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Protein

Homeobox protein CDX-4

Gene

CDX4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi173 – 232HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein CDX-4
Alternative name(s):
Caudal-type homeobox protein 4
Gene namesi
Name:CDX4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000131264.3
HGNCiHGNC:1808 CDX4
MIMi300025 gene
neXtProtiNX_O14627

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi1046
OpenTargetsiENSG00000131264
PharmGKBiPA26353

Polymorphism and mutation databases

BioMutaiCDX4

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000488521 – 284Homeobox protein CDX-4Add BLAST284

Proteomic databases

MaxQBiO14627
PaxDbiO14627
PeptideAtlasiO14627
PRIDEiO14627
ProteomicsDBi48125

PTM databases

PhosphoSitePlusiO14627

Expressioni

Gene expression databases

BgeeiENSG00000131264 Expressed in 5 organ(s), highest expression level in embryo
CleanExiHS_CDX4
GenevisibleiO14627 HS

Organism-specific databases

HPAiHPA056528

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi107476, 6 interactors
IntActiO14627, 7 interactors
STRINGi9606.ENSP00000362613

Structurei

3D structure databases

ProteinModelPortaliO14627
SMRiO14627
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Caudal homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0848 Eukaryota
ENOG4111W2J LUCA
GeneTreeiENSGT00910000143983
HOGENOMiHOG000115975
HOVERGENiHBG005302
InParanoidiO14627
KOiK09312
OMAiTVPMNDM
OrthoDBiEOG091G0LXJ
PhylomeDBiO14627
TreeFamiTF351605

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR006820 Caudal_activation_dom
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
IPR000047 HTH_motif
PfamiView protein in Pfam
PF04731 Caudal_act, 1 hit
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
PR00031 HTHREPRESSR
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

O14627-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYGSCLLEKE AGMYPGTLMS PGGDGTAGTG GTGGGGSPMP ASNFAAAPAF
60 70 80 90 100
SHYMGYPHMP SMDPHWPSLG VWGSPYSPPR EDWSVYPGPS STMGTVPVND
110 120 130 140 150
VTSSPAAFCS TDYSNLGPVG GGTSGSSLPG QAGGSLVPTD AGAAKASSPS
160 170 180 190 200
RSRHSPYAWM RKTVQVTGKT RTKEKYRVVY TDHQRLELEK EFHCNRYITI
210 220 230 240 250
QRKSELAVNL GLSERQVKIW FQNRRAKERK MIKKKISQFE NSGGSVQSDS
260 270 280
DSISPGELPN TFFTTPSAVR GFQPIEIQQV IVSE
Length:284
Mass (Da):30,480
Last modified:January 1, 1998 - v1
Checksum:i96D365D9F5F6D6D7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF003530 Genomic DNA Translation: AAB66319.1
AF029879, AF029877, AF029878 Genomic DNA Translation: AAD01894.1
AL450108 Genomic DNA No translation available.
CH471104 Genomic DNA Translation: EAW98667.1
BC128233 mRNA Translation: AAI28234.1
CCDSiCCDS14424.1
RefSeqiNP_005184.1, NM_005193.1
UniGeneiHs.553488

Genome annotation databases

EnsembliENST00000373514; ENSP00000362613; ENSG00000131264
GeneIDi1046
KEGGihsa:1046
UCSCiuc011mqk.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF003530 Genomic DNA Translation: AAB66319.1
AF029879, AF029877, AF029878 Genomic DNA Translation: AAD01894.1
AL450108 Genomic DNA No translation available.
CH471104 Genomic DNA Translation: EAW98667.1
BC128233 mRNA Translation: AAI28234.1
CCDSiCCDS14424.1
RefSeqiNP_005184.1, NM_005193.1
UniGeneiHs.553488

3D structure databases

ProteinModelPortaliO14627
SMRiO14627
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107476, 6 interactors
IntActiO14627, 7 interactors
STRINGi9606.ENSP00000362613

PTM databases

PhosphoSitePlusiO14627

Polymorphism and mutation databases

BioMutaiCDX4

Proteomic databases

MaxQBiO14627
PaxDbiO14627
PeptideAtlasiO14627
PRIDEiO14627
ProteomicsDBi48125

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373514; ENSP00000362613; ENSG00000131264
GeneIDi1046
KEGGihsa:1046
UCSCiuc011mqk.3 human

Organism-specific databases

CTDi1046
DisGeNETi1046
EuPathDBiHostDB:ENSG00000131264.3
GeneCardsiCDX4
HGNCiHGNC:1808 CDX4
HPAiHPA056528
MIMi300025 gene
neXtProtiNX_O14627
OpenTargetsiENSG00000131264
PharmGKBiPA26353
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0848 Eukaryota
ENOG4111W2J LUCA
GeneTreeiENSGT00910000143983
HOGENOMiHOG000115975
HOVERGENiHBG005302
InParanoidiO14627
KOiK09312
OMAiTVPMNDM
OrthoDBiEOG091G0LXJ
PhylomeDBiO14627
TreeFamiTF351605

Miscellaneous databases

GenomeRNAii1046
PROiPR:O14627
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000131264 Expressed in 5 organ(s), highest expression level in embryo
CleanExiHS_CDX4
GenevisibleiO14627 HS

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR006820 Caudal_activation_dom
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
IPR000047 HTH_motif
PfamiView protein in Pfam
PF04731 Caudal_act, 1 hit
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
PR00031 HTHREPRESSR
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCDX4_HUMAN
AccessioniPrimary (citable) accession number: O14627
Secondary accession number(s): A1A513, Q5JS20
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: November 7, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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