UniProtKB - O14682 (ENC1_HUMAN)

BLAST

>sp|O14682|ENC1_HUMAN Ectoderm-neural cortex protein 1 OS=Homo sapiens OX=9606 GN=ENC1 PE=1 SV=2
MSVSVHENRKSRASSGSINIYLFHKSSYADSVLTHLNLLRQQRLFTDVLLHAGNRTFPCH
RAVLAACSRYFEAMFSGGLKESQDSEVNFDNSIHPEVLELLLDYAYSSRVIINEENAESL
LEAGDMLEFQDIRDACAEFLEKNLHPTNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTIR
KNEDFLQLPQDMVVQLLSSEELETEDERLVYESAINWISYDLKKRYCYLPELLQTVRLAL
LPAIYLMENVAMEELITKQRKSKEIVEEAIRCKLKILQNDGVVTSLCARPRKTGHALFLL
GGQTFMCDKLYLVDQKAKEIIPKADIPSPRKEFSACAIGCKVYITGGRGSENGVSKDVWV
YDTLHEEWSKAAPMLVARFGHGSAELKHCLYVVGGHTAATGCLPASPSVSLKQVEHYDPT
INKWTMVAPLREGVSNAAVVSAKLKLFAFGGTSVSHDKLPKVQCYDQCENRWTVPATCPQ
PWRYTAAAVLGNQIFIMGGDTEFSACSAYKFNSETYQWTKVGDVTAKRMSCHAVASGNKL
YVVGGYFGIQRCKTLDCYDPTLDVWNSITTVPYSLIPTAFVSTWKHLPS

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History
Entry version 170 (07 Nov 2018)
Sequence version 2 (01 Dec 2000)
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Protein

Ectoderm-neural cortex protein 1

Gene

ENC1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells. Down-regulates transcription factor NF2L2/NRF2 by decreasing the rate of protein synthesis and not via a ubiquitin-mediated proteasomal degradation mechanism.1 Publication

GO - Molecular functionⁱ

actin binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

multicellular organism development
Source: ProtInc
Traceable author statementⁱ
- 9566959
negative regulation of translation
Source: UniProtKB
Inferred from direct assayⁱ
- 19424503
nervous system development
Source: ProtInc
Traceable author statementⁱ
- 9566959
positive regulation of neuron projection development Source: Ensembl
proteasomal ubiquitin-independent protein catabolic process
Source: UniProtKB
Inferred from direct assayⁱ
- 19424503
protein ubiquitination
Source: UniProtKB
Inferred from direct assayⁱ
- 15983046

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Actin-binding, Developmental protein

Molecular function

Actin-binding, Developmental protein

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ectoderm-neural cortex protein 1 Short name: ENC-1 Alternative name(s): Kelch-like protein 37 Nuclear matrix protein NRP/B p53-induced gene 10 protein
Gene namesⁱ	Name:ENC1 Synonyms:KLHL37, NRPB, PIG10
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000171617.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:3345 ENC1
MIMⁱ	605173 gene
neXtProtⁱ	NX_O14682

Keywords - Cellular componentⁱ

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	8507
Open Targets More...OpenTargetsⁱ	ENSG00000171617
PharmGKBⁱ	PA27782

Polymorphism and mutation databases

BioMutaⁱ	ENC1

BioMutaⁱ

ENC1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000119068	1 – 589	Ectoderm-neural cortex protein 1Add BLAST		589

Post-translational modificationⁱ

Ubiquitinated by E3 ubiquitin ligase complex formed by CUL3 and RBX1 and probably targeted for proteasome-independent degradation. Quinone-induced oxidative stress increases its ubiquitination.1 Publication

Keywords - PTMⁱ

Ubl conjugation

Proteomic databases

EPDⁱ	O14682
PaxDbⁱ	O14682
PeptideAtlas More...PeptideAtlasⁱ	O14682
PRIDEⁱ	O14682
ProteomicsDBⁱ	48165

PTM databases

iPTMnetⁱ	O14682
PhosphoSitePlusⁱ	O14682

Expressionⁱ

Tissue specificityⁱ

Detected in fetal brain tissue, moderate expression in fetal heart, lung and kidney. Highly expressed in adult brain, particularly high in the hippocampus and amygdala, and spinal chord. Detectable in adult pancreas. May be down-regulated in neuroblastoma tumors.

Developmental stageⁱ

Dramatically up-regulated upon neuronal differentiation.

Inductionⁱ

By p53/TP53.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000171617 Expressed in 230 organ(s), highest expression level in Brodmann (1909) area 10
CleanExⁱ	HS_ENC1
ExpressionAtlasⁱ	O14682 baseline and differential
Genevisibleⁱ	O14682 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA078061

HPAⁱ

HPA078061

Interactionⁱ

Subunit structureⁱ

Binds to RB1. Hypophosphorylated RB1 associates with ENC1 during neuronal differentiation, while hyperphosphorylated RB1 associates with ENC1 in undifferentiating cells. Part of a complex that contains CUL3, RBX1 and ENC1. Interacts indirectly with KEAP1.2 Publications

GO - Molecular functionⁱ

actin binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	114079, 15 interactors
IntActⁱ	O14682, 1 interactor
STRINGⁱ	9606.ENSP00000306356

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O14682
SMRⁱ	O14682
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	46 – 114	BTBPROSITE-ProRule annotationAdd BLAST	69
Repeatⁱ	296 – 340	Kelch 1Add BLAST	45
Repeatⁱ	341 – 388	Kelch 2Add BLAST	48
Repeatⁱ	389 – 444	Kelch 3Add BLAST	56
Repeatⁱ	446 – 492	Kelch 4Add BLAST	47
Repeatⁱ	494 – 538	Kelch 5Add BLAST	45
Repeatⁱ	539 – 585	Kelch 6Add BLAST	47

Keywords - Domainⁱ

Kelch repeat, Repeat

Phylogenomic databases

eggNOGⁱ	KOG4441 Eukaryota ENOG410XNX8 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150826
HOGENOMⁱ	HOG000232171
HOVERGENⁱ	HBG000905
InParanoidⁱ	O14682
KEGG Orthology (KO) More...KOⁱ	K10462
OMAⁱ	MNIYLFH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G03JU
PhylomeDBⁱ	O14682
TreeFamⁱ	TF329218

Family and domain databases

Gene3Dⁱ	2.120.10.80, 1 hit
InterProⁱ	View protein in InterPro IPR011705 BACK IPR017096 BTB-kelch_protein IPR000210 BTB/POZ_dom IPR030562 ENC1 IPR015915 Kelch-typ_b-propeller IPR006652 Kelch_1 IPR011333 SKP1/BTB/POZ_sf
PANTHERⁱ	PTHR24410:SF5 PTHR24410:SF5, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07707 BACK, 1 hit PF00651 BTB, 1 hit PF01344 Kelch_1, 4 hits
PIRSFⁱ	PIRSF037037 Kelch-like_protein_gigaxonin, 1 hit
SMARTⁱ	View protein in SMART SM00875 BACK, 1 hit SM00225 BTB, 1 hit SM00612 Kelch, 6 hits
SUPFAMⁱ	SSF117281 SSF117281, 1 hit SSF54695 SSF54695, 1 hit
PROSITEⁱ	View protein in PROSITE PS50097 BTB, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: O14682-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSVSVHENRK SRASSGSINI YLFHKSSYAD SVLTHLNLLR QQRLFTDVLL 
        60         70         80         90        100
HAGNRTFPCH RAVLAACSRY FEAMFSGGLK ESQDSEVNFD NSIHPEVLEL 
       110        120        130        140        150
LLDYAYSSRV IINEENAESL LEAGDMLEFQ DIRDACAEFL EKNLHPTNCL 
       160        170        180        190        200
GMLLLSDAHQ CTKLYELSWR MCLSNFQTIR KNEDFLQLPQ DMVVQLLSSE 
       210        220        230        240        250
ELETEDERLV YESAINWISY DLKKRYCYLP ELLQTVRLAL LPAIYLMENV 
       260        270        280        290        300
AMEELITKQR KSKEIVEEAI RCKLKILQND GVVTSLCARP RKTGHALFLL 
       310        320        330        340        350
GGQTFMCDKL YLVDQKAKEI IPKADIPSPR KEFSACAIGC KVYITGGRGS 
       360        370        380        390        400
ENGVSKDVWV YDTLHEEWSK AAPMLVARFG HGSAELKHCL YVVGGHTAAT 
       410        420        430        440        450
GCLPASPSVS LKQVEHYDPT INKWTMVAPL REGVSNAAVV SAKLKLFAFG 
       460        470        480        490        500
GTSVSHDKLP KVQCYDQCEN RWTVPATCPQ PWRYTAAAVL GNQIFIMGGD 
       510        520        530        540        550
TEFSACSAYK FNSETYQWTK VGDVTAKRMS CHAVASGNKL YVVGGYFGIQ 
       560        570        580 
RCKTLDCYDP TLDVWNSITT VPYSLIPTAF VSTWKHLPS

