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UniProtKB - O14662 (STX16_HUMAN)

Entry version 183 (13 Feb 2019)
Sequence version 3 (24 Jan 2006)
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Protein

Syntaxin-16

Gene

STX16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • SNAP receptor activity Source: HGNC
  • SNARE binding Source: GO_Central
  • syntaxin binding Source: UniProtKB
View the complete GO annotation on QuickGO ...

GO - Biological processi

  • Golgi ribbon formation Source: UniProtKB
  • intracellular protein transport Source: GO_Central
  • retrograde transport, endosome to Golgi Source: UniProtKB
  • vesicle docking Source: GO_Central
  • vesicle fusion Source: GO_Central
View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-6811438 Intra-Golgi traffic
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network

SIGNOR Signaling Network Open Resource

More...SIGNORi		O14662

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Syntaxin-16
Short name:
Syn16
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:STX16
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000124222.21

Human Gene Nomenclature Database

More...HGNCi		HGNC:11431 STX16

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603666 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O14662

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 301CytoplasmicSequence analysisAdd BLAST301
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei302 – 322Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini323 – 325VesicularSequence analysis3

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Pseudohypoparathyroidism 1B (PHP1B)2 Publications
The gene represented in this entry is involved in disease pathogenesis. Microdeletions involving STX16 can cause loss of methylation at exon A/B of GNAS, resulting in PHP1B.
Disease descriptionA disorder characterized by end-organ resistance to parathyroid hormone, hypocalcemia and hyperphosphatemia. Patients affected with PHP1B lack developmental defects characteristic of Albright hereditary osteodystrophy, and typically show no other endocrine abnormalities besides resistance to PTH.
See also OMIM:603233

Organism-specific databases

DisGeNET

More...DisGeNETi		8675

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		STX16

MalaCards human disease database

More...MalaCardsi		STX16
MIMi603233 phenotype

Open Targets

More...OpenTargetsi		ENSG00000124222

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		94089 Pseudohypoparathyroidism type 1B

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36231

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		STX16

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002102261 – 325Syntaxin-16Add BLAST325

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei41PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O14662

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O14662

MaxQB - The MaxQuant DataBase

More...MaxQBi		O14662

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O14662

PeptideAtlas

More...PeptideAtlasi		O14662

PRoteomics IDEntifications database

More...PRIDEi		O14662

ProteomicsDB human proteome resource

More...ProteomicsDBi		48155
48156 [O14662-2]
48157 [O14662-3]
48158 [O14662-4]
48159 [O14662-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O14662

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O14662

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000124222 Expressed in 232 organ(s), highest expression level in corpus callosum

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O14662 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O14662 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA041019
HPA042033

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with GCC2 (PubMed:18195106). Interacts with BAIAP3; this interaction is increased in the presence of calcium (PubMed:28626000).2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		114223, 21 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		O14662

Database of interacting proteins

More...DIPi		DIP-57570N

Protein interaction database and analysis system

More...IntActi		O14662, 20 interactors

Molecular INTeraction database

More...MINTi		O14662

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000360183

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		O14662

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O14662

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini230 – 292t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST63

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the syntaxin family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0809 Eukaryota
COG5325 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153718

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000190358

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG057612

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O14662

KEGG Orthology (KO)

More...KOi		K08489

Identification of Orthologs from Complete Genome Data

More...OMAi		TKGFHDC

Database of Orthologous Groups

More...OrthoDBi		1182451at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O14662

TreeFam database of animal gene trees

More...TreeFami		TF314090

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR010989 SNARE
IPR028673 STX16
IPR006012 Syntaxin/epimorphin_CS
IPR006011 Syntaxin_N
IPR000727 T_SNARE_dom

The PANTHER Classification System

More...PANTHERi		PTHR19957:SF141 PTHR19957:SF141, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05739 SNARE, 1 hit
PF00804 Syntaxin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00397 t_SNARE, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47661 SSF47661, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00914 SYNTAXIN, 1 hit
PS50192 T_SNARE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform B (identifier: O14662-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATRRLTDAF LLLRNNSIQN RQLLAEQVSS HITSSPLHSR SIAAELDELA 
        60         70         80         90        100
DDRMALVSGI SLDPEAAIGV TKRPPPKWVD GVDEIQYDVG RIKQKMKELA 
       110        120        130        140        150
SLHDKHLNRP TLDDSSEEEH AIEITTQEIT QLFHRCQRAV QALPSRARAC 
       160        170        180        190        200
SEQEGRLLGN VVASLAQALQ ELSTSFRHAQ SGYLKRMKNR EERSQHFFDT 
       210        220        230        240        250
SVPLMDDGDD NTLYHRGFTE DQLVLVEQNT LMVEEREREI RQIVQSISDL 
       260        270        280        290        300
NEIFRDLGAM IVEQGTVLDR IDYNVEQSCI KTEDGLKQLH KAEQYQKKNR 
       310        320 
KMLVILILFV IIIVLIVVLV GVKSR
Length:325
Mass (Da):37,031
Last modified:January 24, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i65F566541A042C3C
GO
Isoform A (identifier: O14662-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     28-48: Missing.

Show »
Length:304
Mass (Da):34,813
Checksum:i9EEF54F753B7AB83
GO
Isoform C (identifier: O14662-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     28-44: Missing.
     132-132: L → A
     133-325: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:115
Mass (Da):13,018
Checksum:i51BBBACE2158720E
GO
Isoform D (identifier: O14662-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     28-44: Missing.

Show »
Length:308
Mass (Da):35,299
Checksum:i1915107ACB686EAA
GO
Isoform E (identifier: O14662-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     45-48: Missing.

Show »
Length:321
Mass (Da):36,545
Checksum:i9F8316610F6C97C0
GO
Isoform 6 (identifier: O14662-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: Missing.

Note: No experimental confirmation available.
Show »
Length:272
Mass (Da):31,074
Checksum:i8EE1A85AE716237C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7ZBM8B7ZBM8_HUMAN
Syntaxin-16
STX16
219Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W9Z6F8W9Z6_HUMAN
Syntaxin-16
STX16
204Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B7ZBM5B7ZBM5_HUMAN
Syntaxin-16
STX16
122Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B7ZBM4B7ZBM4_HUMAN
Syntaxin-16
STX16
120Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q96NX8Q96NX8_HUMAN
Syntaxin-16D
STX16
202Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YEW0H0YEW0_HUMAN
Syntaxin-16
STX16
126Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PND6E9PND6_HUMAN
Syntaxin-16
STX16
79Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PLV7E9PLV7_HUMAN
Syntaxin-16
STX16
46Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB69282 differs from that shown. Reason: Frameshift at positions 142, 163 and 165.Curated
The sequence AAB69283 differs from that shown. Reason: Frameshift at positions 142, 163 and 165.Curated
The sequence AAC05647 differs from that shown. Reason: Frameshift at positions 142, 163 and 165.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti99L → S in AAB69282 (PubMed:9587053).Curated1
Sequence conflicti99L → S in AAB69283 (PubMed:9587053).Curated1
Sequence conflicti147A → E in AAC05647 (PubMed:9587053).Curated1
Sequence conflicti243I → M in AAB69282 (PubMed:9587053).Curated1
Sequence conflicti243I → M in AAB69283 (PubMed:9587053).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0450731 – 53Missing in isoform 6. 1 PublicationAdd BLAST53
Alternative sequenceiVSP_00634828 – 48Missing in isoform A. 2 PublicationsAdd BLAST21
Alternative sequenceiVSP_00634928 – 44Missing in isoform C and isoform D. 2 PublicationsAdd BLAST17
Alternative sequenceiVSP_04384945 – 48Missing in isoform E. 1 Publication4
Alternative sequenceiVSP_006350132L → A in isoform C. 1 Publication1
Alternative sequenceiVSP_006351133 – 325Missing in isoform C. 1 PublicationAdd BLAST193

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF008936 mRNA Translation: AAB69283.1 Frameshift.
AF008935 mRNA Translation: AAB69282.1 Frameshift.
AF008937 mRNA Translation: AAB69284.1
AF038897 mRNA Translation: AAC05647.1 Frameshift.
AL139349 Genomic DNA No translation available.
AL050327 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75481.1
CH471077 Genomic DNA Translation: EAW75482.1
CH471077 Genomic DNA Translation: EAW75484.1
CH471077 Genomic DNA Translation: EAW75485.1
CH471077 Genomic DNA Translation: EAW75486.1
BC019042 mRNA Translation: AAH19042.1
BC073876 mRNA Translation: AAH73876.1
BX396221 mRNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS13468.1 [O14662-1]
CCDS13469.1 [O14662-2]
CCDS46619.1 [O14662-5]
CCDS46620.1 [O14662-4]
CCDS56199.1 [O14662-6]

Protein sequence database of the Protein Information Resource

More...PIRi		JC5927

NCBI Reference Sequences

More...RefSeqi		NP_001001433.1, NM_001001433.2 [O14662-1]
NP_001128244.1, NM_001134772.2 [O14662-5]
NP_001128245.1, NM_001134773.2 [O14662-4]
NP_001191797.1, NM_001204868.1 [O14662-6]
NP_003754.2, NM_003763.5 [O14662-2]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.307913

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000355957; ENSP00000348229; ENSG00000124222 [O14662-4]
ENST00000358029; ENSP00000350723; ENSG00000124222 [O14662-5]
ENST00000359617; ENSP00000352634; ENSG00000124222 [O14662-6]
ENST00000361830; ENSP00000354445; ENSG00000124222 [O14662-6]
ENST00000371132; ENSP00000360173; ENSG00000124222 [O14662-2]
ENST00000371141; ENSP00000360183; ENSG00000124222 [O14662-1]
ENST00000467096; ENSP00000434369; ENSG00000124222 [O14662-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		8675

