TP53I11

Functionⁱ

GO - Biological processⁱ

negative regulation of cell proliferation
Source: ProtInc
Traceable author statementⁱ
- 9305847

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Tumor protein p53-inducible protein 11 Alternative name(s): p53-induced gene 11 protein
Gene namesⁱ	Name:TP53I11 Synonyms:PIG11
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000175274.18
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:16842 TP53I11
MIMⁱ	617867 gene
neXtProtⁱ	NX_O14683

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 63	CytoplasmicSequence analysisAdd BLAST	63
Transmembraneⁱ	64 – 84	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	85 – 108	ExtracellularSequence analysisAdd BLAST	24
Transmembraneⁱ	109 – 129	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	130	CytoplasmicSequence analysis	1
Transmembraneⁱ	131 – 151	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	152 – 155	ExtracellularSequence analysis	4
Transmembraneⁱ	156 – 176	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	177 – 189	CytoplasmicSequence analysisAdd BLAST	13

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	9537
Open Targets More...OpenTargetsⁱ	ENSG00000175274
PharmGKBⁱ	PA134967898

Polymorphism and mutation databases

BioMutaⁱ	TP53I11

BioMutaⁱ

TP53I11

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000058142	1 – 189	Tumor protein p53-inducible protein 11Add BLAST		189

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	14	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	O14683
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O14683
PaxDbⁱ	O14683
PeptideAtlas More...PeptideAtlasⁱ	O14683
PRIDEⁱ	O14683
ProteomicsDBⁱ	48166

PTM databases

iPTMnetⁱ	O14683
PhosphoSitePlusⁱ	O14683

Expressionⁱ

Inductionⁱ

By p53/TP53.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000175274 Expressed in 184 organ(s), highest expression level in blood
CleanExⁱ	HS_TP53I11
ExpressionAtlasⁱ	O14683 baseline and differential
Genevisibleⁱ	O14683 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA059727 HPA061276

HPAⁱ

HPA059727
HPA061276

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	114913, 7 interactors
IntActⁱ	O14683, 4 interactors
Molecular INTeraction database More...MINTⁱ	O14683

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O14683
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	162 – 165	Poly-Leu		4
Compositional biasⁱ	177 – 180	Poly-Tyr		4

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IV8J Eukaryota ENOG4111H6J LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000017249
HOGENOMⁱ	HOG000063728
HOVERGENⁱ	HBG054028
InParanoidⁱ	O14683
OMAⁱ	YYQVGRK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G10KG
PhylomeDBⁱ	O14683
TreeFamⁱ	TF321310

Family and domain databases

InterProⁱ	View protein in InterPro IPR028266 TP53I11
PANTHERⁱ	PTHR31584 PTHR31584, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF14936 p53-inducible11, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 12 potential isoforms that are computationally mapped.Show all Align All

O14683-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAAKQPPPLM KKHSQTDLVS RLKTRKILGV GGEDDDGEVH RSKISQVLGN 
        60         70         80         90        100
EIKFTIREPL GLRVWQFVSA VLFSGIAIMA LAFPDQLYDA VFDGAQVTSK 
       110        120        130        140        150
TPIRLYGGAL LSISLIMWNA LYTAEKVIIR WTLLTEACYF GVQFLVVTAT 
       160        170        180 
LAETGLMSLG ILLLLVSRLL FVVISIYYYY QVGRRPKKA

Length:189

Mass (Da):21,054

Last modified:June 15, 2010 - v2

Checksum:ⁱ5E858F5872FE3171

GO

Computationally mapped potential isoform sequencesⁱ

There are 12 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name	Protein names	Gene names	Length	Annotation

	U3KQ32	U3KQ32_HUMAN	Tumor protein p53-inducible protein... Tumor protein p53-inducible protein 11	TP53I11	154	Annotation score:
	E9PIN5	E9PIN5_HUMAN	Tumor protein p53-inducible protein... Tumor protein p53-inducible protein 11	TP53I11	123	Annotation score:
	E9PKZ4	E9PKZ4_HUMAN	Tumor protein p53-inducible protein... Tumor protein p53-inducible protein 11	TP53I11	158	Annotation score:
	E9PMW4	E9PMW4_HUMAN	Tumor protein p53-inducible protein... Tumor protein p53-inducible protein 11	TP53I11	93	Annotation score:
	E9PQ46	E9PQ46_HUMAN	Tumor protein p53-inducible protein... Tumor protein p53-inducible protein 11	TP53I11	98	Annotation score:
	E9PPM1	E9PPM1_HUMAN	Tumor protein p53-inducible protein... Tumor protein p53-inducible protein 11	TP53I11	236	Annotation score:
	E9PN66	E9PN66_HUMAN	Tumor protein p53-inducible protein... Tumor protein p53-inducible protein 11	TP53I11	62	Annotation score:
	E9PKN9	E9PKN9_HUMAN	Tumor protein p53-inducible protein... Tumor protein p53-inducible protein 11	TP53I11	73	Annotation score:
	E9PMY0	E9PMY0_HUMAN	Tumor protein p53-inducible protein... Tumor protein p53-inducible protein 11	TP53I11	91	Annotation score:
	E9PNB3	E9PNB3_HUMAN	Tumor protein p53-inducible protein... Tumor protein p53-inducible protein 11	TP53I11	64	Annotation score:
There are more potential isoformsShow all

Sequence cautionⁱ

The sequence AAC39533 differs from that shown. Localized in an untranslated region: wrong choice of CDS.Curated

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF010315 mRNA Translation: AAC39533.1 Sequence problems. AK292837 mRNA Translation: BAF85526.1 AC068858 Genomic DNA No translation available. AC092733 Genomic DNA No translation available. CH471064 Genomic DNA Translation: EAW68052.1 CH471064 Genomic DNA Translation: EAW68053.1 CH471064 Genomic DNA Translation: EAW68055.1 CH471064 Genomic DNA Translation: EAW68057.1 BC045666 mRNA Translation: AAH45666.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS7911.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001245249.1, NM_001258320.1 NP_001245250.1, NM_001258321.1 NP_001245251.1, NM_001258322.1 NP_001245252.1, NM_001258323.2 NP_001245253.1, NM_001258324.1 NP_001305313.1, NM_001318384.1 NP_001305314.1, NM_001318385.1 NP_001305315.1, NM_001318386.1 NP_006025.2, NM_006034.4 XP_005253284.1, XM_005253227.4 XP_011518777.1, XM_011520475.2 XP_011518778.1, XM_011520476.2 XP_011518779.1, XM_011520477.2 XP_011518780.1, XM_011520478.2 XP_016874069.1, XM_017018580.1 XP_016874070.1, XM_017018581.1
UniGeneⁱ	Hs.554791

Genome annotation databases

Ensemblⁱ	ENST00000308212; ENSP00000309532; ENSG00000175274 ENST00000395648; ENSP00000379009; ENSG00000175274 ENST00000525680; ENSP00000433474; ENSG00000175274 ENST00000533940; ENSP00000436152; ENSG00000175274 ENST00000616990; ENSP00000481456; ENSG00000175274
GeneIDⁱ	9537
KEGGⁱ	hsa:9537
UCSC genome browser More...UCSCⁱ	uc001myi.5 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O14683	TP53I11 isoform 17		PANTR		189	UniRef100_O14683
Uncharacterized protein		PANPA		189
Tumor protein p53-inducible protein 11 (Fragment)		HUMAN		158
TP53I11 isoform 15 (Fragment)		PANTR		158

Protein	Similar proteins		Species	Score	Length	Source
O14683	Tumor protein p53-inducible protein 11		BOVIN		189	UniRef90_O14683
Tumor protein p53-inducible protein 11		PONAB		189
TP53I11 isoform 17		PANTR		189
Uncharacterized protein		PANPA		189
Tumor protein p53-inducible protein 11 (Fragment)		HUMAN		158
+62

Protein	Similar proteins		Species	Score	Length	Source
O14683	Tumor protein p53-inducible protein 11		PONAB		189	UniRef50_O14683
Tumor protein p53-inducible protein 11		BOVIN		189
TP53I11 isoform 17		PANTR		189
Uncharacterized protein		PANPA		189
Tumor protein p53-inducible protein 11 (Fragment)		HUMAN		158
+90

