UniProtKB - O14626 (GP171_HUMAN)
Protein
Probable G-protein coupled receptor 171
Gene
GPR171
Organism
Homo sapiens (Human)
Status
Functioni
Orphan receptor.
GO - Molecular functioni
- G protein-coupled purinergic nucleotide receptor activity Source: GO_Central
- G protein-coupled receptor activity Source: UniProtKB
GO - Biological processi
- G protein-coupled receptor signaling pathway Source: GO_Central
- negative regulation of myeloid cell differentiation Source: Ensembl
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | O14626 |
Names & Taxonomyi
Protein namesi | Recommended name: Probable G-protein coupled receptor 171Alternative name(s): G-protein coupled receptor H963 |
Gene namesi | Name:GPR171 Synonyms:H963 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000174946.6 |
HGNCi | HGNC:30057, GPR171 |
MIMi | 618925, gene |
neXtProti | NX_O14626 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 21 | ExtracellularSequence analysisAdd BLAST | 21 | |
Transmembranei | 22 – 42 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 43 – 48 | CytoplasmicSequence analysis | 6 | |
Transmembranei | 49 – 69 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 70 – 89 | ExtracellularSequence analysisAdd BLAST | 20 | |
Transmembranei | 90 – 110 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 111 – 132 | CytoplasmicSequence analysisAdd BLAST | 22 | |
Transmembranei | 133 – 153 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 154 – 181 | ExtracellularSequence analysisAdd BLAST | 28 | |
Transmembranei | 182 – 202 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 203 – 224 | CytoplasmicSequence analysisAdd BLAST | 22 | |
Transmembranei | 225 – 245 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 246 – 268 | ExtracellularSequence analysisAdd BLAST | 23 | |
Transmembranei | 269 – 289 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 290 – 319 | CytoplasmicSequence analysisAdd BLAST | 30 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 29909 |
OpenTargetsi | ENSG00000174946 |
PharmGKBi | PA134948560 |
Miscellaneous databases
Pharosi | O14626, Tdark |
Polymorphism and mutation databases
BioMutai | GPR171 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069649 | 1 – 319 | Probable G-protein coupled receptor 171Add BLAST | 319 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 3 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
MassIVEi | O14626 |
PaxDbi | O14626 |
PeptideAtlasi | O14626 |
PRIDEi | O14626 |
ProteomicsDBi | 48124 |
PTM databases
GlyGeni | O14626, 1 site |
PhosphoSitePlusi | O14626 |
Expressioni
Gene expression databases
Bgeei | ENSG00000174946, Expressed in blood and 150 other tissues |
ExpressionAtlasi | O14626, baseline and differential |
Genevisiblei | O14626, HS |
Organism-specific databases
HPAi | ENSG00000174946, Tissue enhanced (blood, intestine, lymphoid tissue) |
Interactioni
Protein-protein interaction databases
IntActi | O14626, 1 interactor |
STRINGi | 9606.ENSP00000308479 |
Miscellaneous databases
RNActi | O14626, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QTCA, Eukaryota |
GeneTreei | ENSGT00950000182658 |
HOGENOMi | CLU_009579_8_2_1 |
InParanoidi | O14626 |
OMAi | RIFHCQV |
OrthoDBi | 1087125at2759 |
PhylomeDBi | O14626 |
TreeFami | TF330969 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
O14626-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTNSSFFCPV YKDLEPFTYF FYLVFLVGII GSCFATWAFI QKNTNHRCVS
60 70 80 90 100
IYLINLLTAD FLLTLALPVK IVVDLGVAPW KLKIFHCQVT ACLIYINMYL
110 120 130 140 150
SIIFLAFVSI DRCLQLTHSC KIYRIQEPGF AKMISTVVWL MVLLIMVPNM
160 170 180 190 200
MIPIKDIKEK SNVGCMEFKK EFGRNWHLLT NFICVAIFLN FSAIILISNC
210 220 230 240 250
LVIRQLYRNK DNENYPNVKK ALINILLVTT GYIICFVPYH IVRIPYTLSQ
260 270 280 290 300
TEVITDCSTR ISLFKAKEAT LLLAVSNLCF DPILYYHLSK AFRSKVTETF
310
ASPKETKAQK EKLRCENNA
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketC9JR91 | C9JR91_HUMAN | Probable G-protein-coupled receptor... | GPR171 | 18 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_049408 | 283 | I → V1 PublicationCorresponds to variant dbSNP:rs3732756Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF002986 mRNA Translation: AAC51846.1 AF411849 Genomic DNA Translation: AAL47763.1 CH471052 Genomic DNA Translation: EAW78811.1 CH471052 Genomic DNA Translation: EAW78812.1 BC036815 mRNA Translation: AAH36815.1 |
CCDSi | CCDS3155.1 |
RefSeqi | NP_037440.3, NM_013308.3 XP_005247459.1, XM_005247402.3 XP_005247460.1, XM_005247403.3 XP_016861763.1, XM_017006274.1 |
Genome annotation databases
Ensembli | ENST00000309180; ENSP00000308479; ENSG00000174946 ENST00000617554; ENSP00000482588; ENSG00000174946 |
GeneIDi | 29909 |
KEGGi | hsa:29909 |
UCSCi | uc003eyq.5, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF002986 mRNA Translation: AAC51846.1 AF411849 Genomic DNA Translation: AAL47763.1 CH471052 Genomic DNA Translation: EAW78811.1 CH471052 Genomic DNA Translation: EAW78812.1 BC036815 mRNA Translation: AAH36815.1 |
CCDSi | CCDS3155.1 |
RefSeqi | NP_037440.3, NM_013308.3 XP_005247459.1, XM_005247402.3 XP_005247460.1, XM_005247403.3 XP_016861763.1, XM_017006274.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | O14626, 1 interactor |
STRINGi | 9606.ENSP00000308479 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | O14626, 1 site |
PhosphoSitePlusi | O14626 |
Polymorphism and mutation databases
BioMutai | GPR171 |
Proteomic databases
MassIVEi | O14626 |
PaxDbi | O14626 |
PeptideAtlasi | O14626 |
PRIDEi | O14626 |
ProteomicsDBi | 48124 |
Protocols and materials databases
Antibodypediai | 18294, 308 antibodies |
DNASUi | 29909 |
Genome annotation databases
Ensembli | ENST00000309180; ENSP00000308479; ENSG00000174946 ENST00000617554; ENSP00000482588; ENSG00000174946 |
GeneIDi | 29909 |
KEGGi | hsa:29909 |
UCSCi | uc003eyq.5, human |
Organism-specific databases
CTDi | 29909 |
DisGeNETi | 29909 |
EuPathDBi | HostDB:ENSG00000174946.6 |
GeneCardsi | GPR171 |
HGNCi | HGNC:30057, GPR171 |
HPAi | ENSG00000174946, Tissue enhanced (blood, intestine, lymphoid tissue) |
MIMi | 618925, gene |
neXtProti | NX_O14626 |
OpenTargetsi | ENSG00000174946 |
PharmGKBi | PA134948560 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QTCA, Eukaryota |
GeneTreei | ENSGT00950000182658 |
HOGENOMi | CLU_009579_8_2_1 |
InParanoidi | O14626 |
OMAi | RIFHCQV |
OrthoDBi | 1087125at2759 |
PhylomeDBi | O14626 |
TreeFami | TF330969 |
Enzyme and pathway databases
PathwayCommonsi | O14626 |
Miscellaneous databases
BioGRID-ORCSi | 29909, 3 hits in 838 CRISPR screens |
ChiTaRSi | GPR171, human |
GeneWikii | GPR171 |
GenomeRNAii | 29909 |
Pharosi | O14626, Tdark |
PROi | PR:O14626 |
RNActi | O14626, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000174946, Expressed in blood and 150 other tissues |
ExpressionAtlasi | O14626, baseline and differential |
Genevisiblei | O14626, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GP171_HUMAN | |
Accessioni | O14626Primary (citable) accession number: O14626 Secondary accession number(s): D3DNJ4, Q8IV06 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | January 1, 1998 | |
Last modified: | December 2, 2020 | |
This is version 154 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries