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Protein

Eukaryotic translation initiation factor 1A, Y-chromosomal

Gene

EIF1AY

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits (By similarity).By similarity

GO - Molecular functioni

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 1A, Y-chromosomal
Short name:
eIF-1A Y isoform
Alternative name(s):
Eukaryotic translation initiation factor 4C
Short name:
eIF-4C
Gene namesi
Name:EIF1AY
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome Y

Organism-specific databases

EuPathDBiHostDB:ENSG00000198692.9
HGNCiHGNC:3252 EIF1AY
MIMi400014 gene
neXtProtiNX_O14602

Pathology & Biotechi

Organism-specific databases

DisGeNETi9086
OpenTargetsiENSG00000198692
PharmGKBiPA27686

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001451021 – 144Eukaryotic translation initiation factor 1A, Y-chromosomalAdd BLAST144

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki88Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiO14602
MaxQBiO14602
PaxDbiO14602
PeptideAtlasiO14602
PRIDEiO14602
ProteomicsDBi48107
TopDownProteomicsiO14602

PTM databases

iPTMnetiO14602
PhosphoSitePlusiO14602

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000198692
CleanExiHS_EIF1AY
ExpressionAtlasiO14602 baseline and differential
GenevisibleiO14602 HS

Organism-specific databases

HPAiHPA002561

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi114542, 8 interactors
IntActiO14602, 5 interactors
STRINGi9606.ENSP00000354722

Structurei

3D structure databases

ProteinModelPortaliO14602
SMRiO14602
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 96S1-likeAdd BLAST75

Sequence similaritiesi

Belongs to the eIF-1A family.Curated

Phylogenomic databases

eggNOGiKOG3403 Eukaryota
COG0361 LUCA
GeneTreeiENSGT00390000008256
HOGENOMiHOG000223675
HOVERGENiHBG001131
InParanoidiO14602
KOiK03236
OMAiCTFEFGD
OrthoDBiEOG091G195V
PhylomeDBiO14602
TreeFamiTF350394

Family and domain databases

CDDicd05793 S1_IF1A, 1 hit
HAMAPiMF_00216 aIF_1A, 1 hit
InterProiView protein in InterPro
IPR012340 NA-bd_OB-fold
IPR006196 RNA-binding_domain_S1_IF1
IPR001253 TIF_eIF-1A
IPR018104 TIF_eIF-1A_CS
PANTHERiPTHR21668 PTHR21668, 1 hit
PfamiView protein in Pfam
PF01176 eIF-1a, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005579 TIF_eIF-1A, 1 hit
SMARTiView protein in SMART
SM00652 eIF1a, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00523 eIF-1A, 1 hit
PROSITEiView protein in PROSITE
PS01262 IF1A, 1 hit
PS50832 S1_IF1_TYPE, 1 hit

Sequencei

Sequence statusi: Complete.

O14602-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKNKGKGGK NRRRGKNENE SEKRELVFKE DGQEYAQVIK MLGNGRLEAL
60 70 80 90 100
CFDGVKRLCH IRGKLRKKVW INTSDIILVG LRDYQDNKAD VILKYNADEA
110 120 130 140
RSLKAYGELP EHAKINETDT FGPGDDDEIQ FDDIGDDDED IDDI
Length:144
Mass (Da):16,442
Last modified:January 23, 2007 - v4
Checksum:i1DE91334F191BEC5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti108E → G in AAC51834 (PubMed:9381176).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000987 mRNA Translation: AAC51834.1
BT007201 mRNA Translation: AAP35865.1
BC005248 mRNA Translation: AAH05248.1
CCDSiCCDS14795.1
PIRiC53045
RefSeqiNP_001265541.1, NM_001278612.1
NP_004672.2, NM_004681.3
UniGeneiHs.461178

Genome annotation databases

EnsembliENST00000361365; ENSP00000354722; ENSG00000198692
GeneIDi9086
KEGGihsa:9086
UCSCiuc004fuk.5 human

Similar proteinsi

Entry informationi

Entry nameiIF1AY_HUMAN
AccessioniPrimary (citable) accession number: O14602
Secondary accession number(s): Q9BS77
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 149 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome Y
    Human chromosome Y: entries, gene names and cross-references to MIM
  2. Translation initiation factors
    List of translation initiation factor entries
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

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