UniProtKB - O14646 (CHD1_HUMAN)
Chromodomain-helicase-DNA-binding protein 1
CHD1
Functioni
Catalytic activityi
- EC:3.6.4.12
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 506 – 513 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- DNA binding Source: UniProtKB-KW
- DNA helicase activity Source: ProtInc
- methylated histone binding Source: UniProtKB
GO - Biological processi
- chromatin remodeling Source: Ensembl
- covalent chromatin modification Source: UniProtKB
- positive regulation by host of viral transcription Source: CACAO
- regulation of transcription by RNA polymerase II Source: ProtInc
Keywordsi
Molecular function | Chromatin regulator, DNA-binding, Helicase, Hydrolase |
Biological process | Transcription, Transcription regulation |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | O14646 |
Reactomei | R-HSA-9018519, Estrogen-dependent gene expression |
Names & Taxonomyi
Protein namesi | Recommended name: Chromodomain-helicase-DNA-binding protein 1 (EC:3.6.4.12)Short name: CHD-1 Alternative name(s): ATP-dependent helicase CHD1 |
Gene namesi | Name:CHD1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1915, CHD1 |
MIMi | 602118, gene |
neXtProti | NX_O14646 |
VEuPathDBi | HostDB:ENSG00000153922.10 |
Subcellular locationi
Nucleus
- nucleoplasm Source: Reactome
- nucleus Source: CACAO
Other locations
- cytoplasm Source: CACAO
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Involvement in diseasei
Pilarowski-Bjornsson syndrome (PILBOS)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_080265 | 141 | R → G in PILBOS. 1 PublicationCorresponds to variant dbSNP:rs1064795875EnsemblClinVar. | 1 | |
Natural variantiVAR_080266 | 460 | R → K in PILBOS. 1 PublicationCorresponds to variant dbSNP:rs1554078856EnsemblClinVar. | 1 | |
Natural variantiVAR_080267 | 618 | R → Q in PILBOS; patient cells show a global increase of methylated histone binding. 1 PublicationCorresponds to variant dbSNP:rs1554078349EnsemblClinVar. | 1 | |
Natural variantiVAR_080268 | 1708 | R → Q in PILBOS. 1 PublicationCorresponds to variant dbSNP:rs1293161341EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease variant, Mental retardationOrganism-specific databases
DisGeNETi | 1105 |
MalaCardsi | CHD1 |
MIMi | 617682, phenotype |
OpenTargetsi | ENSG00000153922 |
PharmGKBi | PA26451 |
Miscellaneous databases
Pharosi | O14646, Tbio |
Genetic variation databases
BioMutai | CHD1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000080224 | 1 – 1710 | Chromodomain-helicase-DNA-binding protein 1Add BLAST | 1710 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Modified residuei | 215 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 216 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 237 | PhosphothreonineCombined sources | 1 | ||
Modified residuei | 241 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 250 | PhosphothreonineCombined sources | 1 | ||
Modified residuei | 252 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 471 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1025 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1040 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1081 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1085 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 1096 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1098 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1100 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1102 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1161 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1353 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1355 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1356 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1360 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1363 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1371 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1373 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 1622 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1677 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1689 | PhosphoserineCombined sources | 1 | ||
Isoform 2 (identifier: O14646-2) | |||||
Modified residuei | 1688 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | O14646 |
jPOSTi | O14646 |
MassIVEi | O14646 |
MaxQBi | O14646 |
PaxDbi | O14646 |
PeptideAtlasi | O14646 |
PRIDEi | O14646 |
ProteomicsDBi | 48142 [O14646-1] 48143 [O14646-2] |
PTM databases
CarbonylDBi | O14646 |
iPTMneti | O14646 |
MetOSitei | O14646 |
PhosphoSitePlusi | O14646 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000153922, Expressed in intestine and 233 other tissues |
ExpressionAtlasi | O14646, baseline and differential |
Genevisiblei | O14646, HS |
Organism-specific databases
HPAi | ENSG00000153922, Tissue enhanced (lymphoid) |
Interactioni
Subunit structurei
Component of the SAGA complex (By similarity).
Interacts with BCLAF1, NCoR, SRP20 and SAFB (By similarity). Specifically interacts with methylated H3K4me2 and H3K4me3.
Interacts with the FACT complex, the PAF complex and the U2 snRNP.
Interacts directly with PAF1, SFA3A1, SFA3A2, SFA3A3, SNF2 and SSRP1.
By similarity4 PublicationsBinary interactionsi
Hide detailsO14646
With | #Exp. | IntAct |
---|---|---|
KDM1A - isoform 1 [O60341-1] | 8 | EBI-1560858,EBI-15599570 |
NS1 [B2BUF1] from Influenza A virus (A/Wyoming/03/2003(H3N2)). | 3 | EBI-1560858,EBI-4291940 |
Isoform 2 [O14646-2]
With | #Exp. | IntAct |
---|---|---|
GRN [P28799] | 3 | EBI-10961487,EBI-747754 |
WFS1 [O76024] | 3 | EBI-10961487,EBI-720609 |
GO - Molecular functioni
- methylated histone binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 107530, 72 interactors |
DIPi | DIP-38922N |
IntActi | O14646, 21 interactors |
MINTi | O14646 |
STRINGi | 9606.ENSP00000483667 |
Miscellaneous databases
RNActi | O14646, protein |
Structurei
Secondary structure
3D structure databases
SMRi | O14646 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O14646 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 272 – 364 | Chromo 1PROSITE-ProRule annotationAdd BLAST | 93 | |
Domaini | 389 – 452 | Chromo 2PROSITE-ProRule annotationAdd BLAST | 64 | |
Domaini | 493 – 663 | Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST | 171 | |
Domaini | 792 – 943 | Helicase C-terminalPROSITE-ProRule annotationAdd BLAST | 152 | |
Repeati | 1628 – 1632 | 1 | 5 | |
Repeati | 1634 – 1638 | 2 | 5 | |
Repeati | 1640 – 1644 | 3 | 5 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1628 – 1644 | 3 X 5 AA repeats of H-S-D-H-RAdd BLAST | 17 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 614 – 617 | DEAH box | 4 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 70 | Ser-richAdd BLAST | 70 | |
Compositional biasi | 117 – 137 | Ser-richAdd BLAST | 21 |
Domaini
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0384, Eukaryota |
GeneTreei | ENSGT00940000156579 |
HOGENOMi | CLU_000315_8_1_1 |
InParanoidi | O14646 |
OMAi | PAWQETF |
OrthoDBi | 57339at2759 |
PhylomeDBi | O14646 |
TreeFami | TF313461 |
Family and domain databases
Gene3Di | 3.40.50.10810, 1 hit |
IDEALi | IID00003 |
InterProi | View protein in InterPro IPR040793, CDH1_2_SANT_HL1 IPR016197, Chromo-like_dom_sf IPR000953, Chromo/chromo_shadow_dom IPR023780, Chromo_domain IPR023779, Chromodomain_CS IPR025260, DUF4208 IPR014001, Helicase_ATP-bd IPR001650, Helicase_C IPR027417, P-loop_NTPase IPR038718, SNF2-like_sf IPR000330, SNF2_N |
Pfami | View protein in Pfam PF18375, CDH1_2_SANT_HL1, 1 hit PF00385, Chromo, 2 hits PF13907, DUF4208, 1 hit PF00271, Helicase_C, 1 hit PF00176, SNF2_N, 1 hit |
SMARTi | View protein in SMART SM00298, CHROMO, 2 hits SM00487, DEXDc, 1 hit SM01176, DUF4208, 1 hit SM00490, HELICc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 2 hits SSF54160, SSF54160, 2 hits |
