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Entry version 182 (08 May 2019)
Sequence version 3 (23 Sep 2008)
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Protein

Actin-binding LIM protein 1

Gene

ABLIM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May act as scaffold protein (By similarity). May play a role in the development of the retina. Has been suggested to play a role in axon guidance.By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • actin binding Source: ProtInc
  • actin filament binding Source: GO_Central
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-418885 DCC mediated attractive signaling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Actin-binding LIM protein 1
Short name:
abLIM-1
Alternative name(s):
Actin-binding LIM protein family member 1
Actin-binding double zinc finger protein
LIMAB1
Limatin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ABLIM1
Synonyms:ABLIM, KIAA0059, LIMAB1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:78 ABLIM1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602330 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O14639

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
3983

Open Targets

More...
OpenTargetsi
ENSG00000099204

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35023

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ABLIM1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000756971 – 778Actin-binding LIM protein 1Add BLAST778

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei216PhosphoserineBy similarity1
Modified residuei367PhosphoserineCombined sources1
Modified residuei373PhosphotyrosineCombined sources1
Modified residuei396PhosphotyrosineCombined sources1
Modified residuei422PhosphoserineCombined sources1
Modified residuei426PhosphoserineCombined sources1
Modified residuei431PhosphoserineCombined sources1
Modified residuei433PhosphothreonineCombined sources1
Modified residuei435PhosphoserineCombined sources1
Modified residuei439PhosphotyrosineCombined sources1
Modified residuei452PhosphoserineCombined sources1
Modified residuei455PhosphoserineCombined sources1
Modified residuei458PhosphoserineCombined sources1
Modified residuei498PhosphoserineBy similarity1
Modified residuei587PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki620Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei640PhosphoserineCombined sources1
Modified residuei655PhosphoserineCombined sources1
Modified residuei677PhosphoserineBy similarity1
Modified residuei706PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O14639

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O14639

MaxQB - The MaxQuant DataBase

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MaxQBi
O14639

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O14639

PeptideAtlas

More...
PeptideAtlasi
O14639

PRoteomics IDEntifications database

More...
PRIDEi
O14639

ProteomicsDB human proteome resource

More...
ProteomicsDBi
48133
48134 [O14639-2]
48135 [O14639-3]
48136 [O14639-4]
48137 [O14639-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O14639

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O14639

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in liver, heart, skeletal muscle, brain and retina, where it is concentrated in the inner segment and in the outer plexiform layers.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000099204 Expressed in 243 organ(s), highest expression level in cerebellum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O14639 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O14639 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA038951
HPA038952

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds F-actin. Interacts with ABRA.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110171, 93 interactors

Protein interaction database and analysis system

More...
IntActi
O14639, 70 interactors

Molecular INTeraction database

More...
MINTi
O14639

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000277895

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O14639

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini97 – 156LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST60
Domaini156 – 216LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST61
Domaini224 – 283LIM zinc-binding 3PROSITE-ProRule annotationAdd BLAST60
Domaini283 – 343LIM zinc-binding 4PROSITE-ProRule annotationAdd BLAST61
Domaini710 – 778HPPROSITE-ProRule annotationAdd BLAST69

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili590 – 614Sequence analysisAdd BLAST25

Keywords - Domaini

Coiled coil, LIM domain, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1044 Eukaryota
ENOG410XRPY LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182850

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000285997

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O14639

KEGG Orthology (KO)

More...
KOi
K07520

Identification of Orthologs from Complete Genome Data

More...
OMAi
HWDPRNA

Database of Orthologous Groups

More...
OrthoDBi
192350at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O14639

TreeFam database of animal gene trees

More...
TreeFami
TF318042

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.950.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028448 ABLIM1
IPR032402 AbLIM_anchor
IPR003128 Villin_headpiece
IPR036886 Villin_headpiece_dom_sf
IPR001781 Znf_LIM

The PANTHER Classification System

More...
PANTHERi
PTHR24213:SF18 PTHR24213:SF18, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16182 AbLIM_anchor, 1 hit
PF00412 LIM, 4 hits
PF02209 VHP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00132 LIM, 4 hits
SM00153 VHP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47050 SSF47050, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51089 HP, 1 hit
PS00478 LIM_DOMAIN_1, 4 hits
PS50023 LIM_DOMAIN_2, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O14639-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPAFLGLKCL GKLCSSEKSK VTSSERTSAR GSNRKRLIVE DRRVSGTSFT
60 70 80 90 100
AHRRATITHL LYLCPKDYCP RGRVCNSVDP FVAHPQDPHH PSEKPVIHCH
110 120 130 140 150
KCGEPCKGEV LRVQTKHFHI KCFTCKVCGC DLAQGGFFIK NGEYLCTLDY
160 170 180 190 200
QRMYGTRCHG CGEFVEGEVV TALGKTYHPN CFACTICKRP FPPGDRVTFN
210 220 230 240 250
GRDCLCQLCA QPMSSSPKET TFSSNCAGCG RDIKNGQALL ALDKQWHLGC
260 270 280 290 300
FKCKSCGKVL TGEYISKDGA PYCEKDYQGL FGVKCEACHQ FITGKVLEAG
310 320 330 340 350
DKHYHPSCAR CSRCNQMFTE GEEMYLQGST VWHPDCKQST KTEEKLRPTR
360 370 380 390 400
TSSESIYSRP GSSIPGSPGH TIYAKVDNEI LDYKDLAAIP KVKAIYDIER
410 420 430 440 450
PDLITYEPFY TSGYDDKQER QSLGESPRTL SPTPSAEGYQ DVRDRMIHRS
460 470 480 490 500
TSQGSINSPV YSRHSYTPTT SRSPQHFHRP GNEPSSGRNS PLPYRPDSRP
510 520 530 540 550
LTPTYAQAPK HFHVPDQGIN IYRKPPIYKQ HAALAAQSKS SEDIIKFSKF
560 570 580 590 600
PAAQAPDPSE TPKIETDHWP GPPSFAVVGP DMKRRSSGRE EDDEELLRRR
610 620 630 640 650
QLQEEQLMKL NSGLGQLILK EEMEKESRER SSLLASRYDS PINSASHIPS
660 670 680 690 700
SKTASLPGYG RNGLHRPVST DFAQYNSYGD VSGGVRDYQT LPDGHMPAMR
710 720 730 740 750
MDRGVSMPNM LEPKIFPYEM LMVTNRGRNK ILREVDRTRL ERHLAPEVFR
760 770
EIFGMSIQEF DRLPLWRRND MKKKAKLF
Length:778
Mass (Da):87,688
Last modified:September 23, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEBC2F14BE558752B
GO
Isoform 2 (identifier: O14639-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-81: MPAFLGLKCL...GRVCNSVDPF → MLMTLEMTELTDPHHTMGDYK

Show »
Length:718
Mass (Da):81,121
Checksum:iA9CAEEBA95BDF15E
GO
Isoform 3 (identifier: O14639-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-316: Missing.
     480-514: Missing.

Show »
Length:427
Mass (Da):48,804
Checksum:i1721FB3EC1D99994
GO
Isoform 4 (identifier: O14639-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-316: Missing.
     348-373: Missing.
     480-514: Missing.

Show »
Length:401
Mass (Da):46,087
Checksum:i0B2AC94C24A5D72F
GO
Isoform 5 (identifier: O14639-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-316: Missing.
     347-347: R → RLPNIRRSSSDFFYSKSLIRRTGRSPSLQ
     480-514: Missing.

Show »
Length:455
Mass (Da):52,056
Checksum:iCA7E610D14878674
GO
Isoform 6 (identifier: O14639-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-81: MPAFLGLKCL...GRVCNSVDPF → MLMTLEMTELTDPHHTMGDYK
     347-347: R → RLPNIRRSSSDFFYSKSLIRRTGRSPSLQ
     531-531: H → HDA

Note: No experimental confirmation available.
Show »
Length:748
Mass (Da):84,559
Checksum:i363E71622011A691
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8W8M4F8W8M4_HUMAN
Actin-binding LIM protein 1
ABLIM1
718Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MRL6A0A0A0MRL6_HUMAN
Actin-binding LIM protein 1
ABLIM1
746Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IS55A0A3B3IS55_HUMAN
Actin-binding LIM protein 1
ABLIM1
834Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QSX6J3QSX6_HUMAN
Actin-binding LIM protein 1
ABLIM1
401Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6XFR5F6XFR5_HUMAN
Actin-binding LIM protein 1
ABLIM1
173Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y7N6H0Y7N6_HUMAN
Actin-binding LIM protein 1
ABLIM1
172Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C1P1A0A494C1P1_HUMAN
Actin-binding LIM protein 1
ABLIM1
426Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C1G0A0A494C1G0_HUMAN
Actin-binding LIM protein 1
ABLIM1
502Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA06681 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti499R → L in AAC51676 (PubMed:9245787).Curated1
Sequence conflicti532A → R in AAC51676 (PubMed:9245787).Curated1
Sequence conflicti563K → E in BAA06681 (PubMed:7584044).Curated1
Sequence conflicti578V → I in BAA06681 (PubMed:7584044).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_050141434P → T. Corresponds to variant dbSNP:rs11593544Ensembl.1
Natural variantiVAR_050142637R → G. Corresponds to variant dbSNP:rs7091419Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0120991 – 316Missing in isoform 3, isoform 4 and isoform 5. 3 PublicationsAdd BLAST316
Alternative sequenceiVSP_0121001 – 81MPAFL…SVDPF → MLMTLEMTELTDPHHTMGDY K in isoform 2 and isoform 6. 2 PublicationsAdd BLAST81
Alternative sequenceiVSP_041185347R → RLPNIRRSSSDFFYSKSLIR RTGRSPSLQ in isoform 5 and isoform 6. 1 Publication1
Alternative sequenceiVSP_012101348 – 373Missing in isoform 4. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_012102480 – 514Missing in isoform 3, isoform 4 and isoform 5. 3 PublicationsAdd BLAST35
Alternative sequenceiVSP_057209531H → HDA in isoform 6. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF005654 mRNA Translation: AAC51676.1
D31883 mRNA Translation: BAA06681.2 Different initiation.
AK098277 mRNA Translation: BAG53605.1
AK122891 mRNA Translation: BAG53784.1
CR749819 mRNA Translation: CAH18679.1
AL133384 Genomic DNA No translation available.
AL354873 Genomic DNA No translation available.
AL590109 Genomic DNA No translation available.
BC002448 mRNA Translation: AAH02448.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS31288.1 [O14639-2]
CCDS31289.1 [O14639-5]
CCDS7590.1 [O14639-1]
CCDS81508.1 [O14639-4]
CCDS81509.1 [O14639-6]

NCBI Reference Sequences

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RefSeqi
NP_001003407.1, NM_001003407.1 [O14639-2]
NP_001309811.1, NM_001322882.1 [O14639-6]
NP_001309821.1, NM_001322892.1 [O14639-3]
NP_001309822.1, NM_001322893.1 [O14639-3]
NP_001309825.1, NM_001322896.1 [O14639-4]
NP_002304.3, NM_002313.5 [O14639-1]
NP_006711.3, NM_006720.3 [O14639-5]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000277895; ENSP00000277895; ENSG00000099204 [O14639-1]
ENST00000369253; ENSP00000358257; ENSG00000099204 [O14639-4]
ENST00000369256; ENSP00000358260; ENSG00000099204 [O14639-6]
ENST00000392952; ENSP00000376679; ENSG00000099204 [O14639-5]
ENST00000392955; ENSP00000376682; ENSG00000099204 [O14639-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
3983

