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Protein

Probable G-protein coupled receptor 171

Gene

GPR171

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

  • G protein-coupled purinergic nucleotide receptor activity Source: GO_Central
  • G protein-coupled receptor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 171
Alternative name(s):
G-protein coupled receptor H963
Gene namesi
Name:GPR171
Synonyms:H963
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000174946.6
HGNCiHGNC:30057 GPR171
neXtProtiNX_O14626

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 21ExtracellularSequence analysisAdd BLAST21
Transmembranei22 – 42Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini43 – 48CytoplasmicSequence analysis6
Transmembranei49 – 69Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini70 – 89ExtracellularSequence analysisAdd BLAST20
Transmembranei90 – 110Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini111 – 132CytoplasmicSequence analysisAdd BLAST22
Transmembranei133 – 153Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini154 – 181ExtracellularSequence analysisAdd BLAST28
Transmembranei182 – 202Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini203 – 224CytoplasmicSequence analysisAdd BLAST22
Transmembranei225 – 245Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini246 – 268ExtracellularSequence analysisAdd BLAST23
Transmembranei269 – 289Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini290 – 319CytoplasmicSequence analysisAdd BLAST30

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi29909
OpenTargetsiENSG00000174946
PharmGKBiPA134948560

Polymorphism and mutation databases

BioMutaiGPR171

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000696491 – 319Probable G-protein coupled receptor 171Add BLAST319

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO14626
PeptideAtlasiO14626
PRIDEiO14626
ProteomicsDBi48124

PTM databases

PhosphoSitePlusiO14626

Expressioni

Gene expression databases

BgeeiENSG00000174946 Expressed in 134 organ(s), highest expression level in blood
CleanExiHS_GPR171
ExpressionAtlasiO14626 baseline and differential
GenevisibleiO14626 HS

Organism-specific databases

HPAiHPA062429

Structurei

3D structure databases

ProteinModelPortaliO14626
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IICW Eukaryota
ENOG410YCG6 LUCA
GeneTreeiENSGT00640000091213
HOGENOMiHOG000273884
HOVERGENiHBG095159
InParanoidiO14626
KOiK08441
OMAiRIFHCQV
OrthoDBiEOG091G0B1Z
PhylomeDBiO14626
TreeFamiTF330969

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O14626-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTNSSFFCPV YKDLEPFTYF FYLVFLVGII GSCFATWAFI QKNTNHRCVS
60 70 80 90 100
IYLINLLTAD FLLTLALPVK IVVDLGVAPW KLKIFHCQVT ACLIYINMYL
110 120 130 140 150
SIIFLAFVSI DRCLQLTHSC KIYRIQEPGF AKMISTVVWL MVLLIMVPNM
160 170 180 190 200
MIPIKDIKEK SNVGCMEFKK EFGRNWHLLT NFICVAIFLN FSAIILISNC
210 220 230 240 250
LVIRQLYRNK DNENYPNVKK ALINILLVTT GYIICFVPYH IVRIPYTLSQ
260 270 280 290 300
TEVITDCSTR ISLFKAKEAT LLLAVSNLCF DPILYYHLSK AFRSKVTETF
310
ASPKETKAQK EKLRCENNA
Length:319
Mass (Da):36,754
Last modified:January 1, 1998 - v1
Checksum:i79B9821C10841114
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JR91C9JR91_HUMAN
Probable G-protein-coupled receptor...
GPR171
18Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049408283I → V1 PublicationCorresponds to variant dbSNP:rs3732756Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF002986 mRNA Translation: AAC51846.1
AF411849 Genomic DNA Translation: AAL47763.1
CH471052 Genomic DNA Translation: EAW78811.1
CH471052 Genomic DNA Translation: EAW78812.1
BC036815 mRNA Translation: AAH36815.1
CCDSiCCDS3155.1
RefSeqiNP_037440.3, NM_013308.3
XP_005247459.1, XM_005247402.3
XP_005247460.1, XM_005247403.3
XP_016861763.1, XM_017006274.1
UniGeneiHs.549152

Genome annotation databases

EnsembliENST00000309180; ENSP00000308479; ENSG00000174946
ENST00000617554; ENSP00000482588; ENSG00000174946
GeneIDi29909
KEGGihsa:29909
UCSCiuc003eyq.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF002986 mRNA Translation: AAC51846.1
AF411849 Genomic DNA Translation: AAL47763.1
CH471052 Genomic DNA Translation: EAW78811.1
CH471052 Genomic DNA Translation: EAW78812.1
BC036815 mRNA Translation: AAH36815.1
CCDSiCCDS3155.1
RefSeqiNP_037440.3, NM_013308.3
XP_005247459.1, XM_005247402.3
XP_005247460.1, XM_005247403.3
XP_016861763.1, XM_017006274.1
UniGeneiHs.549152

3D structure databases

ProteinModelPortaliO14626
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiO14626

Polymorphism and mutation databases

BioMutaiGPR171

Proteomic databases

PaxDbiO14626
PeptideAtlasiO14626
PRIDEiO14626
ProteomicsDBi48124

Protocols and materials databases

DNASUi29909
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309180; ENSP00000308479; ENSG00000174946
ENST00000617554; ENSP00000482588; ENSG00000174946
GeneIDi29909
KEGGihsa:29909
UCSCiuc003eyq.5 human

Organism-specific databases

CTDi29909
DisGeNETi29909
EuPathDBiHostDB:ENSG00000174946.6
GeneCardsiGPR171
HGNCiHGNC:30057 GPR171
HPAiHPA062429
neXtProtiNX_O14626
OpenTargetsiENSG00000174946
PharmGKBiPA134948560
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IICW Eukaryota
ENOG410YCG6 LUCA
GeneTreeiENSGT00640000091213
HOGENOMiHOG000273884
HOVERGENiHBG095159
InParanoidiO14626
KOiK08441
OMAiRIFHCQV
OrthoDBiEOG091G0B1Z
PhylomeDBiO14626
TreeFamiTF330969

Miscellaneous databases

GeneWikiiGPR171
GenomeRNAii29909
PROiPR:O14626

Gene expression databases

BgeeiENSG00000174946 Expressed in 134 organ(s), highest expression level in blood
CleanExiHS_GPR171
ExpressionAtlasiO14626 baseline and differential
GenevisibleiO14626 HS

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGP171_HUMAN
AccessioniPrimary (citable) accession number: O14626
Secondary accession number(s): D3DNJ4, Q8IV06
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: November 7, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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