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Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2

Gene

GNGT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

GO - Molecular functioni

  • GTPase activity Source: MGI

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: UniProtKB
  • phototransduction Source: UniProtKB

Keywordsi

Molecular functionTransducer

Enzyme and pathway databases

ReactomeiR-HSA-1296041 Activation of G protein gated Potassium channels
R-HSA-202040 G-protein activation
R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-HSA-392170 ADP signalling through P2Y purinoceptor 12
R-HSA-392451 G beta:gamma signalling through PI3Kgamma
R-HSA-392851 Prostacyclin signalling through prostacyclin receptor
R-HSA-400042 Adrenaline,noradrenaline inhibits insulin secretion
R-HSA-4086398 Ca2+ pathway
R-HSA-416476 G alpha (q) signalling events
R-HSA-416482 G alpha (12/13) signalling events
R-HSA-418217 G beta:gamma signalling through PLC beta
R-HSA-418555 G alpha (s) signalling events
R-HSA-418592 ADP signalling through P2Y purinoceptor 1
R-HSA-418594 G alpha (i) signalling events
R-HSA-418597 G alpha (z) signalling events
R-HSA-420092 Glucagon-type ligand receptors
R-HSA-428930 Thromboxane signalling through TP receptor
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-456926 Thrombin signalling through proteinase activated receptors (PARs)
R-HSA-500657 Presynaptic function of Kainate receptors
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
R-HSA-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Protein family/group databases

TCDBi8.A.92.1.1 the g-protein AlphaBetaGama complex (gpc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
Alternative name(s):
G gamma-C
G-gamma-8
G-gamma-9
Guanine nucleotide binding protein gamma transducing activity polypeptide 2
Gene namesi
Name:GNGT2
Synonyms:GNG8, GNG9, GNGT8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000167083.6
HGNCiHGNC:4412 GNGT2
MIMi139391 gene
neXtProtiNX_O14610

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2793
OpenTargetsiENSG00000167083
PharmGKBiPA28791

Polymorphism and mutation databases

BioMutaiGNGT2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000126451 – 66Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2Add BLAST66
PropeptideiPRO_000001264667 – 69Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei66Cysteine methyl esterSequence analysis1
Lipidationi66S-farnesyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

MaxQBiO14610
PaxDbiO14610
PeptideAtlasiO14610
PRIDEiO14610
ProteomicsDBi48115

Expressioni

Tissue specificityi

Retinal cones.

Gene expression databases

BgeeiENSG00000167083 Expressed in 111 organ(s), highest expression level in spleen
CleanExiHS_GNG8
HS_GNGT2
ExpressionAtlasiO14610 baseline and differential
GenevisibleiO14610 HS

Organism-specific databases

HPAiHPA043381

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma.

Protein-protein interaction databases

BioGridi109055, 6 interactors
STRINGi9606.ENSP00000300406

Structurei

3D structure databases

ProteinModelPortaliO14610
SMRiO14610
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiKOG4119 Eukaryota
ENOG41122JF LUCA
GeneTreeiENSGT00530000063397
HOGENOMiHOG000231034
HOVERGENiHBG014983
InParanoidiO14610
KOiK04549
PhylomeDBiO14610
TreeFamiTF319909

Family and domain databases

CDDicd00068 GGL, 1 hit
Gene3Di4.10.260.10, 1 hit
InterProiView protein in InterPro
IPR015898 G-protein_gamma-like_dom
IPR036284 GGL_sf
IPR001770 Gprotein-gamma
PANTHERiPTHR13809 PTHR13809, 1 hit
PfamiView protein in Pfam
PF00631 G-gamma, 1 hit
PRINTSiPR00321 GPROTEING
SMARTiView protein in SMART
SM00224 GGL, 1 hit
SUPFAMiSSF48670 SSF48670, 1 hit
PROSITEiView protein in PROSITE
PS50058 G_PROTEIN_GAMMA, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

O14610-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQDLSEKDL LKMEVEQLKK EVKNTRIPIS KAGKEIKEYV EAQAGNDPFL
60
KGIPEDKNPF KEKGGCLIS
Length:69
Mass (Da):7,747
Last modified:January 1, 1998 - v1
Checksum:i7ABD417F097F719B
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RDH5D6RDH5_HUMAN
Guanine nucleotide-binding protein ...
GNGT2
88Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04927111L → F. Corresponds to variant dbSNP:rs9895097Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF001160, AF001159 Genomic DNA Translation: AAB70039.1
AF365870 mRNA Translation: AAK53384.1
AF493876 mRNA Translation: AAM12590.1
AK312839 mRNA Translation: BAG35693.1
CH471109 Genomic DNA Translation: EAW94688.1
CH471109 Genomic DNA Translation: EAW94689.1
BC008663 mRNA Translation: AAH08663.1
CCDSiCCDS11545.1
RefSeqiNP_001185683.1, NM_001198754.1
NP_001185684.1, NM_001198755.1
NP_001185685.1, NM_001198756.1
NP_113686.1, NM_031498.2
UniGeneiHs.181781

Genome annotation databases

EnsembliENST00000300406; ENSP00000300406; ENSG00000167083
ENST00000507680; ENSP00000421710; ENSG00000167083
ENST00000511277; ENSP00000426022; ENSG00000167083
ENST00000511673; ENSP00000422879; ENSG00000167083
ENST00000515635; ENSP00000423924; ENSG00000167083
GeneIDi2793
KEGGihsa:2793
UCSCiuc002ioo.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiGBGT2_HUMAN
AccessioniPrimary (citable) accession number: O14610
Secondary accession number(s): B2R746, D3DTW5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: September 12, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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