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UniProtKB - O14641 (DVL2_HUMAN)

Entry version 210 (02 Jun 2021)
Sequence version 1 (01 Jan 1998)
Previous versions | rss
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Protein

Segment polarity protein dishevelled homolog DVL-2

Gene

DVL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling.

By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processWnt signaling pathway

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O14641

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-201681, TCF dependent signaling in response to WNT
R-HSA-201688, WNT mediated activation of DVL
R-HSA-2028269, Signaling by Hippo
R-HSA-4086400, PCP/CE pathway
R-HSA-4608870, Asymmetric localization of PCP proteins
R-HSA-4641258, Degradation of DVL
R-HSA-4641262, Disassembly of the destruction complex and recruitment of AXIN to the membrane
R-HSA-5099900, WNT5A-dependent internalization of FZD4
R-HSA-5368598, Negative regulation of TCF-dependent signaling by DVL-interacting proteins
R-HSA-5663220, RHO GTPases Activate Formins
R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828, Clathrin-mediated endocytosis
R-HSA-9673324, WNT5:FZD7-mediated leishmania damping

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		O14641

SIGNOR Signaling Network Open Resource

More...SIGNORi		O14641

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Segment polarity protein dishevelled homolog DVL-2
Short name:
Dishevelled-2
Alternative name(s):
DSH homolog 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DVL2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:3086, DVL2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602151, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O14641

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000004975.11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoplasmic vesicle, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi250 – 252TSS → AAA: Almost abolishes interaction with FOXK2. 1 Publication3
Mutagenesisi250T → A: No effect on interaction with FOXK2. 1 Publication1
Mutagenesisi251S → A: No effect on interaction with FOXK2. 1 Publication1
Mutagenesisi252S → A: Almost abolishes interaction with FOXK2. 1 Publication1
Mutagenesisi254 – 257SSVT → AAVA: Almost abolishes interaction with FOXK2. 1 Publication4
Mutagenesisi254S → A: Reduces interaction with FOXK2. 1 Publication1
Mutagenesisi255S → A: Almost abolishes interaction with FOXK2. 1 Publication1
Mutagenesisi257T → A: Almost abolishes interaction with FOXK2. 1 Publication1
Mutagenesisi259 – 262STMS → AAMA: Almost abolishes interaction with FOXK2. 1 Publication4
Mutagenesisi259S → A: Almost abolishes interaction with FOXK2. 1 Publication1
Mutagenesisi260T → A: No effect on interaction with FOXK2. 1 Publication1
Mutagenesisi262S → A: Almost abolishes interaction with FOXK2. 1 Publication1
Mutagenesisi267 – 269TVT → AVA: Almost abolishes interaction with FOXK2. 1 Publication3
Mutagenesisi267T → A: Almost abolishes interaction with FOXK2. 1 Publication1
Mutagenesisi269T → A: Almost abolishes interaction with FOXK2. 1 Publication1
Mutagenesisi275Y → F: No effect on interaction with FOXK2. 1 Publication1
Mutagenesisi281S → A: No effect on interaction with FOXK2. 1 Publication1
Mutagenesisi286S → A: No effect on interaction with FOXK2. 1 Publication1
Mutagenesisi295Y → F: No effect on interaction with FOXK2. 1 Publication1
Mutagenesisi298S → A: No effect on interaction with FOXK2. 1 Publication1
Mutagenesisi329S → A: No effect on interaction with FOXK2. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		1856

Open Targets

More...OpenTargetsi		ENSG00000004975

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA27542

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O14641, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL1255125

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		DVL2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001457461 – 736Segment polarity protein dishevelled homolog DVL-2Add BLAST736

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei211PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by CSNK1D (PubMed:21422228, PubMed:9192851). WNT3A induces DVL2 phosphorylation by CSNK1E and MARK kinases (PubMed:25805136).3 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O14641

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O14641

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O14641

MaxQB - The MaxQuant DataBase

More...MaxQBi		O14641

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O14641

PeptideAtlas

More...PeptideAtlasi		O14641

PRoteomics IDEntifications database

More...PRIDEi		O14641

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		48140

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O14641

MetOSite database of methionine sulfoxide sites

More...MetOSitei		O14641

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O14641

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000004975, Expressed in vagina and 230 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O14641, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O14641, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000004975, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts through its PDZ domain with the C-terminal regions of VANGL1 and VANGL2.

Interacts with Rac.

Interacts with ARRB1; the interaction is enhanced by phosphorylation of DVL1 (By similarity). Can form large oligomers (via DIX domain).

Interacts (via DIX domain) with DIXDC1 (via DIX domain).

Interacts (via DEP domain) with AP2M1 and the AP-2 complex (By similarity).

Interacts with DACT1 and FAM105B/otulin.

Interacts with DCDC2.

Interacts (when phosphorylated) with FOXK1 and FOXK2; the interaction induces DVL2 nuclear translocation (PubMed:25805136).

Interacts with MAPK15 (By similarity).

Interacts with PKD1 (via extracellular domain) (PubMed:27214281).

Interacts with LMBR1L (By similarity).

By similarity7 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		108189, 234 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		O14641

Database of interacting proteins

More...DIPi		DIP-34433N

Protein interaction database and analysis system

More...IntActi		O14641, 163 interactors

Molecular INTeraction database

More...MINTi		O14641

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000005340

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		O14641

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O14641, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1736
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		O14641

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O14641

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		O14641

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini11 – 93DIXPROSITE-ProRule annotationAdd BLAST83
Domaini267 – 339PDZPROSITE-ProRule annotationAdd BLAST73
Domaini433 – 507DEPPROSITE-ProRule annotationAdd BLAST75

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni92 – 254DisorderedSequence analysisAdd BLAST163
Regioni250 – 355Required for interaction with FOXK21 PublicationAdd BLAST106
Regioni558 – 675DisorderedSequence analysisAdd BLAST118

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi99 – 123Pro residuesSequence analysisAdd BLAST25
Compositional biasi147 – 174Basic and acidic residuesSequence analysisAdd BLAST28
Compositional biasi575 – 599Polar residuesSequence analysisAdd BLAST25
Compositional biasi602 – 616Basic and acidic residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The DIX domain mediates homooligomerization.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DSH family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3571, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000182903

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O14641

Identification of Orthologs from Complete Genome Data

More...OMAi		TPWPLLH

Database of Orthologous Groups

More...OrthoDBi		474724at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O14641

TreeFam database of animal gene trees

More...TreeFami		TF318198

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.10.10, 1 hit
2.30.42.10, 1 hit
3.10.20.380, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000591, DEP_dom
IPR024580, Dishevelled_C-dom
IPR008339, Dishevelled_fam
IPR003351, Dishevelled_protein_dom
IPR001158, DIX
IPR038207, DIX_dom_sf
IPR015506, Dsh/Dvl-rel
IPR008341, DVL2
IPR001478, PDZ
IPR036034, PDZ_sf
IPR029071, Ubiquitin-like_domsf
IPR036388, WH-like_DNA-bd_sf
IPR036390, WH_DNA-bd_sf

The PANTHER Classification System

More...PANTHERi		PTHR10878, PTHR10878, 1 hit
PTHR10878:SF8, PTHR10878:SF8, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00610, DEP, 1 hit
PF02377, Dishevelled, 1 hit
PF00778, DIX, 1 hit
PF12316, Dsh_C, 1 hit
PF00595, PDZ, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01760, DISHEVELLED
PR01762, DISHEVELLED2

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00021, DAX, 1 hit
SM00049, DEP, 1 hit
SM00228, PDZ, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46785, SSF46785, 1 hit
SSF50156, SSF50156, 1 hit
SSF54236, SSF54236, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50186, DEP, 1 hit
PS50841, DIX, 1 hit
PS50106, PDZ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

O14641-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGSSTGGGG VGETKVIYHL DEEETPYLVK IPVPAERITL GDFKSVLQRP 
        60         70         80         90        100
AGAKYFFKSM DQDFGVVKEE ISDDNARLPC FNGRVVSWLV SSDNPQPEMA 
       110        120        130        140        150
PPVHEPRAEL APPAPPLPPL PPERTSGIGD SRPPSFHPNV SSSHENLEPE 
       160        170        180        190        200
TETESVVSLR RERPRRRDSS EHGAGGHRTG GPSRLERHLA GYESSSTLMT 
       210        220        230        240        250
SELESTSLGD SDEEDTMSRF SSSTEQSSAS RLLKRHRRRR KQRPPRLERT 
       260        270        280        290        300
SSFSSVTDST MSLNIITVTL NMEKYNFLGI SIVGQSNERG DGGIYIGSIM 
       310        320        330        340        350
KGGAVAADGR IEPGDMLLQV NDMNFENMSN DDAVRVLRDI VHKPGPIVLT 
       360        370        380        390        400
VAKCWDPSPQ AYFTLPRNEP IQPIDPAAWV SHSAALTGTF PAYPGSSSMS 
       410        420        430        440        450
TITSGSSLPD GCEGRGLSVH TDMASVTKAM AAPESGLEVR DRMWLKITIP 
       460        470        480        490        500
NAFLGSDVVD WLYHHVEGFP ERREARKYAS GLLKAGLIRH TVNKITFSEQ 
       510        520        530        540        550
CYYVFGDLSG GCESYLVNLS LNDNDGSSGA SDQDTLAPLP GATPWPLLPT 
       560        570        580        590        600
FSYQYPAPHP YSPQPPPYHE LSSYTYGGGS ASSQHSEGSR SSGSTRSDGG 
       610        620        630        640        650
AGRTGRPEER APESKSGSGS ESEPSSRGGS LRRGGEASGT SDGGPPPSRG 
       660        670        680        690        700
STGGAPNLRA HPGLHPYGPP PGMALPYNPM MVVMMPPPPP PVPPAVQPPG 
       710        720        730 
APPVRDLGSV PPELTASRQS FHMAMGNPSE FFVDVM
Length:736
Mass (Da):78,948
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4BAD95B6C3FE531B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L2N2I3L2N2_HUMAN
Segment polarity protein dishevelle...
DVL2
730Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L0Z8I3L0Z8_HUMAN
Segment polarity protein dishevelle...
DVL2
300Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L2W9I3L2W9_HUMAN
Segment polarity protein dishevelle...
DVL2
363Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L0M7I3L0M7_HUMAN
Segment polarity protein dishevelle...
DVL2
291Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_064708282I → T Found in a renal cell carcinoma case; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF006012 mRNA Translation: AAB65243.1
BT009822 mRNA Translation: AAP88824.1
CH471108 Genomic DNA Translation: EAW90244.1
CH471108 Genomic DNA Translation: EAW90245.1
BC014844 mRNA Translation: AAH14844.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS11091.1

NCBI Reference Sequences

More...RefSeqi		NP_004413.1, NM_004422.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000005340; ENSP00000005340; ENSG00000004975

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1856

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:1856

UCSC genome browser

More...UCSCi		uc002gez.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF006012 mRNA Translation: AAB65243.1
BT009822 mRNA Translation: AAP88824.1
CH471108 Genomic DNA Translation: EAW90244.1
CH471108 Genomic DNA Translation: EAW90245.1
BC014844 mRNA Translation: AAH14844.1
CCDSiCCDS11091.1
RefSeqiNP_004413.1, NM_004422.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2REYX-ray1.55A261-355[»]
3CBXX-ray1.70A/B264-354[»]
3CBYX-ray1.50A/B264-354[»]
3CBZX-ray1.38A264-354[»]
3CC0X-ray1.75A/B/C264-354[»]
4WIPX-ray2.69A/B/C12-106[»]
5LNPX-ray1.99A/B/C/D416-510[»]
5SUYX-ray1.88A/B/C/D416-510[»]
5SUZX-ray1.84A/B416-509[»]
6IW3X-ray1.64A12-93[»]
6JCKX-ray3.09B12-93[»]
BMRBiO14641
SMRiO14641
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi108189, 234 interactors
CORUMiO14641
DIPiDIP-34433N
IntActiO14641, 163 interactors
MINTiO14641
STRINGi9606.ENSP00000005340

Chemistry databases

BindingDBiO14641
ChEMBLiCHEMBL1255125

PTM databases

iPTMnetiO14641
MetOSiteiO14641
PhosphoSitePlusiO14641

Genetic variation databases

BioMutaiDVL2

Proteomic databases

EPDiO14641
jPOSTiO14641
MassIVEiO14641
MaxQBiO14641
PaxDbiO14641
PeptideAtlasiO14641
PRIDEiO14641
ProteomicsDBi48140

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3985, 466 antibodies

The DNASU plasmid repository

More...DNASUi		1856

Genome annotation databases

EnsembliENST00000005340; ENSP00000005340; ENSG00000004975
GeneIDi1856
KEGGihsa:1856
UCSCiuc002gez.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1856
DisGeNETi1856

GeneCards: human genes, protein and diseases

More...GeneCardsi		DVL2
HGNCiHGNC:3086, DVL2
HPAiENSG00000004975, Low tissue specificity
MIMi602151, gene
neXtProtiNX_O14641
OpenTargetsiENSG00000004975
PharmGKBiPA27542
VEuPathDBiHostDB:ENSG00000004975.11

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3571, Eukaryota
GeneTreeiENSGT00950000182903
InParanoidiO14641
OMAiTPWPLLH
OrthoDBi474724at2759
PhylomeDBiO14641
TreeFamiTF318198

Enzyme and pathway databases

PathwayCommonsiO14641
ReactomeiR-HSA-201681, TCF dependent signaling in response to WNT
R-HSA-201688, WNT mediated activation of DVL
R-HSA-2028269, Signaling by Hippo
R-HSA-4086400, PCP/CE pathway
R-HSA-4608870, Asymmetric localization of PCP proteins
R-HSA-4641258, Degradation of DVL
R-HSA-4641262, Disassembly of the destruction complex and recruitment of AXIN to the membrane
R-HSA-5099900, WNT5A-dependent internalization of FZD4
R-HSA-5368598, Negative regulation of TCF-dependent signaling by DVL-interacting proteins
R-HSA-5663220, RHO GTPases Activate Formins
R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828, Clathrin-mediated endocytosis
R-HSA-9673324, WNT5:FZD7-mediated leishmania damping
SignaLinkiO14641
SIGNORiO14641

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		1856, 6 hits in 1001 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		DVL2, human
EvolutionaryTraceiO14641

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		DVL2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		1856
PharosiO14641, Tbio

Protein Ontology

More...PROi		PR:O14641
RNActiO14641, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000004975, Expressed in vagina and 230 other tissues
ExpressionAtlasiO14641, baseline and differential
GenevisibleiO14641, HS

Family and domain databases

Gene3Di1.10.10.10, 1 hit
2.30.42.10, 1 hit
3.10.20.380, 1 hit
InterProiView protein in InterPro
IPR000591, DEP_dom
IPR024580, Dishevelled_C-dom
IPR008339, Dishevelled_fam
IPR003351, Dishevelled_protein_dom
IPR001158, DIX
IPR038207, DIX_dom_sf
IPR015506, Dsh/Dvl-rel
IPR008341, DVL2
IPR001478, PDZ
IPR036034, PDZ_sf
IPR029071, Ubiquitin-like_domsf
IPR036388, WH-like_DNA-bd_sf
IPR036390, WH_DNA-bd_sf
PANTHERiPTHR10878, PTHR10878, 1 hit
PTHR10878:SF8, PTHR10878:SF8, 1 hit
PfamiView protein in Pfam
PF00610, DEP, 1 hit
PF02377, Dishevelled, 1 hit
PF00778, DIX, 1 hit
PF12316, Dsh_C, 1 hit
PF00595, PDZ, 1 hit
PRINTSiPR01760, DISHEVELLED
PR01762, DISHEVELLED2
SMARTiView protein in SMART
SM00021, DAX, 1 hit
SM00049, DEP, 1 hit
SM00228, PDZ, 1 hit
SUPFAMiSSF46785, SSF46785, 1 hit
SSF50156, SSF50156, 1 hit
SSF54236, SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50186, DEP, 1 hit
PS50841, DIX, 1 hit
PS50106, PDZ, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDVL2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O14641
Secondary accession number(s): D3DTN3, Q53XM0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: June 2, 2021
This is version 210 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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