UniProtKB - O14604 (TYB4Y_HUMAN)
Protein
Thymosin beta-4, Y-chromosomal
Gene
TMSB4Y
Organism
Homo sapiens (Human)
Status
Functioni
Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity).By similarity
GO - Molecular functioni
- actin monomer binding Source: GO_Central
GO - Biological processi
- actin filament organization Source: InterPro
- regulation of actin polymerization or depolymerization Source: ProtInc
- regulation of cell migration Source: GO_Central
- sequestering of actin monomers Source: GO_Central
Keywordsi
Molecular function | Actin-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Thymosin beta-4, Y-chromosomal |
Gene namesi | Name:TMSB4Y Synonyms:TB4Y |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000154620.5 |
HGNCi | HGNC:11882 TMSB4Y |
MIMi | 400017 gene |
neXtProti | NX_O14604 |
Subcellular locationi
Cytoskeleton
- cytoskeleton By similarity
Cytoskeleton
- cytoskeleton Source: UniProtKB-SubCell
Cytosol
- cytosol Source: Ensembl
Nucleus
- nucleus Source: Ensembl
Other locations
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
Cytoplasm, CytoskeletonPathology & Biotechi
Organism-specific databases
DisGeNETi | 9087 |
OpenTargetsi | ENSG00000154620 |
PharmGKBi | PA36582 |
Polymorphism and mutation databases
BioMutai | TMSB4Y |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000045921 | 1 – 44 | Thymosin beta-4, Y-chromosomalAdd BLAST | 44 |
Proteomic databases
MaxQBi | O14604 |
PaxDbi | O14604 |
PeptideAtlasi | O14604 |
PRIDEi | O14604 |
ProteomicsDBi | 48110 |
PTM databases
iPTMneti | O14604 |
PhosphoSitePlusi | O14604 |
Expressioni
Tissue specificityi
Ubiquitous.
Gene expression databases
Bgeei | ENSG00000154620 Expressed in 193 organ(s), highest expression level in myocardium |
Genevisiblei | O14604 HS |
Interactioni
Binary interactionsi
With | Entry | #Exp. | IntAct | Notes |
---|---|---|---|---|
TERF2IP | Q9NYB0 | 2 | EBI-751196,EBI-750109 |
GO - Molecular functioni
- actin monomer binding Source: GO_Central
Protein-protein interaction databases
BioGridi | 114543, 5 interactors |
IntActi | O14604, 4 interactors |
STRINGi | 9606.ENSP00000284856 |
Structurei
3D structure databases
ProteinModelPortali | O14604 |
SMRi | O14604 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the thymosin beta family.Curated
Phylogenomic databases
eggNOGi | KOG4794 Eukaryota ENOG410Y3I4 LUCA |
GeneTreei | ENSGT00940000154433 |
HOGENOMi | HOG000231370 |
HOVERGENi | HBG012534 |
InParanoidi | O14604 |
KOi | K05764 |
OrthoDBi | 1632292at2759 |
PhylomeDBi | O14604 |
Family and domain databases
Gene3Di | 1.20.5.520, 1 hit |
InterProi | View protein in InterPro IPR001152 Beta-thymosin IPR038386 Beta-thymosin_sf |
PANTHERi | PTHR12021 PTHR12021, 1 hit |
Pfami | View protein in Pfam PF01290 Thymosin, 1 hit |
PIRSFi | PIRSF001828 Thymosin_beta, 1 hit |
ProDomi | View protein in ProDom or Entries sharing at least one domain PD005116 Thymosin_b4, 1 hit |
SMARTi | View protein in SMART SM00152 THY, 1 hit |
PROSITEi | View protein in PROSITE PS00500 THYMOSIN_B4, 1 hit |
i Sequence
Sequence statusi: Complete.
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF000989 mRNA Translation: AAC51836.1 AC006371 Genomic DNA Translation: AAD54509.1 BC022482 mRNA No translation available. BC119763 mRNA Translation: AAI19764.1 BC119764 mRNA Translation: AAI19765.1 |
CCDSi | CCDS14786.1 |
RefSeqi | NP_004193.1, NM_004202.2 |
UniGenei | Hs.159201 |
Genome annotation databases
Ensembli | ENST00000284856; ENSP00000284856; ENSG00000154620 |
GeneIDi | 9087 |
KEGGi | hsa:9087 |
UCSCi | uc004ftb.4 human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF000989 mRNA Translation: AAC51836.1 AC006371 Genomic DNA Translation: AAD54509.1 BC022482 mRNA No translation available. BC119763 mRNA Translation: AAI19764.1 BC119764 mRNA Translation: AAI19765.1 |
CCDSi | CCDS14786.1 |
RefSeqi | NP_004193.1, NM_004202.2 |
UniGenei | Hs.159201 |
3D structure databases
ProteinModelPortali | O14604 |
SMRi | O14604 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
BioGridi | 114543, 5 interactors |
IntActi | O14604, 4 interactors |
STRINGi | 9606.ENSP00000284856 |
PTM databases
iPTMneti | O14604 |
PhosphoSitePlusi | O14604 |
Polymorphism and mutation databases
BioMutai | TMSB4Y |
Proteomic databases
MaxQBi | O14604 |
PaxDbi | O14604 |
PeptideAtlasi | O14604 |
PRIDEi | O14604 |
ProteomicsDBi | 48110 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENST00000284856; ENSP00000284856; ENSG00000154620 |
GeneIDi | 9087 |
KEGGi | hsa:9087 |
UCSCi | uc004ftb.4 human |
Organism-specific databases
CTDi | 9087 |
DisGeNETi | 9087 |
EuPathDBi | HostDB:ENSG00000154620.5 |
GeneCardsi | TMSB4Y |
HGNCi | HGNC:11882 TMSB4Y |
MIMi | 400017 gene |
neXtProti | NX_O14604 |
OpenTargetsi | ENSG00000154620 |
PharmGKBi | PA36582 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4794 Eukaryota ENOG410Y3I4 LUCA |
GeneTreei | ENSGT00940000154433 |
HOGENOMi | HOG000231370 |
HOVERGENi | HBG012534 |
InParanoidi | O14604 |
KOi | K05764 |
OrthoDBi | 1632292at2759 |
PhylomeDBi | O14604 |
Miscellaneous databases
GeneWikii | Thymosin_beta-4,_Y-chromosomal |
GenomeRNAii | 9087 |
PROi | PR:O14604 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000154620 Expressed in 193 organ(s), highest expression level in myocardium |
Genevisiblei | O14604 HS |
Family and domain databases
Gene3Di | 1.20.5.520, 1 hit |
InterProi | View protein in InterPro IPR001152 Beta-thymosin IPR038386 Beta-thymosin_sf |
PANTHERi | PTHR12021 PTHR12021, 1 hit |
Pfami | View protein in Pfam PF01290 Thymosin, 1 hit |
PIRSFi | PIRSF001828 Thymosin_beta, 1 hit |
ProDomi | View protein in ProDom or Entries sharing at least one domain PD005116 Thymosin_b4, 1 hit |
SMARTi | View protein in SMART SM00152 THY, 1 hit |
PROSITEi | View protein in PROSITE PS00500 THYMOSIN_B4, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | TYB4Y_HUMAN | |
Accessioni | O14604Primary (citable) accession number: O14604 Secondary accession number(s): Q0VDA2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 13, 2019 | |
This is version 155 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome Y
Human chromosome Y: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot