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Protein

Thymosin beta-4, Y-chromosomal

Gene

TMSB4Y

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity).By similarity

GO - Molecular functioni

  • actin monomer binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionActin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thymosin beta-4, Y-chromosomal
Gene namesi
Name:TMSB4Y
Synonyms:TB4Y
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome Y

Organism-specific databases

EuPathDBiHostDB:ENSG00000154620.5
HGNCiHGNC:11882 TMSB4Y
MIMi400017 gene
neXtProtiNX_O14604

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi9087
OpenTargetsiENSG00000154620
PharmGKBiPA36582

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000459211 – 44Thymosin beta-4, Y-chromosomalAdd BLAST44

Proteomic databases

MaxQBiO14604
PaxDbiO14604
PeptideAtlasiO14604
PRIDEiO14604
ProteomicsDBi48110

PTM databases

iPTMnetiO14604
PhosphoSitePlusiO14604

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000154620 Expressed in 193 organ(s), highest expression level in myocardium
CleanExiHS_TMSB4Y
GenevisibleiO14604 HS

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TERF2IPQ9NYB02EBI-751196,EBI-750109

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114543, 5 interactors
IntActiO14604, 4 interactors
STRINGi9606.ENSP00000284856

Structurei

3D structure databases

ProteinModelPortaliO14604
SMRiO14604
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymosin beta family.Curated

Phylogenomic databases

eggNOGiKOG4794 Eukaryota
ENOG410Y3I4 LUCA
GeneTreeiENSGT00390000007040
HOGENOMiHOG000231370
HOVERGENiHBG012534
InParanoidiO14604
KOiK05764
OrthoDBiEOG091G1AVI
PhylomeDBiO14604

Family and domain databases

Gene3Di1.20.5.520, 1 hit
InterProiView protein in InterPro
IPR001152 Beta-thymosin
IPR038386 Beta-thymosin_sf
PANTHERiPTHR12021 PTHR12021, 1 hit
PfamiView protein in Pfam
PF01290 Thymosin, 1 hit
PIRSFiPIRSF001828 Thymosin_beta, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005116 Thymosin_b4, 1 hit
SMARTiView protein in SMART
SM00152 THY, 1 hit
PROSITEiView protein in PROSITE
PS00500 THYMOSIN_B4, 1 hit

Sequencei

Sequence statusi: Complete.

O14604-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40 
MSDKPGMAEI EKFDKSKLKK TETQEKNPLS SKETIEQERQ AGES
Length:44
Mass (Da):5,013
Last modified:January 23, 2007 - v3
Checksum:i7B336158483A9BE2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000989 mRNA Translation: AAC51836.1
AC006371 Genomic DNA Translation: AAD54509.1
BC022482 mRNA No translation available.
BC119763 mRNA Translation: AAI19764.1
BC119764 mRNA Translation: AAI19765.1
CCDSiCCDS14786.1
RefSeqiNP_004193.1, NM_004202.2
UniGeneiHs.159201

Genome annotation databases

EnsembliENST00000284856; ENSP00000284856; ENSG00000154620
GeneIDi9087
KEGGihsa:9087
UCSCiuc004ftb.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000989 mRNA Translation: AAC51836.1
AC006371 Genomic DNA Translation: AAD54509.1
BC022482 mRNA No translation available.
BC119763 mRNA Translation: AAI19764.1
BC119764 mRNA Translation: AAI19765.1
CCDSiCCDS14786.1
RefSeqiNP_004193.1, NM_004202.2
UniGeneiHs.159201

3D structure databases

ProteinModelPortaliO14604
SMRiO14604
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114543, 5 interactors
IntActiO14604, 4 interactors
STRINGi9606.ENSP00000284856

PTM databases

iPTMnetiO14604
PhosphoSitePlusiO14604

Proteomic databases

MaxQBiO14604
PaxDbiO14604
PeptideAtlasiO14604
PRIDEiO14604
ProteomicsDBi48110

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000284856; ENSP00000284856; ENSG00000154620
GeneIDi9087
KEGGihsa:9087
UCSCiuc004ftb.4 human

Organism-specific databases

CTDi9087
DisGeNETi9087
EuPathDBiHostDB:ENSG00000154620.5
GeneCardsiTMSB4Y
HGNCiHGNC:11882 TMSB4Y
MIMi400017 gene
neXtProtiNX_O14604
OpenTargetsiENSG00000154620
PharmGKBiPA36582
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4794 Eukaryota
ENOG410Y3I4 LUCA
GeneTreeiENSGT00390000007040
HOGENOMiHOG000231370
HOVERGENiHBG012534
InParanoidiO14604
KOiK05764
OrthoDBiEOG091G1AVI
PhylomeDBiO14604

Miscellaneous databases

GeneWikiiThymosin_beta-4,_Y-chromosomal
GenomeRNAii9087
PROiPR:O14604
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000154620 Expressed in 193 organ(s), highest expression level in myocardium
CleanExiHS_TMSB4Y
GenevisibleiO14604 HS

Family and domain databases

Gene3Di1.20.5.520, 1 hit
InterProiView protein in InterPro
IPR001152 Beta-thymosin
IPR038386 Beta-thymosin_sf
PANTHERiPTHR12021 PTHR12021, 1 hit
PfamiView protein in Pfam
PF01290 Thymosin, 1 hit
PIRSFiPIRSF001828 Thymosin_beta, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005116 Thymosin_b4, 1 hit
SMARTiView protein in SMART
SM00152 THY, 1 hit
PROSITEiView protein in PROSITE
PS00500 THYMOSIN_B4, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTYB4Y_HUMAN
AccessioniPrimary (citable) accession number: O14604
Secondary accession number(s): Q0VDA2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 152 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome Y
    Human chromosome Y: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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