UniProtKB - O14641 (DVL2_HUMAN)
Segment polarity protein dishevelled homolog DVL-2
DVL2
Functioni
GO - Molecular functioni
- frizzled binding Source: UniProtKB
- identical protein binding Source: IntAct
- protein domain specific binding Source: Ensembl
- protein kinase binding Source: Ensembl
- protein-macromolecule adaptor activity Source: Ensembl
- protein self-association Source: Ensembl
- Rac GTPase binding Source: Ensembl
GO - Biological processi
- beta-catenin destruction complex disassembly Source: Reactome
- canonical Wnt signaling pathway Source: BHF-UCL
- canonical Wnt signaling pathway involved in regulation of cell proliferation Source: BHF-UCL
- cellular protein localization Source: Ensembl
- cochlea morphogenesis Source: Ensembl
- convergent extension involved in neural plate elongation Source: Ensembl
- heart development Source: BHF-UCL
- hippo signaling Source: Reactome
- membrane organization Source: Reactome
- negative regulation of canonical Wnt signaling pathway Source: Reactome
- neural tube closure Source: BHF-UCL
- non-canonical Wnt signaling pathway Source: BHF-UCL
- outflow tract morphogenesis Source: BHF-UCL
- planar cell polarity pathway involved in neural tube closure Source: GO_Central
- positive regulation of DNA-binding transcription factor activity Source: BHF-UCL
- positive regulation of GTPase activity Source: Ensembl
- positive regulation of JUN kinase activity Source: BHF-UCL
- positive regulation of neuron projection arborization Source: ARUK-UCL
- positive regulation of protein phosphorylation Source: BHF-UCL
- positive regulation of protein tyrosine kinase activity Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: BHF-UCL
- regulation of transcription, DNA-templated Source: UniProtKB
- segment specification Source: BHF-UCL
- Wnt signaling pathway, planar cell polarity pathway Source: BHF-UCL
Keywordsi
Molecular function | Developmental protein |
Biological process | Wnt signaling pathway |
Enzyme and pathway databases
PathwayCommonsi | O14641 |
Reactomei | R-HSA-201681, TCF dependent signaling in response to WNT R-HSA-201688, WNT mediated activation of DVL R-HSA-2028269, Signaling by Hippo R-HSA-4086400, PCP/CE pathway R-HSA-4608870, Asymmetric localization of PCP proteins R-HSA-4641258, Degradation of DVL R-HSA-4641262, Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-5099900, WNT5A-dependent internalization of FZD4 R-HSA-5368598, Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5663220, RHO GTPases Activate Formins R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis R-HSA-8856828, Clathrin-mediated endocytosis R-HSA-9673324, WNT5:FZD7-mediated leishmania damping |
SignaLinki | O14641 |
SIGNORi | O14641 |
Names & Taxonomyi
Protein namesi | Recommended name: Segment polarity protein dishevelled homolog DVL-2Short name: Dishevelled-2 Alternative name(s): DSH homolog 2 |
Gene namesi | Name:DVL2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000004975.11 |
HGNCi | HGNC:3086, DVL2 |
MIMi | 602151, gene |
neXtProti | NX_O14641 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Cytosol
- cytosol By similarity
Plasma membrane
- Cell membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
Other locations
- Cytoplasmic vesicle By similarity
Note: Localizes at the cell membrane upon interaction with frizzled family members and promotes their internalization. Localizes to cytoplasmic puncta (By similarity). Interaction with FOXK1 and FOXK2 induces nuclear translocation (PubMed:25805136).By similarity1 Publication
Cytosol
- cytosol Source: GO_Central
Nucleus
- nuclear body Source: HPA
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Plasma Membrane
- lateral plasma membrane Source: Ensembl
Other locations
- aggresome Source: HPA