PROSITEi | View protein in PROSITE PS00598, CHROMO_1, 2 hits PS50013, CHROMO_2, 2 hits PS51192, HELICASE_ATP_BIND_1, 1 hit PS51194, HELICASE_CTER, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MNGHSDEESV RNSSGESSQS DDDSGSASGS GSGSSSGSSS DGSSSQSGSS
60 70 80 90 100
DSDSGSESGS QSESESDTSR ENKVQAKPPK VDGAEFWKSS PSILAVQRSA
110 120 130 140 150
ILKKQQQQQQ QQQHQASSNS GSEEDSSSSE DSDDSSSEVK RKKHKDEDWQ
160 170 180 190 200
MSGSGSPSQS GSDSESEEER EKSSCDETES DYEPKNKVKS RKPQNRSKSK
210 220 230 240 250
NGKKILGQKK RQIDSSEEDD DEEDYDNDKR SSRRQATVNV SYKEDEEMKT
260 270 280 290 300
DSDDLLEVCG EDVPQPEEEE FETIERFMDC RIGRKGATGA TTTIYAVEAD
310 320 330 340 350
GDPNAGFEKN KEPGEIQYLI KWKGWSHIHN TWETEETLKQ QNVRGMKKLD
360 370 380 390 400
NYKKKDQETK RWLKNASPED VEYYNCQQEL TDDLHKQYQI VERIIAHSNQ
410 420 430 440 450
KSAAGYPDYY CKWQGLPYSE CSWEDGALIS KKFQACIDEY FSRNQSKTTP
460 470 480 490 500
FKDCKVLKQR PRFVALKKQP SYIGGHEGLE LRDYQLNGLN WLAHSWCKGN
510 520 530 540 550
SCILADEMGL GKTIQTISFL NYLFHEHQLY GPFLLVVPLS TLTSWQREIQ
560 570 580 590 600
TWASQMNAVV YLGDINSRNM IRTHEWTHHQ TKRLKFNILL TTYEILLKDK
610 620 630 640 650
AFLGGLNWAF IGVDEAHRLK NDDSLLYKTL IDFKSNHRLL ITGTPLQNSL
660 670 680 690 700
KELWSLLHFI MPEKFSSWED FEEEHGKGRE YGYASLHKEL EPFLLRRVKK
710 720 730 740 750
DVEKSLPAKV EQILRMEMSA LQKQYYKWIL TRNYKALSKG SKGSTSGFLN
760 770 780 790 800
IMMELKKCCN HCYLIKPPDN NEFYNKQEAL QHLIRSSGKL ILLDKLLIRL
810 820 830 840 850
RERGNRVLIF SQMVRMLDIL AEYLKYRQFP FQRLDGSIKG ELRKQALDHF
860 870 880 890 900
NAEGSEDFCF LLSTRAGGLG INLASADTVV IFDSDWNPQN DLQAQARAHR
910 920 930 940 950
IGQKKQVNIY RLVTKGSVEE DILERAKKKM VLDHLVIQRM DTTGKTVLHT
960 970 980 990 1000
GSAPSSSTPF NKEELSAILK FGAEELFKEP EGEEQEPQEM DIDEILKRAE
1010 1020 1030 1040 1050
THENEPGPLT VGDELLSQFK VANFSNMDED DIELEPERNS KNWEEIIPED
1060 1070 1080 1090 1100
QRRRLEEEER QKELEEIYML PRMRNCAKQI SFNGSEGRRS RSRRYSGSDS
1110 1120 1130 1140 1150
DSISEGKRPK KRGRPRTIPR ENIKGFSDAE IRRFIKSYKK FGGPLERLDA
1160 1170 1180 1190 1200
IARDAELVDK SETDLRRLGE LVHNGCIKAL KDSSSGTERT GGRLGKVKGP
1210 1220 1230 1240 1250
TFRISGVQVN AKLVISHEEE LIPLHKSIPS DPEERKQYTI PCHTKAAHFD
1260 1270 1280 1290 1300
IDWGKEDDSN LLIGIYEYGY GSWEMIKMDP DLSLTHKILP DDPDKKPQAK
1310 1320 1330 1340 1350
QLQTRADYLI KLLSRDLAKK EALSGAGSSK RRKARAKKNK AMKSIKVKEE
1360 1370 1380 1390 1400
IKSDSSPLPS EKSDEDDDKL SESKSDGRER SKKSSVSDAP VHITASGEPV
1410 1420 1430 1440 1450
PISEESEELD QKTFSICKER MRPVKAALKQ LDRPEKGLSE REQLEHTRQC
1460 1470 1480 1490 1500
LIKIGDHITE CLKEYTNPEQ IKQWRKNLWI FVSKFTEFDA RKLHKLYKHA
1510 1520 1530 1540 1550
IKKRQESQQN SDQNSNLNPH VIRNPDVERL KENTNHDDSS RDSYSSDRHL
1560 1570 1580 1590 1600
TQYHDHHKDR HQGDSYKKSD SRKRPYSSFS NGKDHRDWDH YKQDSRYYSD
1610 1620 1630 1640 1650
REKHRKLDDH RSRDHRSNLE GSLKDRSHSD HRSHSDHRLH SDHRSSSEYT
1660 1670 1680 1690 1700
HHKSSRDYRY HSDWQMDHRA SSSGPRSPLD QRSPYGSRSP FEHSVEHKST
1710
PEHTWSSRKT
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0Y8V4 | H0Y8V4_HUMAN | Chromodomain-helicase-DNA-binding p... | CHD1 | 113 | Annotation score: | ||
