UniProtKB - O14672 (ADA10_HUMAN)
Disintegrin and metalloproteinase domain-containing protein 10
ADAM10
Functioni
Catalytic activityi
Cofactori
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 173 | Zinc; in inhibited formBy similarity | 1 | |
Metal bindingi | 383 | Zinc; via tele nitrogen; catalyticCombined sources2 Publications | 1 | |
Active sitei | 384 | 2 Publications | 1 | |
Metal bindingi | 387 | Zinc; via tele nitrogen; catalyticCombined sources1 Publication | 1 | |
Metal bindingi | 393 | Zinc; via tele nitrogen; catalyticCombined sources2 Publications | 1 |
GO - Molecular functioni
- endopeptidase activity Source: UniProtKB
- integrin binding Source: UniProtKB
- metal ion binding Source: UniProtKB-KW
- metalloendopeptidase activity Source: BHF-UCL
- metalloendopeptidase activity involved in amyloid precursor protein catabolic process Source: UniProtKB
- metallopeptidase activity Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
- protein kinase binding Source: UniProtKB
- SH3 domain binding Source: UniProtKB-KW
- signaling receptor binding Source: UniProtKB
GO - Biological processi
- adherens junction organization Source: Ensembl
- amyloid-beta formation Source: Ensembl
- amyloid precursor protein catabolic process Source: UniProtKB
- cell-cell signaling Source: UniProtKB
- cellular protein metabolic process Source: Reactome
- cochlea development Source: Ensembl
- constitutive protein ectodomain proteolysis Source: UniProtKB
- extracellular matrix disassembly Source: Reactome
- integrin-mediated signaling pathway Source: UniProtKB
- in utero embryonic development Source: UniProtKB
- membrane protein ectodomain proteolysis Source: UniProtKB
- monocyte activation Source: BHF-UCL
- negative regulation of apoptotic process Source: ARUK-UCL
- negative regulation of cell adhesion Source: UniProtKB
- negative regulation of cell cycle arrest Source: ARUK-UCL
- negative regulation of gene expression Source: ARUK-UCL
- neutrophil degranulation Source: Reactome
- Notch receptor processing, ligand-dependent Source: Reactome
- Notch signaling pathway Source: UniProtKB
- pore complex assembly Source: UniProtKB
- positive regulation of apoptotic process Source: Ensembl
- positive regulation of cell growth Source: BHF-UCL
- positive regulation of cell migration Source: BHF-UCL
- positive regulation of cell population proliferation Source: BHF-UCL
- positive regulation of T cell chemotaxis Source: BHF-UCL
- postsynapse organization Source: Ensembl
- post-translational protein modification Source: Reactome
- protein phosphorylation Source: UniProtKB
- protein processing Source: Ensembl
- regulation of dendritic spine morphogenesis Source: Ensembl
- regulation of neurotransmitter receptor localization to postsynaptic specialization membrane Source: Ensembl
- regulation of Notch signaling pathway Source: Ensembl
- regulation of vasculature development Source: Ensembl
- response to antineoplastic agent Source: Ensembl
- response to tumor necrosis factor Source: BHF-UCL
- spermatogenesis Source: Ensembl
- toxin transport Source: UniProtKB
Keywordsi
Molecular function | Hydrolase, Metalloprotease, Protease |
Biological process | Notch signaling pathway |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
BioCyci | MetaCyc:ENSG00000137845-MONOMER |
BRENDAi | 3.4.24.81, 2681 |
PathwayCommonsi | O14672 |
Reactomei | R-HSA-1442490, Collagen degradation R-HSA-1474228, Degradation of the extracellular matrix R-HSA-177929, Signaling by EGFR R-HSA-2122948, Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2644606, Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2660826, Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2691232, Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2894862, Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2979096, NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-3928665, EPH-ephrin mediated repulsion of cells R-HSA-6798695, Neutrophil degranulation R-HSA-8957275, Post-translational protein phosphorylation R-HSA-9013507, NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013700, NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-977225, Amyloid fiber formation |
