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Protein

Testis-specific basic protein Y 2

Gene

BPY2

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • HECT domain binding Source: HGNC

GO - Biological processi

  • single fertilization Source: ProtInc
  • spermatogenesis Source: HGNC

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Testis-specific basic protein Y 2
Alternative name(s):
Basic charge, Y-linked 2
Variably charged protein Y 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BPY2
Synonyms:BPY2A, VCY2, VCY2A
AND
Name:BPY2B
Synonyms:VCY2B
AND
Name:BPY2C
Synonyms:VCY2C
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome Y

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000183753.10
HostDB:ENSG00000183795.8
HostDB:ENSG00000185894.8

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13508 BPY2
HGNC:25449 BPY2B
HGNC:18225 BPY2C

Online Mendelian Inheritance in Man (OMIM)

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MIMi
400013 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O14599

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
442867
442868
9083

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
BPY2

MalaCards human disease database

More...
MalaCardsi
BPY2

Open Targets

More...
OpenTargetsi
ENSG00000183753

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37794

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001846641 – 106Testis-specific basic protein Y 2Add BLAST106

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O14599

PRoteomics IDEntifications database

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PRIDEi
O14599

ProteomicsDB human proteome resource

More...
ProteomicsDBi
48106

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed exclusively in testis. Expressed in ejaculated spermatozoa of germ cell. Expressed in the nuclei of spermatogonia, spermatocytes, and round spermatids, except elongated spermatids (at protein level).3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000183753 Expressed in 12 organ(s), highest expression level in right testis

CleanEx database of gene expression profiles

More...
CleanExi
HS_BPY2
HS_BPY2B

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O14599 baseline

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O14599 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MAP1S. Interacts with UBE3A (via HECT domain).2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
MAP1SQ66K743EBI-2133713,EBI-2133734

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
114539, 2 interactors

Protein interaction database and analysis system

More...
IntActi
O14599, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000371829

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O14599

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the VCX/VCY family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410KCDT Eukaryota
ENOG4110P2K LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000015738

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000206609

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O14599

Identification of Orthologs from Complete Genome Data

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OMAi
CLANHLS

Database of Orthologous Groups

More...
OrthoDBi
EOG09371J79

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O14599

TreeFam database of animal gene trees

More...
TreeFami
TF342588

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O14599-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMTLVPRART RAGQDHYSHP CPRFSQVLLT EGIMTYCLTK NLSDVNILHR
60 70 80 90 100
LLKNGNVRNT LLQSKVGLLT YYVKLYPGEV TLLTRPSIQM RLCCITGSVS

RPRSQK
Length:106
Mass (Da):12,063
Last modified:April 14, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2573EC02A2C99788
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
R4GMN0R4GMN0_HUMAN
Testis-specific basic protein Y 2
BPY2C BPY2, BPY2B
11Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti101R → K in AAC51828 (PubMed:9381176).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF000980 mRNA Translation: AAC51828.1
AC016728 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14800.1
CCDS44029.1
CCDS44030.1

NCBI Reference Sequences

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RefSeqi
NP_001002760.1, NM_001002760.1
NP_001002761.1, NM_001002761.1
NP_004669.2, NM_004678.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.632848
Hs.664724

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000331070; ENSP00000329106; ENSG00000183753
ENST00000382287; ENSP00000371724; ENSG00000185894
ENST00000382392; ENSP00000371829; ENSG00000183795
ENST00000382585; ENSP00000372028; ENSG00000183753
ENST00000615850; ENSP00000480184; ENSG00000183795
ENST00000618574; ENSP00000480751; ENSG00000185894

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
442867
442868
9083

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:442867
hsa:442868
hsa:9083

UCSC genome browser

More...
UCSCi
uc004fwi.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000980 mRNA Translation: AAC51828.1
AC016728 Genomic DNA No translation available.
CCDSiCCDS14800.1
CCDS44029.1
CCDS44030.1
RefSeqiNP_001002760.1, NM_001002760.1
NP_001002761.1, NM_001002761.1
NP_004669.2, NM_004678.2
UniGeneiHs.632848
Hs.664724

3D structure databases

ProteinModelPortaliO14599
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114539, 2 interactors
IntActiO14599, 1 interactor
STRINGi9606.ENSP00000371829

Proteomic databases

PaxDbiO14599
PRIDEiO14599
ProteomicsDBi48106

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
442867
442868
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000331070; ENSP00000329106; ENSG00000183753
ENST00000382287; ENSP00000371724; ENSG00000185894
ENST00000382392; ENSP00000371829; ENSG00000183795
ENST00000382585; ENSP00000372028; ENSG00000183753
ENST00000615850; ENSP00000480184; ENSG00000183795
ENST00000618574; ENSP00000480751; ENSG00000185894
GeneIDi442867
442868
9083
KEGGihsa:442867
hsa:442868
hsa:9083
UCSCiuc004fwi.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
442867
442868
9083
DisGeNETi442867
442868
9083
EuPathDBiHostDB:ENSG00000183753.10
HostDB:ENSG00000183795.8
HostDB:ENSG00000185894.8

GeneCards: human genes, protein and diseases

More...
GeneCardsi
BPY2
BPY2B
BPY2C
GeneReviewsiBPY2

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0177613
HIX0177614
HIX0177615
HGNCiHGNC:13508 BPY2
HGNC:25449 BPY2B
HGNC:18225 BPY2C
MalaCardsiBPY2
MIMi400013 gene
neXtProtiNX_O14599
OpenTargetsiENSG00000183753
PharmGKBiPA37794

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410KCDT Eukaryota
ENOG4110P2K LUCA
GeneTreeiENSGT00390000015738
HOGENOMiHOG000206609
InParanoidiO14599
OMAiCLANHLS
OrthoDBiEOG09371J79
PhylomeDBiO14599
TreeFamiTF342588

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
BPY2

Protein Ontology

More...
PROi
PR:O14599

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000183753 Expressed in 12 organ(s), highest expression level in right testis
CleanExiHS_BPY2
HS_BPY2B
ExpressionAtlasiO14599 baseline
GenevisibleiO14599 HS

Family and domain databases

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVCY2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O14599
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: April 14, 2009
Last modified: September 12, 2018
This is version 119 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome Y
    Human chromosome Y: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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