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UniProtKB - O14662 (STX16_HUMAN)
Protein
Syntaxin-16
Gene
STX16
Organism
Homo sapiens (Human)
Status
Functioni
SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.
1 PublicationGO - Molecular functioni
- SNAP receptor activity Source: HGNC-UCL
- SNARE binding Source: GO_Central
- syntaxin binding Source: UniProtKB
GO - Biological processi
- Golgi ribbon formation Source: UniProtKB
- intracellular protein transport Source: GO_Central
- retrograde transport, endosome to Golgi Source: UniProtKB
- vesicle docking Source: GO_Central
- vesicle fusion Source: GO_Central
Keywordsi
Biological process | Protein transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | O14662 |
Reactomei | R-HSA-6811438, Intra-Golgi traffic R-HSA-6811440, Retrograde transport at the Trans-Golgi-Network |
SignaLinki | O14662 |
SIGNORi | O14662 |
Names & Taxonomyi
Protein namesi | Recommended name: Syntaxin-16Short name: Syn16 |
Gene namesi | Name:STX16 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11431, STX16 |
MIMi | 603666, gene |
neXtProti | NX_O14662 |
VEuPathDBi | HostDB:ENSG00000124222 |
Subcellular locationi
Golgi apparatus
Cytoplasm and Cytosol
Cytosol
- cytosol Source: UniProtKB
Golgi apparatus
- Golgi apparatus Source: UniProtKB
- Golgi cisterna Source: UniProtKB
- Golgi membrane Source: Reactome
- trans-Golgi network Source: UniProtKB
- trans-Golgi network membrane Source: Reactome
Other locations
- cytoplasm Source: UniProtKB
- endomembrane system Source: GO_Central
- focal adhesion Source: UniProtKB
- integral component of membrane Source: GO_Central
- intracellular membrane-bounded organelle Source: UniProtKB
- membrane Source: UniProtKB
- perinuclear region of cytoplasm Source: UniProtKB
- SNARE complex Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 301 | CytoplasmicSequence analysisAdd BLAST | 301 | |
Transmembranei | 302 – 322 | Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST | 21 | |
Topological domaini | 323 – 325 | VesicularSequence analysis | 3 |
Keywords - Cellular componenti
Cytoplasm, Golgi apparatus, MembranePathology & Biotechi
Involvement in diseasei
Pseudohypoparathyroidism 1B (PHP1B)2 Publications
The gene represented in this entry is involved in disease pathogenesis. Microdeletions involving STX16 can cause loss of methylation at exon A/B of GNAS, resulting in PHP1B.
Disease descriptionA disorder characterized by end-organ resistance to parathyroid hormone, hypocalcemia and hyperphosphatemia. Patients affected with PHP1B lack developmental defects characteristic of Albright hereditary osteodystrophy, and typically show no other endocrine abnormalities besides resistance to PTH.
Related information in OMIMOrganism-specific databases
DisGeNETi | 8675 |
GeneReviewsi | STX16 |
MalaCardsi | STX16 |
MIMi | 603233, phenotype |
OpenTargetsi | ENSG00000124222 |
Orphaneti | 94089, Pseudohypoparathyroidism type 1B |
PharmGKBi | PA36231 |
Miscellaneous databases
Pharosi | O14662, Tbio |
Genetic variation databases
BioMutai | STX16 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000210226 | 1 – 325 | Syntaxin-16Add BLAST | 325 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 41 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | O14662 |
jPOSTi | O14662 |
MassIVEi | O14662 |
MaxQBi | O14662 |
PaxDbi | O14662 |
PeptideAtlasi | O14662 |
PRIDEi | O14662 |
ProteomicsDBi | 15209 48155 [O14662-1] 48156 [O14662-2] 48157 [O14662-3] 48158 [O14662-4] 48159 [O14662-5] |
PTM databases
iPTMneti | O14662 |
PhosphoSitePlusi | O14662 |
Expressioni
Tissue specificityi
Ubiquitous.
