Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tumor protein p53-inducible protein 11

Gene

TP53I11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • negative regulation of cell proliferation Source: ProtInc

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor protein p53-inducible protein 11
Alternative name(s):
p53-induced gene 11 protein
Gene namesi
Name:TP53I11
Synonyms:PIG11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000175274.18
HGNCiHGNC:16842 TP53I11
MIMi617867 gene
neXtProtiNX_O14683

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 63CytoplasmicSequence analysisAdd BLAST63
Transmembranei64 – 84HelicalSequence analysisAdd BLAST21
Topological domaini85 – 108ExtracellularSequence analysisAdd BLAST24
Transmembranei109 – 129HelicalSequence analysisAdd BLAST21
Topological domaini130CytoplasmicSequence analysis1
Transmembranei131 – 151HelicalSequence analysisAdd BLAST21
Topological domaini152 – 155ExtracellularSequence analysis4
Transmembranei156 – 176HelicalSequence analysisAdd BLAST21
Topological domaini177 – 189CytoplasmicSequence analysisAdd BLAST13

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9537
OpenTargetsiENSG00000175274
PharmGKBiPA134967898

Polymorphism and mutation databases

BioMutaiTP53I11

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000581421 – 189Tumor protein p53-inducible protein 11Add BLAST189

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO14683
MaxQBiO14683
PaxDbiO14683
PeptideAtlasiO14683
PRIDEiO14683
ProteomicsDBi48166

PTM databases

iPTMnetiO14683
PhosphoSitePlusiO14683

Expressioni

Inductioni

By p53/TP53.1 Publication

Gene expression databases

BgeeiENSG00000175274 Expressed in 184 organ(s), highest expression level in blood
CleanExiHS_TP53I11
ExpressionAtlasiO14683 baseline and differential
GenevisibleiO14683 HS

Organism-specific databases

HPAiHPA059727
HPA061276

Interactioni

Protein-protein interaction databases

BioGridi114913, 7 interactors
IntActiO14683, 4 interactors
MINTiO14683

Structurei

3D structure databases

ProteinModelPortaliO14683
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi162 – 165Poly-Leu4
Compositional biasi177 – 180Poly-Tyr4

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IV8J Eukaryota
ENOG4111H6J LUCA
GeneTreeiENSGT00390000017249
HOGENOMiHOG000063728
HOVERGENiHBG054028
InParanoidiO14683
OMAiYYQVGRK
OrthoDBiEOG091G10KG
PhylomeDBiO14683
TreeFamiTF321310

Family and domain databases

InterProiView protein in InterPro
IPR028266 TP53I11
PANTHERiPTHR31584 PTHR31584, 1 hit
PfamiView protein in Pfam
PF14936 p53-inducible11, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 12 potential isoforms that are computationally mapped.Show allAlign All

O14683-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAKQPPPLM KKHSQTDLVS RLKTRKILGV GGEDDDGEVH RSKISQVLGN
60 70 80 90 100
EIKFTIREPL GLRVWQFVSA VLFSGIAIMA LAFPDQLYDA VFDGAQVTSK
110 120 130 140 150
TPIRLYGGAL LSISLIMWNA LYTAEKVIIR WTLLTEACYF GVQFLVVTAT
160 170 180
LAETGLMSLG ILLLLVSRLL FVVISIYYYY QVGRRPKKA
Length:189
Mass (Da):21,054
Last modified:June 15, 2010 - v2
Checksum:i5E858F5872FE3171
GO

Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
U3KQ32U3KQ32_HUMAN
Tumor protein p53-inducible protein...
TP53I11
154Annotation score:
E9PIN5E9PIN5_HUMAN
Tumor protein p53-inducible protein...
TP53I11
123Annotation score:
E9PKZ4E9PKZ4_HUMAN
Tumor protein p53-inducible protein...
TP53I11
158Annotation score:
E9PMW4E9PMW4_HUMAN
Tumor protein p53-inducible protein...
TP53I11
93Annotation score:
E9PQ46E9PQ46_HUMAN
Tumor protein p53-inducible protein...
TP53I11
98Annotation score:
E9PPM1E9PPM1_HUMAN
Tumor protein p53-inducible protein...
TP53I11
236Annotation score:
E9PN66E9PN66_HUMAN
Tumor protein p53-inducible protein...
TP53I11
62Annotation score:
E9PKN9E9PKN9_HUMAN
Tumor protein p53-inducible protein...
TP53I11
73Annotation score:
E9PMY0E9PMY0_HUMAN
Tumor protein p53-inducible protein...
TP53I11
91Annotation score:
E9PNB3E9PNB3_HUMAN
Tumor protein p53-inducible protein...
TP53I11
64Annotation score:
There are more potential isoformsShow all

