KCNK3

Functionⁱ

pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward.2 Publications

Miscellaneous

Inhibited by external acidification. Activated by halothane and isoflurane.

GO - Molecular functionⁱ

growth factor activity Source: InterPro
ion channel activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 12198146
open rectifier potassium channel activity Source: Ensembl
potassium channel activity Source: Reactome
potassium ion leak channel activity
Source: UniProtKB
Inferred from direct assayⁱ
- 9312005
protein C-terminus binding Source: Ensembl
S100 protein binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 12198146

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

brain development Source: Ensembl
cardiac conduction Source: Reactome
cellular response to hypoxia Source: Ensembl
cellular response to zinc ion Source: Ensembl
chemical synaptic transmission
Source: ProtInc
Traceable author statementⁱ
- 9312005
cochlea development Source: Ensembl
ion transmembrane transport
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 12198146
negative regulation of cytosolic calcium ion concentration Source: Ensembl
potassium ion transmembrane transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
potassium ion transport
Source: ProtInc
Traceable author statementⁱ
- 9312005
response to drug Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Ion channel, Potassium channel
Biological process	Ion transport, Potassium transport, Transport
Ligand	Potassium

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1299316 TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-5576886 Phase 4 - resting membrane potential
SIGNORⁱ	O14649

Protein family/group databases

TCDBⁱ	1.A.1.9.2 the voltage-gated ion channel (vic) superfamily

TCDBⁱ

1.A.1.9.2 the voltage-gated ion channel (vic) superfamily

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Potassium channel subfamily K member 3 Alternative name(s): Acid-sensitive potassium channel protein TASK-1 TWIK-related acid-sensitive K(+) channel 1 Two pore potassium channel KT3.1 Short name: Two pore K(+) channel KT3.1
Gene namesⁱ	Name:KCNK3 Synonyms:TASK, TASK1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000171303.6
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6278 KCNK3
MIMⁱ	603220 gene
neXtProtⁱ	NX_O14649

Subcellular locationⁱ

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 8	CytoplasmicSequence analysis	8
Transmembraneⁱ	9 – 29	HelicalSequence analysisAdd BLAST	21
Intramembraneⁱ	78 – 101	Pore-forming; Name=Pore-forming 1Sequence analysisAdd BLAST	24
Transmembraneⁱ	108 – 128	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	129 – 158	CytoplasmicSequence analysisAdd BLAST	30
Transmembraneⁱ	159 – 179	HelicalSequence analysisAdd BLAST	21
Intramembraneⁱ	184 – 207	Pore-forming; Name=Pore-forming 2Sequence analysisAdd BLAST	24
Transmembraneⁱ	223 – 243	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	244 – 394	CytoplasmicSequence analysisAdd BLAST	151

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Pulmonary hypertension, primary, 4 (PPH4)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA rare disorder characterized by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated pulmonary arterial pression, right ventricular failure, and death. The disease can occur from infancy throughout life and it has a mean age at onset of 36 years. Penetrance is reduced. Although familial pulmonary hypertension is rare, cases secondary to known etiologies are more common and include those associated with the appetite-suppressant drugs.

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	98	H → N: Greatly reduces pH sensitivity. 1 Publication		1

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3777
MalaCards human disease database More...MalaCardsⁱ	KCNK3
MIMⁱ	615344 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000171303
Orphanetⁱ	275777 Heritable pulmonary arterial hypertension
PharmGKBⁱ	PA30060

Chemistry databases

ChEMBLⁱ	CHEMBL2321613
Drug and drug target database More...DrugBankⁱ	DB00561 Doxapram DB01159 Halothane
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	515

Polymorphism and mutation databases

BioMutaⁱ	KCNK3

BioMutaⁱ

KCNK3

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000101744	1 – 394	Potassium channel subfamily K member 3Add BLAST		394

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	53	N-linked (GlcNAc...) asparagineSequence analysis		1

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

PaxDbⁱ	O14649
PeptideAtlas More...PeptideAtlasⁱ	O14649
PRIDEⁱ	O14649
ProteomicsDBⁱ	48147

PTM databases

iPTMnetⁱ	O14649
PhosphoSitePlusⁱ	O14649

Expressionⁱ

Tissue specificityⁱ

Widespread expression in adult. Strongest expression in pancreas and placenta. Lower expression in brain, lung, prostate, heart, kidney, uterus, small intestine and colon.