Gene expression databases
Bgeei | ENSG00000124222, Expressed in corpus callosum and 243 other tissues |
ExpressionAtlasi | O14662, baseline and differential |
Genevisiblei | O14662, HS |
Organism-specific databases
HPAi | ENSG00000124222, Low tissue specificity |
Interactioni
Subunit structurei
Binary interactionsi
O14662
With | #Exp. | IntAct |
---|---|---|
MEOX2 [P50222] | 3 | EBI-2853548,EBI-748397 |
NAPB [Q9H115] | 3 | EBI-2853548,EBI-3921185 |
STX4 [Q12846] | 3 | EBI-2853548,EBI-744942 |
VAMP5 [O95183] | 4 | EBI-2853548,EBI-10191195 |
Isoform E [O14662-5]
GO - Molecular functioni
- SNARE binding Source: GO_Central
- syntaxin binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 114223, 47 interactors |
CORUMi | O14662 |
DIPi | DIP-57570N |
IntActi | O14662, 27 interactors |
MINTi | O14662 |
STRINGi | 9606.ENSP00000360183 |
Miscellaneous databases
RNActi | O14662, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 230 – 292 | t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST | 63 |
Sequence similaritiesi
Belongs to the syntaxin family.Curated
Keywords - Domaini
Coiled coil, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0809, Eukaryota |
GeneTreei | ENSGT01000000214380 |
HOGENOMi | CLU_038177_3_0_1 |
InParanoidi | O14662 |
OMAi | QTMIIDQ |
OrthoDBi | 1182451at2759 |
PhylomeDBi | O14662 |
TreeFami | TF314090 |
Family and domain databases
InterProi | View protein in InterPro IPR010989, SNARE IPR028673, STX16 IPR045242, Syntaxin IPR006012, Syntaxin/epimorphin_CS IPR006011, Syntaxin_N IPR000727, T_SNARE_dom |
PANTHERi | PTHR19957, PTHR19957, 1 hit PTHR19957:SF83, PTHR19957:SF83, 1 hit |
Pfami | View protein in Pfam PF05739, SNARE, 1 hit PF00804, Syntaxin, 1 hit |
SMARTi | View protein in SMART SM00397, t_SNARE, 1 hit |
SUPFAMi | SSF47661, SSF47661, 1 hit |
PROSITEi | View protein in PROSITE PS00914, SYNTAXIN, 1 hit PS50192, T_SNARE, 1 hit |
s (6+)i Sequence
Sequence statusi: Complete.
This entry describes 6 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 6 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All
Isoform B (identifier: O14662-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MATRRLTDAF LLLRNNSIQN RQLLAEQVSS HITSSPLHSR SIAAELDELA
60 70 80 90 100
DDRMALVSGI SLDPEAAIGV TKRPPPKWVD GVDEIQYDVG RIKQKMKELA
110 120 130 140 150
SLHDKHLNRP TLDDSSEEEH AIEITTQEIT QLFHRCQRAV QALPSRARAC
160 170 180 190 200
SEQEGRLLGN VVASLAQALQ ELSTSFRHAQ SGYLKRMKNR EERSQHFFDT
210 220 230 240 250
SVPLMDDGDD NTLYHRGFTE DQLVLVEQNT LMVEEREREI RQIVQSISDL
260 270 280 290 300
NEIFRDLGAM IVEQGTVLDR IDYNVEQSCI KTEDGLKQLH KAEQYQKKNR
310 320
KMLVILILFV IIIVLIVVLV GVKSR
Isoform C (identifier: O14662-3) [UniParc]FASTAAdd to basket
The sequence of this isoform differs from the canonical sequence as follows:
28-44: Missing.
132-132: L → A
133-325: Missing.
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB7ZBM8 | B7ZBM8_HUMAN | Syntaxin-16 | STX16 | 219 | Annotation score: | ||
F8W9Z6 | F8W9Z6_HUMAN | Syntaxin-16 | STX16 | 204 | Annotation score: | ||
B7ZBM5 | B7ZBM5_HUMAN | Syntaxin-16 | STX16 | 122 | Annotation score: | ||
B7ZBM4 | B7ZBM4_HUMAN | Syntaxin-16 | STX16 | 120 | Annotation score: | ||
H0YEW0 | H0YEW0_HUMAN | Syntaxin-16 | STX16 | 126 | Annotation score: | ||
Q96NX8 | Q96NX8_HUMAN | Syntaxin-16 | STX16 | 202 | Annotation score: | ||
E9PND6 | E9PND6_HUMAN | Syntaxin-16 | STX16 | 79 | Annotation score: | ||
E9PLV7 | E9PLV7_HUMAN | Syntaxin-16 | STX16 | 46 | Annotation score: |
Sequence cautioni
The sequence AAB69282 differs from that shown. Reason: Frameshift.Curated
The sequence AAB69283 differs from that shown. Reason: Frameshift.Curated
The sequence AAC05647 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 99 | L → S in AAB69282 (PubMed:9587053).Curated | 1 | |
Sequence conflicti | 99 | L → S in AAB69283 (PubMed:9587053).Curated | 1 | |
Sequence conflicti | 147 | A → E in AAC05647 (PubMed:9587053).Curated | 1 | |
Sequence conflicti | 243 | I → M in AAB69282 (PubMed:9587053).Curated | 1 | |
Sequence conflicti | 243 | I → M in AAB69283 (PubMed:9587053).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_045073 | 1 – 53 | Missing in isoform 6. 1 PublicationAdd BLAST | 53 | |
Alternative sequenceiVSP_006348 | 28 – 48 | Missing in isoform A. 2 PublicationsAdd BLAST | 21 | |
Alternative sequenceiVSP_006349 | 28 – 44 | Missing in isoform C and isoform D. 2 PublicationsAdd BLAST | 17 | |
Alternative sequenceiVSP_043849 | 45 – 48 | Missing in isoform E. 1 Publication | 4 | |
Alternative sequenceiVSP_006350 | 132 | L → A in isoform C. 1 Publication | 1 | |
Alternative sequenceiVSP_006351 | 133 – 325 | Missing in isoform C. 1 PublicationAdd BLAST | 193 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF008936 mRNA Translation: AAB69283.1 Frameshift. AF008935 mRNA Translation: AAB69282.1 Frameshift. AF008937 mRNA Translation: AAB69284.1 AF038897 mRNA Translation: AAC05647.1 Frameshift. AL139349 Genomic DNA No translation available. AL050327 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW75481.1 CH471077 Genomic DNA Translation: EAW75482.1 CH471077 Genomic DNA Translation: EAW75484.1 CH471077 Genomic DNA Translation: EAW75485.1 CH471077 Genomic DNA Translation: EAW75486.1 BC019042 mRNA Translation: AAH19042.1 BC073876 mRNA Translation: AAH73876.1 BX396221 mRNA No translation available. |
CCDSi | CCDS13468.1 [O14662-1] CCDS13469.1 [O14662-2] CCDS46619.1 [O14662-5] CCDS46620.1 [O14662-4] CCDS56199.1 [O14662-6] |
PIRi | JC5927 |
RefSeqi | NP_001001433.1, NM_001001433.2 [O14662-1] NP_001128244.1, NM_001134772.2 [O14662-5] NP_001128245.1, NM_001134773.2 [O14662-4] NP_001191797.1, NM_001204868.1 [O14662-6] NP_003754.2, NM_003763.5 [O14662-2] |
Genome annotation databases
Ensembli | ENST00000355957; ENSP00000348229; ENSG00000124222 [O14662-4] ENST00000358029; ENSP00000350723; ENSG00000124222 [O14662-5] ENST00000359617; ENSP00000352634; ENSG00000124222 [O14662-6] ENST00000361830; ENSP00000354445; ENSG00000124222 [O14662-6] ENST00000371132; ENSP00000360173; ENSG00000124222 [O14662-2] ENST00000371141; ENSP00000360183; ENSG00000124222 ENST00000467096; ENSP00000434369; ENSG00000124222 [O14662-3] |
GeneIDi | 8675 |
KEGGi | hsa:8675 |
MANE-Selecti | ENST00000371141.8; ENSP00000360183.4; NM_001001433.3; NP_001001433.1 |
UCSCi | uc002xzi.4, human [O14662-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF008936 mRNA Translation: AAB69283.1 Frameshift. AF008935 mRNA Translation: AAB69282.1 Frameshift. AF008937 mRNA Translation: AAB69284.1 AF038897 mRNA Translation: AAC05647.1 Frameshift. AL139349 Genomic DNA No translation available. AL050327 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW75481.1 CH471077 Genomic DNA Translation: EAW75482.1 CH471077 Genomic DNA Translation: EAW75484.1 CH471077 Genomic DNA Translation: EAW75485.1 CH471077 Genomic DNA Translation: EAW75486.1 BC019042 mRNA Translation: AAH19042.1 BC073876 mRNA Translation: AAH73876.1 BX396221 mRNA No translation available. |
CCDSi | CCDS13468.1 [O14662-1] CCDS13469.1 [O14662-2] CCDS46619.1 [O14662-5] CCDS46620.1 [O14662-4] CCDS56199.1 [O14662-6] |
PIRi | JC5927 |
RefSeqi | NP_001001433.1, NM_001001433.2 [O14662-1] NP_001128244.1, NM_001134772.2 [O14662-5] NP_001128245.1, NM_001134773.2 [O14662-4] NP_001191797.1, NM_001204868.1 [O14662-6] NP_003754.2, NM_003763.5 [O14662-2] |
3D structure databases
SMRi | O14662 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 114223, 47 interactors |
CORUMi | O14662 |
DIPi | DIP-57570N |
IntActi | O14662, 27 interactors |
MINTi | O14662 |
STRINGi | 9606.ENSP00000360183 |
PTM databases
iPTMneti | O14662 |
PhosphoSitePlusi | O14662 |
Genetic variation databases
BioMutai | STX16 |
Proteomic databases
EPDi | O14662 |
jPOSTi | O14662 |
MassIVEi | O14662 |
MaxQBi | O14662 |
PaxDbi | O14662 |
PeptideAtlasi | O14662 |
PRIDEi | O14662 |
ProteomicsDBi | 15209 48155 [O14662-1] 48156 [O14662-2] 48157 [O14662-3] 48158 [O14662-4] 48159 [O14662-5] |
Protocols and materials databases
Antibodypediai | 29123, 166 antibodies from 27 providers |
DNASUi | 8675 |
Genome annotation databases
Ensembli | ENST00000355957; ENSP00000348229; ENSG00000124222 [O14662-4] ENST00000358029; ENSP00000350723; ENSG00000124222 [O14662-5] ENST00000359617; ENSP00000352634; ENSG00000124222 [O14662-6] ENST00000361830; ENSP00000354445; ENSG00000124222 [O14662-6] ENST00000371132; ENSP00000360173; ENSG00000124222 [O14662-2] ENST00000371141; ENSP00000360183; ENSG00000124222 ENST00000467096; ENSP00000434369; ENSG00000124222 [O14662-3] |
GeneIDi | 8675 |
KEGGi | hsa:8675 |
MANE-Selecti | ENST00000371141.8; ENSP00000360183.4; NM_001001433.3; NP_001001433.1 |
UCSCi | uc002xzi.4, human [O14662-1] |
Organism-specific databases
CTDi | 8675 |
DisGeNETi | 8675 |
GeneCardsi | STX16 |
GeneReviewsi | STX16 |
HGNCi | HGNC:11431, STX16 |
HPAi | ENSG00000124222, Low tissue specificity |
MalaCardsi | STX16 |
MIMi | 603233, phenotype 603666, gene |
neXtProti | NX_O14662 |
OpenTargetsi | ENSG00000124222 |
Orphaneti | 94089, Pseudohypoparathyroidism type 1B |
PharmGKBi | PA36231 |
VEuPathDBi | HostDB:ENSG00000124222 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0809, Eukaryota |
GeneTreei | ENSGT01000000214380 |
HOGENOMi | CLU_038177_3_0_1 |
InParanoidi | O14662 |
OMAi | QTMIIDQ |
OrthoDBi | 1182451at2759 |
PhylomeDBi | O14662 |
TreeFami | TF314090 |
Enzyme and pathway databases
PathwayCommonsi | O14662 |
Reactomei | R-HSA-6811438, Intra-Golgi traffic R-HSA-6811440, Retrograde transport at the Trans-Golgi-Network |
SignaLinki | O14662 |
SIGNORi | O14662 |
Miscellaneous databases
BioGRID-ORCSi | 8675, 7 hits in 1048 CRISPR screens |
GeneWikii | STX16 |
GenomeRNAii | 8675 |
Pharosi | O14662, Tbio |
PROi | PR:O14662 |
RNActi | O14662, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000124222, Expressed in corpus callosum and 243 other tissues |
ExpressionAtlasi | O14662, baseline and differential |
Genevisiblei | O14662, HS |
Family and domain databases
InterProi | View protein in InterPro IPR010989, SNARE IPR028673, STX16 IPR045242, Syntaxin IPR006012, Syntaxin/epimorphin_CS IPR006011, Syntaxin_N IPR000727, T_SNARE_dom |
PANTHERi | PTHR19957, PTHR19957, 1 hit PTHR19957:SF83, PTHR19957:SF83, 1 hit |
Pfami | View protein in Pfam PF05739, SNARE, 1 hit PF00804, Syntaxin, 1 hit |
SMARTi | View protein in SMART SM00397, t_SNARE, 1 hit |
SUPFAMi | SSF47661, SSF47661, 1 hit |
PROSITEi | View protein in PROSITE PS00914, SYNTAXIN, 1 hit PS50192, T_SNARE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | STX16_HUMAN | |
Accessioni | O14662Primary (citable) accession number: O14662 Secondary accession number(s): A6NK32 Q9UIX5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 21, 2001 |
Last sequence update: | January 24, 2006 | |
Last modified: | February 23, 2022 | |
This is version 200 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families