SignaLinki | O14672 |
SIGNORi | O14672 |
Protein family/group databases
MEROPSi | M12.210 |
TCDBi | 8.A.77.1.4, the sheddase (sheddase) family |
Names & Taxonomyi
Protein namesi | Recommended name: Disintegrin and metalloproteinase domain-containing protein 10 (EC:3.4.24.817 Publications)Short name: ADAM 10 Alternative name(s): CDw156 Kuzbanian protein homolog Mammalian disintegrin-metalloprotease CD_antigen: CD156c |
Gene namesi | Name:ADAM10 Synonyms:KUZ, MADM |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:188, ADAM10 |
MIMi | 602192, gene |
neXtProti | NX_O14672 |
VEuPathDBi | HostDB:ENSG00000137845.14 |
Subcellular locationi
Plasma membrane
- Cell membrane 6 Publications; Single-pass type I membrane protein Curated
Golgi apparatus
- Golgi apparatus membrane 1 Publication; Single-pass type I membrane protein Curated
Other locations
- clathrin-coated vesicle 1 Publication
- axon By similarity
- dendrite By similarity
- adherens junction 1 Publication
- Cytoplasm 1 Publication
Note: Is localized in the plasma membrane but is also expressed in the Golgi apparatus and in clathrin-coated vesicles derived likely from the Golgi (PubMed:12475894). During long term depression, it is recruited to the cell membrane by DLG1 (PubMed:23676497). The immature form is mainly located near cytoplasmic fibrillar structures, while the mature form is predominantly located at zonula adherens and the cell membrane (PubMed:30463011). The localization and clustering of mature ADAM10 to zonula adherens is regulated by AFDN, TSPAN33, PLEKHA7 and PDZD11 (PubMed:30463011).3 Publications
Endoplasmic reticulum
- endoplasmic reticulum lumen Source: Reactome
- perinuclear endoplasmic reticulum Source: UniProtKB
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Golgi apparatus
- Golgi apparatus Source: UniProtKB
- Golgi membrane Source: UniProtKB-SubCell
- trans-Golgi network Source: Ensembl
Nucleus
- nucleus Source: UniProtKB
Plasma Membrane
- plasma membrane Source: HPA
- postsynaptic membrane Source: Ensembl
- synaptic membrane Source: UniProtKB
- tetraspanin-enriched microdomain Source: UniProtKB
Other locations
- adherens junction Source: UniProtKB-SubCell
- axon Source: UniProtKB-SubCell
- cell surface Source: UniProtKB
- clathrin-coated vesicle Source: UniProtKB-SubCell
- cytoplasm Source: UniProtKB
- dendritic spine Source: Ensembl
- focal adhesion Source: UniProtKB
- glutamatergic synapse Source: Ensembl
- Golgi-associated vesicle Source: UniProtKB
- integral component of membrane Source: UniProtKB
- intracellular membrane-bounded organelle Source: HPA
- membrane Source: UniProtKB
- neuronal cell body Source: Ensembl
- pore complex Source: UniProtKB
- postsynaptic density Source: Ensembl
- specific granule membrane Source: Reactome
- synaptic vesicle Source: Ensembl
- tertiary granule membrane Source: Reactome
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 20 – 672 | ExtracellularSequence analysisAdd BLAST | 653 | |
Transmembranei | 673 – 693 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 694 – 748 | CytoplasmicSequence analysisAdd BLAST | 55 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, MembranePathology & Biotechi
Involvement in diseasei
Reticulate acropigmentation of Kitamura (RAK)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_070907 | 139 | P → S in RAK. 1 PublicationCorresponds to variant dbSNP:rs483352912EnsemblClinVar. | 1 | |
Natural variantiVAR_070910 | 524 | C → Y in RAK. 1 PublicationCorresponds to variant dbSNP:rs483352916EnsemblClinVar. | 1 |
Alzheimer disease 18 (AD18)2 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_070908 | 170 | Q → H in AD18; associated with disease susceptibility; significantly attenuates alpha-secretase activity of the enzyme; shifts APP processing toward beta-secretase-mediated cleavage resulting in enhanced amyloid-beta plaque load and reactive gliosis. 2 PublicationsCorresponds to variant dbSNP:rs61751103EnsemblClinVar. | 1 | |
Natural variantiVAR_070909 | 181 | R → G in AD18; associated with disease susceptibility; significantly attenuates alpha-secretase activity of the enzyme; shifts APP processing toward beta-secretase-mediated cleavage resulting in enhanced amyloid-beta plaque load and reactive gliosis. 2 PublicationsCorresponds to variant dbSNP:rs145518263EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 384 | E → A: Abrogates APP cleavage. Reduces Notch signaling. Loss of proteolytic activity. 2 Publications | 1 |
Keywords - Diseasei
Alzheimer disease, Amyloidosis, Disease variant, NeurodegenerationOrganism-specific databases
DisGeNETi | 102 |
MalaCardsi | ADAM10 |
MIMi | 615537, phenotype 615590, phenotype |
NIAGADSi | ENSG00000137845 |
OpenTargetsi | ENSG00000137845 |
Orphaneti | 178307, Reticulate acropigmentation of Kitamura |
PharmGKBi | PA24505 |
Miscellaneous databases
Pharosi | O14672, Tchem |
Chemistry databases
ChEMBLi | CHEMBL5028 |
DrugBanki | DB04991, XL784 |
GuidetoPHARMACOLOGYi | 1658 |
Genetic variation databases
BioMutai | ADAM10 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Sequence analysisAdd BLAST | 19 | |
PropeptideiPRO_0000029066 | 20 – 213 | By similarityAdd BLAST | 194 | |
ChainiPRO_0000029067 | 214 – 748 | Disintegrin and metalloproteinase domain-containing protein 10Add BLAST | 535 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 222 ↔ 313 | Combined sources1 Publication | ||
Glycosylationi | 267 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 278 | N-linked (GlcNAc...) asparagineCombined sources4 Publications | 1 | |
Disulfide bondi | 344 ↔ 451 | Combined sources1 Publication | ||
Disulfide bondi | 399 ↔ 435 | Combined sources1 Publication | ||
Glycosylationi | 439 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 460 ↔ 495 | Combined sources1 Publication | ||
Disulfide bondi | 471 ↔ 484 | Combined sources1 Publication | ||
Disulfide bondi | 473 ↔ 479 | Combined sources1 Publication | ||
Disulfide bondi | 483 ↔ 515 | Combined sources1 Publication | ||
Disulfide bondi | 503 ↔ 511 | Combined sources1 Publication | ||
Disulfide bondi | 510 ↔ 536 | Combined sources1 Publication | ||
Disulfide bondi | 524 ↔ 543 | Combined sources1 Publication | ||
Disulfide bondi | 530 ↔ 562 | Combined sources1 Publication | ||
Glycosylationi | 551 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 555 ↔ 567 | Combined sources1 Publication | ||
Disulfide bondi | 572 ↔ 598 | Combined sources1 Publication | ||
Disulfide bondi | 580 ↔ 607 | Combined sources1 Publication | ||
Disulfide bondi | 582 ↔ 597 | Combined sources1 Publication | ||
Disulfide bondi | 594 ↔ 639 | Combined sources1 Publication | ||
Disulfide bondi | 632 ↔ 645 | Combined sources1 Publication | ||
Modified residuei | 719 | Phosphothreonine; by FAM20CCombined sources1 Publication | 1 |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 213 – 214 | Cleavage; by furin and PCSK7By similarity | 2 |
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Phosphoprotein, ZymogenProteomic databases
EPDi | O14672 |
jPOSTi | O14672 |
MassIVEi | O14672 |
MaxQBi | O14672 |
PaxDbi | O14672 |
PeptideAtlasi | O14672 |
PRIDEi | O14672 |
ProteomicsDBi | 48162 [O14672-1] 5144 |
PTM databases
GlyConnecti | 1178, 5 N-Linked glycans (2 sites) |
GlyGeni | O14672, 7 sites, 1 O-linked glycan (1 site) |
iPTMneti | O14672 |
PhosphoSitePlusi | O14672 |
SwissPalmi | O14672 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000137845, Expressed in testis and 251 other tissues |
ExpressionAtlasi | O14672, baseline and differential |
Genevisiblei | O14672, HS |
Organism-specific databases
HPAi | ENSG00000137845, Low tissue specificity |
Interactioni
Subunit structurei
Forms a ternary EFNA5-EPHA3-ADAM10 complex mediating EFNA5 extracellular domain shedding by ADAM10 which regulates the EFNA5-EPHA3 complex internalization and function, the cleavage occurs in trans, with ADAM10 and its substrate being on the membranes of opposing cells (PubMed:16239146).
Interacts with the clathrin adapter AP2 complex subunits AP2A1, AP2A2, AP2B1, and AP2M1; this interaction facilitates ADAM10 endocytosis from the plasma membrane during long-term potentiation in hippocampal neurons (PubMed:23676497).
Interacts (via extracellular domain) with TSPAN33 (via extracellular domain) and (via cytoplasmic domain) with AFDN; interaction with TSPAN33 allows the docking of ADAM10 to zonula adherens through a PDZ11-dependent interaction between TSPAN33 and PLEKHA7 while interaction with AFDN locks ADAM10 at zonula adherens (PubMed:30463011).
Forms a ternary complex composed of ADAM10, EPHA4 and CADH1; within the complex, ADAM10 cleaves CADH1 which disrupts adherens junctions (By similarity).
Interacts with EPHA2 (By similarity).
Interacts with NGF in a divalent cation-dependent manner (PubMed:20164177).
Interacts with TSPAN14; the interaction promotes ADAM10 maturation and cell surface expression (PubMed:26686862, PubMed:26668317).
Interacts with TSPAN5, TSPAN10, TSPAN15, TSPAN17 and TSPAN33; these interactions regulate ADAM10 substrate specificity (PubMed:26686862).
Interacts with DLG1; this interaction recruits ADAM10 to the cell membrane during long-term depression in hippocampal neurons (PubMed:23676497).
Interacts (via extracellular domain) with BACE1 (via extracellular domain) (By similarity).
Interacts with FAM171A1 (PubMed:30312582).
By similarity7 Publications(Microbial infection) Interacts with S.aureus hly; this interaction is necessary for toxin pore formation, disruption of focal adhesions and S.aureus hly-mediated cytotoxicity.
2 PublicationsBinary interactionsi
Hide detailsO14672
Disintegrin and metalloproteinase domain-containing protein 10 (PRO_0000029067)
With | #Exp. | IntAct |
---|---|---|
CD81 [P60033] | 2 | EBI-21222747,EBI-712921 |
TSPAN12 [O95859] | 2 | EBI-21222747,EBI-2466403 |
GO - Molecular functioni
- integrin binding Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
- protein kinase binding Source: UniProtKB
- SH3 domain binding Source: UniProtKB-KW
- signaling receptor binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 106616, 49 interactors |
DIPi | DIP-39889N |
IntActi | O14672, 102 interactors |
MINTi | O14672 |
STRINGi | 9606.ENSP00000260408 |
Chemistry databases
BindingDBi | O14672 |
Miscellaneous databases
RNActi | O14672, protein |
Structurei
Secondary structure
3D structure databases
SMRi | O14672 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 220 – 456 | Peptidase M12BPROSITE-ProRule annotationAdd BLAST | 237 | |
Domaini | 457 – 551 | DisintegrinPROSITE-ProRule annotationAdd BLAST | 95 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 734 – 748 | Interaction with AP2A1, AP2A2 and AP2M1By similarityAdd BLAST | 15 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 171 – 178 | Cysteine switchBy similarity | 8 | |
Motifi | 708 – 715 | SH3-bindingSequence analysis | 8 | |
Motifi | 722 – 728 | SH3-bindingSequence analysis | 7 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 555 – 673 | Cys-richCuratedAdd BLAST | 119 |
Domaini
Keywords - Domaini
SH3-binding, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3658, Eukaryota |
GeneTreei | ENSGT00940000160579 |
HOGENOMi | CLU_004602_0_0_1 |
InParanoidi | O14672 |
OMAi | YTGHIYV |
PhylomeDBi | O14672 |
TreeFami | TF352021 |
Family and domain databases
CDDi | cd04270, ZnMc_TACE_like, 1 hit |
DisProti | DP02318 |
Gene3Di | 3.40.390.10, 1 hit 4.10.70.10, 1 hit |
InterProi | View protein in InterPro IPR034025, ADAM10_ADAM17 IPR027053, ADAM_10 IPR001762, Disintegrin_dom IPR036436, Disintegrin_dom_sf IPR024079, MetalloPept_cat_dom_sf IPR001590, Peptidase_M12B IPR002870, Peptidase_M12B_N |
PANTHERi | PTHR45702:SF4, PTHR45702:SF4, 1 hit |
Pfami | View protein in Pfam PF00200, Disintegrin, 1 hit PF01562, Pep_M12B_propep, 1 hit |
SMARTi | View protein in SMART SM00050, DISIN, 1 hit |
SUPFAMi | SSF57552, SSF57552, 1 hit |
PROSITEi | View protein in PROSITE PS50215, ADAM_MEPRO, 1 hit PS50214, DISINTEGRIN_2, 1 hit PS00142, ZINC_PROTEASE, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MVLLRVLILL LSWAAGMGGQ YGNPLNKYIR HYEGLSYNVD SLHQKHQRAK
60 70 80 90 100
RAVSHEDQFL RLDFHAHGRH FNLRMKRDTS LFSDEFKVET SNKVLDYDTS
110 120 130 140 150
HIYTGHIYGE EGSFSHGSVI DGRFEGFIQT RGGTFYVEPA ERYIKDRTLP
160 170 180 190 200
FHSVIYHEDD INYPHKYGPQ GGCADHSVFE RMRKYQMTGV EEVTQIPQEE
210 220 230 240 250
HAANGPELLR KKRTTSAEKN TCQLYIQTDH LFFKYYGTRE AVIAQISSHV
260 270 280 290 300
KAIDTIYQTT DFSGIRNISF MVKRIRINTT ADEKDPTNPF RFPNIGVEKF
310 320 330 340 350
LELNSEQNHD DYCLAYVFTD RDFDDGVLGL AWVGAPSGSS GGICEKSKLY
360 370 380 390 400
SDGKKKSLNT GIITVQNYGS HVPPKVSHIT FAHEVGHNFG SPHDSGTECT
410 420 430 440 450
PGESKNLGQK ENGNYIMYAR ATSGDKLNNN KFSLCSIRNI SQVLEKKRNN
460 470 480 490 500
CFVESGQPIC GNGMVEQGEE CDCGYSDQCK DECCFDANQP EGRKCKLKPG
510 520 530 540 550
KQCSPSQGPC CTAQCAFKSK SEKCRDDSDC AREGICNGFT ALCPASDPKP
560 570 580 590 600
NFTDCNRHTQ VCINGQCAGS ICEKYGLEEC TCASSDGKDD KELCHVCCMK
610 620 630 640 650
KMDPSTCAST GSVQWSRHFS GRTITLQPGS PCNDFRGYCD VFMRCRLVDA
660 670 680 690 700
DGPLARLKKA IFSPELYENI AEWIVAHWWA VLLMGIALIM LMAGFIKICS
710 720 730 740
VHTPSSNPKL PPPKPLPGTL KRRRPPQPIQ QPQRQRPRES YQMGHMRR
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YNC5 | H0YNC5_HUMAN | Mammalian disintegrin-metalloprotea... | ADAM10 | 148 | Annotation score: | ||
C9J9B4 | C9J9B4_HUMAN | Disintegrin and metalloproteinase d... | ADAM10 | 125 | Annotation score: | ||
B5MC71 | B5MC71_HUMAN | Disintegrin and metalloproteinase d... | ADAM10 | 71 | Annotation score: | ||
H0YK87 | H0YK87_HUMAN | Disintegrin and metalloproteinase d... | ADAM10 | 115 | Annotation score: | ||
H3BS53 | H3BS53_HUMAN | Disintegrin and metalloproteinase d... | ADAM10 | 58 | Annotation score: | ||
H0YK32 | H0YK32_HUMAN | Disintegrin and metalloproteinase d... | ADAM10 | 38 | Annotation score: | ||
A0A087WYG1 | A0A087WYG1_HUMAN | Disintegrin and metalloproteinase d... | ADAM10 | 59 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 162 | N → SERLKLRLRKLMSLELWTSC CLPCALLLHSWKKAVNSHCL YFKDFWGFSEIY in CAA88463 (PubMed:8694785).Curated | 1 | |
Sequence conflicti | 212 | K → R in CAA88463 (PubMed:8694785).Curated | 1 | |
Sequence conflicti | 296 | G → S in CAA88463 (PubMed:8694785).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_070907 | 139 | P → S in RAK. 1 PublicationCorresponds to variant dbSNP:rs483352912EnsemblClinVar. | 1 | |
Natural variantiVAR_070908 | 170 | Q → H in AD18; associated with disease susceptibility; significantly attenuates alpha-secretase activity of the enzyme; shifts APP processing toward beta-secretase-mediated cleavage resulting in enhanced amyloid-beta plaque load and reactive gliosis. 2 PublicationsCorresponds to variant dbSNP:rs61751103EnsemblClinVar. | 1 | |
Natural variantiVAR_066309 | 176 | H → Y in a cutaneous metastatic melanoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs267604273Ensembl. | 1 | |
Natural variantiVAR_070909 | 181 | R → G in AD18; associated with disease susceptibility; significantly attenuates alpha-secretase activity of the enzyme; shifts APP processing toward beta-secretase-mediated cleavage resulting in enhanced amyloid-beta plaque load and reactive gliosis. 2 PublicationsCorresponds to variant dbSNP:rs145518263EnsemblClinVar. | 1 | |
Natural variantiVAR_070910 | 524 | C → Y in RAK. 1 PublicationCorresponds to variant dbSNP:rs483352916EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056401 | 19 – 319 | Missing in isoform 2. 1 PublicationAdd BLAST | 301 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF009615 mRNA Translation: AAC51766.1 AK300472 mRNA Translation: BAG62190.1 AC018904 Genomic DNA No translation available. AC091046 Genomic DNA No translation available. Z48579 mRNA Translation: CAA88463.1 |
CCDSi | CCDS10167.1 [O14672-1] |
RefSeqi | NP_001101.1, NM_001110.3 [O14672-1] |
Genome annotation databases
Ensembli | ENST00000260408; ENSP00000260408; ENSG00000137845 [O14672-1] |
GeneIDi | 102 |
KEGGi | hsa:102 |
UCSCi | uc002afd.3, human [O14672-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF009615 mRNA Translation: AAC51766.1 AK300472 mRNA Translation: BAG62190.1 AC018904 Genomic DNA No translation available. AC091046 Genomic DNA No translation available. Z48579 mRNA Translation: CAA88463.1 |
CCDSi | CCDS10167.1 [O14672-1] |
RefSeqi | NP_001101.1, NM_001110.3 [O14672-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1M1I | model | - | A | 207-453 | [»] | |
6BDZ | X-ray | 3.10 | A | 220-654 | [»] | |
6BE6 | X-ray | 2.80 | A/B/C/D | 214-654 | [»] | |
SMRi | O14672 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 106616, 49 interactors |
DIPi | DIP-39889N |
IntActi | O14672, 102 interactors |
MINTi | O14672 |
STRINGi | 9606.ENSP00000260408 |
Chemistry databases
BindingDBi | O14672 |
ChEMBLi | CHEMBL5028 |
DrugBanki | DB04991, XL784 |
GuidetoPHARMACOLOGYi | 1658 |
Protein family/group databases
MEROPSi | M12.210 |
TCDBi | 8.A.77.1.4, the sheddase (sheddase) family |
PTM databases
GlyConnecti | 1178, 5 N-Linked glycans (2 sites) |
GlyGeni | O14672, 7 sites, 1 O-linked glycan (1 site) |
iPTMneti | O14672 |
PhosphoSitePlusi | O14672 |
SwissPalmi | O14672 |
Genetic variation databases
BioMutai | ADAM10 |
Proteomic databases
EPDi | O14672 |
jPOSTi | O14672 |
MassIVEi | O14672 |
MaxQBi | O14672 |
PaxDbi | O14672 |
PeptideAtlasi | O14672 |
PRIDEi | O14672 |
ProteomicsDBi | 48162 [O14672-1] 5144 |
Protocols and materials databases
ABCDi | O14672, 29 sequenced antibodies |
Antibodypediai | 3441, 562 antibodies |
Genome annotation databases
Ensembli | ENST00000260408; ENSP00000260408; ENSG00000137845 [O14672-1] |
GeneIDi | 102 |
KEGGi | hsa:102 |
UCSCi | uc002afd.3, human [O14672-1] |
Organism-specific databases
CTDi | 102 |
DisGeNETi | 102 |
GeneCardsi | ADAM10 |
HGNCi | HGNC:188, ADAM10 |
HPAi | ENSG00000137845, Low tissue specificity |
MalaCardsi | ADAM10 |
MIMi | 602192, gene 615537, phenotype 615590, phenotype |
neXtProti | NX_O14672 |
NIAGADSi | ENSG00000137845 |
OpenTargetsi | ENSG00000137845 |
Orphaneti | 178307, Reticulate acropigmentation of Kitamura |
PharmGKBi | PA24505 |
VEuPathDBi | HostDB:ENSG00000137845.14 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3658, Eukaryota |
GeneTreei | ENSGT00940000160579 |
HOGENOMi | CLU_004602_0_0_1 |
InParanoidi | O14672 |
OMAi | YTGHIYV |
PhylomeDBi | O14672 |
TreeFami | TF352021 |
Enzyme and pathway databases
BioCyci | MetaCyc:ENSG00000137845-MONOMER |
BRENDAi | 3.4.24.81, 2681 |
PathwayCommonsi | O14672 |
Reactomei | R-HSA-1442490, Collagen degradation R-HSA-1474228, Degradation of the extracellular matrix R-HSA-177929, Signaling by EGFR R-HSA-2122948, Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2644606, Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2660826, Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2691232, Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2894862, Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2979096, NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-3928665, EPH-ephrin mediated repulsion of cells R-HSA-6798695, Neutrophil degranulation R-HSA-8957275, Post-translational protein phosphorylation R-HSA-9013507, NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013700, NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-977225, Amyloid fiber formation |
SignaLinki | O14672 |
SIGNORi | O14672 |
Miscellaneous databases
BioGRID-ORCSi | 102, 21 hits in 880 CRISPR screens |
ChiTaRSi | ADAM10, human |
GeneWikii | ADAM10 |
GenomeRNAii | 102 |
Pharosi | O14672, Tchem |
PROi | PR:O14672 |
RNActi | O14672, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000137845, Expressed in testis and 251 other tissues |
ExpressionAtlasi | O14672, baseline and differential |
Genevisiblei | O14672, HS |
Family and domain databases
CDDi | cd04270, ZnMc_TACE_like, 1 hit |
DisProti | DP02318 |
Gene3Di | 3.40.390.10, 1 hit 4.10.70.10, 1 hit |
InterProi | View protein in InterPro IPR034025, ADAM10_ADAM17 IPR027053, ADAM_10 IPR001762, Disintegrin_dom IPR036436, Disintegrin_dom_sf IPR024079, MetalloPept_cat_dom_sf IPR001590, Peptidase_M12B IPR002870, Peptidase_M12B_N |
PANTHERi | PTHR45702:SF4, PTHR45702:SF4, 1 hit |
Pfami | View protein in Pfam PF00200, Disintegrin, 1 hit PF01562, Pep_M12B_propep, 1 hit |
SMARTi | View protein in SMART SM00050, DISIN, 1 hit |
SUPFAMi | SSF57552, SSF57552, 1 hit |
PROSITEi | View protein in PROSITE PS50215, ADAM_MEPRO, 1 hit PS50214, DISINTEGRIN_2, 1 hit PS00142, ZINC_PROTEASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ADA10_HUMAN | |
Accessioni | O14672Primary (citable) accession number: O14672 Secondary accession number(s): B4DU28, Q10742, Q92650 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 28, 2003 |
Last sequence update: | January 1, 1998 | |
Last modified: | February 10, 2021 | |
This is version 208 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries - Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references