- apical part of cell Source: Ensembl
- clathrin-coated endocytic vesicle Source: Reactome
- cytoplasm Source: BHF-UCL
- cytoplasmic vesicle Source: MGI
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Cytoplasmic vesicle, Membrane, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 250 – 252 | TSS → AAA: Almost abolishes interaction with FOXK2. 1 Publication | 3 | |
Mutagenesisi | 250 | T → A: No effect on interaction with FOXK2. 1 Publication | 1 | |
Mutagenesisi | 251 | S → A: No effect on interaction with FOXK2. 1 Publication | 1 | |
Mutagenesisi | 252 | S → A: Almost abolishes interaction with FOXK2. 1 Publication | 1 | |
Mutagenesisi | 254 – 257 | SSVT → AAVA: Almost abolishes interaction with FOXK2. 1 Publication | 4 | |
Mutagenesisi | 254 | S → A: Reduces interaction with FOXK2. 1 Publication | 1 | |
Mutagenesisi | 255 | S → A: Almost abolishes interaction with FOXK2. 1 Publication | 1 | |
Mutagenesisi | 257 | T → A: Almost abolishes interaction with FOXK2. 1 Publication | 1 | |
Mutagenesisi | 259 – 262 | STMS → AAMA: Almost abolishes interaction with FOXK2. 1 Publication | 4 | |
Mutagenesisi | 259 | S → A: Almost abolishes interaction with FOXK2. 1 Publication | 1 | |
Mutagenesisi | 260 | T → A: No effect on interaction with FOXK2. 1 Publication | 1 | |
Mutagenesisi | 262 | S → A: Almost abolishes interaction with FOXK2. 1 Publication | 1 | |
Mutagenesisi | 267 – 269 | TVT → AVA: Almost abolishes interaction with FOXK2. 1 Publication | 3 | |
Mutagenesisi | 267 | T → A: Almost abolishes interaction with FOXK2. 1 Publication | 1 | |
Mutagenesisi | 269 | T → A: Almost abolishes interaction with FOXK2. 1 Publication | 1 | |
Mutagenesisi | 275 | Y → F: No effect on interaction with FOXK2. 1 Publication | 1 | |
Mutagenesisi | 281 | S → A: No effect on interaction with FOXK2. 1 Publication | 1 | |
Mutagenesisi | 286 | S → A: No effect on interaction with FOXK2. 1 Publication | 1 | |
Mutagenesisi | 295 | Y → F: No effect on interaction with FOXK2. 1 Publication | 1 | |
Mutagenesisi | 298 | S → A: No effect on interaction with FOXK2. 1 Publication | 1 | |
Mutagenesisi | 329 | S → A: No effect on interaction with FOXK2. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 1856 |
OpenTargetsi | ENSG00000004975 |
PharmGKBi | PA27542 |
Miscellaneous databases
Pharosi | O14641, Tbio |
Chemistry databases
ChEMBLi | CHEMBL1255125 |
Polymorphism and mutation databases
BioMutai | DVL2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000145746 | 1 – 736 | Segment polarity protein dishevelled homolog DVL-2Add BLAST | 736 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 211 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | O14641 |
jPOSTi | O14641 |
MassIVEi | O14641 |
MaxQBi | O14641 |
PaxDbi | O14641 |
PeptideAtlasi | O14641 |
PRIDEi | O14641 |
ProteomicsDBi | 48140 |
PTM databases
iPTMneti | O14641 |
MetOSitei | O14641 |
PhosphoSitePlusi | O14641 |
Expressioni
Gene expression databases
Bgeei | ENSG00000004975, Expressed in vagina and 229 other tissues |
ExpressionAtlasi | O14641, baseline and differential |
Genevisiblei | O14641, HS |
Organism-specific databases
HPAi | ENSG00000004975, Low tissue specificity |
Interactioni
Subunit structurei
Interacts through its PDZ domain with the C-terminal regions of VANGL1 and VANGL2.
Interacts with Rac.
Interacts with ARRB1; the interaction is enhanced by phosphorylation of DVL1 (By similarity). Can form large oligomers (via DIX domain).
Interacts (via DIX domain) with DIXDC1 (via DIX domain).
Interacts (via DEP domain) with AP2M1 and the AP-2 complex (By similarity).
Interacts with DACT1 and FAM105B/otulin.
Interacts with DCDC2.
Interacts (when phosphorylated) with FOXK1 and FOXK2; the interaction induces DVL2 nuclear translocation (PubMed:25805136).