Gene expression databases

Bgeeⁱ	ENSG00000171303 Expressed in 163 organ(s), highest expression level in adrenal gland
CleanExⁱ	HS_KCNK3
ExpressionAtlasⁱ	O14649 baseline and differential
Genevisibleⁱ	O14649 HS

Interactionⁱ

Subunit structureⁱ

Homodimer (Probable). Heterodimer with KCNK1.Curated1 Publication

GO - Molecular functionⁱ

growth factor activity Source: InterPro
protein C-terminus binding Source: Ensembl
S100 protein binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 12198146

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	109978, 3 interactors
IntActⁱ	O14649, 1 interactor
Molecular INTeraction database More...MINTⁱ	O14649
STRINGⁱ	9606.ENSP00000306275

Chemistry databases

BindingDBⁱ

O14649

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O14649
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. [View classification]Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG4404 Eukaryota ENOG410XRZJ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118858
HOGENOMⁱ	HOG000231463
HOVERGENⁱ	HBG052239
InParanoidⁱ	O14649
KEGG Orthology (KO) More...KOⁱ	K04914
OMAⁱ	IGFISCM
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G08DH
PhylomeDBⁱ	O14649
TreeFamⁱ	TF313947

Family and domain databases

InterProⁱ	View protein in InterPro IPR003280 2pore_dom_K_chnl IPR003092 2pore_dom_K_chnl_TASK IPR013099 K_chnl_dom IPR005406 KCNK3
PANTHERⁱ	PTHR11003:SF138 PTHR11003:SF138, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07885 Ion_trans_2, 2 hits
PIRSFⁱ	PIRSF038061 K_channel_subfamily_K_type, 1 hit
PRINTSⁱ	PR01333 2POREKCHANEL PR01584 TASK1CHANNEL PR01095 TASKCHANNEL

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

O14649-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKRQNVRTLA LIVCTFTYLL VGAAVFDALE SEPELIERQR LELRQQELRA 
        60         70         80         90        100
RYNLSQGGYE ELERVVLRLK PHKAGVQWRF AGSFYFAITV ITTIGYGHAA 
       110        120        130        140        150
PSTDGGKVFC MFYALLGIPL TLVMFQSLGE RINTLVRYLL HRAKKGLGMR 
       160        170        180        190        200
RADVSMANMV LIGFFSCIST LCIGAAAFSH YEHWTFFQAY YYCFITLTTI 
       210        220        230        240        250
GFGDYVALQK DQALQTQPQY VAFSFVYILT GLTVIGAFLN LVVLRFMTMN 
       260        270        280        290        300
AEDEKRDAEH RALLTRNGQA GGGGGGGSAH TTDTASSTAA AGGGGFRNVY 
       310        320        330        340        350
AEVLHFQSMC SCLWYKSREK LQYSIPMIIP RDLSTSDTCV EQSHSSPGGG 
       360        370        380        390 
GRYSDTPSRR CLCSGAPRSA ISSVSTGLHS LSTFRGLMKR RSSV

Length:394

Mass (Da):43,518

Last modified:January 1, 1998 - v1

Checksum:ⁱ9FF4C8266F615FB7

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	B9EIJ4	B9EIJ4_HUMAN		KCNK3 protein KCNK3 protein (Potassium channel subfamily K member 3)	KCNK3	271	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_070126	8	T → K in PPH4; loss of function; channel activity can be rescued with the use of the phospholipase A2 inhibitor ONO-RS-082. 1 PublicationCorresponds to variant dbSNP:rs1085307438Ensembl.	1
Natural variantⁱVAR_070127	97	G → R in PPH4; loss of function. 1 PublicationCorresponds to variant dbSNP:rs398123040EnsemblClinVar.	1
Natural variantⁱVAR_070128	182	E → K in PPH4; loss of function; channel activity can be rescued with the use of the phospholipase A2 inhibitor ONO-RS-082. 1 PublicationCorresponds to variant dbSNP:rs398123042EnsemblClinVar.	1
Natural variantⁱVAR_070129	192	Y → C in PPH4; loss of function. 1 PublicationCorresponds to variant dbSNP:rs398123043EnsemblClinVar.	1
Natural variantⁱVAR_070130	203	G → D in PPH4; loss of function; channel activity cannot be rescued with the use of the phospholipase A2 inhibitor ONO-RS-082. 1 PublicationCorresponds to variant dbSNP:rs398123039EnsemblClinVar.	1
Natural variantⁱVAR_070131	221	V → L in PPH4; loss of function. 1 PublicationCorresponds to variant dbSNP:rs398123041EnsemblClinVar.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF006823 mRNA Translation: AAC51777.1 AF065163 mRNA Translation: AAG29340.1 AC015977 Genomic DNA Translation: AAY24312.1 CH471053 Genomic DNA Translation: EAX00678.1 CH471053 Genomic DNA Translation: EAX00679.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1727.1
NCBI Reference Sequences More...RefSeqⁱ	NP_002237.1, NM_002246.2
UniGeneⁱ	Hs.24040 Hs.645288

Genome annotation databases

Ensemblⁱ	ENST00000302909; ENSP00000306275; ENSG00000171303
GeneIDⁱ	3777
KEGGⁱ	hsa:3777
UCSC genome browser More...UCSCⁱ	uc002rhn.3 human

Protein	Similar proteins		Species	Score	Length	Source
O14649	Potassium channel subfamily K member		PONAB		394	UniRef100_O14649
Potassium channel subfamily K member 3 (Fragment)		MACMU		199
KCNK3 protein		HUMAN		271
Uncharacterized protein		NOMLE		271
Uncharacterized protein		GORGO		271
+2

Protein	Similar proteins		Species	Score	Length	Source
O14649	Potassium channel subfamily K member		PONAB		394	UniRef90_O14649
Potassium channel subfamily K member 3 (Fragment)		MACMU		199
KCNK3 protein		HUMAN		271
Uncharacterized protein		NOMLE		271
Uncharacterized protein		GORGO		271
+70

Protein	Similar proteins		Species	Score	Length	Source
O14649	Potassium channel subfamily K member		PONAB		394	UniRef50_O14649
Potassium channel subfamily K member 3 (Fragment)		MACMU		199
KCNK3 protein		HUMAN		271
Uncharacterized protein		NOMLE		271
Uncharacterized protein		GORGO		271
+99

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF006823 mRNA Translation: AAC51777.1 AF065163 mRNA Translation: AAG29340.1 AC015977 Genomic DNA Translation: AAY24312.1 CH471053 Genomic DNA Translation: EAX00678.1 CH471053 Genomic DNA Translation: EAX00679.1
CCDSⁱ	CCDS1727.1
RefSeqⁱ	NP_002237.1, NM_002246.2
UniGeneⁱ	Hs.24040 Hs.645288

3D structure databases

ProteinModelPortalⁱ	O14649
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109978, 3 interactors
IntActⁱ	O14649, 1 interactor
MINTⁱ	O14649
STRINGⁱ	9606.ENSP00000306275

Chemistry databases

BindingDBⁱ	O14649
ChEMBLⁱ	CHEMBL2321613
DrugBankⁱ	DB00561 Doxapram DB01159 Halothane
GuidetoPHARMACOLOGYⁱ	515

Protein family/group databases

TCDBⁱ	1.A.1.9.2 the voltage-gated ion channel (vic) superfamily

TCDBⁱ

1.A.1.9.2 the voltage-gated ion channel (vic) superfamily

PTM databases

iPTMnetⁱ	O14649
PhosphoSitePlusⁱ	O14649

Polymorphism and mutation databases

BioMutaⁱ	KCNK3

BioMutaⁱ

KCNK3

Proteomic databases

PaxDbⁱ	O14649
PeptideAtlasⁱ	O14649
PRIDEⁱ	O14649
ProteomicsDBⁱ	48147

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000302909; ENSP00000306275; ENSG00000171303
GeneIDⁱ	3777
KEGGⁱ	hsa:3777
UCSCⁱ	uc002rhn.3 human

Organism-specific databases

CTDⁱ	3777
DisGeNETⁱ	3777
EuPathDBⁱ	HostDB:ENSG00000171303.6
GeneCardsⁱ	KCNK3
HGNCⁱ	HGNC:6278 KCNK3
MalaCardsⁱ	KCNK3
MIMⁱ	603220 gene 615344 phenotype
neXtProtⁱ	NX_O14649
OpenTargetsⁱ	ENSG00000171303
Orphanetⁱ	275777 Heritable pulmonary arterial hypertension
PharmGKBⁱ	PA30060
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4404 Eukaryota ENOG410XRZJ LUCA
GeneTreeⁱ	ENSGT00760000118858
HOGENOMⁱ	HOG000231463
HOVERGENⁱ	HBG052239
InParanoidⁱ	O14649
KOⁱ	K04914
OMAⁱ	IGFISCM
OrthoDBⁱ	EOG091G08DH
PhylomeDBⁱ	O14649
TreeFamⁱ	TF313947

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1299316 TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-5576886 Phase 4 - resting membrane potential
SIGNORⁱ	O14649

Miscellaneous databases

GeneWikiⁱ	KCNK3
GenomeRNAiⁱ	3777
Protein Ontology More...PROⁱ	PR:O14649
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000171303 Expressed in 163 organ(s), highest expression level in adrenal gland
CleanExⁱ	HS_KCNK3
ExpressionAtlasⁱ	O14649 baseline and differential
Genevisibleⁱ	O14649 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR003280 2pore_dom_K_chnl IPR003092 2pore_dom_K_chnl_TASK IPR013099 K_chnl_dom IPR005406 KCNK3
PANTHERⁱ	PTHR11003:SF138 PTHR11003:SF138, 1 hit
Pfamⁱ	View protein in Pfam PF07885 Ion_trans_2, 2 hits
PIRSFⁱ	PIRSF038061 K_channel_subfamily_K_type, 1 hit
PRINTSⁱ	PR01333 2POREKCHANEL PR01584 TASK1CHANNEL PR01095 TASKCHANNEL
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	KCNK3_HUMAN
Accessionⁱ	O14649Primary (citable) accession number: O14649 Secondary accession number(s): Q53SU2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
	Last sequence update:	January 1, 1998
	Last modified:	November 7, 2018
	This is version 165 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniParc

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UniRef

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Supporting data

UniProtKB - O14649 (KCNK3_HUMAN)

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Potassium channel subfamily K member 3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Extracellular region or secreted

Plasma Membrane

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