A0A087WVF4 | A0A087WVF4_HUMAN | Chromodomain-helicase-DNA-binding p... | CHD1 | 272 | Annotation score: | ||
H0Y8Z0 | H0Y8Z0_HUMAN | Chromodomain-helicase-DNA-binding p... | CHD1 | 22 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 392 | E → G in AAB87381 (PubMed:9326634).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_080265 | 141 | R → G in PILBOS. 1 PublicationCorresponds to variant dbSNP:rs1064795875EnsemblClinVar. | 1 | |
Natural variantiVAR_055652 | 264 | P → T. Corresponds to variant dbSNP:rs10062803Ensembl. | 1 | |
Natural variantiVAR_080266 | 460 | R → K in PILBOS. 1 PublicationCorresponds to variant dbSNP:rs1554078856EnsemblClinVar. | 1 | |
Natural variantiVAR_080267 | 618 | R → Q in PILBOS; patient cells show a global increase of methylated histone binding. 1 PublicationCorresponds to variant dbSNP:rs1554078349EnsemblClinVar. | 1 | |
Natural variantiVAR_080268 | 1708 | R → Q in PILBOS. 1 PublicationCorresponds to variant dbSNP:rs1293161341EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_038432 | 1684 | Missing in isoform 2. 2 Publications | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF006513 mRNA Translation: AAB87381.1 AC022121 Genomic DNA No translation available. BC117134 mRNA Translation: AAI17135.1 |
CCDSi | CCDS34204.1 [O14646-1] |
RefSeqi | NP_001261.2, NM_001270.2 [O14646-1] XP_005271924.1, XM_005271867.4 |
Genome annotation databases
Ensembli | ENST00000284049; ENSP00000284049; ENSG00000153922 [O14646-1] ENST00000614616; ENSP00000483667; ENSG00000153922 [O14646-1] |
GeneIDi | 1105 |
KEGGi | hsa:1105 |
UCSCi | uc003knf.3, human [O14646-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF006513 mRNA Translation: AAB87381.1 AC022121 Genomic DNA No translation available. BC117134 mRNA Translation: AAI17135.1 |
CCDSi | CCDS34204.1 [O14646-1] |
RefSeqi | NP_001261.2, NM_001270.2 [O14646-1] XP_005271924.1, XM_005271867.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2B2T | X-ray | 2.45 | A/B | 268-443 | [»] | |
C | 268-373 | [»] | ||||
2B2U | X-ray | 2.95 | A/B | 268-443 | [»] | |
C | 268-373 | [»] | ||||
2B2V | X-ray | 2.65 | A/B | 268-443 | [»] | |
C | 268-373 | [»] | ||||
2B2W | X-ray | 2.40 | A/B | 268-443 | [»] | |
C | 268-373 | [»] | ||||
2B2Y | X-ray | 2.35 | A/B | 268-443 | [»] | |
C | 268-373 | [»] | ||||
2N39 | NMR | - | A | 1409-1511 | [»] | |
4B4C | X-ray | 1.62 | A | 1119-1327 | [»] | |
4NW2 | X-ray | 1.90 | A/C | 268-443 | [»] | |
4O42 | X-ray | 1.87 | A | 268-443 | [»] | |
5AFW | X-ray | 1.60 | A | 270-443 | [»] | |
SMRi | O14646 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107530, 72 interactors |
DIPi | DIP-38922N |
IntActi | O14646, 21 interactors |
MINTi | O14646 |
STRINGi | 9606.ENSP00000483667 |
PTM databases
CarbonylDBi | O14646 |
iPTMneti | O14646 |
MetOSitei | O14646 |
PhosphoSitePlusi | O14646 |
Genetic variation databases
BioMutai | CHD1 |
Proteomic databases
EPDi | O14646 |
jPOSTi | O14646 |
MassIVEi | O14646 |
MaxQBi | O14646 |
PaxDbi | O14646 |
PeptideAtlasi | O14646 |
PRIDEi | O14646 |
ProteomicsDBi | 48142 [O14646-1] 48143 [O14646-2] |
Protocols and materials databases
ABCDi | O14646, 1 sequenced antibody |
Antibodypediai | 25129, 175 antibodies |
Genome annotation databases
Ensembli | ENST00000284049; ENSP00000284049; ENSG00000153922 [O14646-1] ENST00000614616; ENSP00000483667; ENSG00000153922 [O14646-1] |
GeneIDi | 1105 |
KEGGi | hsa:1105 |
UCSCi | uc003knf.3, human [O14646-1] |
Organism-specific databases
CTDi | 1105 |
DisGeNETi | 1105 |
GeneCardsi | CHD1 |
HGNCi | HGNC:1915, CHD1 |
HPAi | ENSG00000153922, Tissue enhanced (lymphoid) |
MalaCardsi | CHD1 |
MIMi | 602118, gene 617682, phenotype |
neXtProti | NX_O14646 |
OpenTargetsi | ENSG00000153922 |
PharmGKBi | PA26451 |
VEuPathDBi | HostDB:ENSG00000153922.10 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0384, Eukaryota |
GeneTreei | ENSGT00940000156579 |
HOGENOMi | CLU_000315_8_1_1 |
InParanoidi | O14646 |
OMAi | PAWQETF |
OrthoDBi | 57339at2759 |
PhylomeDBi | O14646 |
TreeFami | TF313461 |
Enzyme and pathway databases
PathwayCommonsi | O14646 |
Reactomei | R-HSA-9018519, Estrogen-dependent gene expression |
Miscellaneous databases
BioGRID-ORCSi | 1105, 103 hits in 882 CRISPR screens |
ChiTaRSi | CHD1, human |
EvolutionaryTracei | O14646 |
GeneWikii | CHD1 |
GenomeRNAii | 1105 |
Pharosi | O14646, Tbio |
PROi | PR:O14646 |
RNActi | O14646, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000153922, Expressed in intestine and 233 other tissues |
ExpressionAtlasi | O14646, baseline and differential |
Genevisiblei | O14646, HS |
Family and domain databases
Gene3Di | 3.40.50.10810, 1 hit |
IDEALi | IID00003 |
InterProi | View protein in InterPro IPR040793, CDH1_2_SANT_HL1 IPR016197, Chromo-like_dom_sf IPR000953, Chromo/chromo_shadow_dom IPR023780, Chromo_domain IPR023779, Chromodomain_CS IPR025260, DUF4208 IPR014001, Helicase_ATP-bd IPR001650, Helicase_C IPR027417, P-loop_NTPase IPR038718, SNF2-like_sf IPR000330, SNF2_N |
Pfami | View protein in Pfam PF18375, CDH1_2_SANT_HL1, 1 hit PF00385, Chromo, 2 hits PF13907, DUF4208, 1 hit PF00271, Helicase_C, 1 hit PF00176, SNF2_N, 1 hit |
SMARTi | View protein in SMART SM00298, CHROMO, 2 hits SM00487, DEXDc, 1 hit SM01176, DUF4208, 1 hit SM00490, HELICc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 2 hits SSF54160, SSF54160, 2 hits |
PROSITEi | View protein in PROSITE PS00598, CHROMO_1, 2 hits PS50013, CHROMO_2, 2 hits PS51192, HELICASE_ATP_BIND_1, 1 hit PS51194, HELICASE_CTER, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CHD1_HUMAN | |
Accessioni | O14646Primary (citable) accession number: O14646 Secondary accession number(s): Q17RZ3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | November 24, 2009 | |
Last modified: | February 10, 2021 | |
This is version 197 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families