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF010315 mRNA Translation: AAC39533.1 Sequence problems. AK292837 mRNA Translation: BAF85526.1 AC068858 Genomic DNA No translation available. AC092733 Genomic DNA No translation available. CH471064 Genomic DNA Translation: EAW68052.1 CH471064 Genomic DNA Translation: EAW68053.1 CH471064 Genomic DNA Translation: EAW68055.1 CH471064 Genomic DNA Translation: EAW68057.1 BC045666 mRNA Translation: AAH45666.1
CCDSⁱ	CCDS7911.1
RefSeqⁱ	NP_001245249.1, NM_001258320.1 NP_001245250.1, NM_001258321.1 NP_001245251.1, NM_001258322.1 NP_001245252.1, NM_001258323.2 NP_001245253.1, NM_001258324.1 NP_001305313.1, NM_001318384.1 NP_001305314.1, NM_001318385.1 NP_001305315.1, NM_001318386.1 NP_006025.2, NM_006034.4 XP_005253284.1, XM_005253227.4 XP_011518777.1, XM_011520475.2 XP_011518778.1, XM_011520476.2 XP_011518779.1, XM_011520477.2 XP_011518780.1, XM_011520478.2 XP_016874069.1, XM_017018580.1 XP_016874070.1, XM_017018581.1
UniGeneⁱ	Hs.554791

3D structure databases

ProteinModelPortalⁱ	O14683
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114913, 7 interactors
IntActⁱ	O14683, 4 interactors
MINTⁱ	O14683

PTM databases

iPTMnetⁱ	O14683
PhosphoSitePlusⁱ	O14683

Polymorphism and mutation databases

BioMutaⁱ	TP53I11

BioMutaⁱ

TP53I11

Proteomic databases

EPDⁱ	O14683
MaxQBⁱ	O14683
PaxDbⁱ	O14683
PeptideAtlasⁱ	O14683
PRIDEⁱ	O14683
ProteomicsDBⁱ	48166

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000308212; ENSP00000309532; ENSG00000175274 ENST00000395648; ENSP00000379009; ENSG00000175274 ENST00000525680; ENSP00000433474; ENSG00000175274 ENST00000533940; ENSP00000436152; ENSG00000175274 ENST00000616990; ENSP00000481456; ENSG00000175274
GeneIDⁱ	9537
KEGGⁱ	hsa:9537
UCSCⁱ	uc001myi.5 human

Organism-specific databases

CTDⁱ	9537
DisGeNETⁱ	9537
EuPathDBⁱ	HostDB:ENSG00000175274.18
GeneCardsⁱ	TP53I11
HGNCⁱ	HGNC:16842 TP53I11
HPAⁱ	HPA059727 HPA061276
MIMⁱ	617867 gene
neXtProtⁱ	NX_O14683
OpenTargetsⁱ	ENSG00000175274
PharmGKBⁱ	PA134967898
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IV8J Eukaryota ENOG4111H6J LUCA
GeneTreeⁱ	ENSGT00390000017249
HOGENOMⁱ	HOG000063728
HOVERGENⁱ	HBG054028
InParanoidⁱ	O14683
OMAⁱ	YYQVGRK
OrthoDBⁱ	EOG091G10KG
PhylomeDBⁱ	O14683
TreeFamⁱ	TF321310

Miscellaneous databases

ChiTaRSⁱ	TP53I11 human
GeneWikiⁱ	TP53I11
GenomeRNAiⁱ	9537
Protein Ontology More...PROⁱ	PR:O14683
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000175274 Expressed in 184 organ(s), highest expression level in blood
CleanExⁱ	HS_TP53I11
ExpressionAtlasⁱ	O14683 baseline and differential
Genevisibleⁱ	O14683 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR028266 TP53I11
PANTHERⁱ	PTHR31584 PTHR31584, 1 hit
Pfamⁱ	View protein in Pfam PF14936 p53-inducible11, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	P5I11_HUMAN
Accessionⁱ	O14683Primary (citable) accession number: O14683 Secondary accession number(s): Q3ZCS0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
	Last sequence update:	June 15, 2010
	Last modified:	September 12, 2018
	This is version 106 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM

UniProtKB

UniParc

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UniRef

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Annotation systems

Supporting data

UniProtKB - O14683 (P5I11_HUMAN)

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Tumor protein p53-inducible protein 11

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