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Protein

Olfactory receptor 7A17

Gene

OR7A17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  • G protein-coupled receptor activity Source: UniProtKB-KW
  • olfactory receptor activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 7A17
Gene namesi
Name:OR7A17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000185385.3
HGNCiHGNC:8363 OR7A17
neXtProtiNX_O14581

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 54CytoplasmicSequence analysis8
Transmembranei55 – 75Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini76 – 99ExtracellularSequence analysisAdd BLAST24
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 197ExtracellularSequence analysisAdd BLAST37
Transmembranei198 – 217Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini218 – 237CytoplasmicSequence analysisAdd BLAST20
Transmembranei238 – 258Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini259 – 271ExtracellularSequence analysisAdd BLAST13
Transmembranei272 – 292Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini293 – 309CytoplasmicSequence analysisAdd BLAST17

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000185385
PharmGKBiPA32616

Polymorphism and mutation databases

BioMutaiOR7A17

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506451 – 309Olfactory receptor 7A17Add BLAST309

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO14581
PRIDEiO14581
ProteomicsDBi48100

PTM databases

iPTMnetiO14581
PhosphoSitePlusiO14581

Expressioni

Gene expression databases

BgeeiENSG00000185385 Expressed in 3 organ(s), highest expression level in vagina
CleanExiHS_OR7A17
ExpressionAtlasiO14581 differential
GenevisibleiO14581 HS

Interactioni

Protein-protein interaction databases

IntActiO14581, 2 interactors
STRINGi9606.ENSP00000328144

Structurei

3D structure databases

ProteinModelPortaliO14581
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVB1 Eukaryota
ENOG410YBQN LUCA
GeneTreeiENSGT00760000118801
HOGENOMiHOG000041362
HOVERGENiHBG017625
InParanoidiO14581
KOiK04257
OMAiVLASWMI
OrthoDBiEOG091G0B53
PhylomeDBiO14581
TreeFamiTF337210

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

O14581-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPENDTGIS EFVLLGLSEE PELQPFLFGL FLSMYLVTVL GNLLIILATI
60 70 80 90 100
SDSHLHTPMY FFLSNLSFAD ICFISTTIPK MLINIQTQSR VITYAGCITQ
110 120 130 140 150
MCFFVLFGGL DSLLLAVMAY DRFVAICHPL HYTVIMNPRL CGLLVLASWM
160 170 180 190 200
IAALNSLSQS LMVLWLSFCT DLEIPHFFCE LNQVIHLACS DTFLNDMGMY
210 220 230 240 250
FAAGLLAGGP LVGILCSYSK IVSSIRAISS AQGKYKAFST CASHLSVVSL
260 270 280 290 300
FCCTGLGVYL TSAATHNSHT SATASVMYTV ATPMLNPFIY SLRNKDIKRA

LKMSFRGKQ
Length:309
Mass (Da):34,013
Last modified:January 1, 1998 - v1
Checksum:i7D3CED8A480C13D0
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05322837V → A. Corresponds to variant dbSNP:rs10405148Ensembl.1
Natural variantiVAR_05322946I → T. Corresponds to variant dbSNP:rs10405129Ensembl.1
Natural variantiVAR_05323069A → S. Corresponds to variant dbSNP:rs10404119Ensembl.1
Natural variantiVAR_053231237A → T. Corresponds to variant dbSNP:rs13345394Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002988 Genomic DNA Translation: AAB82060.1
BC101587 mRNA Translation: AAI01588.1
BC117357 mRNA Translation: AAI17358.1
AF399541 Genomic DNA Translation: AAK95026.1
BK004206 Genomic DNA Translation: DAA04604.1
CCDSiCCDS12319.1
RefSeqiNP_112163.1, NM_030901.1
UniGeneiHs.247717

Genome annotation databases

EnsembliENST00000327462; ENSP00000328144; ENSG00000185385
ENST00000641113; ENSP00000493283; ENSG00000185385
ENST00000642123; ENSP00000493071; ENSG00000185385
GeneIDi26333
KEGGihsa:26333
UCSCiuc010xob.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002988 Genomic DNA Translation: AAB82060.1
BC101587 mRNA Translation: AAI01588.1
BC117357 mRNA Translation: AAI17358.1
AF399541 Genomic DNA Translation: AAK95026.1
BK004206 Genomic DNA Translation: DAA04604.1
CCDSiCCDS12319.1
RefSeqiNP_112163.1, NM_030901.1
UniGeneiHs.247717

3D structure databases

ProteinModelPortaliO14581
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO14581, 2 interactors
STRINGi9606.ENSP00000328144

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiO14581
PhosphoSitePlusiO14581

Polymorphism and mutation databases

BioMutaiOR7A17

Proteomic databases

PaxDbiO14581
PRIDEiO14581
ProteomicsDBi48100

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000327462; ENSP00000328144; ENSG00000185385
ENST00000641113; ENSP00000493283; ENSG00000185385
ENST00000642123; ENSP00000493071; ENSG00000185385
GeneIDi26333
KEGGihsa:26333
UCSCiuc010xob.3 human

Organism-specific databases

CTDi26333
EuPathDBiHostDB:ENSG00000185385.3
GeneCardsiOR7A17
HGNCiHGNC:8363 OR7A17
neXtProtiNX_O14581
OpenTargetsiENSG00000185385
PharmGKBiPA32616
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVB1 Eukaryota
ENOG410YBQN LUCA
GeneTreeiENSGT00760000118801
HOGENOMiHOG000041362
HOVERGENiHBG017625
InParanoidiO14581
KOiK04257
OMAiVLASWMI
OrthoDBiEOG091G0B53
PhylomeDBiO14581
TreeFamiTF337210

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiiOR7A17
GenomeRNAii26333
PROiPR:O14581

Gene expression databases

BgeeiENSG00000185385 Expressed in 3 organ(s), highest expression level in vagina
CleanExiHS_OR7A17
ExpressionAtlasiO14581 differential
GenevisibleiO14581 HS

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOR7AH_HUMAN
AccessioniPrimary (citable) accession number: O14581
Secondary accession number(s): Q6IFQ6, Q96R98
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: January 1, 1998
Last modified: November 7, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  5. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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