GPR171

Functionⁱ

Orphan receptor.

GO - Molecular functionⁱ

G protein-coupled purinergic nucleotide receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
G protein-coupled receptor activity
Source: UniProtKB
Non-traceable author statementⁱ
- 9370294

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

G protein-coupled receptor signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
negative regulation of myeloid cell differentiation Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer

Molecular function

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Probable G-protein coupled receptor 171 Alternative name(s): G-protein coupled receptor H963
Gene namesⁱ	Name:GPR171 Synonyms:H963
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000174946.6
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:30057 GPR171
neXtProtⁱ	NX_O14626

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 21	ExtracellularSequence analysisAdd BLAST	21
Transmembraneⁱ	22 – 42	Helical; Name=1Sequence analysisAdd BLAST	21
Topological domainⁱ	43 – 48	CytoplasmicSequence analysis	6
Transmembraneⁱ	49 – 69	Helical; Name=2Sequence analysisAdd BLAST	21
Topological domainⁱ	70 – 89	ExtracellularSequence analysisAdd BLAST	20
Transmembraneⁱ	90 – 110	Helical; Name=3Sequence analysisAdd BLAST	21
Topological domainⁱ	111 – 132	CytoplasmicSequence analysisAdd BLAST	22
Transmembraneⁱ	133 – 153	Helical; Name=4Sequence analysisAdd BLAST	21
Topological domainⁱ	154 – 181	ExtracellularSequence analysisAdd BLAST	28
Transmembraneⁱ	182 – 202	Helical; Name=5Sequence analysisAdd BLAST	21
Topological domainⁱ	203 – 224	CytoplasmicSequence analysisAdd BLAST	22
Transmembraneⁱ	225 – 245	Helical; Name=6Sequence analysisAdd BLAST	21
Topological domainⁱ	246 – 268	ExtracellularSequence analysisAdd BLAST	23
Transmembraneⁱ	269 – 289	Helical; Name=7Sequence analysisAdd BLAST	21
Topological domainⁱ	290 – 319	CytoplasmicSequence analysisAdd BLAST	30

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	29909
Open Targets More...OpenTargetsⁱ	ENSG00000174946
PharmGKBⁱ	PA134948560

Polymorphism and mutation databases

BioMutaⁱ	GPR171

BioMutaⁱ

GPR171

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000069649	1 – 319	Probable G-protein coupled receptor 171Add BLAST		319

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	3	N-linked (GlcNAc...) asparagineSequence analysis		1

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

PaxDbⁱ	O14626
PeptideAtlas More...PeptideAtlasⁱ	O14626
PRIDEⁱ	O14626
ProteomicsDBⁱ	48124

PTM databases

PhosphoSitePlusⁱ	O14626

PhosphoSitePlusⁱ

O14626

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000174946 Expressed in 134 organ(s), highest expression level in blood
CleanExⁱ	HS_GPR171
ExpressionAtlasⁱ	O14626 baseline and differential
Genevisibleⁱ	O14626 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA062429

HPAⁱ

HPA062429

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O14626
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IICW Eukaryota ENOG410YCG6 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00640000091213
HOGENOMⁱ	HOG000273884
HOVERGENⁱ	HBG095159
InParanoidⁱ	O14626
KEGG Orthology (KO) More...KOⁱ	K08441
OMAⁱ	RIFHCQV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0B1Z
PhylomeDBⁱ	O14626
TreeFamⁱ	TF330969

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

O14626-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTNSSFFCPV YKDLEPFTYF FYLVFLVGII GSCFATWAFI QKNTNHRCVS 
        60         70         80         90        100
IYLINLLTAD FLLTLALPVK IVVDLGVAPW KLKIFHCQVT ACLIYINMYL 
       110        120        130        140        150
SIIFLAFVSI DRCLQLTHSC KIYRIQEPGF AKMISTVVWL MVLLIMVPNM 
       160        170        180        190        200
MIPIKDIKEK SNVGCMEFKK EFGRNWHLLT NFICVAIFLN FSAIILISNC 
       210        220        230        240        250
LVIRQLYRNK DNENYPNVKK ALINILLVTT GYIICFVPYH IVRIPYTLSQ 
       260        270        280        290        300
TEVITDCSTR ISLFKAKEAT LLLAVSNLCF DPILYYHLSK AFRSKVTETF 
       310 
ASPKETKAQK EKLRCENNA

Length:319

Mass (Da):36,754

Last modified:January 1, 1998 - v1

Checksum:ⁱ79B9821C10841114

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	C9JR91	C9JR91_HUMAN		Probable G-protein-coupled receptor... Probable G-protein-coupled receptor 171	GPR171	18	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_049408	283	I → V1 PublicationCorresponds to variant dbSNP:rs3732756Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF002986 mRNA Translation: AAC51846.1 AF411849 Genomic DNA Translation: AAL47763.1 CH471052 Genomic DNA Translation: EAW78811.1 CH471052 Genomic DNA Translation: EAW78812.1 BC036815 mRNA Translation: AAH36815.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3155.1
NCBI Reference Sequences More...RefSeqⁱ	NP_037440.3, NM_013308.3 XP_005247459.1, XM_005247402.3 XP_005247460.1, XM_005247403.3 XP_016861763.1, XM_017006274.1
UniGeneⁱ	Hs.549152

Genome annotation databases

Ensemblⁱ	ENST00000309180; ENSP00000308479; ENSG00000174946 ENST00000617554; ENSP00000482588; ENSG00000174946
GeneIDⁱ	29909
KEGGⁱ	hsa:29909
UCSC genome browser More...UCSCⁱ	uc003eyq.5 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O14626	G protein-coupled receptor 171		PANTR		319	UniRef100_O14626
Uncharacterized protein		RHIRO		319
G protein-coupled receptor 171		GORGO		319

Protein	Similar proteins		Species	Score	Length	Source
O14626	Probable G-protein coupled receptor 171		BOVIN		319	UniRef90_O14626
G protein-coupled receptor 171		PANTR		319
Uncharacterized protein		RHIRO		319
G protein-coupled receptor 171		GORGO		319
probable G-protein coupled receptor 171		BALAS		319
+62

Protein	Similar proteins		Species	Score	Length	Source
O14626	Probable G-protein coupled receptor 171		BOVIN		319	UniRef50_O14626
G protein-coupled receptor 171		PANTR		319
Uncharacterized protein		RHIRO		319
G protein-coupled receptor 171		GORGO		319
probable G-protein coupled receptor 171		LIPVE		319
+98

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF002986 mRNA Translation: AAC51846.1 AF411849 Genomic DNA Translation: AAL47763.1 CH471052 Genomic DNA Translation: EAW78811.1 CH471052 Genomic DNA Translation: EAW78812.1 BC036815 mRNA Translation: AAH36815.1
CCDSⁱ	CCDS3155.1
RefSeqⁱ	NP_037440.3, NM_013308.3 XP_005247459.1, XM_005247402.3 XP_005247460.1, XM_005247403.3 XP_016861763.1, XM_017006274.1
UniGeneⁱ	Hs.549152

3D structure databases

ProteinModelPortalⁱ	O14626
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

PTM databases

PhosphoSitePlusⁱ	O14626

PhosphoSitePlusⁱ

O14626

Polymorphism and mutation databases

BioMutaⁱ	GPR171

BioMutaⁱ

GPR171

Proteomic databases

PaxDbⁱ	O14626
PeptideAtlasⁱ	O14626
PRIDEⁱ	O14626
ProteomicsDBⁱ	48124

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	29909
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000309180; ENSP00000308479; ENSG00000174946 ENST00000617554; ENSP00000482588; ENSG00000174946
GeneIDⁱ	29909
KEGGⁱ	hsa:29909
UCSCⁱ	uc003eyq.5 human

Organism-specific databases

CTDⁱ	29909
DisGeNETⁱ	29909
EuPathDBⁱ	HostDB:ENSG00000174946.6
GeneCardsⁱ	GPR171
HGNCⁱ	HGNC:30057 GPR171
HPAⁱ	HPA062429
neXtProtⁱ	NX_O14626
OpenTargetsⁱ	ENSG00000174946
PharmGKBⁱ	PA134948560
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IICW Eukaryota ENOG410YCG6 LUCA
GeneTreeⁱ	ENSGT00640000091213
HOGENOMⁱ	HOG000273884
HOVERGENⁱ	HBG095159
InParanoidⁱ	O14626
KOⁱ	K08441
OMAⁱ	RIFHCQV
OrthoDBⁱ	EOG091G0B1Z
PhylomeDBⁱ	O14626
TreeFamⁱ	TF330969

Miscellaneous databases

GeneWikiⁱ	GPR171
GenomeRNAiⁱ	29909
Protein Ontology More...PROⁱ	PR:O14626

Gene expression databases

Bgeeⁱ	ENSG00000174946 Expressed in 134 organ(s), highest expression level in blood
CleanExⁱ	HS_GPR171
ExpressionAtlasⁱ	O14626 baseline and differential
Genevisibleⁱ	O14626 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GP171_HUMAN
Accessionⁱ	O14626Primary (citable) accession number: O14626 Secondary accession number(s): D3DNJ4, Q8IV06
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
	Last sequence update:	January 1, 1998
	Last modified:	November 7, 2018
	This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries

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UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O14626 (GP171_HUMAN)

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Probable G-protein coupled receptor 171

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