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Protein

Prostaglandin E synthase

Gene

PTGES

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2).1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

glutathione1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei117Glutathione1
Binding sitei126Glutathione1
Binding sitei130Glutathione1
Binding sitei134Glutathione1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • glutathione binding Source: UniProtKB
  • glutathione transferase activity Source: GO_Central
  • prostaglandin-E synthase activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIsomerase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Prostaglandin biosynthesis, Prostaglandin metabolism

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS07518-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
5.3.99.3 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
O14684

SIGNOR Signaling Network Open Resource

More...
SIGNORi
O14684

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000001631

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Prostaglandin E synthase (EC:5.3.99.3)
Alternative name(s):
Microsomal glutathione S-transferase 1-like 1
Short name:
MGST1-L1
Microsomal prostaglandin E synthase 1
Short name:
MPGES-1
p53-induced gene 12 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PTGES
Synonyms:MGST1L1, MPGES1, PGES, PIG12
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000148344.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9599 PTGES

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605172 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O14684

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 12LumenalAdd BLAST12
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei13 – 41HelicalAdd BLAST29
Topological domaini42 – 60CytoplasmicAdd BLAST19
Transmembranei61 – 90HelicalAdd BLAST30
Topological domaini91 – 95Lumenal5
Transmembranei96 – 119HelicalAdd BLAST24
Topological domaini120 – 123Cytoplasmic4
Transmembranei124 – 152HelicalAdd BLAST29

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi66E → A: Reduces enzyme activity by 50%. 1 Publication1
Mutagenesisi67R → A: Loss of enzyme activity. 1 Publication1
Mutagenesisi70R → A: Slightly reduced enzyme activity. 1 Publication1
Mutagenesisi72H → A: Reduces enzyme activity by 70%. 1 Publication1
Mutagenesisi110R → A or S: Loss of enzyme activity. 1 Publication1
Mutagenesisi117Y → A: Loss of enzyme activity. 1 Publication1
Mutagenesisi117Y → F: No effect on enzyme activity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
9536

Open Targets

More...
OpenTargetsi
ENSG00000148344

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33948

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5658

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
1377

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PTGES

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002177451 – 152Prostaglandin E synthaseAdd BLAST152

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O14684

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O14684

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O14684

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O14684

PeptideAtlas

More...
PeptideAtlasi
O14684

PRoteomics IDEntifications database

More...
PRIDEi
O14684

ProteomicsDB human proteome resource

More...
ProteomicsDBi
48167

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
O14684

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O14684

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
O14684

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By p53/TP53.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000148344 Expressed in 182 organ(s), highest expression level in palpebral conjunctiva

CleanEx database of gene expression profiles

More...
CleanExi
HS_PTGES

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O14684 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA045064

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotrimer.1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114912, 3 interactors

Protein interaction database and analysis system

More...
IntActi
O14684, 10 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000342385

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
O14684

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1152
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3DWWelectron microscopy3.50A/B/C1-152[»]
4AL0X-ray1.16A1-152[»]
4AL1X-ray1.95A1-152[»]
4BPMX-ray2.08A10-152[»]
4WABX-ray2.70A10-151[»]
4YK5X-ray1.42A2-152[»]
4YL0X-ray1.52A5-152[»]
4YL1X-ray1.41A5-152[»]
4YL3X-ray1.41A5-152[»]
5BQGX-ray1.44A2-152[»]
5BQHX-ray1.60A2-152[»]
5BQIX-ray1.88A2-152[»]
5K0IX-ray1.30A2-152[»]
5T36X-ray1.40A2-152[»]
5T37X-ray1.76A2-152[»]
5TL9X-ray1.20A2-152[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O14684

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O14684

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
O14684

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni28 – 38Glutathione bindingAdd BLAST11
Regioni70 – 77Glutathione binding8
Regioni110 – 113Glutathione binding4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MAPEG family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IY81 Eukaryota
ENOG4111VJG LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000011980

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231759

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG052470

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O14684

KEGG Orthology (KO)

More...
KOi
K15729

Identification of Orthologs from Complete Genome Data

More...
OMAi
CFSMALQ

Database of Orthologous Groups

More...
OrthoDBi
1591261at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O14684

TreeFam database of animal gene trees

More...
TreeFami
TF105327

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.120.550, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR023352 MAPEG-like_dom_sf
IPR001129 Membr-assoc_MAPEG
IPR040162 MGST1-like

The PANTHER Classification System

More...
PANTHERi
PTHR10689 PTHR10689, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01124 MAPEG, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF161084 SSF161084, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O14684-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPAHSLVMSS PALPAFLLCS TLLVIKMYVV AIITGQVRLR KKAFANPEDA
60 70 80 90 100
LRHGGPQYCR SDPDVERCLR AHRNDMETIY PFLFLGFVYS FLGPNPFVAW
110 120 130 140 150
MHFLVFLVGR VAHTVAYLGK LRAPIRSVTY TLAQLPCASM ALQILWEAAR

HL
Length:152
Mass (Da):17,102
Last modified:May 30, 2000 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBF9B9ED81CA67A3D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti55G → GG in AAC39534 (PubMed:9305847).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF010316 mRNA Translation: AAC39534.1
AF027740 mRNA Translation: AAB82299.1
AJ271802, AJ271803, AJ271804 Genomic DNA Translation: CAB72099.1
AK311947 mRNA Translation: BAG34888.1
EF543149 Genomic DNA Translation: ABQ01233.1
AL590369 Genomic DNA No translation available.
AL592219 Genomic DNA No translation available.
BC008280 mRNA Translation: AAH08280.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6927.1

NCBI Reference Sequences

More...
RefSeqi
NP_004869.1, NM_004878.4

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.146688

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000340607; ENSP00000342385; ENSG00000148344

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9536

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9536

UCSC genome browser

More...
UCSCi
uc004byi.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF010316 mRNA Translation: AAC39534.1
AF027740 mRNA Translation: AAB82299.1
AJ271802, AJ271803, AJ271804 Genomic DNA Translation: CAB72099.1
AK311947 mRNA Translation: BAG34888.1
EF543149 Genomic DNA Translation: ABQ01233.1
AL590369 Genomic DNA No translation available.
AL592219 Genomic DNA No translation available.
BC008280 mRNA Translation: AAH08280.1
CCDSiCCDS6927.1
RefSeqiNP_004869.1, NM_004878.4
UniGeneiHs.146688

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3DWWelectron microscopy3.50A/B/C1-152[»]
4AL0X-ray1.16A1-152[»]
4AL1X-ray1.95A1-152[»]
4BPMX-ray2.08A10-152[»]
4WABX-ray2.70A10-151[»]
4YK5X-ray1.42A2-152[»]
4YL0X-ray1.52A5-152[»]
4YL1X-ray1.41A5-152[»]
4YL3X-ray1.41A5-152[»]
5BQGX-ray1.44A2-152[»]
5BQHX-ray1.60A2-152[»]
5BQIX-ray1.88A2-152[»]
5K0IX-ray1.30A2-152[»]
5T36X-ray1.40A2-152[»]
5T37X-ray1.76A2-152[»]
5TL9X-ray1.20A2-152[»]
ProteinModelPortaliO14684
SMRiO14684
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114912, 3 interactors
IntActiO14684, 10 interactors
STRINGi9606.ENSP00000342385

Chemistry databases

BindingDBiO14684
ChEMBLiCHEMBL5658
GuidetoPHARMACOLOGYi1377
SwissLipidsiSLP:000001631

PTM databases

PhosphoSitePlusiO14684
SwissPalmiO14684

Polymorphism and mutation databases

BioMutaiPTGES

Proteomic databases

EPDiO14684
jPOSTiO14684
MaxQBiO14684
PaxDbiO14684
PeptideAtlasiO14684
PRIDEiO14684
ProteomicsDBi48167
TopDownProteomicsiO14684

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340607; ENSP00000342385; ENSG00000148344
GeneIDi9536
KEGGihsa:9536
UCSCiuc004byi.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9536
DisGeNETi9536
EuPathDBiHostDB:ENSG00000148344.10

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PTGES
HGNCiHGNC:9599 PTGES
HPAiHPA045064
MIMi605172 gene
neXtProtiNX_O14684
OpenTargetsiENSG00000148344
PharmGKBiPA33948

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IY81 Eukaryota
ENOG4111VJG LUCA
GeneTreeiENSGT00390000011980
HOGENOMiHOG000231759
HOVERGENiHBG052470
InParanoidiO14684
KOiK15729
OMAiCFSMALQ
OrthoDBi1591261at2759
PhylomeDBiO14684
TreeFamiTF105327

Enzyme and pathway databases

BioCyciMetaCyc:HS07518-MONOMER
BRENDAi5.3.99.3 2681
ReactomeiR-HSA-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
SABIO-RKiO14684
SIGNORiO14684

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PTGES human
EvolutionaryTraceiO14684

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PTGES

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9536

Protein Ontology

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PROi
PR:O14684

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000148344 Expressed in 182 organ(s), highest expression level in palpebral conjunctiva
CleanExiHS_PTGES
GenevisibleiO14684 HS

Family and domain databases

Gene3Di1.20.120.550, 1 hit
InterProiView protein in InterPro
IPR023352 MAPEG-like_dom_sf
IPR001129 Membr-assoc_MAPEG
IPR040162 MGST1-like
PANTHERiPTHR10689 PTHR10689, 1 hit
PfamiView protein in Pfam
PF01124 MAPEG, 1 hit
SUPFAMiSSF161084 SSF161084, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPTGES_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O14684
Secondary accession number(s): O14900, Q5SZC0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: January 16, 2019
This is version 150 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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