Interacts with MAPK15 (By similarity).
Interacts with PKD1 (via extracellular domain) (PubMed:27214281).
Interacts with LMBR1L (By similarity).
By similarity7 PublicationsBinary interactionsi
Hide detailsO14641
GO - Molecular functioni
- frizzled binding Source: UniProtKB
- identical protein binding Source: IntAct
- protein domain specific binding Source: Ensembl
- protein kinase binding Source: Ensembl
- protein self-association Source: Ensembl
- Rac GTPase binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 108189, 229 interactors |
CORUMi | O14641 |
DIPi | DIP-34433N |
IntActi | O14641, 156 interactors |
MINTi | O14641 |
STRINGi | 9606.ENSP00000005340 |
Chemistry databases
BindingDBi | O14641 |
Miscellaneous databases
RNActi | O14641, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | O14641 |
SMRi | O14641 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O14641 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 11 – 93 | DIXPROSITE-ProRule annotationAdd BLAST | 83 | |
Domaini | 267 – 339 | PDZPROSITE-ProRule annotationAdd BLAST | 73 | |
Domaini | 433 – 507 | DEPPROSITE-ProRule annotationAdd BLAST | 75 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 250 – 355 | Required for interaction with FOXK21 PublicationAdd BLAST | 106 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 7 – 12 | Poly-Gly | 6 | |
Compositional biasi | 235 – 240 | Poly-Arg | 6 | |
Compositional biasi | 686 – 694 | Poly-Pro | 9 |
Domaini
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3571, Eukaryota |
GeneTreei | ENSGT00950000182903 |
InParanoidi | O14641 |
OMAi | TPWPLLH |
OrthoDBi | 474724at2759 |
PhylomeDBi | O14641 |
TreeFami | TF318198 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit 2.30.42.10, 1 hit 3.10.20.380, 1 hit |
InterProi | View protein in InterPro IPR000591, DEP_dom IPR024580, Dishevelled_C-dom IPR008339, Dishevelled_fam IPR003351, Dishevelled_protein_dom IPR001158, DIX IPR038207, DIX_dom_sf IPR015506, Dsh/Dvl-rel IPR008341, DVL2 IPR001478, PDZ IPR036034, PDZ_sf IPR029071, Ubiquitin-like_domsf IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR10878, PTHR10878, 1 hit PTHR10878:SF8, PTHR10878:SF8, 1 hit |
Pfami | View protein in Pfam PF00610, DEP, 1 hit PF02377, Dishevelled, 1 hit PF00778, DIX, 1 hit PF12316, Dsh_C, 1 hit PF00595, PDZ, 1 hit |
PRINTSi | PR01760, DISHEVELLED PR01762, DISHEVELLED2 |
SMARTi | View protein in SMART SM00021, DAX, 1 hit SM00049, DEP, 1 hit SM00228, PDZ, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF50156, SSF50156, 1 hit SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS50186, DEP, 1 hit PS50841, DIX, 1 hit PS50106, PDZ, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MAGSSTGGGG VGETKVIYHL DEEETPYLVK IPVPAERITL GDFKSVLQRP
60 70 80 90 100
AGAKYFFKSM DQDFGVVKEE ISDDNARLPC FNGRVVSWLV SSDNPQPEMA
110 120 130 140 150
PPVHEPRAEL APPAPPLPPL PPERTSGIGD SRPPSFHPNV SSSHENLEPE
160 170 180 190 200
TETESVVSLR RERPRRRDSS EHGAGGHRTG GPSRLERHLA GYESSSTLMT
210 220 230 240 250
SELESTSLGD SDEEDTMSRF SSSTEQSSAS RLLKRHRRRR KQRPPRLERT
260 270 280 290 300
SSFSSVTDST MSLNIITVTL NMEKYNFLGI SIVGQSNERG DGGIYIGSIM
310 320 330 340 350
KGGAVAADGR IEPGDMLLQV NDMNFENMSN DDAVRVLRDI VHKPGPIVLT
