The new UniProt website is here!
Take me to UniProt BETA
UniProtKB - O14683 (P5I11_HUMAN)
Protein
Tumor protein p53-inducible protein 11
Gene
TP53I11
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- negative regulation of cell population proliferation Source: ProtInc
Enzyme and pathway databases
PathwayCommonsi | O14683 |
SignaLinki | O14683 |
Names & Taxonomyi
Protein namesi | Recommended name: Tumor protein p53-inducible protein 11Alternative name(s): p53-induced gene 11 protein |
Gene namesi | Name:TP53I11 Synonyms:PIG11 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16842, TP53I11 |
MIMi | 617867, gene |
neXtProti | NX_O14683 |
VEuPathDBi | HostDB:ENSG00000175274 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 63 | CytoplasmicSequence analysisAdd BLAST | 63 | |
Transmembranei | 64 – 84 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 85 – 108 | ExtracellularSequence analysisAdd BLAST | 24 | |
Transmembranei | 109 – 129 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 130 | CytoplasmicSequence analysis | 1 | |
Transmembranei | 131 – 151 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 152 – 155 | ExtracellularSequence analysis | 4 | |
Transmembranei | 156 – 176 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 177 – 189 | CytoplasmicSequence analysisAdd BLAST | 13 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 9537 |
OpenTargetsi | ENSG00000175274 |
PharmGKBi | PA134967898 |
Miscellaneous databases
Pharosi | O14683, Tbio |
Genetic variation databases
BioMutai | TP53I11 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000058142 | 1 – 189 | Tumor protein p53-inducible protein 11Add BLAST | 189 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 14 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | O14683 |
jPOSTi | O14683 |
MassIVEi | O14683 |
MaxQBi | O14683 |
PaxDbi | O14683 |
PeptideAtlasi | O14683 |
PRIDEi | O14683 |
ProteomicsDBi | 48166 |
PTM databases
iPTMneti | O14683 |
PhosphoSitePlusi | O14683 |
Expressioni
Inductioni
By p53/TP53.1 Publication
Gene expression databases
Bgeei | ENSG00000175274, Expressed in cortical plate and 197 other tissues |
ExpressionAtlasi | O14683, baseline and differential |
Genevisiblei | O14683, HS |
Organism-specific databases
HPAi | ENSG00000175274, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 114913, 36 interactors |
IntActi | O14683, 10 interactors |
MINTi | O14683 |
STRINGi | 9606.ENSP00000436152 |
Miscellaneous databases
RNActi | O14683, protein |
Structurei
3D structure databases
AlphaFoldDBi | O14683 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QQ2K, Eukaryota |
GeneTreei | ENSGT00390000017249 |
InParanoidi | O14683 |
OMAi | VQFVVVT |
OrthoDBi | 1573043at2759 |
PhylomeDBi | O14683 |
TreeFami | TF321310 |
Family and domain databases
InterProi | View protein in InterPro IPR028266, TP53I11 |
PANTHERi | PTHR31584, PTHR31584, 1 hit |
Pfami | View protein in Pfam PF14936, p53-inducible11, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 12 potential isoforms that are computationally mapped.Show allAlign All
O14683-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAKQPPPLM KKHSQTDLVS RLKTRKILGV GGEDDDGEVH RSKISQVLGN
60 70 80 90 100
EIKFTIREPL GLRVWQFVSA VLFSGIAIMA LAFPDQLYDA VFDGAQVTSK
110 120 130 140 150
TPIRLYGGAL LSISLIMWNA LYTAEKVIIR WTLLTEACYF GVQFLVVTAT
160 170 180
LAETGLMSLG ILLLLVSRLL FVVISIYYYY QVGRRPKKA
Computationally mapped potential isoform sequencesi
There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PPM1 | E9PPM1_HUMAN | Tumor protein p53-inducible protein... | TP53I11 | 236 | Annotation score: | ||
E9PIN5 | E9PIN5_HUMAN | Tumor protein p53-inducible protein... | TP53I11 | 123 | Annotation score: | ||
U3KQ32 | U3KQ32_HUMAN | Tumor protein p53-inducible protein... | TP53I11 | 154 | Annotation score: | ||
E9PKZ4 | E9PKZ4_HUMAN | Tumor protein p53-inducible protein... | TP53I11 | 158 | Annotation score: | ||
E9PQ46 | E9PQ46_HUMAN | Tumor protein p53-inducible protein... | TP53I11 | 98 | Annotation score: | ||
E9PMW4 | E9PMW4_HUMAN | Tumor protein p53-inducible protein... | TP53I11 | 93 | Annotation score: | ||
E9PMY0 | E9PMY0_HUMAN | Tumor protein p53-inducible protein... | TP53I11 | 91 | Annotation score: | ||
E9PN66 | E9PN66_HUMAN | Tumor protein p53-inducible protein... | TP53I11 | 62 | Annotation score: | ||
E9PKN9 | E9PKN9_HUMAN | Tumor protein p53-inducible protein... | TP53I11 | 73 | Annotation score: | ||
E9PS55 | E9PS55_HUMAN | Tumor protein p53-inducible protein... | TP53I11 | 79 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence cautioni
The sequence AAC39533 differs from that shown. Localized in an untranslated region: wrong choice of CDS.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF010315 mRNA Translation: AAC39533.1 Sequence problems. AK292837 mRNA Translation: BAF85526.1 AC068858 Genomic DNA No translation available. AC092733 Genomic DNA No translation available. CH471064 Genomic DNA Translation: EAW68052.1 CH471064 Genomic DNA Translation: EAW68053.1 CH471064 Genomic DNA Translation: EAW68055.1 CH471064 Genomic DNA Translation: EAW68057.1 BC045666 mRNA Translation: AAH45666.1 |
CCDSi | CCDS7911.1 |
RefSeqi | NP_001245249.1, NM_001258320.1 NP_001245250.1, NM_001258321.1 NP_001245251.1, NM_001258322.1 NP_001245252.1, NM_001258323.2 NP_001245253.1, NM_001258324.1 NP_001305313.1, NM_001318384.1 NP_001305314.1, NM_001318385.1 NP_001305315.1, NM_001318386.1 NP_006025.2, NM_006034.4 XP_005253284.1, XM_005253227.4 XP_011518777.1, XM_011520475.2 XP_011518778.1, XM_011520476.2 XP_011518779.1, XM_011520477.2 XP_011518780.1, XM_011520478.2 XP_016874069.1, XM_017018580.1 XP_016874070.1, XM_017018581.1 |
Genome annotation databases
Ensembli | ENST00000308212.9; ENSP00000309532.5; ENSG00000175274.19 ENST00000395648.7; ENSP00000379009.3; ENSG00000175274.19 ENST00000525680.6; ENSP00000433474.1; ENSG00000175274.19 ENST00000533940.5; ENSP00000436152.1; ENSG00000175274.19 ENST00000616990.4; ENSP00000481456.1; ENSG00000175274.19 |
GeneIDi | 9537 |
KEGGi | hsa:9537 |
MANE-Selecti | ENST00000525680.6; ENSP00000433474.1; NM_006034.5; NP_006025.2 |
UCSCi | uc001myi.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF010315 mRNA Translation: AAC39533.1 Sequence problems. AK292837 mRNA Translation: BAF85526.1 AC068858 Genomic DNA No translation available. AC092733 Genomic DNA No translation available. CH471064 Genomic DNA Translation: EAW68052.1 CH471064 Genomic DNA Translation: EAW68053.1 CH471064 Genomic DNA Translation: EAW68055.1 CH471064 Genomic DNA Translation: EAW68057.1 BC045666 mRNA Translation: AAH45666.1 |
CCDSi | CCDS7911.1 |
RefSeqi | NP_001245249.1, NM_001258320.1 NP_001245250.1, NM_001258321.1 NP_001245251.1, NM_001258322.1 NP_001245252.1, NM_001258323.2 NP_001245253.1, NM_001258324.1 NP_001305313.1, NM_001318384.1 NP_001305314.1, NM_001318385.1 NP_001305315.1, NM_001318386.1 NP_006025.2, NM_006034.4 XP_005253284.1, XM_005253227.4 XP_011518777.1, XM_011520475.2 XP_011518778.1, XM_011520476.2 XP_011518779.1, XM_011520477.2 XP_011518780.1, XM_011520478.2 XP_016874069.1, XM_017018580.1 XP_016874070.1, XM_017018581.1 |
3D structure databases
AlphaFoldDBi | O14683 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 114913, 36 interactors |
IntActi | O14683, 10 interactors |
MINTi | O14683 |
STRINGi | 9606.ENSP00000436152 |
PTM databases
iPTMneti | O14683 |
PhosphoSitePlusi | O14683 |
Genetic variation databases
BioMutai | TP53I11 |
Proteomic databases
EPDi | O14683 |
jPOSTi | O14683 |
MassIVEi | O14683 |
MaxQBi | O14683 |
PaxDbi | O14683 |
PeptideAtlasi | O14683 |
PRIDEi | O14683 |
ProteomicsDBi | 48166 |
Protocols and materials databases
Antibodypediai | 26149, 185 antibodies from 27 providers |
DNASUi | 9537 |
Genome annotation databases
Organism-specific databases
CTDi | 9537 |
DisGeNETi | 9537 |
GeneCardsi | TP53I11 |
HGNCi | HGNC:16842, TP53I11 |
HPAi | ENSG00000175274, Low tissue specificity |
MIMi | 617867, gene |
neXtProti | NX_O14683 |
OpenTargetsi | ENSG00000175274 |
PharmGKBi | PA134967898 |
VEuPathDBi | HostDB:ENSG00000175274 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QQ2K, Eukaryota |
GeneTreei | ENSGT00390000017249 |
InParanoidi | O14683 |
OMAi | VQFVVVT |
OrthoDBi | 1573043at2759 |
PhylomeDBi | O14683 |
TreeFami | TF321310 |
Enzyme and pathway databases
PathwayCommonsi | O14683 |
SignaLinki | O14683 |
Miscellaneous databases
BioGRID-ORCSi | 9537, 16 hits in 1075 CRISPR screens |
ChiTaRSi | TP53I11, human |
GeneWikii | TP53I11 |
GenomeRNAii | 9537 |
Pharosi | O14683, Tbio |
PROi | PR:O14683 |
RNActi | O14683, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000175274, Expressed in cortical plate and 197 other tissues |
ExpressionAtlasi | O14683, baseline and differential |
Genevisiblei | O14683, HS |
Family and domain databases
InterProi | View protein in InterPro IPR028266, TP53I11 |
PANTHERi | PTHR31584, PTHR31584, 1 hit |
Pfami | View protein in Pfam PF14936, p53-inducible11, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | P5I11_HUMAN | |
Accessioni | O14683Primary (citable) accession number: O14683 Secondary accession number(s): Q3ZCS0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | June 15, 2010 | |
Last modified: | May 25, 2022 | |
This is version 125 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot