TMSB4Y

Functionⁱ

Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity).By similarity

GO - Molecular functionⁱ

actin monomer binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

actin filament organization Source: InterPro
regulation of actin polymerization or depolymerization
Source: ProtInc
Traceable author statementⁱ
- 8838802
regulation of cell migration
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
sequestering of actin monomers
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Actin-binding

Molecular function

Actin-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Thymosin beta-4, Y-chromosomal
Gene namesⁱ	Name:TMSB4Y Synonyms:TB4Y
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome Y

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000154620.5
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11882 TMSB4Y
MIMⁱ	400017 gene
neXtProtⁱ	NX_O14604

Keywords - Cellular componentⁱ

Cytoplasm, Cytoskeleton

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	9087
Open Targets More...OpenTargetsⁱ	ENSG00000154620
PharmGKBⁱ	PA36582

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000045921	1 – 44	Thymosin beta-4, Y-chromosomalAdd BLAST		44

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O14604
PaxDbⁱ	O14604
PeptideAtlas More...PeptideAtlasⁱ	O14604
PRIDEⁱ	O14604
ProteomicsDBⁱ	48110

PTM databases

iPTMnetⁱ	O14604
PhosphoSitePlusⁱ	O14604

Expressionⁱ

Tissue specificityⁱ

Ubiquitous.

Gene expression databases

Bgeeⁱ	ENSG00000154620 Expressed in 193 organ(s), highest expression level in myocardium
CleanExⁱ	HS_TMSB4Y
Genevisibleⁱ	O14604 HS

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
TERF2IP	Q9NYB0	2	EBI-751196,EBI-750109

With

Entry

#Exp.

IntAct

Notes

TERF2IP

Q9NYB0

2

EBI-751196,EBI-750109

GO - Molecular functionⁱ

actin monomer binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	114543, 5 interactors
IntActⁱ	O14604, 4 interactors
STRINGⁱ	9606.ENSP00000284856

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O14604
SMRⁱ	O14604
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the thymosin beta family.Curated

Phylogenomic databases

eggNOGⁱ	KOG4794 Eukaryota ENOG410Y3I4 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000007040
HOGENOMⁱ	HOG000231370
HOVERGENⁱ	HBG012534
InParanoidⁱ	O14604
KEGG Orthology (KO) More...KOⁱ	K05764
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G1AVI
PhylomeDBⁱ	O14604

Family and domain databases

Gene3Dⁱ	1.20.5.520, 1 hit
InterProⁱ	View protein in InterPro IPR001152 Beta-thymosin IPR038386 Beta-thymosin_sf
PANTHERⁱ	PTHR12021 PTHR12021, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01290 Thymosin, 1 hit
PIRSFⁱ	PIRSF001828 Thymosin_beta, 1 hit
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD005116 Thymosin_b4, 1 hit
SMARTⁱ	View protein in SMART SM00152 THY, 1 hit
PROSITEⁱ	View protein in PROSITE PS00500 THYMOSIN_B4, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

O14604-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40 
MSDKPGMAEI EKFDKSKLKK TETQEKNPLS SKETIEQERQ AGES

Length:44

Mass (Da):5,013

Last modified:January 23, 2007 - v3

Checksum:ⁱ7B336158483A9BE2

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF000989 mRNA Translation: AAC51836.1 AC006371 Genomic DNA Translation: AAD54509.1 BC022482 mRNA No translation available. BC119763 mRNA Translation: AAI19764.1 BC119764 mRNA Translation: AAI19765.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS14786.1
NCBI Reference Sequences More...RefSeqⁱ	NP_004193.1, NM_004202.2
UniGeneⁱ	Hs.159201

Genome annotation databases

Ensemblⁱ	ENST00000284856; ENSP00000284856; ENSG00000154620
GeneIDⁱ	9087
KEGGⁱ	hsa:9087
UCSC genome browser More...UCSCⁱ	uc004ftb.4 human

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O14604	Thymosin beta-4		RABIT		44	UniRef90_P34032
Thymosin beta-4		MACEU		44
Thymosin beta-4		XENLA		44
Uncharacterized protein		PANTR		54
Thymosin beta		ODORO		45
+42

Protein	Similar proteins		Species	Score	Length	Source
O14604	Thymosin beta-4		RABIT		44	UniRef50_P34032
Thymosin beta-4		MACEU		44
Thymosin beta-4		XENLA		44
Uncharacterized protein		PANTR		54
Thymosin beta		CHICK		45
+50

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF000989 mRNA Translation: AAC51836.1 AC006371 Genomic DNA Translation: AAD54509.1 BC022482 mRNA No translation available. BC119763 mRNA Translation: AAI19764.1 BC119764 mRNA Translation: AAI19765.1
CCDSⁱ	CCDS14786.1
RefSeqⁱ	NP_004193.1, NM_004202.2
UniGeneⁱ	Hs.159201

3D structure databases

ProteinModelPortalⁱ	O14604
SMRⁱ	O14604
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114543, 5 interactors
IntActⁱ	O14604, 4 interactors
STRINGⁱ	9606.ENSP00000284856

PTM databases

iPTMnetⁱ	O14604
PhosphoSitePlusⁱ	O14604

Proteomic databases

MaxQBⁱ	O14604
PaxDbⁱ	O14604
PeptideAtlasⁱ	O14604
PRIDEⁱ	O14604
ProteomicsDBⁱ	48110

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000284856; ENSP00000284856; ENSG00000154620
GeneIDⁱ	9087
KEGGⁱ	hsa:9087
UCSCⁱ	uc004ftb.4 human

Organism-specific databases

CTDⁱ	9087
DisGeNETⁱ	9087
EuPathDBⁱ	HostDB:ENSG00000154620.5
GeneCardsⁱ	TMSB4Y
HGNCⁱ	HGNC:11882 TMSB4Y
MIMⁱ	400017 gene
neXtProtⁱ	NX_O14604
OpenTargetsⁱ	ENSG00000154620
PharmGKBⁱ	PA36582
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4794 Eukaryota ENOG410Y3I4 LUCA
GeneTreeⁱ	ENSGT00390000007040
HOGENOMⁱ	HOG000231370
HOVERGENⁱ	HBG012534
InParanoidⁱ	O14604
KOⁱ	K05764
OrthoDBⁱ	EOG091G1AVI
PhylomeDBⁱ	O14604

Miscellaneous databases

GeneWikiⁱ	Thymosin_beta-4,_Y-chromosomal
GenomeRNAiⁱ	9087
Protein Ontology More...PROⁱ	PR:O14604
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000154620 Expressed in 193 organ(s), highest expression level in myocardium
CleanExⁱ	HS_TMSB4Y
Genevisibleⁱ	O14604 HS

Family and domain databases

Gene3Dⁱ	1.20.5.520, 1 hit
InterProⁱ	View protein in InterPro IPR001152 Beta-thymosin IPR038386 Beta-thymosin_sf
PANTHERⁱ	PTHR12021 PTHR12021, 1 hit
Pfamⁱ	View protein in Pfam PF01290 Thymosin, 1 hit
PIRSFⁱ	PIRSF001828 Thymosin_beta, 1 hit
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD005116 Thymosin_b4, 1 hit
SMARTⁱ	View protein in SMART SM00152 THY, 1 hit
PROSITEⁱ	View protein in PROSITE PS00500 THYMOSIN_B4, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TYB4Y_HUMAN
Accessionⁱ	O14604Primary (citable) accession number: O14604 Secondary accession number(s): Q0VDA2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
	Last sequence update:	January 23, 2007
	Last modified:	November 7, 2018
	This is version 152 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome Y
Human chromosome Y: entries, gene names and cross-references to MIM

UniProtKB

UniParc

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Supporting data

UniProtKB - O14604 (TYB4Y_HUMAN)

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Thymosin beta-4, Y-chromosomal

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Cytoskeleton

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