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UniProtKB - O14604 (TYB4Y_HUMAN)

Entry version 155 (13 Feb 2019)
Sequence version 3 (23 Jan 2007)
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Protein

Thymosin beta-4, Y-chromosomal

Gene

TMSB4Y

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • actin monomer binding Source: GO_Central
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Thymosin beta-4, Y-chromosomal
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMSB4Y
Synonyms:TB4Y
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome Y

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000154620.5

Human Gene Nomenclature Database

More...HGNCi		HGNC:11882 TMSB4Y

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		400017 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O14604

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		9087

Open Targets

More...OpenTargetsi		ENSG00000154620

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36582

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TMSB4Y

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000459211 – 44Thymosin beta-4, Y-chromosomalAdd BLAST44

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		O14604

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O14604

PeptideAtlas

More...PeptideAtlasi		O14604

PRoteomics IDEntifications database

More...PRIDEi		O14604

ProteomicsDB human proteome resource

More...ProteomicsDBi		48110

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O14604

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O14604

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000154620 Expressed in 193 organ(s), highest expression level in myocardium

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O14604 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
TERF2IPQ9NYB02EBI-751196,EBI-750109

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		114543, 5 interactors

Protein interaction database and analysis system

More...IntActi		O14604, 4 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000284856

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		O14604

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O14604

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the thymosin beta family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4794 Eukaryota
ENOG410Y3I4 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154433

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000231370

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG012534

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O14604

KEGG Orthology (KO)

More...KOi		K05764

Database of Orthologous Groups

More...OrthoDBi		1632292at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O14604

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.5.520, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001152 Beta-thymosin
IPR038386 Beta-thymosin_sf

The PANTHER Classification System

More...PANTHERi		PTHR12021 PTHR12021, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01290 Thymosin, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF001828 Thymosin_beta, 1 hit

ProDom; a protein domain database

More...ProDomi		View protein in ProDom or Entries sharing at least one domain
PD005116 Thymosin_b4, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00152 THY, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00500 THYMOSIN_B4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O14604-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40 
MSDKPGMAEI EKFDKSKLKK TETQEKNPLS SKETIEQERQ AGES
Length:44
Mass (Da):5,013
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7B336158483A9BE2
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF000989 mRNA Translation: AAC51836.1
AC006371 Genomic DNA Translation: AAD54509.1
BC022482 mRNA No translation available.
BC119763 mRNA Translation: AAI19764.1
BC119764 mRNA Translation: AAI19765.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS14786.1

NCBI Reference Sequences

More...RefSeqi		NP_004193.1, NM_004202.2

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.159201

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000284856; ENSP00000284856; ENSG00000154620

Database of genes from NCBI RefSeq genomes

More...GeneIDi		9087

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:9087

UCSC genome browser

More...UCSCi		uc004ftb.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000989 mRNA Translation: AAC51836.1
AC006371 Genomic DNA Translation: AAD54509.1
BC022482 mRNA No translation available.
BC119763 mRNA Translation: AAI19764.1
BC119764 mRNA Translation: AAI19765.1
CCDSiCCDS14786.1
RefSeqiNP_004193.1, NM_004202.2
UniGeneiHs.159201

3D structure databases

ProteinModelPortaliO14604
SMRiO14604
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114543, 5 interactors
IntActiO14604, 4 interactors
STRINGi9606.ENSP00000284856

PTM databases

iPTMnetiO14604
PhosphoSitePlusiO14604

Polymorphism and mutation databases

BioMutaiTMSB4Y

Proteomic databases

MaxQBiO14604
PaxDbiO14604
PeptideAtlasiO14604
PRIDEiO14604
ProteomicsDBi48110

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000284856; ENSP00000284856; ENSG00000154620
GeneIDi9087
KEGGihsa:9087
UCSCiuc004ftb.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9087
DisGeNETi9087
EuPathDBiHostDB:ENSG00000154620.5

GeneCards: human genes, protein and diseases

More...GeneCardsi		TMSB4Y
HGNCiHGNC:11882 TMSB4Y
MIMi400017 gene
neXtProtiNX_O14604
OpenTargetsiENSG00000154620
PharmGKBiPA36582

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4794 Eukaryota
ENOG410Y3I4 LUCA
GeneTreeiENSGT00940000154433
HOGENOMiHOG000231370
HOVERGENiHBG012534
InParanoidiO14604
KOiK05764
OrthoDBi1632292at2759
PhylomeDBiO14604

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Thymosin_beta-4,_Y-chromosomal

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		9087

Protein Ontology

More...PROi		PR:O14604

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000154620 Expressed in 193 organ(s), highest expression level in myocardium
GenevisibleiO14604 HS

Family and domain databases

Gene3Di1.20.5.520, 1 hit
InterProiView protein in InterPro
IPR001152 Beta-thymosin
IPR038386 Beta-thymosin_sf
PANTHERiPTHR12021 PTHR12021, 1 hit
PfamiView protein in Pfam
PF01290 Thymosin, 1 hit
PIRSFiPIRSF001828 Thymosin_beta, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005116 Thymosin_b4, 1 hit
SMARTiView protein in SMART
SM00152 THY, 1 hit
PROSITEiView protein in PROSITE
PS00500 THYMOSIN_B4, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTYB4Y_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O14604
Secondary accession number(s): Q0VDA2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 23, 2007
Last modified: February 13, 2019
This is version 155 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome Y
    Human chromosome Y: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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