360 370 380 390 400
VAKCWDPSPQ AYFTLPRNEP IQPIDPAAWV SHSAALTGTF PAYPGSSSMS
410 420 430 440 450
TITSGSSLPD GCEGRGLSVH TDMASVTKAM AAPESGLEVR DRMWLKITIP
460 470 480 490 500
NAFLGSDVVD WLYHHVEGFP ERREARKYAS GLLKAGLIRH TVNKITFSEQ
510 520 530 540 550
CYYVFGDLSG GCESYLVNLS LNDNDGSSGA SDQDTLAPLP GATPWPLLPT
560 570 580 590 600
FSYQYPAPHP YSPQPPPYHE LSSYTYGGGS ASSQHSEGSR SSGSTRSDGG
610 620 630 640 650
AGRTGRPEER APESKSGSGS ESEPSSRGGS LRRGGEASGT SDGGPPPSRG
660 670 680 690 700
STGGAPNLRA HPGLHPYGPP PGMALPYNPM MVVMMPPPPP PVPPAVQPPG
710 720 730
APPVRDLGSV PPELTASRQS FHMAMGNPSE FFVDVM
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketI3L2N2 | I3L2N2_HUMAN | Segment polarity protein dishevelle... | DVL2 | 730 | Annotation score: | ||
I3L0Z8 | I3L0Z8_HUMAN | Segment polarity protein dishevelle... | DVL2 | 300 | Annotation score: | ||
I3L2W9 | I3L2W9_HUMAN | Segment polarity protein dishevelle... | DVL2 | 363 | Annotation score: | ||
I3L0M7 | I3L0M7_HUMAN | Segment polarity protein dishevelle... | DVL2 | 291 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_064708 | 282 | I → T Found in a renal cell carcinoma case; somatic mutation. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF006012 mRNA Translation: AAB65243.1 BT009822 mRNA Translation: AAP88824.1 CH471108 Genomic DNA Translation: EAW90244.1 CH471108 Genomic DNA Translation: EAW90245.1 BC014844 mRNA Translation: AAH14844.1 |
CCDSi | CCDS11091.1 |
RefSeqi | NP_004413.1, NM_004422.2 |
Genome annotation databases
Ensembli | ENST00000005340; ENSP00000005340; ENSG00000004975 |
GeneIDi | 1856 |
KEGGi | hsa:1856 |
UCSCi | uc002gez.2, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF006012 mRNA Translation: AAB65243.1 BT009822 mRNA Translation: AAP88824.1 CH471108 Genomic DNA Translation: EAW90244.1 CH471108 Genomic DNA Translation: EAW90245.1 BC014844 mRNA Translation: AAH14844.1 |
CCDSi | CCDS11091.1 |
RefSeqi | NP_004413.1, NM_004422.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2REY | X-ray | 1.55 | A | 261-355 | [»] | |
3CBX | X-ray | 1.70 | A/B | 264-354 | [»] | |
3CBY | X-ray | 1.50 | A/B | 264-354 | [»] | |
3CBZ | X-ray | 1.38 | A | 264-354 | [»] | |
3CC0 | X-ray | 1.75 | A/B/C | 264-354 | [»] | |
4WIP | X-ray | 2.69 | A/B/C | 12-106 | [»] | |
5LNP | X-ray | 1.99 | A/B/C/D | 416-510 | [»] | |
5SUY | X-ray | 1.88 | A/B/C/D | 416-510 | [»] | |
5SUZ | X-ray | 1.84 | A/B | 416-509 | [»] | |
6IW3 | X-ray | 1.64 | A | 12-93 | [»] | |
6JCK | X-ray | 3.09 | B | 12-93 | [»] | |
BMRBi | O14641 | |||||
SMRi | O14641 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 108189, 229 interactors |
CORUMi | O14641 |
DIPi | DIP-34433N |
IntActi | O14641, 156 interactors |
MINTi | O14641 |
STRINGi | 9606.ENSP00000005340 |
Chemistry databases
BindingDBi | O14641 |
ChEMBLi | CHEMBL1255125 |
PTM databases
iPTMneti | O14641 |
MetOSitei | O14641 |
PhosphoSitePlusi | O14641 |
Polymorphism and mutation databases
BioMutai | DVL2 |
Proteomic databases
EPDi | O14641 |
jPOSTi | O14641 |
MassIVEi | O14641 |
MaxQBi | O14641 |
PaxDbi | O14641 |
PeptideAtlasi | O14641 |
PRIDEi | O14641 |
ProteomicsDBi | 48140 |
Protocols and materials databases
Antibodypediai | 3985, 459 antibodies |
DNASUi | 1856 |
Genome annotation databases
Ensembli | ENST00000005340; ENSP00000005340; ENSG00000004975 |
GeneIDi | 1856 |
KEGGi | hsa:1856 |
UCSCi | uc002gez.2, human |
Organism-specific databases
CTDi | 1856 |
DisGeNETi | 1856 |
EuPathDBi | HostDB:ENSG00000004975.11 |
GeneCardsi | DVL2 |
HGNCi | HGNC:3086, DVL2 |
HPAi | ENSG00000004975, Low tissue specificity |
MIMi | 602151, gene |
neXtProti | NX_O14641 |
OpenTargetsi | ENSG00000004975 |
PharmGKBi | PA27542 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3571, Eukaryota |
GeneTreei | ENSGT00950000182903 |
InParanoidi | O14641 |
OMAi | TPWPLLH |
OrthoDBi | 474724at2759 |
PhylomeDBi | O14641 |
TreeFami | TF318198 |
Enzyme and pathway databases
PathwayCommonsi | O14641 |
Reactomei | R-HSA-201681, TCF dependent signaling in response to WNT R-HSA-201688, WNT mediated activation of DVL R-HSA-2028269, Signaling by Hippo R-HSA-4086400, PCP/CE pathway R-HSA-4608870, Asymmetric localization of PCP proteins R-HSA-4641258, Degradation of DVL R-HSA-4641262, Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-5099900, WNT5A-dependent internalization of FZD4 R-HSA-5368598, Negative regulation of TCF-dependent signaling by DVL-interacting proteins R-HSA-5663220, RHO GTPases Activate Formins R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis R-HSA-8856828, Clathrin-mediated endocytosis R-HSA-9673324, WNT5:FZD7-mediated leishmania damping |
SignaLinki | O14641 |
SIGNORi | O14641 |
Miscellaneous databases
BioGRID-ORCSi | 1856, 6 hits in 849 CRISPR screens |
ChiTaRSi | DVL2, human |
EvolutionaryTracei | O14641 |
GeneWikii | DVL2 |
GenomeRNAii | 1856 |
Pharosi | O14641, Tbio |
PROi | PR:O14641 |
RNActi | O14641, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000004975, Expressed in vagina and 229 other tissues |
ExpressionAtlasi | O14641, baseline and differential |
Genevisiblei | O14641, HS |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit 2.30.42.10, 1 hit 3.10.20.380, 1 hit |
InterProi | View protein in InterPro IPR000591, DEP_dom IPR024580, Dishevelled_C-dom IPR008339, Dishevelled_fam IPR003351, Dishevelled_protein_dom IPR001158, DIX IPR038207, DIX_dom_sf IPR015506, Dsh/Dvl-rel IPR008341, DVL2 IPR001478, PDZ IPR036034, PDZ_sf IPR029071, Ubiquitin-like_domsf IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR10878, PTHR10878, 1 hit PTHR10878:SF8, PTHR10878:SF8, 1 hit |
Pfami | View protein in Pfam PF00610, DEP, 1 hit PF02377, Dishevelled, 1 hit PF00778, DIX, 1 hit PF12316, Dsh_C, 1 hit PF00595, PDZ, 1 hit |
PRINTSi | PR01760, DISHEVELLED PR01762, DISHEVELLED2 |
SMARTi | View protein in SMART SM00021, DAX, 1 hit SM00049, DEP, 1 hit SM00228, PDZ, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF50156, SSF50156, 1 hit SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS50186, DEP, 1 hit PS50841, DIX, 1 hit PS50106, PDZ, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DVL2_HUMAN | |
Accessioni | O14641Primary (citable) accession number: O14641 Secondary accession number(s): D3DTN3, Q53XM0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | January 1, 1998 | |
Last modified: | December 2, 2020 | |
This is version 207 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations