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Protein

Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Gene

ENPP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP (PubMed:29717535). Limits mast cell and basophil responses during inflammation and during the chronic phases of allergic responses by eliminating the extracellular ATP that functions as signaling molecule and activates basophils and mast cells and induces the release of inflammatory cytokines. Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic cells (By similarity). Has also alkaline phosphodiesterase activity (PubMed:11342463).By similarity2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+1 PublicationNote: Binds 2 zinc ions per subunit.1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=61.5 µM for ATP
  2. KM=120.3 µM for UTP
  3. KM=120.2 µM for CTP
  4. KM=123.7 µM for GTP

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi167Zinc 1; catalyticCombined sources1 Publication1
    <p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei204SubstrateCombined sources1 Publication1
    <p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei205Nucleophile1 Publication1
    Metal bindingi205Zinc 1; catalyticCombined sources1 Publication1
    Binding sitei226SubstrateCombined sources1 Publication1
    Binding sitei275SubstrateCombined sources1 Publication1
    Binding sitei289SubstrateCombined sources1 Publication1
    Metal bindingi325Zinc 2; catalyticCombined sources1 Publication1
    Metal bindingi329Zinc 2; via tele nitrogen; catalyticCombined sources1 Publication1
    Metal bindingi372Zinc 1; catalyticCombined sources1 Publication1
    Metal bindingi373Zinc 1; via tele nitrogen; catalyticCombined sources1 Publication1
    Metal bindingi483Zinc 2; via tele nitrogen; catalyticCombined sources1 Publication1
    Metal bindingi752CalciumCombined sources1 Publication1
    Metal bindingi754CalciumCombined sources1 Publication1
    Metal bindingi756CalciumCombined sources1 Publication1
    Metal bindingi758Calcium; via carbonyl oxygenCombined sources1 Publication1
    Metal bindingi760CalciumCombined sources1 Publication1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionHydrolase
    LigandCalcium, Metal-binding, Zinc

    Enzyme and pathway databases

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    3.6.1.9 2681

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-199220 Vitamin B5 (pantothenate) metabolism

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
    Short name:
    E-NPP 3
    Short name:
    NPP31 Publication
    Alternative name(s):
    Phosphodiesterase I beta1 Publication
    Short name:
    PD-Ibeta1 Publication
    Phosphodiesterase I/nucleotide pyrophosphatase 3
    CD_antigen: CD203c2 Publications
    Including the following 2 domains:
    Alkaline phosphodiesterase I (EC:3.1.4.11 Publication)
    Nucleotide pyrophosphatase (EC:3.6.1.91 Publication)
    Short name:
    NPPase
    Alternative name(s):
    Nucleotide diphosphataseCurated
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:ENPP3
    Synonyms:PDNP31 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    HostDB:ENSG00000154269.14

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:3358 ENPP3

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    602182 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_O14638

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 11CytoplasmicSequence analysisAdd BLAST11
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei12 – 30Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST19
    Topological domaini31 – 875ExtracellularSequence analysisAdd BLAST845

    Keywords - Cellular componenti

    Cell membrane, Membrane, Secreted

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi179T → C: Causes the formation of covalently linked homodimers in solution; when associated with C-336. 1 Publication1
    Mutagenesisi204K → A: Strongly decreases affinity for nucleotides and slows their hydrolysis. 1 Publication1
    Mutagenesisi227N → A: No effect on affinity for nucleotides and enzyme activity. 1 Publication1
    Mutagenesisi275E → A: No effect on substrate specificity. Increases affinity for nucleotides and slows their hydrolysis. 1 Publication1
    Mutagenesisi336A → C: Causes the formation of covalently linked homodimers in solution; when associated with C-179. 1 Publication1

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    5169

    Open Targets

    More...
    OpenTargetsi
    ENSG00000154269

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA27793

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL5580

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    ENPP3

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001885701 – 875Ectonucleotide pyrophosphatase/phosphodiesterase family member 3Add BLAST875

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi54 ↔ 71PROSITE-ProRule annotationCombined sources1 Publication
    Disulfide bondi58 ↔ 89PROSITE-ProRule annotationCombined sources1 Publication
    Disulfide bondi69 ↔ 82PROSITE-ProRule annotationCombined sources1 Publication
    Disulfide bondi75 ↔ 81PROSITE-ProRule annotationCombined sources1 Publication
    Disulfide bondi98 ↔ 115PROSITE-ProRule annotationCombined sources1 Publication
    Disulfide bondi103 ↔ 133PROSITE-ProRule annotationCombined sources1 Publication
    Disulfide bondi113 ↔ 126PROSITE-ProRule annotationCombined sources1 Publication
    Disulfide bondi119 ↔ 125PROSITE-ProRule annotationCombined sources1 Publication
    Disulfide bondi144 ↔ 190PROSITE-ProRule annotationCombined sources1 Publication
    Disulfide bondi152 ↔ 364PROSITE-ProRule annotationCombined sources1 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi236N-linked (GlcNAc...) asparagineCombined sources1 Publication1
    Glycosylationi279N-linked (GlcNAc...) asparagineCombined sources1 Publication1
    Glycosylationi290N-linked (GlcNAc...) asparagineCombined sources1 Publication1
    Disulfide bondi380 ↔ 478PROSITE-ProRule annotationCombined sources1 Publication
    Glycosylationi426N-linked (GlcNAc...) asparagineCombined sources1 Publication1
    Disulfide bondi429 ↔ 818PROSITE-ProRule annotationCombined sources1 Publication
    Glycosylationi533N-linked (GlcNAc...) asparagineCombined sources1 Publication1
    Disulfide bondi562 ↔ 623Combined sources1 Publication
    Disulfide bondi575 ↔ 679PROSITE-ProRule annotationCombined sources1 Publication
    Disulfide bondi577 ↔ 664PROSITE-ProRule annotationCombined sources1 Publication
    Glycosylationi582N-linked (GlcNAc...) asparagineCombined sources1 Publication1
    Glycosylationi594N-linked (GlcNAc...) asparagineCombined sources1 Publication1
    Glycosylationi687N-linked (GlcNAc...) asparagine1 Publication1
    Glycosylationi699N-linked (GlcNAc...) asparagineCombined sources1 Publication1
    Disulfide bondi787 ↔ 797PROSITE-ProRule annotationCombined sources1 Publication
    Glycosylationi789N-linked (GlcNAc...) asparagineCombined sources1 Publication1

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    N-glycosylated. N-glycosylation is necessary for normal transport to the cell membrane, but is not the apical targeting signal.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    O14638

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    O14638

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    O14638

    PeptideAtlas

    More...
    PeptideAtlasi
    O14638

    PRoteomics IDEntifications database

    More...
    PRIDEi
    O14638

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    48132

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    O14638

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    O14638

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Detected on bile ducts in liver, and in blood serum (at protein level) (PubMed:15072822). Detected in prostate and uterus (PubMed:9344668). Detected on basophils, but not neutrophils (PubMed:11342463).3 Publications

    <p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

    Up-regulated by stimulation by allergen or by cross-linking with IgE. The IgE-mediated activation is enhanced by tetradecanoyl phorbol acetate (TPA), a stimulator of the PKC pathway, and inhibited by the P13 kinase inhibitors, LY294002 and wortmannin. Up-regulated in invasive bile duct cancers.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000154269 Expressed in 118 organ(s), highest expression level in jejunal mucosa

    CleanEx database of gene expression profiles

    More...
    CleanExi
    HS_ENPP3

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    O14638 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    O14638 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    HPA043772

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Monomer and homodimer.1 Publication

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    111195, 1 interactor

    Protein interaction database and analysis system

    More...
    IntActi
    O14638, 1 interactor

    Molecular INTeraction database

    More...
    MINTi
    O14638

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000350265

    Chemistry databases

    BindingDB database of measured binding affinities

    More...
    BindingDBi
    O14638

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1875
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    6C01X-ray2.30A/B48-875[»]
    6C02X-ray1.94A/B48-875[»]

    Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

    More...
    ProteinModelPortali
    O14638

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    O14638

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini50 – 93SMB 1PROSITE-ProRule annotationAdd BLAST44
    Domaini94 – 138SMB 2PROSITE-ProRule annotationAdd BLAST45

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni140 – 510PhosphodiesteraseAdd BLAST371
    Regioni605 – 875NucleaseAdd BLAST271

    Motif

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi78 – 80Cell attachment siteSequence analysis3

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Keywords - Domaini

    Repeat, Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG2645 Eukaryota
    COG1524 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000159640

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000037439

    The HOVERGEN Database of Homologous Vertebrate Genes

    More...
    HOVERGENi
    HBG051484

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    O14638

    KEGG Orthology (KO)

    More...
    KOi
    K01513

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    TRIWTCN

    Database of Orthologous Groups

    More...
    OrthoDBi
    999163at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    O14638

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF330032

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.40.720.10, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR017849 Alkaline_Pase-like_a/b/a
    IPR017850 Alkaline_phosphatase_core_sf
    IPR001604 DNA/RNA_non-sp_Endonuclease
    IPR020821 Extracellular_endonuc_su_A
    IPR002591 Phosphodiest/P_Trfase
    IPR036024 Somatomedin_B-like_dom_sf
    IPR001212 Somatomedin_B_dom

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF01223 Endonuclease_NS, 1 hit
    PF01663 Phosphodiest, 1 hit
    PF01033 Somatomedin_B, 2 hits

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00892 Endonuclease_NS, 1 hit
    SM00477 NUC, 1 hit
    SM00201 SO, 2 hits

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF53649 SSF53649, 1 hit
    SSF90188 SSF90188, 2 hits

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00524 SMB_1, 2 hits
    PS50958 SMB_2, 2 hits

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

    O14638-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MESTLTLATE QPVKKNTLKK YKIACIVLLA LLVIMSLGLG LGLGLRKLEK
    60 70 80 90 100
    QGSCRKKCFD ASFRGLENCR CDVACKDRGD CCWDFEDTCV ESTRIWMCNK
    110 120 130 140 150
    FRCGETRLEA SLCSCSDDCL QRKDCCADYK SVCQGETSWL EENCDTAQQS
    160 170 180 190 200
    QCPEGFDLPP VILFSMDGFR AEYLYTWDTL MPNINKLKTC GIHSKYMRAM
    210 220 230 240 250
    YPTKTFPNHY TIVTGLYPES HGIIDNNMYD VNLNKNFSLS SKEQNNPAWW
    260 270 280 290 300
    HGQPMWLTAM YQGLKAATYF WPGSEVAING SFPSIYMPYN GSVPFEERIS
    310 320 330 340 350
    TLLKWLDLPK AERPRFYTMY FEEPDSSGHA GGPVSARVIK ALQVVDHAFG
    360 370 380 390 400
    MLMEGLKQRN LHNCVNIILL ADHGMDQTYC NKMEYMTDYF PRINFFYMYE
    410 420 430 440 450
    GPAPRIRAHN IPHDFFSFNS EEIVRNLSCR KPDQHFKPYL TPDLPKRLHY
    460 470 480 490 500
    AKNVRIDKVH LFVDQQWLAV RSKSNTNCGG GNHGYNNEFR SMEAIFLAHG
    510 520 530 540 550
    PSFKEKTEVE PFENIEVYNL MCDLLRIQPA PNNGTHGSLN HLLKVPFYEP
    560 570 580 590 600
    SHAEEVSKFS VCGFANPLPT ESLDCFCPHL QNSTQLEQVN QMLNLTQEEI
    610 620 630 640 650
    TATVKVNLPF GRPRVLQKNV DHCLLYHREY VSGFGKAMRM PMWSSYTVPQ
    660 670 680 690 700
    LGDTSPLPPT VPDCLRADVR VPPSESQKCS FYLADKNITH GFLYPPASNR
    710 720 730 740 750
    TSDSQYDALI TSNLVPMYEE FRKMWDYFHS VLLIKHATER NGVNVVSGPI
    760 770 780 790 800
    FDYNYDGHFD APDEITKHLA NTDVPIPTHY FVVLTSCKNK SHTPENCPGW
    810 820 830 840 850
    LDVLPFIIPH RPTNVESCPE GKPEALWVEE RFTAHIARVR DVELLTGLDF
    860 870
    YQDKVQPVSE ILQLKTYLPT FETTI
    Length:875
    Mass (Da):100,124
    Last modified:September 23, 2008 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i629D2E33B4C45196
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    F8W6H5F8W6H5_HUMAN
    Ectonucleotide pyrophosphatase/phos...
    ENPP3
    663Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    E9PDB4E9PDB4_HUMAN
    Ectonucleotide pyrophosphatase/phos...
    ENPP3
    53Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    E7ETI7E7ETI7_HUMAN
    Ectonucleotide pyrophosphatase/phos...
    ENPP3
    53Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    <p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence AAD05192 differs from that shown. Reason: Erroneous gene model prediction.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti122R → K in AAC51813 (PubMed:9344668).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_018516620V → M. Corresponds to variant dbSNP:rs9321309Ensembl.1
    Natural variantiVAR_046538744N → H. Corresponds to variant dbSNP:rs36094194Ensembl.1
    Natural variantiVAR_031253786S → N. Corresponds to variant dbSNP:rs17601580Ensembl.1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AF005632 mRNA Translation: AAC51813.1
    EF560735 mRNA Translation: ABQ59045.1
    AC005587 Genomic DNA Translation: AAD05192.1 Sequence problems.
    AL121575 Genomic DNA No translation available.
    AL355150 Genomic DNA No translation available.
    CH471051 Genomic DNA Translation: EAW48045.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS5148.1

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_005012.2, NM_005021.4

    UniGene gene-oriented nucleotide sequence clusters

    More...
    UniGenei
    Hs.486489

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000357639; ENSP00000350265; ENSG00000154269
    ENST00000414305; ENSP00000406261; ENSG00000154269

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    5169

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:5169

    UCSC genome browser

    More...
    UCSCi
    uc003qcu.5 human

    Keywords - Coding sequence diversityi

    Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF005632 mRNA Translation: AAC51813.1
    EF560735 mRNA Translation: ABQ59045.1
    AC005587 Genomic DNA Translation: AAD05192.1 Sequence problems.
    AL121575 Genomic DNA No translation available.
    AL355150 Genomic DNA No translation available.
    CH471051 Genomic DNA Translation: EAW48045.1
    CCDSiCCDS5148.1
    RefSeqiNP_005012.2, NM_005021.4
    UniGeneiHs.486489

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    6C01X-ray2.30A/B48-875[»]
    6C02X-ray1.94A/B48-875[»]
    ProteinModelPortaliO14638
    SMRiO14638
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi111195, 1 interactor
    IntActiO14638, 1 interactor
    MINTiO14638
    STRINGi9606.ENSP00000350265

    Chemistry databases

    BindingDBiO14638
    ChEMBLiCHEMBL5580

    PTM databases

    iPTMnetiO14638
    PhosphoSitePlusiO14638

    Polymorphism and mutation databases

    BioMutaiENPP3

    Proteomic databases

    jPOSTiO14638
    MaxQBiO14638
    PaxDbiO14638
    PeptideAtlasiO14638
    PRIDEiO14638
    ProteomicsDBi48132

    Protocols and materials databases

    The DNASU plasmid repository

    More...
    DNASUi
    5169
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000357639; ENSP00000350265; ENSG00000154269
    ENST00000414305; ENSP00000406261; ENSG00000154269
    GeneIDi5169
    KEGGihsa:5169
    UCSCiuc003qcu.5 human

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    5169
    DisGeNETi5169
    EuPathDBiHostDB:ENSG00000154269.14

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    ENPP3
    HGNCiHGNC:3358 ENPP3
    HPAiHPA043772
    MIMi602182 gene
    neXtProtiNX_O14638
    OpenTargetsiENSG00000154269
    PharmGKBiPA27793

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG2645 Eukaryota
    COG1524 LUCA
    GeneTreeiENSGT00940000159640
    HOGENOMiHOG000037439
    HOVERGENiHBG051484
    InParanoidiO14638
    KOiK01513
    OMAiTRIWTCN
    OrthoDBi999163at2759
    PhylomeDBiO14638
    TreeFamiTF330032

    Enzyme and pathway databases

    BRENDAi3.6.1.9 2681
    ReactomeiR-HSA-199220 Vitamin B5 (pantothenate) metabolism

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    ENPP3 human

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    ENPP3

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    5169

    Protein Ontology

    More...
    PROi
    PR:O14638

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000154269 Expressed in 118 organ(s), highest expression level in jejunal mucosa
    CleanExiHS_ENPP3
    ExpressionAtlasiO14638 baseline and differential
    GenevisibleiO14638 HS

    Family and domain databases

    Gene3Di3.40.720.10, 1 hit
    InterProiView protein in InterPro
    IPR017849 Alkaline_Pase-like_a/b/a
    IPR017850 Alkaline_phosphatase_core_sf
    IPR001604 DNA/RNA_non-sp_Endonuclease
    IPR020821 Extracellular_endonuc_su_A
    IPR002591 Phosphodiest/P_Trfase
    IPR036024 Somatomedin_B-like_dom_sf
    IPR001212 Somatomedin_B_dom
    PfamiView protein in Pfam
    PF01223 Endonuclease_NS, 1 hit
    PF01663 Phosphodiest, 1 hit
    PF01033 Somatomedin_B, 2 hits
    SMARTiView protein in SMART
    SM00892 Endonuclease_NS, 1 hit
    SM00477 NUC, 1 hit
    SM00201 SO, 2 hits
    SUPFAMiSSF53649 SSF53649, 1 hit
    SSF90188 SSF90188, 2 hits
    PROSITEiView protein in PROSITE
    PS00524 SMB_1, 2 hits
    PS50958 SMB_2, 2 hits

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiENPP3_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O14638
    Secondary accession number(s): Q5JTL3
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
    Last sequence update: September 23, 2008
    Last modified: January 16, 2019
    This is version 165 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. SIMILARITY comments
      Index of protein domains and families
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
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