Sequence cautioni

The sequence AAC39533 differs from that shown. Localized in an untranslated region: wrong choice of CDS.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF010315 mRNA Translation: AAC39533.1 Sequence problems.
AK292837 mRNA Translation: BAF85526.1
AC068858 Genomic DNA No translation available.
AC092733 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68052.1
CH471064 Genomic DNA Translation: EAW68053.1
CH471064 Genomic DNA Translation: EAW68055.1
CH471064 Genomic DNA Translation: EAW68057.1
BC045666 mRNA Translation: AAH45666.1
CCDSiCCDS7911.1
RefSeqiNP_001245249.1, NM_001258320.1
NP_001245250.1, NM_001258321.1
NP_001245251.1, NM_001258322.1
NP_001245252.1, NM_001258323.2
NP_001245253.1, NM_001258324.1
NP_001305313.1, NM_001318384.1
NP_001305314.1, NM_001318385.1
NP_001305315.1, NM_001318386.1
NP_006025.2, NM_006034.4
XP_005253284.1, XM_005253227.4
XP_011518777.1, XM_011520475.2
XP_011518778.1, XM_011520476.2
XP_011518779.1, XM_011520477.2
XP_011518780.1, XM_011520478.2
XP_016874069.1, XM_017018580.1
XP_016874070.1, XM_017018581.1
UniGeneiHs.554791

Genome annotation databases

EnsembliENST00000308212; ENSP00000309532; ENSG00000175274
ENST00000395648; ENSP00000379009; ENSG00000175274
ENST00000525680; ENSP00000433474; ENSG00000175274
ENST00000533940; ENSP00000436152; ENSG00000175274
ENST00000616990; ENSP00000481456; ENSG00000175274
GeneIDi9537
KEGGihsa:9537
UCSCiuc001myi.5 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF010315 mRNA Translation: AAC39533.1 Sequence problems.
AK292837 mRNA Translation: BAF85526.1
AC068858 Genomic DNA No translation available.
AC092733 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68052.1
CH471064 Genomic DNA Translation: EAW68053.1
CH471064 Genomic DNA Translation: EAW68055.1
CH471064 Genomic DNA Translation: EAW68057.1
BC045666 mRNA Translation: AAH45666.1
CCDSiCCDS7911.1
RefSeqiNP_001245249.1, NM_001258320.1
NP_001245250.1, NM_001258321.1
NP_001245251.1, NM_001258322.1
NP_001245252.1, NM_001258323.2
NP_001245253.1, NM_001258324.1
NP_001305313.1, NM_001318384.1
NP_001305314.1, NM_001318385.1
NP_001305315.1, NM_001318386.1
NP_006025.2, NM_006034.4
XP_005253284.1, XM_005253227.4
XP_011518777.1, XM_011520475.2
XP_011518778.1, XM_011520476.2
XP_011518779.1, XM_011520477.2
XP_011518780.1, XM_011520478.2
XP_016874069.1, XM_017018580.1
XP_016874070.1, XM_017018581.1
UniGeneiHs.554791

3D structure databases

ProteinModelPortaliO14683
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114913, 7 interactors
IntActiO14683, 4 interactors
MINTiO14683

PTM databases

iPTMnetiO14683
PhosphoSitePlusiO14683

Polymorphism and mutation databases

BioMutaiTP53I11

Proteomic databases

EPDiO14683
MaxQBiO14683
PaxDbiO14683
PeptideAtlasiO14683
PRIDEiO14683
ProteomicsDBi48166

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308212; ENSP00000309532; ENSG00000175274
ENST00000395648; ENSP00000379009; ENSG00000175274
ENST00000525680; ENSP00000433474; ENSG00000175274
ENST00000533940; ENSP00000436152; ENSG00000175274
ENST00000616990; ENSP00000481456; ENSG00000175274
GeneIDi9537
KEGGihsa:9537
UCSCiuc001myi.5 human

Organism-specific databases

CTDi9537
DisGeNETi9537
EuPathDBiHostDB:ENSG00000175274.18
GeneCardsiTP53I11
HGNCiHGNC:16842 TP53I11
HPAiHPA059727
HPA061276
MIMi617867 gene
neXtProtiNX_O14683
OpenTargetsiENSG00000175274
PharmGKBiPA134967898
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IV8J Eukaryota
ENOG4111H6J LUCA
GeneTreeiENSGT00390000017249
HOGENOMiHOG000063728
HOVERGENiHBG054028
InParanoidiO14683
OMAiYYQVGRK
OrthoDBiEOG091G10KG
PhylomeDBiO14683
TreeFamiTF321310

Miscellaneous databases

ChiTaRSiTP53I11 human
GeneWikiiTP53I11
GenomeRNAii9537
PROiPR:O14683
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000175274 Expressed in 184 organ(s), highest expression level in blood
CleanExiHS_TP53I11
ExpressionAtlasiO14683 baseline and differential
GenevisibleiO14683 HS

Family and domain databases

InterProiView protein in InterPro
IPR028266 TP53I11
PANTHERiPTHR31584 PTHR31584, 1 hit
PfamiView protein in Pfam
PF14936 p53-inducible11, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiP5I11_HUMAN
AccessioniPrimary (citable) accession number: O14683
Secondary accession number(s): Q3ZCS0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 15, 2010
Last modified: September 12, 2018
This is version 106 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again