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Protein

C-X-C motif chemokine 11

Gene

CXCL11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses.

GO - Molecular functioni

  • chemokine activity Source: UniProtKB
  • CXCR3 chemokine receptor binding Source: UniProtKB
  • heparin binding Source: UniProtKB

GO - Biological processi

  • antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
  • cell-cell signaling Source: ProtInc
  • chemokine-mediated signaling pathway Source: UniProtKB
  • chemotaxis Source: UniProtKB
  • G-protein coupled receptor signaling pathway Source: GO_Central
  • immune response Source: GO_Central
  • inflammatory response Source: GO_Central
  • killing of cells of other organism Source: UniProtKB
  • positive regulation of cAMP-mediated signaling Source: UniProtKB
  • positive regulation of cAMP metabolic process Source: UniProtKB
  • positive regulation of leukocyte chemotaxis Source: GO_Central
  • positive regulation of release of sequestered calcium ion into cytosol Source: UniProtKB
  • regulation of cell proliferation Source: UniProtKB
  • response to lipopolysaccharide Source: GO_Central
  • signal transduction Source: ProtInc
  • T cell chemotaxis Source: UniProtKB

Keywordsi

Molecular functionCytokine
Biological processChemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiR-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C motif chemokine 11
Alternative name(s):
Beta-R1
H174
Interferon gamma-inducible protein 9
Short name:
IP-9
Interferon-inducible T-cell alpha chemoattractant
Short name:
I-TAC
Small-inducible cytokine B11
Gene namesi
Name:CXCL11
Synonyms:ITAC, SCYB11, SCYB9B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000169248.12
HGNCiHGNC:10638 CXCL11
MIMi604852 gene
neXtProtiNX_O14625

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi6373
OpenTargetsiENSG00000169248
PharmGKBiPA35569

Polymorphism and mutation databases

BioMutaiCXCL11

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 211 PublicationAdd BLAST21
ChainiPRO_000000510622 – 94C-X-C motif chemokine 11Add BLAST73

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei27Citrulline; by PAD21 Publication1
Disulfide bondi30 ↔ 571 Publication
Disulfide bondi32 ↔ 741 Publication

Keywords - PTMi

Citrullination, Disulfide bond

Proteomic databases

PaxDbiO14625
PeptideAtlasiO14625
PRIDEiO14625
ProteomicsDBi48123

PTM databases

iPTMnetiO14625
PhosphoSitePlusiO14625

Miscellaneous databases

PMAP-CutDBiO14625

Expressioni

Tissue specificityi

High levels in peripheral blood leukocytes, pancreas and liver astrocytes. Moderate levels in thymus, spleen and lung. Low levels in placenta, prostate and small intestine. Also found in epidermal basal layer keratinocytes in skin disorders.

Inductioni

By IFNG/IFN-gamma and IFNB1/IFN-beta. Induction by IFNG/IFN-gamma is enhanced by TNF in monocytes, dermal fibroblasts and endothelial cells, and by IL1/interleukin-1 in astrocytes.

Gene expression databases

BgeeiENSG00000169248
CleanExiHS_CXCL11
GenevisibleiO14625 HS

Organism-specific databases

HPAiCAB009921

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • chemokine activity Source: UniProtKB
  • CXCR3 chemokine receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi112275, 3 interactors
DIPiDIP-5890N
IntActiO14625, 6 interactors
MINTiO14625
STRINGi9606.ENSP00000306884

Structurei

Secondary structure

194
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni54 – 56Combined sources3
Beta strandi57 – 59Combined sources3
Beta strandi67 – 69Combined sources3
Helixi82 – 89Combined sources8

3D structure databases

ProteinModelPortaliO14625
SMRiO14625
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO14625

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JDG9 Eukaryota
ENOG41117T8 LUCA
GeneTreeiENSGT00530000064263
HOVERGENiHBG107789
InParanoidiO14625
KOiK12672
OMAiGGRCLCI
OrthoDBiEOG091G0Z10
PhylomeDBiO14625
TreeFamiTF333433

Family and domain databases

CDDicd00273 Chemokine_CXC, 1 hit
InterProiView protein in InterPro
IPR001089 Chemokine_CXC
IPR018048 Chemokine_CXC_CS
IPR001811 Chemokine_IL8-like_dom
IPR033899 CXC_Chemokine_domain
IPR027221 CXCL11
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR10179 PTHR10179, 1 hit
PTHR10179:SF28 PTHR10179:SF28, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
PRINTSiPR00437 SMALLCYTKCXC
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00471 SMALL_CYTOKINES_CXC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O14625-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVKGMAIAL AVILCATVVQ GFPMFKRGRC LCIGPGVKAV KVADIEKASI
60 70 80 90
MYPSNNCDKI EVIITLKENK GQRCLNPKSK QARLIIKKVE RKNF
Length:94
Mass (Da):10,365
Last modified:January 1, 1998 - v1
Checksum:i9D9D8585749EA4CE
GO

Sequence cautioni

The sequence AAB17374 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti69 – 72NKGQ → IRK in AAB17374 (PubMed:8798467).Curated4
Sequence conflicti78K → NRA in AAB17374 (PubMed:8798467).Curated1
Sequence conflicti89V → A in AAB17374 (PubMed:8798467).Curated1

Mass spectrometryi

Molecular mass is 8303 Da from positions 22 - 94. Determined by MALDI. 1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04870055N → S. Corresponds to variant dbSNP:rs4859596Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U59286 mRNA Translation: AAB17374.1 Different initiation.
AF002985 mRNA Translation: AAC51845.1
AF030514 mRNA Translation: AAC39775.1
Y15220 mRNA Translation: CAA75510.1
U66096 mRNA Translation: AAD38867.1
AF077867 Genomic DNA Translation: AAD38327.1
Y15221 Genomic DNA Translation: CAB51859.1
BT006787 mRNA Translation: AAP35433.1
BC005292 mRNA Translation: AAH05292.1
BC012532 mRNA Translation: AAH12532.1
BC110986 mRNA Translation: AAI10987.1
AF053972 Genomic DNA Translation: AAD10206.1
CCDSiCCDS3574.1
RefSeqiNP_001289052.1, NM_001302123.1
NP_005400.1, NM_005409.4
UniGeneiHs.632592

Genome annotation databases

EnsembliENST00000306621; ENSP00000306884; ENSG00000169248
ENST00000503860; ENSP00000425819; ENSG00000169248
GeneIDi6373
KEGGihsa:6373
UCSCiuc003hjm.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCXL11_HUMAN
AccessioniPrimary (citable) accession number: O14625
Secondary accession number(s): Q53YA3, Q92840
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: June 20, 2018
This is version 172 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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