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:8675

UCSC genome browser

More...UCSCi		uc002xzi.4 human [O14662-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF008936 mRNA Translation: AAB69283.1 Frameshift.
AF008935 mRNA Translation: AAB69282.1 Frameshift.
AF008937 mRNA Translation: AAB69284.1
AF038897 mRNA Translation: AAC05647.1 Frameshift.
AL139349 Genomic DNA No translation available.
AL050327 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75481.1
CH471077 Genomic DNA Translation: EAW75482.1
CH471077 Genomic DNA Translation: EAW75484.1
CH471077 Genomic DNA Translation: EAW75485.1
CH471077 Genomic DNA Translation: EAW75486.1
BC019042 mRNA Translation: AAH19042.1
BC073876 mRNA Translation: AAH73876.1
BX396221 mRNA No translation available.
CCDSiCCDS13468.1 [O14662-1]
CCDS13469.1 [O14662-2]
CCDS46619.1 [O14662-5]
CCDS46620.1 [O14662-4]
CCDS56199.1 [O14662-6]
PIRiJC5927
RefSeqiNP_001001433.1, NM_001001433.2 [O14662-1]
NP_001128244.1, NM_001134772.2 [O14662-5]
NP_001128245.1, NM_001134773.2 [O14662-4]
NP_001191797.1, NM_001204868.1 [O14662-6]
NP_003754.2, NM_003763.5 [O14662-2]
UniGeneiHs.307913

3D structure databases

ProteinModelPortaliO14662
SMRiO14662
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114223, 21 interactors
CORUMiO14662
DIPiDIP-57570N
IntActiO14662, 20 interactors
MINTiO14662
STRINGi9606.ENSP00000360183

PTM databases

iPTMnetiO14662
PhosphoSitePlusiO14662

Polymorphism and mutation databases

BioMutaiSTX16

Proteomic databases

EPDiO14662
jPOSTiO14662
MaxQBiO14662
PaxDbiO14662
PeptideAtlasiO14662
PRIDEiO14662
ProteomicsDBi48155
48156 [O14662-2]
48157 [O14662-3]
48158 [O14662-4]
48159 [O14662-5]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		8675
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355957; ENSP00000348229; ENSG00000124222 [O14662-4]
ENST00000358029; ENSP00000350723; ENSG00000124222 [O14662-5]
ENST00000359617; ENSP00000352634; ENSG00000124222 [O14662-6]
ENST00000361830; ENSP00000354445; ENSG00000124222 [O14662-6]
ENST00000371132; ENSP00000360173; ENSG00000124222 [O14662-2]
ENST00000371141; ENSP00000360183; ENSG00000124222 [O14662-1]
ENST00000467096; ENSP00000434369; ENSG00000124222 [O14662-3]
GeneIDi8675
KEGGihsa:8675
UCSCiuc002xzi.4 human [O14662-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8675
DisGeNETi8675
EuPathDBiHostDB:ENSG00000124222.21

GeneCards: human genes, protein and diseases

More...GeneCardsi		STX16
GeneReviewsiSTX16
HGNCiHGNC:11431 STX16
HPAiHPA041019
HPA042033
MalaCardsiSTX16
MIMi603233 phenotype
603666 gene
neXtProtiNX_O14662
OpenTargetsiENSG00000124222
Orphaneti94089 Pseudohypoparathyroidism type 1B
PharmGKBiPA36231

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0809 Eukaryota
COG5325 LUCA
GeneTreeiENSGT00940000153718
HOGENOMiHOG000190358
HOVERGENiHBG057612
InParanoidiO14662
KOiK08489
OMAiTKGFHDC
OrthoDBi1182451at2759
PhylomeDBiO14662
TreeFamiTF314090

Enzyme and pathway databases

ReactomeiR-HSA-6811438 Intra-Golgi traffic
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network
SIGNORiO14662

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		STX16 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		STX16

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		8675

Protein Ontology

More...PROi		PR:O14662

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000124222 Expressed in 232 organ(s), highest expression level in corpus callosum
ExpressionAtlasiO14662 baseline and differential
GenevisibleiO14662 HS

Family and domain databases

InterProiView protein in InterPro
IPR010989 SNARE
IPR028673 STX16
IPR006012 Syntaxin/epimorphin_CS
IPR006011 Syntaxin_N
IPR000727 T_SNARE_dom
PANTHERiPTHR19957:SF141 PTHR19957:SF141, 1 hit
PfamiView protein in Pfam
PF05739 SNARE, 1 hit
PF00804 Syntaxin, 1 hit
SMARTiView protein in SMART
SM00397 t_SNARE, 1 hit
SUPFAMiSSF47661 SSF47661, 1 hit
PROSITEiView protein in PROSITE
PS00914 SYNTAXIN, 1 hit
PS50192 T_SNARE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSTX16_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O14662
Secondary accession number(s): A6NK32
, A6NN69, A8MPP0, B7ZBN1, B7ZBN2, B7ZBN3, E1P5M0, E1P607, O14661, O14663, O60517, Q5W084, Q5W086, Q5W087, Q5XKI6, Q6GMS8, Q9H0Z0, Q9H1T7, Q9H1T8, Q9UIX5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: January 24, 2006
Last modified: February 13, 2019
This is version 183 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
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