E synthase 1 Short name: MPGES-1 p53-induced gene 12 protein
Gene namesⁱ	Name:PTGES Synonyms:MGST1L1, MPGES1, PGES, PIG12
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 9

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000148344.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9599 PTGES
MIMⁱ	605172 gene
neXtProtⁱ	NX_O14684

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 12	LumenalAdd BLAST	12
Transmembraneⁱ	13 – 41	HelicalAdd BLAST	29
Topological domainⁱ	42 – 60	CytoplasmicAdd BLAST	19
Transmembraneⁱ	61 – 90	HelicalAdd BLAST	30
Topological domainⁱ	91 – 95	Lumenal	5
Transmembraneⁱ	96 – 119	HelicalAdd BLAST	24
Topological domainⁱ	120 – 123	Cytoplasmic	4
Transmembraneⁱ	124 – 152	HelicalAdd BLAST	29

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	66	E → A: Reduces enzyme activity by 50%. 1 Publication	1
Mutagenesisⁱ	67	R → A: Loss of enzyme activity. 1 Publication	1
Mutagenesisⁱ	70	R → A: Slightly reduced enzyme activity. 1 Publication	1
Mutagenesisⁱ	72	H → A: Reduces enzyme activity by 70%. 1 Publication	1
Mutagenesisⁱ	110	R → A or S: Loss of enzyme activity. 1 Publication	1
Mutagenesisⁱ	117	Y → A: Loss of enzyme activity. 1 Publication	1
Mutagenesisⁱ	117	Y → F: No effect on enzyme activity. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	9536
Open Targets More...OpenTargetsⁱ	ENSG00000148344
PharmGKBⁱ	PA33948

Chemistry databases

ChEMBLⁱ	CHEMBL5658
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	1377

Polymorphism and mutation databases

BioMutaⁱ	PTGES

BioMutaⁱ

PTGES

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000217745	1 – 152	Prostaglandin E synthaseAdd BLAST		152

Proteomic databases

EPDⁱ	O14684
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O14684
PaxDbⁱ	O14684
PeptideAtlas More...PeptideAtlasⁱ	O14684
PRIDEⁱ	O14684
ProteomicsDBⁱ	48167
TopDownProteomicsⁱ	O14684

PTM databases

PhosphoSitePlusⁱ	O14684
SwissPalmⁱ	O14684

Expressionⁱ

Inductionⁱ

By p53/TP53.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000148344 Expressed in 182 organ(s), highest expression level in palpebral conjunctiva
CleanExⁱ	HS_PTGES
Genevisibleⁱ	O14684 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA045064

HPAⁱ

HPA045064

Interactionⁱ

Subunit structureⁱ

Homotrimer.1 Publication

Protein-protein interaction databases

BioGridⁱ	114912, 3 interactors
IntActⁱ	O14684, 10 interactors
STRINGⁱ	9606.ENSP00000342385

Chemistry databases

BindingDBⁱ

O14684

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	6 – 9	Combined sources	4
Helixⁱ	13 – 41	Combined sources	29
Beta strandⁱ	44 – 46	Combined sources	3
Helixⁱ	47 – 52	Combined sources	6
Helixⁱ	56 – 58	Combined sources	3
Helixⁱ	63 – 90	Combined sources	28
Helixⁱ	96 – 118	Combined sources	23
Helixⁱ	125 – 150	Combined sources	26

Show more details

3D structure databases

ProteinModelPortalⁱ	O14684
SMRⁱ	O14684
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	O14684

EvolutionaryTraceⁱ

O14684

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	28 – 38	Glutathione bindingAdd BLAST	11
Regionⁱ	70 – 77	Glutathione binding	8
Regionⁱ	110 – 113	Glutathione binding	4

Sequence similaritiesⁱ

Belongs to the MAPEG family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IY81 Eukaryota ENOG4111VJG LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000011980
HOGENOMⁱ	HOG000231759
HOVERGENⁱ	HBG052470
InParanoidⁱ	O14684
KEGG Orthology (KO) More...KOⁱ	K15729
OMAⁱ	CFSMALQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G14I4
PhylomeDBⁱ	O14684
TreeFamⁱ	TF105327

Family and domain databases

Gene3Dⁱ	1.20.120.550, 1 hit
InterProⁱ	View protein in InterPro IPR023352 MAPEG-like_dom_sf IPR001129 Membr-assoc_MAPEG
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01124 MAPEG, 1 hit
SUPFAMⁱ	SSF161084 SSF161084, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

O14684-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPAHSLVMSS PALPAFLLCS TLLVIKMYVV AIITGQVRLR KKAFANPEDA 
        60         70         80         90        100
LRHGGPQYCR SDPDVERCLR AHRNDMETIY PFLFLGFVYS FLGPNPFVAW 
       110        120        130        140        150
MHFLVFLVGR VAHTVAYLGK LRAPIRSVTY TLAQLPCASM ALQILWEAAR 

HL

Length:152

Mass (Da):17,102

Last modified:May 30, 2000 - v2

Checksum:ⁱBF9B9ED81CA67A3D

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	55	G → GG in AAC39534 (PubMed:9305847).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF010316 mRNA Translation: AAC39534.1 AF027740 mRNA Translation: AAB82299.1 AJ271802, AJ271803, AJ271804 Genomic DNA Translation: CAB72099.1 AK311947 mRNA Translation: BAG34888.1 EF543149 Genomic DNA Translation: ABQ01233.1 AL590369 Genomic DNA No translation available. AL592219 Genomic DNA No translation available. BC008280 mRNA Translation: AAH08280.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS6927.1
NCBI Reference Sequences More...RefSeqⁱ	NP_004869.1, NM_004878.4
UniGeneⁱ	Hs.146688

Genome annotation databases

Ensemblⁱ	ENST00000340607; ENSP00000342385; ENSG00000148344
GeneIDⁱ	9536
KEGGⁱ	hsa:9536
UCSC genome browser More...UCSCⁱ	uc004byi.4 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O14684	HCG30600, isoform CRA_a		HUMAN		180	UniRef100_O14684
Microsomal prostaglandin E synthase-1 (Fragment)		MACFA		55
UPI0006418886		HUMAN		148

Protein	Similar proteins		Species	Score	Length	Source
O14684	Prostaglandin E synthase		MACFA		152	UniRef90_O14684
HCG30600, isoform CRA_a		HUMAN		180
Uncharacterized protein		NOMLE		163
Prostaglandin E synthase		PANTR		160
Prostaglandin E synthase		AOTNA		152
+30

Protein	Similar proteins		Species	Score	Length	Source
O14684	Prostaglandin E synthase		MACFA		152	UniRef50_O14684
Prostaglandin E synthase		BOVIN		153
Prostaglandin E synthase		MOUSE		153
HCG30600, isoform CRA_a		HUMAN		180
Uncharacterized protein		NOMLE		163
+136

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF010316 mRNA Translation: AAC39534.1 AF027740 mRNA Translation: AAB82299.1 AJ271802, AJ271803, AJ271804 Genomic DNA Translation: CAB72099.1 AK311947 mRNA Translation: BAG34888.1 EF543149 Genomic DNA Translation: ABQ01233.1 AL590369 Genomic DNA No translation available. AL592219 Genomic DNA No translation available. BC008280 mRNA Translation: AAH08280.1
CCDSⁱ	CCDS6927.1
RefSeqⁱ	NP_004869.1, NM_004878.4
UniGeneⁱ	Hs.146688

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3DWW	electron microscopy	3.50	A/B/C	1-152	[»]
	4AL0	X-ray	1.16	A	1-152	[»]
	4AL1	X-ray	1.95	A	1-152	[»]
	4BPM	X-ray	2.08	A	10-152	[»]
	4WAB	X-ray	2.70	A	10-151	[»]
	4YK5	X-ray	1.42	A	2-152	[»]
	4YL0	X-ray	1.52	A	5-152	[»]
	4YL1	X-ray	1.41	A	5-152	[»]
	4YL3	X-ray	1.41	A	5-152	[»]
	5BQG	X-ray	1.44	A	2-152	[»]
	5BQH	X-ray	1.60	A	2-152	[»]
	5BQI	X-ray	1.88	A	2-152	[»]
	5K0I	X-ray	1.30	A	2-152	[»]
	5T36	X-ray	1.40	A	2-152	[»]
	5T37	X-ray	1.76	A	2-152	[»]
	5TL9	X-ray	1.20	A	2-152	[»]
ProteinModelPortalⁱ	O14684
SMRⁱ	O14684
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114912, 3 interactors
IntActⁱ	O14684, 10 interactors
STRINGⁱ	9606.ENSP00000342385

Chemistry databases

BindingDBⁱ	O14684
ChEMBLⁱ	CHEMBL5658
GuidetoPHARMACOLOGYⁱ	1377
SwissLipidsⁱ	SLP:000001631

PTM databases

PhosphoSitePlusⁱ	O14684
SwissPalmⁱ	O14684

Polymorphism and mutation databases

BioMutaⁱ	PTGES

BioMutaⁱ

PTGES

Proteomic databases

EPDⁱ	O14684
MaxQBⁱ	O14684
PaxDbⁱ	O14684
PeptideAtlasⁱ	O14684
PRIDEⁱ	O14684
ProteomicsDBⁱ	48167
TopDownProteomicsⁱ	O14684

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000340607; ENSP00000342385; ENSG00000148344
GeneIDⁱ	9536
KEGGⁱ	hsa:9536
UCSCⁱ	uc004byi.4 human

Organism-specific databases

CTDⁱ	9536
DisGeNETⁱ	9536
EuPathDBⁱ	HostDB:ENSG00000148344.10
GeneCardsⁱ	PTGES
HGNCⁱ	HGNC:9599 PTGES
HPAⁱ	HPA045064
MIMⁱ	605172 gene
neXtProtⁱ	NX_O14684
OpenTargetsⁱ	ENSG00000148344
PharmGKBⁱ	PA33948
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IY81 Eukaryota ENOG4111VJG LUCA
GeneTreeⁱ	ENSGT00390000011980
HOGENOMⁱ	HOG000231759
HOVERGENⁱ	HBG052470
InParanoidⁱ	O14684
KOⁱ	K15729
OMAⁱ	CFSMALQ
OrthoDBⁱ	EOG091G14I4
PhylomeDBⁱ	O14684
TreeFamⁱ	TF105327

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS07518-MONOMER
BRENDAⁱ	5.3.99.3 2681
Reactomeⁱ	R-HSA-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
SABIO-RKⁱ	O14684
SIGNORⁱ	O14684

Miscellaneous databases

ChiTaRSⁱ	PTGES human
EvolutionaryTraceⁱ	O14684
GeneWikiⁱ	PTGES
GenomeRNAiⁱ	9536
Protein Ontology More...PROⁱ	PR:O14684
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000148344 Expressed in 182 organ(s), highest expression level in palpebral conjunctiva
CleanExⁱ	HS_PTGES
Genevisibleⁱ	O14684 HS

Family and domain databases

Gene3Dⁱ	1.20.120.550, 1 hit
InterProⁱ	View protein in InterPro IPR023352 MAPEG-like_dom_sf IPR001129 Membr-assoc_MAPEG
Pfamⁱ	View protein in Pfam PF01124 MAPEG, 1 hit
SUPFAMⁱ	SSF161084 SSF161084, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PTGES_HUMAN
Accessionⁱ	O14684Primary (citable) accession number: O14684 Secondary accession number(s): O14900, Q5SZC0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
	Last sequence update:	May 30, 2000
	Last modified:	November 7, 2018
	This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM

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UniProtKB - O14684 (PTGES_HUMAN)

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Prostaglandin E synthase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Endoplasmic reticulum

Mitochondrion

Nucleus

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