UniProtKB - O14682 (ENC1_HUMAN)
Ectoderm-neural cortex protein 1
ENC1
Functioni
GO - Molecular functioni
- actin binding Source: UniProtKB-KW
GO - Biological processi
- multicellular organism development Source: ProtInc
- negative regulation of translation Source: UniProtKB
- nervous system development Source: ProtInc
- positive regulation of neuron projection development Source: Ensembl
- proteasomal ubiquitin-independent protein catabolic process Source: UniProtKB
- protein ubiquitination Source: UniProtKB
Keywordsi
Molecular function | Actin-binding, Developmental protein |
Enzyme and pathway databases
PathwayCommonsi | O14682 |
Names & Taxonomyi
Protein namesi | Recommended name: Ectoderm-neural cortex protein 1Short name: ENC-1 Alternative name(s): Kelch-like protein 37 Nuclear matrix protein NRP/B p53-induced gene 10 protein |
Gene namesi | Name:ENC1 Synonyms:KLHL37, NRPB, PIG10 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3345, ENC1 |
MIMi | 605173, gene |
neXtProti | NX_O14682 |
VEuPathDBi | HostDB:ENSG00000171617.13 |
Subcellular locationi
Cytoskeleton
- cytoskeleton 1 Publication
Nucleus
- Nucleus matrix 1 Publication
Other locations
- Cytoplasm 1 Publication
Cytoskeleton
- cytoskeleton Source: UniProtKB-SubCell
Nucleus
- nuclear chromatin Source: Ensembl
- nuclear matrix Source: UniProtKB-SubCell
- nucleolus Source: Ensembl
- nucleoplasm Source: Ensembl
- nucleus Source: ProtInc
Other locations
- Cul3-RING ubiquitin ligase complex Source: UniProtKB
- cytoplasm Source: UniProtKB
- neuronal cell body Source: Ensembl
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 8507 |
OpenTargetsi | ENSG00000171617 |
PharmGKBi | PA27782 |
Miscellaneous databases
Pharosi | O14682, Tbio |
Genetic variation databases
BioMutai | ENC1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000119068 | 1 – 589 | Ectoderm-neural cortex protein 1Add BLAST | 589 |
Post-translational modificationi
Keywords - PTMi
Ubl conjugationProteomic databases
EPDi | O14682 |
jPOSTi | O14682 |
MassIVEi | O14682 |
PaxDbi | O14682 |
PeptideAtlasi | O14682 |
PRIDEi | O14682 |
ProteomicsDBi | 20177 48165 [O14682-1] |
PTM databases
iPTMneti | O14682 |
PhosphoSitePlusi | O14682 |
Expressioni
Tissue specificityi
Developmental stagei
Inductioni
Gene expression databases
Bgeei | ENSG00000171617, Expressed in Brodmann (1909) area 10 and 242 other tissues |
ExpressionAtlasi | O14682, baseline and differential |
Genevisiblei | O14682, HS |
Organism-specific databases
HPAi | ENSG00000171617, Tissue enriched (brain) |
Interactioni
Subunit structurei
Binds to RB1. Hypophosphorylated RB1 associates with ENC1 during neuronal differentiation, while hyperphosphorylated RB1 associates with ENC1 in undifferentiating cells.
Part of a complex that contains CUL3, RBX1 and ENC1.
Interacts indirectly with KEAP1.
2 PublicationsGO - Molecular functioni
- actin binding Source: UniProtKB-KW
Protein-protein interaction databases
BioGRIDi | 114079, 16 interactors |
CORUMi | O14682 |
IntActi | O14682, 6 interactors |
STRINGi | 9606.ENSP00000479101 |
Miscellaneous databases
RNActi | O14682, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 46 – 114 | BTBPROSITE-ProRule annotationAdd BLAST | 69 | |
Repeati | 296 – 340 | Kelch 1Add BLAST | 45 | |
Repeati | 341 – 388 | Kelch 2Add BLAST | 48 | |
Repeati | 389 – 444 | Kelch 3Add BLAST | 56 | |
Repeati | 446 – 492 | Kelch 4Add BLAST | 47 | |
Repeati | 494 – 538 | Kelch 5Add BLAST | 45 | |
Repeati | 539 – 585 | Kelch 6Add BLAST | 47 |
Keywords - Domaini
Kelch repeat, RepeatPhylogenomic databases
eggNOGi | KOG4441, Eukaryota |
GeneTreei | ENSGT00950000182983 |
HOGENOMi | CLU_004253_14_6_1 |