Length:589

Mass (Da):66,130

Last modified:December 1, 2000 - v2

Checksum:ⁱDB003A1DFA65BAA0

Isoform 2 (identifier: O14682-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-73: Missing.

« Hide

        10         20         30         40         50
MFSGGLKESQ DSEVNFDNSI HPEVLELLLD YAYSSRVIIN EENAESLLEA 
        60         70         80         90        100
GDMLEFQDIR DACAEFLEKN LHPTNCLGML LLSDAHQCTK LYELSWRMCL 
       110        120        130        140        150
SNFQTIRKNE DFLQLPQDMV VQLLSSEELE TEDERLVYES AINWISYDLK 
       160        170        180        190        200
KRYCYLPELL QTVRLALLPA IYLMENVAME ELITKQRKSK EIVEEAIRCK 
       210        220        230        240        250
LKILQNDGVV TSLCARPRKT GHALFLLGGQ TFMCDKLYLV DQKAKEIIPK 
       260        270        280        290        300
ADIPSPRKEF SACAIGCKVY ITGGRGSENG VSKDVWVYDT LHEEWSKAAP 
       310        320        330        340        350
MLVARFGHGS AELKHCLYVV GGHTAATGCL PASPSVSLKQ VEHYDPTINK 
       360        370        380        390        400
WTMVAPLREG VSNAAVVSAK LKLFAFGGTS VSHDKLPKVQ CYDQCENRWT 
       410        420        430        440        450
VPATCPQPWR YTAAAVLGNQ IFIMGGDTEF SACSAYKFNS ETYQWTKVGD 
       460        470        480        490        500
VTAKRMSCHA VASGNKLYVV GGYFGIQRCK TLDCYDPTLD VWNSITTVPY 
       510 
SLIPTAFVST WKHLPS

Note: No experimental confirmation available.

Show »

Length:516

Mass (Da):57,854

Checksum:ⁱ4A30529496E087EB

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	D6R9D7	D6R9D7_HUMAN		Ectoderm-neural cortex protein 1 Ectoderm-neural cortex protein 1	ENC1	49	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	108	S → F in BAG58153 (PubMed:14702039).Curated	1
Sequence conflictⁱ	112 – 130	INEEN…MLEFQ → HQLEGKCRNSLLGSLVTCWS FK (PubMed:9305847).CuratedAdd BLAST	19
Sequence conflictⁱ	237 – 238	RL → TR in AAC39532 (PubMed:9305847).Curated	2
Sequence conflictⁱ	378	R → M in BAG58153 (PubMed:14702039).Curated	1
Sequence conflictⁱ	402	C → S in AAC64498 (PubMed:9683534).Curated	1
Sequence conflictⁱ	427	V → A (PubMed:9305847).Curated	1
Sequence conflictⁱ	430 – 438	LREGVSNAA → RPRRRYNCAQ (PubMed:9305847).Curated	9
Sequence conflictⁱ	484 – 589	YTAAA…KHLPS → IHSQASCPGGTQDFLLWGVI QNFSACFCL in AAC39532 (PubMed:9305847).CuratedAdd BLAST	106

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_050040	256	I → S. Corresponds to variant dbSNP:rs16872126Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_045074	1 – 73	Missing in isoform 2. 1 PublicationAdd BLAST		73

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF010314 mRNA Translation: AAC39532.1 AF005381 mRNA Translation: AAC64498.1 AF059611 mRNA Translation: AAC26109.1 AK295128 mRNA Translation: BAG58153.1 AC026405 Genomic DNA No translation available. BC000418 mRNA Translation: AAH00418.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4021.1 [O14682-1] CCDS58958.1 [O14682-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001243503.1, NM_001256574.1 [O14682-1] NP_001243504.1, NM_001256575.1 [O14682-1] NP_001243505.1, NM_001256576.1 [O14682-2] NP_003624.1, NM_003633.3 [O14682-1] XP_011541998.1, XM_011543696.2 [O14682-1] XP_011541999.1, XM_011543697.2 [O14682-1]
UniGeneⁱ	Hs.104925 Hs.744844

Genome annotation databases

Ensemblⁱ	ENST00000302351; ENSP00000306356; ENSG00000171617 [O14682-1] ENST00000510316; ENSP00000423804; ENSG00000171617 [O14682-2] ENST00000537006; ENSP00000446289; ENSG00000171617 [O14682-1] ENST00000618628; ENSP00000479101; ENSG00000171617 [O14682-1]
GeneIDⁱ	8507
KEGGⁱ	hsa:8507
UCSC genome browser More...UCSCⁱ	uc011css.4 human [O14682-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O14682	Ectodermal-neural cortex (With BTB-like domain)		HUMAN		589	UniRef100_O14682
Isoform 2 of Ectoderm-neural cortex protein 1		HUMAN		516
cDNA FLJ57577, highly similar to Ectoderm-neural cortex 1 protein		HUMAN		284

Protein	Similar proteins		Species	Score	Length	Source
O14682	Ectoderm-neural cortex protein 1		MOUSE		589	UniRef90_O14682
Ectodermal-neural cortex (With BTB-like domain)		HUMAN		589
Ectodermal-neural cortex 1		POEFO		736
ENC1 (Fragment)		blackstripe livebearer		371
Ectodermal-neural cortex protein (Fragment)		Jenynsia unitaenia		270
+1158

Protein	Similar proteins		Species	Score	Length	Source
O14682	Ectoderm-neural cortex protein 1		MOUSE		589	UniRef50_O14682
Kelch-like protein 25		RAT		589
Kelch-like protein 25		HUMAN		589
Ectodermal-neural cortex 1		POEFO		736
ENC1 (Fragment)		blackstripe livebearer		371
+1660

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF010314 mRNA Translation: AAC39532.1 AF005381 mRNA Translation: AAC64498.1 AF059611 mRNA Translation: AAC26109.1 AK295128 mRNA Translation: BAG58153.1 AC026405 Genomic DNA No translation available. BC000418 mRNA Translation: AAH00418.1
CCDSⁱ	CCDS4021.1 [O14682-1] CCDS58958.1 [O14682-2]
RefSeqⁱ	NP_001243503.1, NM_001256574.1 [O14682-1] NP_001243504.1, NM_001256575.1 [O14682-1] NP_001243505.1, NM_001256576.1 [O14682-2] NP_003624.1, NM_003633.3 [O14682-1] XP_011541998.1, XM_011543696.2 [O14682-1] XP_011541999.1, XM_011543697.2 [O14682-1]
UniGeneⁱ	Hs.104925 Hs.744844

3D structure databases

ProteinModelPortalⁱ	O14682
SMRⁱ	O14682
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114079, 15 interactors
IntActⁱ	O14682, 1 interactor
STRINGⁱ	9606.ENSP00000306356

PTM databases

iPTMnetⁱ	O14682
PhosphoSitePlusⁱ	O14682

Polymorphism and mutation databases

BioMutaⁱ	ENC1

BioMutaⁱ

ENC1

Proteomic databases

EPDⁱ	O14682
PaxDbⁱ	O14682
PeptideAtlasⁱ	O14682
PRIDEⁱ	O14682
ProteomicsDBⁱ	48165

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	8507
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000302351; ENSP00000306356; ENSG00000171617 [O14682-1] ENST00000510316; ENSP00000423804; ENSG00000171617 [O14682-2] ENST00000537006; ENSP00000446289; ENSG00000171617 [O14682-1] ENST00000618628; ENSP00000479101; ENSG00000171617 [O14682-1]
GeneIDⁱ	8507
KEGGⁱ	hsa:8507
UCSCⁱ	uc011css.4 human [O14682-1]

Organism-specific databases

CTDⁱ	8507
DisGeNETⁱ	8507
EuPathDBⁱ	HostDB:ENSG00000171617.13
GeneCardsⁱ	ENC1
HGNCⁱ	HGNC:3345 ENC1
HPAⁱ	HPA078061
MIMⁱ	605173 gene
neXtProtⁱ	NX_O14682
OpenTargetsⁱ	ENSG00000171617
PharmGKBⁱ	PA27782
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4441 Eukaryota ENOG410XNX8 LUCA
GeneTreeⁱ	ENSGT00930000150826
HOGENOMⁱ	HOG000232171
HOVERGENⁱ	HBG000905
InParanoidⁱ	O14682
KOⁱ	K10462
OMAⁱ	MNIYLFH
OrthoDBⁱ	EOG091G03JU
PhylomeDBⁱ	O14682
TreeFamⁱ	TF329218

Miscellaneous databases

ChiTaRSⁱ	ENC1 human
GeneWikiⁱ	ENC1
GenomeRNAiⁱ	8507
Protein Ontology More...PROⁱ	PR:O14682
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000171617 Expressed in 230 organ(s), highest expression level in Brodmann (1909) area 10
CleanExⁱ	HS_ENC1
ExpressionAtlasⁱ	O14682 baseline and differential
Genevisibleⁱ	O14682 HS

Family and domain databases

Gene3Dⁱ	2.120.10.80, 1 hit
InterProⁱ	View protein in InterPro IPR011705 BACK IPR017096 BTB-kelch_protein IPR000210 BTB/POZ_dom IPR030562 ENC1 IPR015915 Kelch-typ_b-propeller IPR006652 Kelch_1 IPR011333 SKP1/BTB/POZ_sf
PANTHERⁱ	PTHR24410:SF5 PTHR24410:SF5, 1 hit
Pfamⁱ	View protein in Pfam PF07707 BACK, 1 hit PF00651 BTB, 1 hit PF01344 Kelch_1, 4 hits
PIRSFⁱ	PIRSF037037 Kelch-like_protein_gigaxonin, 1 hit
SMARTⁱ	View protein in SMART SM00875 BACK, 1 hit SM00225 BTB, 1 hit SM00612 Kelch, 6 hits
SUPFAMⁱ	SSF117281 SSF117281, 1 hit SSF54695 SSF54695, 1 hit
PROSITEⁱ	View protein in PROSITE PS50097 BTB, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ENC1_HUMAN
Accessionⁱ	O14682Primary (citable) accession number: O14682 Secondary accession number(s): B4DHJ1 , E9PFU0, O75464, Q9UPG9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
	Last sequence update:	December 1, 2000
	Last modified:	November 7, 2018
	This is version 170 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O14682 (ENC1_HUMAN)

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Ectoderm-neural cortex protein 1

ENC1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytoskeleton

Other locations

Cytoskeleton

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