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Entry version 174 (08 May 2019)
Sequence version 2 (23 Sep 2008)
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Protein

Zinc finger protein 195

Gene

ZNF195

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri244 – 266C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri272 – 294C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri410 – 432C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri438 – 460C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri466 – 488C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri494 – 516C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri522 – 544C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri550 – 572C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri578 – 600C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri606 – 628C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-212436 Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 195
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF195
Synonyms:ZNFP104
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:12986 ZNF195

Online Mendelian Inheritance in Man (OMIM)

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MIMi
602187 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O14628

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
7748

Open Targets

More...
OpenTargetsi
ENSG00000005801

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37566

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF195

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000474471 – 629Zinc finger protein 195Add BLAST629

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki383Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei408N6-acetyllysineCombined sources1
Cross-linki492Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O14628

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O14628

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O14628

PeptideAtlas

More...
PeptideAtlasi
O14628

PRoteomics IDEntifications database

More...
PRIDEi
O14628

ProteomicsDB human proteome resource

More...
ProteomicsDBi
48126
48127 [O14628-4]
48128 [O14628-5]
48129 [O14628-6]
48130 [O14628-7]

2D gel databases

REPRODUCTION-2DPAGE

More...
REPRODUCTION-2DPAGEi
O14628

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O14628

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O14628

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in adult heart, brain, placenta, skeletal muscle and pancreas, and in fetal lung, kidney and brain. There is little expression in adult lung, liver and kidney.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000005801 Expressed in 210 organ(s), highest expression level in buccal mucosa cell

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O14628 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O14628 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA030605

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
113532, 16 interactors

Protein interaction database and analysis system

More...
IntActi
O14628, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000382511

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O14628

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4 – 75KRABPROSITE-ProRule annotationAdd BLAST72

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni76 – 243SpacerAdd BLAST168

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri244 – 266C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri272 – 294C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri410 – 432C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri438 – 460C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri466 – 488C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri494 – 516C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri522 – 544C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri550 – 572C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri578 – 600C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri606 – 628C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153165

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234617

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O14628

KEGG Orthology (KO)

More...
KOi
K09228

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O14628

TreeFam database of animal gene trees

More...
TreeFami
TF342117

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765 KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 7 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 9 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 8 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 9 hits
PS50157 ZINC_FINGER_C2H2_2, 10 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (8+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 8 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 8 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O14628-1) [UniParc]FASTAAdd to basket
Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTLLTFRDVA IEFSLEEWKC LDLAQQNLYR DVMLENYRNL FSVGLTVCKP
60 70 80 90 100
GLITCLEQRK EPWNVKRQEA ADGHPEMGFH HATQACLELL GSSDLPASAS
110 120 130 140 150
QSAGITGVNH RAQPGLNVSV DKFTALCSPG VLQTVKWFLE FRCIFSLAMS
160 170 180 190 200
SHFTQDLLPE QGIQDAFPKR ILRGYGNCGL DNLYLRKDWE SLDECKLQKD
210 220 230 240 250
YNGLNQCSST THSKIFQYNK YVKIFDNFSN LHRRNISNTG EKPFKCQECG
260 270 280 290 300
KSFQMLSFLT EHQKIHTGKK FQKCGECGKT FIQCSHFTEP ENIDTGEKPY
310 320 330 340 350
KCQECNNVIK TCSVLTKNRI YAGGEHYRCE EFGKVFNQCS HLTEHEHGTE
360 370 380 390 400
EKPCKYEECS SVFISCSSLS NQQMILAGEK LSKCETWYKG FNHSPNPSKH
410 420 430 440 450
QRNEIGGKPF KCEECDSIFK WFSDLTKHKR IHTGEKPYKC DECGKAYTQS
460 470 480 490 500
SHLSEHRRIH TGEKPYQCEE CGKVFRTCSS LSNHKRTHSE EKPYTCEECG
510 520 530 540 550
NIFKQLSDLT KHKKTHTGEK PYKCDECGKN FTQSSNLIVH KRIHTGEKPY
560 570 580 590 600
KCEECGRVFM WFSDITKHKK THTGEKPYKC DECGKNFTQS SNLIVHKRIH
610 620
TGEKPYKCEK CGKAFTQFSH LTVHESIHT
Length:629
Mass (Da):72,332
Last modified:September 23, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD048217DFC6BFDFB
GO
Isoform 2 (identifier: O14628-2)
Also known as: B
Sequence is not available
Length:
Mass (Da):
Isoform 3 (identifier: O14628-3)
Also known as: C
Sequence is not available
Length:
Mass (Da):
Isoform 4 (identifier: O14628-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     76-147: Missing.

Show »
Length:557
Mass (Da):64,658
Checksum:i5E06D5041ACBAB0E
GO
Isoform 5 (identifier: O14628-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     125-147: Missing.

Show »
Length:606
Mass (Da):69,692
Checksum:i2D48AE52C8AE69F8
GO
Isoform 6 (identifier: O14628-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MAGAQ
     125-147: Missing.

Show »
Length:610
Mass (Da):70,019
Checksum:iBE8A3DF20C7FF02C
GO
Isoform 7 (identifier: O14628-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MAGAQ
     76-147: Missing.

Show »
Length:561
Mass (Da):64,986
Checksum:i2BDEFB89E8A73BA4
GO
Isoform 8 (identifier: O14628-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MAGAQ
     76-86: EMGFHHATQAC → GIFFVVTMEII
     87-629: Missing.

Note: No experimental confirmation available.
Show »
Length:90
Mass (Da):10,364
Checksum:i2190262F0173ED6D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WT67A0A087WT67_HUMAN
Zinc finger protein 195
ZNF195
633Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PIY8E9PIY8_HUMAN
Zinc finger protein 195
ZNF195
278Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PIT0E9PIT0_HUMAN
Zinc finger protein 195
ZNF195
217Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PMX5E9PMX5_HUMAN
Zinc finger protein 195
ZNF195
115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PPF8E9PPF8_HUMAN
Zinc finger protein 195
ZNF195
79Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PLF5E9PLF5_HUMAN
Zinc finger protein 195
ZNF195
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PIN4E9PIN4_HUMAN
Zinc finger protein 195
ZNF195
79Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PLW9E9PLW9_HUMAN
Zinc finger protein 195
ZNF195
80Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JG37C9JG37_HUMAN
Zinc finger protein 195
ZNF195
119Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PSE6E9PSE6_HUMAN
Zinc finger protein 195
ZNF195
146Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAG57121 differs from that shown. Reason: Frameshift at position 118.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti290P → R in BAG53114 (PubMed:14702039).Curated1
Sequence conflicti352 – 407Missing in BAD18466 (PubMed:14702039).CuratedAdd BLAST56
Sequence conflicti558V → A in AAB86596 (PubMed:9344677).Curated1
Sequence conflicti570K → Q in AAB86596 (PubMed:9344677).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0368791M → MAGAQ in isoform 6, isoform 7 and isoform 8. 2 Publications1
Alternative sequenceiVSP_03688076 – 147Missing in isoform 4 and isoform 7. 3 PublicationsAdd BLAST72
Alternative sequenceiVSP_04507176 – 86EMGFHHATQAC → GIFFVVTMEII in isoform 8. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_04507287 – 629Missing in isoform 8. 1 PublicationAdd BLAST543
Alternative sequenceiVSP_036881125 – 147Missing in isoform 5 and isoform 6. 2 PublicationsAdd BLAST23

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF003540 mRNA Translation: AAB86596.1
AK095720 mRNA Translation: BAG53114.1
AK131296 mRNA Translation: BAD18466.1
AK290099 mRNA Translation: BAF82788.1
AK293679 mRNA Translation: BAG57121.1 Frameshift.
AL833722 mRNA Translation: CAH56261.1
AC123788 Genomic DNA No translation available.
CH471158 Genomic DNA Translation: EAX02548.1
CH471158 Genomic DNA Translation: EAX02549.1
BC121028 mRNA Translation: AAI21029.1
BC121029 mRNA Translation: AAI21030.1
BM462194 mRNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS41604.1 [O14628-4]
CCDS44521.1 [O14628-5]
CCDS44522.1 [O14628-1]
CCDS55736.1 [O14628-7]
CCDS55737.1 [O14628-6]
CCDS58111.1 [O14628-8]

NCBI Reference Sequences

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RefSeqi
NP_001123991.1, NM_001130519.2 [O14628-5]
NP_001123992.1, NM_001130520.2 [O14628-1]
NP_001229770.1, NM_001242841.1 [O14628-6]
NP_001229771.1, NM_001242842.1
NP_001229772.1, NM_001242843.1 [O14628-7]
NP_001243752.1, NM_001256823.1 [O14628-8]
NP_001243753.1, NM_001256824.1
NP_001243754.1, NM_001256825.1 [O14628-7]
NP_009083.2, NM_007152.4 [O14628-4]
XP_016873752.1, XM_017018263.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000005082; ENSP00000005082; ENSG00000005801 [O14628-5]
ENST00000343338; ENSP00000344483; ENSG00000005801 [O14628-7]
ENST00000354599; ENSP00000346613; ENSG00000005801 [O14628-4]
ENST00000399602; ENSP00000382511; ENSG00000005801 [O14628-1]
ENST00000429541; ENSP00000387998; ENSG00000005801 [O14628-7]
ENST00000438262; ENSP00000414353; ENSG00000005801 [O14628-8]
ENST00000526601; ENSP00000435828; ENSG00000005801 [O14628-6]
ENST00000528218; ENSP00000436384; ENSG00000005801 [O14628-8]
ENST00000618467; ENSP00000482411; ENSG00000005801 [O14628-8]

Database of genes from NCBI RefSeq genomes

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GeneIDi
7748

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:7748

UCSC genome browser

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UCSCi
uc001lxs.4 human [O14628-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF003540 mRNA Translation: AAB86596.1
AK095720 mRNA Translation: BAG53114.1
AK131296 mRNA Translation: BAD18466.1
AK290099 mRNA Translation: BAF82788.1
AK293679 mRNA Translation: BAG57121.1 Frameshift.
AL833722 mRNA Translation: CAH56261.1
AC123788 Genomic DNA No translation available.
CH471158 Genomic DNA Translation: EAX02548.1
CH471158 Genomic DNA Translation: EAX02549.1
BC121028 mRNA Translation: AAI21029.1
BC121029 mRNA Translation: AAI21030.1
BM462194 mRNA No translation available.
CCDSiCCDS41604.1 [O14628-4]
CCDS44521.1 [O14628-5]
CCDS44522.1 [O14628-1]
CCDS55736.1 [O14628-7]
CCDS55737.1 [O14628-6]
CCDS58111.1 [O14628-8]
RefSeqiNP_001123991.1, NM_001130519.2 [O14628-5]
NP_001123992.1, NM_001130520.2 [O14628-1]
NP_001229770.1, NM_001242841.1 [O14628-6]
NP_001229771.1, NM_001242842.1
NP_001229772.1, NM_001242843.1 [O14628-7]
NP_001243752.1, NM_001256823.1 [O14628-8]
NP_001243753.1, NM_001256824.1
NP_001243754.1, NM_001256825.1 [O14628-7]
NP_009083.2, NM_007152.4 [O14628-4]
XP_016873752.1, XM_017018263.1

3D structure databases

SMRiO14628
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113532, 16 interactors
IntActiO14628, 2 interactors
STRINGi9606.ENSP00000382511

PTM databases

iPTMnetiO14628
PhosphoSitePlusiO14628

Polymorphism and mutation databases

BioMutaiZNF195

2D gel databases

REPRODUCTION-2DPAGEiO14628

Proteomic databases

EPDiO14628
jPOSTiO14628
PaxDbiO14628
PeptideAtlasiO14628
PRIDEiO14628
ProteomicsDBi48126
48127 [O14628-4]
48128 [O14628-5]
48129 [O14628-6]
48130 [O14628-7]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000005082; ENSP00000005082; ENSG00000005801 [O14628-5]
ENST00000343338; ENSP00000344483; ENSG00000005801 [O14628-7]
ENST00000354599; ENSP00000346613; ENSG00000005801 [O14628-4]
ENST00000399602; ENSP00000382511; ENSG00000005801 [O14628-1]
ENST00000429541; ENSP00000387998; ENSG00000005801 [O14628-7]
ENST00000438262; ENSP00000414353; ENSG00000005801 [O14628-8]
ENST00000526601; ENSP00000435828; ENSG00000005801 [O14628-6]
ENST00000528218; ENSP00000436384; ENSG00000005801 [O14628-8]
ENST00000618467; ENSP00000482411; ENSG00000005801 [O14628-8]
GeneIDi7748
KEGGihsa:7748
UCSCiuc001lxs.4 human [O14628-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
7748
DisGeNETi7748

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF195
HGNCiHGNC:12986 ZNF195
HPAiHPA030605
MIMi602187 gene
neXtProtiNX_O14628
OpenTargetsiENSG00000005801
PharmGKBiPA37566

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000153165
HOGENOMiHOG000234617
InParanoidiO14628
KOiK09228
OrthoDBi1318335at2759
PhylomeDBiO14628
TreeFamiTF342117

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZNF195 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
7748

Protein Ontology

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PROi
PR:O14628

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000005801 Expressed in 210 organ(s), highest expression level in buccal mucosa cell
ExpressionAtlasiO14628 baseline and differential
GenevisibleiO14628 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 7 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 9 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 9 hits
PS50157 ZINC_FINGER_C2H2_2, 10 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN195_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O14628
Secondary accession number(s): A8K234
, B3KTK2, B4DEL0, C9JLY9, L7MNK2, Q0VAJ6, Q658N8, Q6ZNA9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: September 23, 2008
Last modified: May 8, 2019
This is version 174 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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