InParanoidi | O14682 |
OMAi | SENYQWT |
PhylomeDBi | O14682 |
TreeFami | TF329218 |
Family and domain databases
Gene3Di | 2.120.10.80, 1 hit |
InterProi | View protein in InterPro IPR011705, BACK IPR017096, BTB-kelch_protein IPR000210, BTB/POZ_dom IPR030562, ENC1 IPR015915, Kelch-typ_b-propeller IPR006652, Kelch_1 IPR011333, SKP1/BTB/POZ_sf |
PANTHERi | PTHR24410:SF5, PTHR24410:SF5, 1 hit |
Pfami | View protein in Pfam PF07707, BACK, 1 hit PF00651, BTB, 1 hit PF01344, Kelch_1, 4 hits |
PIRSFi | PIRSF037037, Kelch-like_protein_gigaxonin, 1 hit |
SMARTi | View protein in SMART SM00875, BACK, 1 hit SM00225, BTB, 1 hit SM00612, Kelch, 6 hits |
SUPFAMi | SSF117281, SSF117281, 1 hit SSF54695, SSF54695, 1 hit |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSVSVHENRK SRASSGSINI YLFHKSSYAD SVLTHLNLLR QQRLFTDVLL
60 70 80 90 100
HAGNRTFPCH RAVLAACSRY FEAMFSGGLK ESQDSEVNFD NSIHPEVLEL
110 120 130 140 150
LLDYAYSSRV IINEENAESL LEAGDMLEFQ DIRDACAEFL EKNLHPTNCL
160 170 180 190 200
GMLLLSDAHQ CTKLYELSWR MCLSNFQTIR KNEDFLQLPQ DMVVQLLSSE
210 220 230 240 250
ELETEDERLV YESAINWISY DLKKRYCYLP ELLQTVRLAL LPAIYLMENV
260 270 280 290 300
AMEELITKQR KSKEIVEEAI RCKLKILQND GVVTSLCARP RKTGHALFLL
310 320 330 340 350
GGQTFMCDKL YLVDQKAKEI IPKADIPSPR KEFSACAIGC KVYITGGRGS
360 370 380 390 400
ENGVSKDVWV YDTLHEEWSK AAPMLVARFG HGSAELKHCL YVVGGHTAAT
410 420 430 440 450
GCLPASPSVS LKQVEHYDPT INKWTMVAPL REGVSNAAVV SAKLKLFAFG
460 470 480 490 500
GTSVSHDKLP KVQCYDQCEN RWTVPATCPQ PWRYTAAAVL GNQIFIMGGD
510 520 530 540 550
TEFSACSAYK FNSETYQWTK VGDVTAKRMS CHAVASGNKL YVVGGYFGIQ
560 570 580
RCKTLDCYDP TLDVWNSITT VPYSLIPTAF VSTWKHLPS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketD6R9D7 | D6R9D7_HUMAN | Ectoderm-neural cortex protein 1 | ENC1 | 49 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 108 | S → F in BAG58153 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 112 – 130 | INEEN…MLEFQ → HQLEGKCRNSLLGSLVTCWS FK (PubMed:9305847).CuratedAdd BLAST | 19 | |
Sequence conflicti | 237 – 238 | RL → TR in AAC39532 (PubMed:9305847).Curated | 2 | |
Sequence conflicti | 378 | R → M in BAG58153 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 402 | C → S in AAC64498 (PubMed:9683534).Curated | 1 | |
Sequence conflicti | 427 | V → A (PubMed:9305847).Curated | 1 | |
Sequence conflicti | 430 – 438 | LREGVSNAA → RPRRRYNCAQ (PubMed:9305847).Curated | 9 | |
Sequence conflicti | 484 – 589 | YTAAA…KHLPS → IHSQASCPGGTQDFLLWGVI QNFSACFCL in AAC39532 (PubMed:9305847).CuratedAdd BLAST | 106 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_050040 | 256 | I → S. Corresponds to variant dbSNP:rs16872126Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_045074 | 1 – 73 | Missing in isoform 2. 1 PublicationAdd BLAST | 73 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF010314 mRNA Translation: AAC39532.1 AF005381 mRNA Translation: AAC64498.1 AF059611 mRNA Translation: AAC26109.1 AK295128 mRNA Translation: BAG58153.1 AC026405 Genomic DNA No translation available. BC000418 mRNA Translation: AAH00418.1 |
CCDSi | CCDS4021.1 [O14682-1] CCDS58958.1 [O14682-2] |
RefSeqi | NP_001243503.1, NM_001256574.1 [O14682-1] NP_001243504.1, NM_001256575.1 [O14682-1] NP_001243505.1, NM_001256576.1 [O14682-2] NP_003624.1, NM_003633.3 [O14682-1] XP_011541998.1, XM_011543696.2 [O14682-1] XP_011541999.1, XM_011543697.2 [O14682-1] |
Genome annotation databases
Ensembli | ENST00000302351; ENSP00000306356; ENSG00000171617 [O14682-1] ENST00000510316; ENSP00000423804; ENSG00000171617 [O14682-2] ENST00000537006; ENSP00000446289; ENSG00000171617 [O14682-1] ENST00000618628; ENSP00000479101; ENSG00000171617 [O14682-1] ENST00000651128; ENSP00000499185; ENSG00000171617 [O14682-1] |
GeneIDi | 8507 |
KEGGi | hsa:8507 |
UCSCi | uc011css.4, human [O14682-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF010314 mRNA Translation: AAC39532.1 AF005381 mRNA Translation: AAC64498.1 AF059611 mRNA Translation: AAC26109.1 AK295128 mRNA Translation: BAG58153.1 AC026405 Genomic DNA No translation available. BC000418 mRNA Translation: AAH00418.1 |
CCDSi | CCDS4021.1 [O14682-1] CCDS58958.1 [O14682-2] |
RefSeqi | NP_001243503.1, NM_001256574.1 [O14682-1] NP_001243504.1, NM_001256575.1 [O14682-1] NP_001243505.1, NM_001256576.1 [O14682-2] NP_003624.1, NM_003633.3 [O14682-1] XP_011541998.1, XM_011543696.2 [O14682-1] XP_011541999.1, XM_011543697.2 [O14682-1] |
3D structure databases
SMRi | O14682 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 114079, 16 interactors |
CORUMi | O14682 |
IntActi | O14682, 6 interactors |
STRINGi | 9606.ENSP00000479101 |
PTM databases
iPTMneti | O14682 |
PhosphoSitePlusi | O14682 |
Genetic variation databases
BioMutai | ENC1 |
Proteomic databases
EPDi | O14682 |
jPOSTi | O14682 |
MassIVEi | O14682 |
PaxDbi | O14682 |
PeptideAtlasi | O14682 |
PRIDEi | O14682 |
ProteomicsDBi | 20177 48165 [O14682-1] |
Protocols and materials databases
Antibodypediai | 24333, 262 antibodies |
DNASUi | 8507 |
Genome annotation databases
Ensembli | ENST00000302351; ENSP00000306356; ENSG00000171617 [O14682-1] ENST00000510316; ENSP00000423804; ENSG00000171617 [O14682-2] ENST00000537006; ENSP00000446289; ENSG00000171617 [O14682-1] ENST00000618628; ENSP00000479101; ENSG00000171617 [O14682-1] ENST00000651128; ENSP00000499185; ENSG00000171617 [O14682-1] |
GeneIDi | 8507 |
KEGGi | hsa:8507 |
UCSCi | uc011css.4, human [O14682-1] |
Organism-specific databases
CTDi | 8507 |
DisGeNETi | 8507 |
GeneCardsi | ENC1 |
HGNCi | HGNC:3345, ENC1 |
HPAi | ENSG00000171617, Tissue enriched (brain) |
MIMi | 605173, gene |
neXtProti | NX_O14682 |
OpenTargetsi | ENSG00000171617 |
PharmGKBi | PA27782 |
VEuPathDBi | HostDB:ENSG00000171617.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4441, Eukaryota |
GeneTreei | ENSGT00950000182983 |
HOGENOMi | CLU_004253_14_6_1 |
InParanoidi | O14682 |
OMAi | SENYQWT |
PhylomeDBi | O14682 |
TreeFami | TF329218 |
Enzyme and pathway databases
PathwayCommonsi | O14682 |
Miscellaneous databases
BioGRID-ORCSi | 8507, 3 hits in 881 CRISPR screens |
ChiTaRSi | ENC1, human |
GeneWikii | ENC1 |
GenomeRNAii | 8507 |
Pharosi | O14682, Tbio |
PROi | PR:O14682 |
RNActi | O14682, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000171617, Expressed in Brodmann (1909) area 10 and 242 other tissues |
ExpressionAtlasi | O14682, baseline and differential |
Genevisiblei | O14682, HS |
Family and domain databases
Gene3Di | 2.120.10.80, 1 hit |
InterProi | View protein in InterPro IPR011705, BACK IPR017096, BTB-kelch_protein IPR000210, BTB/POZ_dom IPR030562, ENC1 IPR015915, Kelch-typ_b-propeller IPR006652, Kelch_1 IPR011333, SKP1/BTB/POZ_sf |
PANTHERi | PTHR24410:SF5, PTHR24410:SF5, 1 hit |
Pfami | View protein in Pfam PF07707, BACK, 1 hit PF00651, BTB, 1 hit PF01344, Kelch_1, 4 hits |
PIRSFi | PIRSF037037, Kelch-like_protein_gigaxonin, 1 hit |
SMARTi | View protein in SMART SM00875, BACK, 1 hit SM00225, BTB, 1 hit SM00612, Kelch, 6 hits |
SUPFAMi | SSF117281, SSF117281, 1 hit SSF54695, SSF54695, 1 hit |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ENC1_HUMAN | |
Accessioni | O14682Primary (citable) accession number: O14682 Secondary accession number(s): B4DHJ1 Q9UPG9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | December 1, 2000 | |
Last modified: | February 10, 2021 | |
This is version 187 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants