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Protein

Etoposide-induced protein 2.4 homolog

Gene

EI24

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a negative growth regulator via p53-mediated apoptosis pathway. Regulates formation of degradative autolysosomes during autophagy (By similarity).By similarity

GO - Biological processi

  • apoptotic process Source: GO_Central
  • macroautophagy Source: GO_Central
  • negative regulation of cell growth Source: MGI

Keywordsi

Biological processApoptosis, Autophagy

Protein family/group databases

TCDBi2.A.121.3.1 the sulfate transporter (cysz) family

Names & Taxonomyi

Protein namesi
Recommended name:
Etoposide-induced protein 2.4 homolog
Alternative name(s):
p53-induced gene 8 protein
Gene namesi
Name:EI24
Synonyms:PIG8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000149547.14
HGNCiHGNC:13276 EI24
MIMi605170 gene
neXtProtiNX_O14681

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei77 – 97HelicalSequence analysisAdd BLAST21
Transmembranei117 – 137HelicalSequence analysisAdd BLAST21
Transmembranei179 – 199HelicalSequence analysisAdd BLAST21
Transmembranei238 – 255HelicalSequence analysisAdd BLAST18
Transmembranei257 – 277HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Membrane, Nucleus

Pathology & Biotechi

Involvement in diseasei

EI24 is on a chromosomal region frequently deleted in solid tumors, and it is thought to play a role in breast and cervical cancer. Particularly, expression analysis of EI24 in cancerous tissues shows that EI24 loss is associated with tumor invasiveness.

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi9538
OpenTargetsiENSG00000149547
PharmGKBiPA134937367

Polymorphism and mutation databases

BioMutaiEI24

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000869452 – 340Etoposide-induced protein 2.4 homologAdd BLAST339

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei46PhosphoserineBy similarity1
Modified residuei47PhosphoserineBy similarity1
Modified residuei56PhosphoserineCombined sources1
Modified residuei320PhosphoserineBy similarity1
Modified residuei326PhosphoserineCombined sources1
Modified residuei330PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO14681
MaxQBiO14681
PaxDbiO14681
PeptideAtlasiO14681
PRIDEiO14681
ProteomicsDBi48164

PTM databases

iPTMnetiO14681
PhosphoSitePlusiO14681

Expressioni

Inductioni

By p53/TP53.1 Publication

Gene expression databases

BgeeiENSG00000149547 Expressed in 234 organ(s), highest expression level in liver
CleanExiHS_EI24
ExpressionAtlasiO14681 baseline and differential
GenevisibleiO14681 HS

Organism-specific databases

HPAiHPA047165
HPA051029

Interactioni

Subunit structurei

Interacts with BCL2.By similarity

Protein-protein interaction databases

BioGridi114914, 4 interactors
IntActiO14681, 14 interactors
MINTiO14681
STRINGi9606.ENSP00000278903

Structurei

3D structure databases

ProteinModelPortaliO14681
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi41 – 44Poly-Arg4

Sequence similaritiesi

Belongs to the EI24 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3966 Eukaryota
ENOG410XRPU LUCA
GeneTreeiENSGT00390000018633
HOGENOMiHOG000293197
HOVERGENiHBG001857
InParanoidiO14681
KOiK10134
OMAiVMIGIGE
OrthoDBiEOG091G0E3F
PhylomeDBiO14681
TreeFamiTF314441

Family and domain databases

InterProiView protein in InterPro
IPR009890 EI24
PANTHERiPTHR21389 PTHR21389, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O14681-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADSVKTFLQ DLARGIKDSI WGICTISKLD ARIQQKREEQ RRRRASSVLA
60 70 80 90 100
QRRAQSIERK QESEPRIVSR IFQCCAWNGG VFWFSLLLFY RVFIPVLQSV
110 120 130 140 150
TARIIGDPSL HGDVWSWLEF FLTSIFSALW VLPLFVLSKV VNAIWFQDIA
160 170 180 190 200
DLAFEVSGRK PHPFPSVSKI IADMLFNLLL QALFLIQGMF VSLFPIHLVG
210 220 230 240 250
QLVSLLHMSL LYSLYCFEYR WFNKGIEMHQ RLSNIERNWP YYFGFGLPLA
260 270 280 290 300
FLTAMQSSYI ISGCLFSILF PLFIISANEA KTPGKAYLFQ LRLFSLVVFL
310 320 330 340
SNRLFHKTVY LQSALSSSTS AEKFPSPHPS PAKLKATAGH
Length:340
Mass (Da):38,965
Last modified:May 5, 2009 - v4
Checksum:i928DB15D9B34146E
GO
Isoform 2 (identifier: O14681-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     15-28: Missing.

Note: No experimental confirmation available.
Show »
Length:326
Mass (Da):37,462
Checksum:iEFC6A2CA5E6B46E5
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7ZB74B7ZB74_HUMAN
Etoposide-induced protein 2.4 homol...
EI24
167Annotation score:
E9PK61E9PK61_HUMAN
Etoposide-induced protein 2.4 homol...
EI24
262Annotation score:
E9PM05E9PM05_HUMAN
Etoposide-induced protein 2.4 homol...
EI24
187Annotation score:
E9PS58E9PS58_HUMAN
Etoposide-induced protein 2.4 homol...
EI24
217Annotation score:
E9PLB8E9PLB8_HUMAN
Etoposide-induced protein 2.4 homol...
EI24
91Annotation score:
E9PL33E9PL33_HUMAN
Etoposide-induced protein 2.4 homol...
EI24
125Annotation score:
E9PQN7E9PQN7_HUMAN
Etoposide-induced protein 2.4 homol...
EI24
14Annotation score:
A0A087WV44A0A087WV44_HUMAN
Etoposide-induced protein 2.4 homol...
EI24
41Annotation score:

Sequence cautioni

The sequence AAC39531 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti54A → P in AAC39531 (PubMed:9305847).Curated1
Sequence conflicti119E → G in AAC39531 (PubMed:9305847).Curated1
Sequence conflicti129L → V in AAC39531 (PubMed:9305847).Curated1
Sequence conflicti132L → V in BAF84640 (PubMed:14702039).Curated1
Sequence conflicti254A → S in BAG59228 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06545930D → G in some patients with early onset breast cancer. 1 Publication1
Natural variantiVAR_065460195P → W in some patients with early onset breast cancer; requires 2 nucleotide substitutions. 1 Publication1
Natural variantiVAR_065461196I → D in some patients with early onset breast cancer; requires 2 nucleotide substitutions. 1 Publication1
Natural variantiVAR_065462197H → Y in some patients with early onset breast cancer. 1 Publication1
Natural variantiVAR_065463199V → H in some patients with early onset breast cancer; requires 2 nucleotide substitutions. 1 Publication1
Natural variantiVAR_065464319T → A in some patients with early onset breast cancer. 1 PublicationCorresponds to variant dbSNP:rs375652371Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05546615 – 28Missing in isoform 2. 1 PublicationAdd BLAST14

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF010313 mRNA Translation: AAC39531.2 Different initiation.
AK291951 mRNA Translation: BAF84640.1
AK296620 mRNA Translation: BAG59228.1
AK315841 mRNA Translation: BAF98732.1
CH471065 Genomic DNA Translation: EAW67641.1
BC002390 mRNA Translation: AAH02390.1
CCDSiCCDS73410.1 [O14681-1]
CCDS76493.1 [O14681-3]
RefSeqiNP_001277064.1, NM_001290135.1 [O14681-3]
NP_004870.3, NM_004879.4 [O14681-1]
XP_011541371.1, XM_011543069.1 [O14681-1]
UniGeneiHs.643514

Genome annotation databases

EnsembliENST00000278903; ENSP00000278903; ENSG00000149547 [O14681-1]
ENST00000534546; ENSP00000479943; ENSG00000149547 [O14681-3]
ENST00000620753; ENSP00000484510; ENSG00000149547 [O14681-1]
GeneIDi9538
KEGGihsa:9538
UCSCiuc031yiu.2 human [O14681-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF010313 mRNA Translation: AAC39531.2 Different initiation.
AK291951 mRNA Translation: BAF84640.1
AK296620 mRNA Translation: BAG59228.1
AK315841 mRNA Translation: BAF98732.1
CH471065 Genomic DNA Translation: EAW67641.1
BC002390 mRNA Translation: AAH02390.1
CCDSiCCDS73410.1 [O14681-1]
CCDS76493.1 [O14681-3]
RefSeqiNP_001277064.1, NM_001290135.1 [O14681-3]
NP_004870.3, NM_004879.4 [O14681-1]
XP_011541371.1, XM_011543069.1 [O14681-1]
UniGeneiHs.643514

3D structure databases

ProteinModelPortaliO14681
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114914, 4 interactors
IntActiO14681, 14 interactors
MINTiO14681
STRINGi9606.ENSP00000278903

Protein family/group databases

TCDBi2.A.121.3.1 the sulfate transporter (cysz) family

PTM databases

iPTMnetiO14681
PhosphoSitePlusiO14681

Polymorphism and mutation databases

BioMutaiEI24

Proteomic databases

EPDiO14681
MaxQBiO14681
PaxDbiO14681
PeptideAtlasiO14681
PRIDEiO14681
ProteomicsDBi48164

Protocols and materials databases

DNASUi9538
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000278903; ENSP00000278903; ENSG00000149547 [O14681-1]
ENST00000534546; ENSP00000479943; ENSG00000149547 [O14681-3]
ENST00000620753; ENSP00000484510; ENSG00000149547 [O14681-1]
GeneIDi9538
KEGGihsa:9538
UCSCiuc031yiu.2 human [O14681-1]

Organism-specific databases

CTDi9538
DisGeNETi9538
EuPathDBiHostDB:ENSG00000149547.14
GeneCardsiEI24
H-InvDBiHIX0010241
HGNCiHGNC:13276 EI24
HPAiHPA047165
HPA051029
MIMi605170 gene
neXtProtiNX_O14681
OpenTargetsiENSG00000149547
PharmGKBiPA134937367
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3966 Eukaryota
ENOG410XRPU LUCA
GeneTreeiENSGT00390000018633
HOGENOMiHOG000293197
HOVERGENiHBG001857
InParanoidiO14681
KOiK10134
OMAiVMIGIGE
OrthoDBiEOG091G0E3F
PhylomeDBiO14681
TreeFamiTF314441

Miscellaneous databases

ChiTaRSiEI24 human
GeneWikiiEI24
GenomeRNAii9538
PROiPR:O14681
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000149547 Expressed in 234 organ(s), highest expression level in liver
CleanExiHS_EI24
ExpressionAtlasiO14681 baseline and differential
GenevisibleiO14681 HS

Family and domain databases

InterProiView protein in InterPro
IPR009890 EI24
PANTHERiPTHR21389 PTHR21389, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEI24_HUMAN
AccessioniPrimary (citable) accession number: O14681
Secondary accession number(s): A8K7D6, B4DKL6, Q9BUQ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 5, 2009
Last modified: September 12, 2018
This is version 140 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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