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:3983

UCSC genome browser

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UCSCi
uc057wcr.1 human [O14639-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF005654 mRNA Translation: AAC51676.1
D31883 mRNA Translation: BAA06681.2 Different initiation.
AK098277 mRNA Translation: BAG53605.1
AK122891 mRNA Translation: BAG53784.1
CR749819 mRNA Translation: CAH18679.1
AL133384 Genomic DNA No translation available.
AL354873 Genomic DNA No translation available.
AL590109 Genomic DNA No translation available.
BC002448 mRNA Translation: AAH02448.1
CCDSiCCDS31288.1 [O14639-2]
CCDS31289.1 [O14639-5]
CCDS7590.1 [O14639-1]
CCDS81508.1 [O14639-4]
CCDS81509.1 [O14639-6]
RefSeqiNP_001003407.1, NM_001003407.1 [O14639-2]
NP_001309811.1, NM_001322882.1 [O14639-6]
NP_001309821.1, NM_001322892.1 [O14639-3]
NP_001309822.1, NM_001322893.1 [O14639-3]
NP_001309825.1, NM_001322896.1 [O14639-4]
NP_002304.3, NM_002313.5 [O14639-1]
NP_006711.3, NM_006720.3 [O14639-5]

3D structure databases

SMRiO14639
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110171, 93 interactors
IntActiO14639, 70 interactors
MINTiO14639
STRINGi9606.ENSP00000277895

PTM databases

iPTMnetiO14639
PhosphoSitePlusiO14639

Polymorphism and mutation databases

BioMutaiABLIM1

Proteomic databases

EPDiO14639
jPOSTiO14639
MaxQBiO14639
PaxDbiO14639
PeptideAtlasiO14639
PRIDEiO14639
ProteomicsDBi48133
48134 [O14639-2]
48135 [O14639-3]
48136 [O14639-4]
48137 [O14639-5]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000277895; ENSP00000277895; ENSG00000099204 [O14639-1]
ENST00000369253; ENSP00000358257; ENSG00000099204 [O14639-4]
ENST00000369256; ENSP00000358260; ENSG00000099204 [O14639-6]
ENST00000392952; ENSP00000376679; ENSG00000099204 [O14639-5]
ENST00000392955; ENSP00000376682; ENSG00000099204 [O14639-2]
GeneIDi3983
KEGGihsa:3983
UCSCiuc057wcr.1 human [O14639-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3983
DisGeNETi3983

GeneCards: human genes, protein and diseases

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GeneCardsi
ABLIM1
HGNCiHGNC:78 ABLIM1
HPAiHPA038951
HPA038952
MIMi602330 gene
neXtProtiNX_O14639
OpenTargetsiENSG00000099204
PharmGKBiPA35023

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1044 Eukaryota
ENOG410XRPY LUCA
GeneTreeiENSGT00950000182850
HOGENOMiHOG000285997
InParanoidiO14639
KOiK07520
OMAiHWDPRNA
OrthoDBi192350at2759
PhylomeDBiO14639
TreeFamiTF318042

Enzyme and pathway databases

ReactomeiR-HSA-418885 DCC mediated attractive signaling

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ABLIM1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ABLIM1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3983

Protein Ontology

More...
PROi
PR:O14639

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000099204 Expressed in 243 organ(s), highest expression level in cerebellum
ExpressionAtlasiO14639 baseline and differential
GenevisibleiO14639 HS

Family and domain databases

Gene3Di1.10.950.10, 1 hit
InterProiView protein in InterPro
IPR028448 ABLIM1
IPR032402 AbLIM_anchor
IPR003128 Villin_headpiece
IPR036886 Villin_headpiece_dom_sf
IPR001781 Znf_LIM
PANTHERiPTHR24213:SF18 PTHR24213:SF18, 2 hits
PfamiView protein in Pfam
PF16182 AbLIM_anchor, 1 hit
PF00412 LIM, 4 hits
PF02209 VHP, 1 hit
SMARTiView protein in SMART
SM00132 LIM, 4 hits
SM00153 VHP, 1 hit
SUPFAMiSSF47050 SSF47050, 1 hit
PROSITEiView protein in PROSITE
PS51089 HP, 1 hit
PS00478 LIM_DOMAIN_1, 4 hits
PS50023 LIM_DOMAIN_2, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiABLM1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O14639
Secondary accession number(s): A6NI16
, A6NJ06, A8MXA9, B3KVH2, Q15039, Q5JVV1, Q5JVV2, Q5T6N2, Q5T6N3, Q5T6N5, Q68CQ9, Q9BUP1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: September 23, 2008
Last modified: May 8, 2019
This is version 182 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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