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UniProtKB - O14645 (IDLC_HUMAN)

Entry version 149 (10 Feb 2021)
Sequence version 2 (27 Sep 2005)
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Protein

Axonemal dynein light intermediate polypeptide 1

Gene

DNALI1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a dynamic role in flagellar motility.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMotor protein

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O14645

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Axonemal dynein light intermediate polypeptide 1Curated
Alternative name(s):
Inner dynein arm light chain, axonemal
hp28
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DNALI1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:14353, DNALI1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602135, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O14645

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000163879.10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Dynein, Flagellum

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		7802

Open Targets

More...OpenTargetsi		ENSG00000163879

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA38381

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O14645, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		DNALI1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001146751 – 258Axonemal dynein light intermediate polypeptide 1Add BLAST258

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O14645

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O14645

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O14645

PeptideAtlas

More...PeptideAtlasi		O14645

PRoteomics IDEntifications database

More...PRIDEi		O14645

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		4231
48141 [O14645-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O14645

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O14645

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in many tissues. A smaller 0.9 kb and a larger 2.5 kb transcripts were detected at the highest level in the testis, at medium levels in the prostate, heart, liver, lung and pancreas, at low levels in the ovary, skeletal muscle and small intestine. Not detected in spleen, colon epithelium, thymus or peripheral blood leukocytes. The 0.9 kb transcript is expressed at a 20-fold higher level than the 2.5 kb transcript in the testis. Expressed in spermatozoa and airway epithelial cells (at protein level) (PubMed:31178125).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000163879, Expressed in testis and 165 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O14645, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O14645, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000163879, Tissue enhanced (fallopian tube, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

O14645
With#Exp.IntAct
AK8 [Q96MA6]3EBI-395638,EBI-8466265
AKAP9 - isoform 3 [Q99996-3]3EBI-395638,EBI-11022349
ALAS1 [P13196]3EBI-395638,EBI-3905054
ANXA4 [Q6LES2]3EBI-395638,EBI-10250835
ANXA8 [P13928]3EBI-395638,EBI-2556915
AP3B1 [O00203]3EBI-395638,EBI-1044383
APP [P05067]3EBI-395638,EBI-77613
ASB9 - isoform 3 [Q96DX5-3]3EBI-395638,EBI-25843552
ASIC4 - isoform 3 [Q96FT7-4]3EBI-395638,EBI-9089489
ATP6V1B1 [P15313]3EBI-395638,EBI-2891281
BCAT1 - isoform 4 [P54687-4]3EBI-395638,EBI-25834445
BECN1 [Q14457]3EBI-395638,EBI-949378
CD209 - isoform 10 [Q9NNX6-10]3EBI-395638,EBI-12300031
CENPV [Q7Z7K6]3EBI-395638,EBI-1210604
CHMP7 [Q8WUX9]3EBI-395638,EBI-749253
DBNL [Q9UJU6]3EBI-395638,EBI-751783
DDI1 [Q8WTU0]3EBI-395638,EBI-748248
DOM3Z [A0A024RCP2]3EBI-395638,EBI-25847826
DPP9 - isoform 2 [Q86TI2-2]3EBI-395638,EBI-21529239
DPYS [Q14117]3EBI-395638,EBI-12275416
E2F8 [A0AVK6]3EBI-395638,EBI-7779316
EIF3F [O00303]3EBI-395638,EBI-711990
EIF3K [Q9UBQ5]4EBI-395638,EBI-354344
ESRP1 [Q6NXG1]3EBI-395638,EBI-10213520
ESRP1 - isoform 3 [Q6NXG1-3]3EBI-395638,EBI-21567429
FAM135B - isoform 4 [Q49AJ0-4]3EBI-395638,EBI-25835236
FGF21 [Q9NSA1]3EBI-395638,EBI-3909329
FYN - isoform 3 [P06241-3]3EBI-395638,EBI-10691738
GABPB1 - isoform 3 [Q06547-3]3EBI-395638,EBI-9088619
GINS3 [Q9BRX5]3EBI-395638,EBI-2857315
GMPPA [Q96IJ6]3EBI-395638,EBI-750953
HTT [P42858]15EBI-395638,EBI-466029
IFI35 - isoform 2 [P80217-2]3EBI-395638,EBI-12823003
IQUB [Q8NA54]3EBI-395638,EBI-10220600
ITGB3BP [Q13352]3EBI-395638,EBI-712105
KLF15 [Q9UIH9]3EBI-395638,EBI-2796400
KLF5 [Q13887]3EBI-395638,EBI-2696013
LGALS9C [Q6DKI2]3EBI-395638,EBI-9088829
LRRC61 [Q9BV99]3EBI-395638,EBI-2350424
LZTS2 [Q9BRK4]3EBI-395638,EBI-741037
METTL27 [Q8N6F8]3EBI-395638,EBI-8487781
MSGN1 [A6NI15]3EBI-395638,EBI-11991020
MT2A [P02795]3EBI-395638,EBI-996616
OTUB1 [Q96FW1]3EBI-395638,EBI-1058491
OTUD7B - isoform 2 [Q6GQQ9-2]3EBI-395638,EBI-25830200
PADI3 [Q9ULW8]3EBI-395638,EBI-10488185
PAIP2 [Q9BPZ3]3EBI-395638,EBI-2957445
PIGP [P57054]3EBI-395638,EBI-17630288
PPP1R21 - isoform 5 [Q6ZMI0-5]3EBI-395638,EBI-25835994
PRMT6 [Q96LA8]2EBI-395638,EBI-912440
RAP1GAP [P47736]3EBI-395638,EBI-722307
REX1BD [Q96EN9]3EBI-395638,EBI-745810
RGR - isoform 3 [P47804-3]3EBI-395638,EBI-25834767
RNF31 [Q96EP0]3EBI-395638,EBI-948111
SIAH1 [Q8IUQ4]3EBI-395638,EBI-747107
SMARCD1 [Q96GM5]3EBI-395638,EBI-358489
SPATA12 [Q7Z6I5]3EBI-395638,EBI-10696971
TBL1XR1 [Q9BZK7]3EBI-395638,EBI-765729
TBRG1 [Q3YBR2]3EBI-395638,EBI-2800552
THAP3 [Q8WTV1]3EBI-395638,EBI-17438286
TMTC1 - isoform 4 [Q8IUR5-4]3EBI-395638,EBI-9089156
TP53BP1 [Q12888]3EBI-395638,EBI-396540
TSC1 [Q86WV8]3EBI-395638,EBI-12806590
TTC33 [Q6PID6]3EBI-395638,EBI-2555404
UBE2A [P49459]3EBI-395638,EBI-2339348
VSX2 [P58304]3EBI-395638,EBI-6427899
WDR83 [Q9BRX9]3EBI-395638,EBI-7705033
YRDC [Q86U90]3EBI-395638,EBI-21659356
ZNF333 - isoform 2 [Q96JL9-2]3EBI-395638,EBI-25835852
ZNF488 - isoform 2 [Q96MN9-2]3EBI-395638,EBI-25831733
ZXDC [Q2QGD7]3EBI-395638,EBI-1538838
B7Z3E83EBI-395638,EBI-25831617

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		113577, 17 interactors

Protein interaction database and analysis system

More...IntActi		O14645, 84 interactors

Molecular INTeraction database

More...MINTi		O14645

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000296218

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O14645, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O14645

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili176 – 255Sequence analysisAdd BLAST80

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the inner dynein arm light chain family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4001, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000003012

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_072652_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O14645

Database of Orthologous Groups

More...OrthoDBi		1375694at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O14645

TreeFam database of animal gene trees

More...TreeFami		TF314891

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR019347, Axonemal_dynein_light_chain

The PANTHER Classification System

More...PANTHERi		PTHR13183, PTHR13183, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF10211, Ax_dynein_light, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O14645-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIPPADSLLK YDTPVLVSRN TEKRSPKARL LKVSPQQPGP SGSAPQPPKT 
        60         70         80         90        100
KLPSTPCVPD PTKQAEEILN AILPPREWVE DTQLWIQQVS STPSTRMDVV 
       110        120        130        140        150
HLQEQLDLKL QQRQARETGI CPVRRELYSQ CFDELIREVT INCAERGLLL 
       160        170        180        190        200
LRVRDEIRMT IAAYQTLYES SVAFGMRKAL QAEQGKSDME RKIAELETEK 
       210        220        230        240        250
RDLERQVNEQ KAKCEATEKR ESERRQVEEK KHNEEIQFLK RTNQQLKAQL 

EGIIAPKK
Length:258
Mass (Da):29,662
Last modified:September 27, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5E95F15FE4476BF7
GO
Isoform 2 (identifier: O14645-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: MIPPAD → MPYYPQ
     7-132: Missing.

Show »
Length:132
Mass (Da):15,583
Checksum:iD0AD5D94C2965156
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A499FIY3A0A499FIY3_HUMAN
Axonemal dynein light intermediate ...
DNALI1
280Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB69193 differs from that shown. Reason: Frameshift.Curated
The sequence CAI46082 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti54S → P in CAI46082 (PubMed:17974005).Curated1
Sequence conflicti76R → K in BAF83191 (PubMed:14702039).Curated1
Sequence conflicti152R → Q in AAB69193 (PubMed:9284741).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01447365A → V. Corresponds to variant dbSNP:rs11749Ensembl.1
Natural variantiVAR_035701120I → M in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1266159589Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0569651 – 6MIPPAD → MPYYPQ in isoform 2. 1 Publication6
Alternative sequenceiVSP_0569667 – 132Missing in isoform 2. 1 PublicationAdd BLAST126

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF006386 mRNA Translation: AAB69193.1 Frameshift.
AK295199 mRNA Translation: BAG58198.1
AK290502 mRNA Translation: BAF83191.1
BX647913 mRNA Translation: CAI46082.1 Different initiation.
AL034379 Genomic DNA No translation available.
BC039074 mRNA Translation: AAH39074.1
BC046117 mRNA Translation: AAH46117.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS420.1 [O14645-1]

NCBI Reference Sequences

More...RefSeqi		NP_003453.2, NM_003462.3 [O14645-1]
XP_005271229.1, XM_005271172.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000652629; ENSP00000498620; ENSG00000163879 [O14645-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		7802

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:7802

UCSC genome browser

More...UCSCi		uc001cbj.3, human [O14645-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF006386 mRNA Translation: AAB69193.1 Frameshift.
AK295199 mRNA Translation: BAG58198.1
AK290502 mRNA Translation: BAF83191.1
BX647913 mRNA Translation: CAI46082.1 Different initiation.
AL034379 Genomic DNA No translation available.
BC039074 mRNA Translation: AAH39074.1
BC046117 mRNA Translation: AAH46117.1
CCDSiCCDS420.1 [O14645-1]
RefSeqiNP_003453.2, NM_003462.3 [O14645-1]
XP_005271229.1, XM_005271172.2

3D structure databases

SMRiO14645
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi113577, 17 interactors
IntActiO14645, 84 interactors
MINTiO14645
STRINGi9606.ENSP00000296218

PTM databases

iPTMnetiO14645
PhosphoSitePlusiO14645

Genetic variation databases

BioMutaiDNALI1

Proteomic databases

EPDiO14645
MassIVEiO14645
PaxDbiO14645
PeptideAtlasiO14645
PRIDEiO14645
ProteomicsDBi4231
48141 [O14645-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		31735, 193 antibodies

The DNASU plasmid repository

More...DNASUi		7802

Genome annotation databases

EnsembliENST00000652629; ENSP00000498620; ENSG00000163879 [O14645-1]
GeneIDi7802
KEGGihsa:7802
UCSCiuc001cbj.3, human [O14645-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7802
DisGeNETi7802

GeneCards: human genes, protein and diseases

More...GeneCardsi		DNALI1
HGNCiHGNC:14353, DNALI1
HPAiENSG00000163879, Tissue enhanced (fallopian tube, testis)
MIMi602135, gene
neXtProtiNX_O14645
OpenTargetsiENSG00000163879
PharmGKBiPA38381
VEuPathDBiHostDB:ENSG00000163879.10

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4001, Eukaryota
GeneTreeiENSGT00390000003012
HOGENOMiCLU_072652_0_0_1
InParanoidiO14645
OrthoDBi1375694at2759
PhylomeDBiO14645
TreeFamiTF314891

Enzyme and pathway databases

PathwayCommonsiO14645

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		7802, 5 hits in 873 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		DNALI1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		7802
PharosiO14645, Tdark

Protein Ontology

More...PROi		PR:O14645
RNActiO14645, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000163879, Expressed in testis and 165 other tissues
ExpressionAtlasiO14645, baseline and differential
GenevisibleiO14645, HS

Family and domain databases

InterProiView protein in InterPro
IPR019347, Axonemal_dynein_light_chain
PANTHERiPTHR13183, PTHR13183, 1 hit
PfamiView protein in Pfam
PF10211, Ax_dynein_light, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIDLC_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O14645
Secondary accession number(s): A8K387
, B4DHN6, Q05BL9, Q5HYE2, Q5TGH0, Q7L0I5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: September 27, 2005
Last modified: February 10, 2021
This is version 149 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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