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Protein

Coatomer subunit epsilon

Gene

COPE

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-6807878 COPI-mediated anterograde transport
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Names & Taxonomyi

Protein namesi
Recommended name:
Coatomer subunit epsilon
Alternative name(s):
Epsilon-coat protein
Short name:
Epsilon-COP
Gene namesi
Name:COPE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000105669.12
HGNCiHGNC:2234 COPE
MIMi606942 gene
neXtProtiNX_O14579

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi11316
OpenTargetsiENSG00000105669
PharmGKBiPA26750

Polymorphism and mutation databases

BioMutaiCOPE

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001938512 – 308Coatomer subunit epsilonAdd BLAST307

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei13PhosphoserineCombined sources1
Modified residuei45PhosphoserineCombined sources1
Modified residuei99PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated by PKA.
Polyubiquitinated by RCHY1 in the presence of androgen, leading to proteasomal degradation.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO14579
MaxQBiO14579
PaxDbiO14579
PeptideAtlasiO14579
PRIDEiO14579
ProteomicsDBi48098
48099 [O14579-2]

2D gel databases

OGPiO14579

PTM databases

iPTMnetiO14579
PhosphoSitePlusiO14579
SwissPalmiO14579

Expressioni

Gene expression databases

BgeeiENSG00000105669 Expressed in 219 organ(s), highest expression level in right testis
CleanExiHS_COPE
ExpressionAtlasiO14579 baseline and differential
GenevisibleiO14579 HS

Organism-specific databases

HPAiCAB034345
HPA041605
HPA043576

Interactioni

Subunit structurei

Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.

Binary interactionsi

WithEntry#Exp.IntActNotes
EFHC2Q5JST65EBI-711301,EBI-2349927

Protein-protein interaction databases

BioGridi116447, 77 interactors
IntActiO14579, 36 interactors
MINTiO14579
STRINGi9606.ENSP00000262812

Structurei

3D structure databases

ProteinModelPortaliO14579
SMRiO14579
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the COPE family.Curated

Phylogenomic databases

eggNOGiKOG3081 Eukaryota
ENOG410XS5P LUCA
GeneTreeiENSGT00390000003478
HOGENOMiHOG000205825
HOVERGENiHBG002201
InParanoidiO14579
KOiK17268
PhylomeDBiO14579
TreeFamiTF313390

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR006822 Coatomer_esu
IPR011990 TPR-like_helical_dom_sf
PANTHERiPTHR10805 PTHR10805, 1 hit
PIRSFiPIRSF016478 Coatomer_esu, 1 hit
SUPFAMiSSF48452 SSF48452, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O14579-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPPAPGPAS GGSGEVDELF DVKNAFYIGS YQQCINEAQR VKLSSPERDV
60 70 80 90 100
ERDVFLYRAY LAQRKFGVVL DEIKPSSAPE LQAVRMFADY LAHESRRDSI
110 120 130 140 150
VAELDREMSR SVDVTNTTFL LMAASIYLHD QNPDAALRAL HQGDSLECTA
160 170 180 190 200
MTVQILLKLD RLDLARKELK RMQDLDEDAT LTQLATAWVS LATGGEKLQD
210 220 230 240 250
AYYIFQEMAD KCSPTLLLLN GQAACHMAQG RWEAAEGLLQ EALDKDSGYP
260 270 280 290 300
ETLVNLIVLS QHLGKPPEVT NRYLSQLKDA HRSHPFIKEY QAKENDFDRL

VLQYAPSA
Length:308
Mass (Da):34,482
Last modified:January 23, 2007 - v3
Checksum:iA71146F3332F6BA9
GO
Isoform 2 (identifier: O14579-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     97-97: R → S
     98-148: Missing.

Note: No experimental confirmation available.
Show »
Length:257
Mass (Da):28,797
Checksum:i0F26BDC0A83D65BF
GO
Isoform 3 (identifier: O14579-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     194-245: Missing.

Note: No experimental confirmation available.
Show »
Length:256
Mass (Da):28,773
Checksum:i4B35360D41136F1A
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QXB4M0QXB4_HUMAN
Coatomer protein complex, subunit e...
COPE hCG_2001439
331Annotation score:
M0R061M0R061_HUMAN
Coatomer subunit epsilon
COPE
146Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05403213S → C. Corresponds to variant dbSNP:rs2231987Ensembl.1
Natural variantiVAR_054033117T → I2 PublicationsCorresponds to variant dbSNP:rs10330Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04277097R → S in isoform 2. 1 Publication1
Alternative sequenceiVSP_04277198 – 148Missing in isoform 2. 1 PublicationAdd BLAST51
Alternative sequenceiVSP_045070194 – 245Missing in isoform 3. 1 PublicationAdd BLAST52

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ131182 mRNA Translation: CAA10316.1
AJ249366 mRNA Translation: CAB55628.1
AL136928 mRNA Translation: CAB66862.1
AK126476 mRNA Translation: BAG54333.1
AK315281 mRNA Translation: BAG37690.1
CR456886 mRNA Translation: CAG33167.1
AC002985 Genomic DNA Translation: AAB81543.1
AC005197 Genomic DNA Translation: AAC24612.1
CH471106 Genomic DNA Translation: EAW84749.1
CH471106 Genomic DNA Translation: EAW84752.1
CH471106 Genomic DNA Translation: EAW84756.1
BC003155 mRNA Translation: AAH03155.1
BC007250 mRNA Translation: AAH07250.1
BC017285 mRNA Translation: AAH17285.1
BM454494 mRNA No translation available.
CCDSiCCDS12387.1 [O14579-1]
CCDS12388.1 [O14579-2]
CCDS12389.1 [O14579-3]
RefSeqiNP_009194.2, NM_007263.3 [O14579-1]
NP_955474.1, NM_199442.1 [O14579-2]
NP_955476.1, NM_199444.1 [O14579-3]
UniGeneiHs.10326

Genome annotation databases

EnsembliENST00000262812; ENSP00000262812; ENSG00000105669 [O14579-1]
ENST00000349893; ENSP00000343134; ENSG00000105669 [O14579-3]
ENST00000351079; ENSP00000345674; ENSG00000105669 [O14579-2]
GeneIDi11316
KEGGihsa:11316
UCSCiuc002nkk.4 human [O14579-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ131182 mRNA Translation: CAA10316.1
AJ249366 mRNA Translation: CAB55628.1
AL136928 mRNA Translation: CAB66862.1
AK126476 mRNA Translation: BAG54333.1
AK315281 mRNA Translation: BAG37690.1
CR456886 mRNA Translation: CAG33167.1
AC002985 Genomic DNA Translation: AAB81543.1
AC005197 Genomic DNA Translation: AAC24612.1
CH471106 Genomic DNA Translation: EAW84749.1
CH471106 Genomic DNA Translation: EAW84752.1
CH471106 Genomic DNA Translation: EAW84756.1
BC003155 mRNA Translation: AAH03155.1
BC007250 mRNA Translation: AAH07250.1
BC017285 mRNA Translation: AAH17285.1
BM454494 mRNA No translation available.
CCDSiCCDS12387.1 [O14579-1]
CCDS12388.1 [O14579-2]
CCDS12389.1 [O14579-3]
RefSeqiNP_009194.2, NM_007263.3 [O14579-1]
NP_955474.1, NM_199442.1 [O14579-2]
NP_955476.1, NM_199444.1 [O14579-3]
UniGeneiHs.10326

3D structure databases

ProteinModelPortaliO14579
SMRiO14579
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116447, 77 interactors
IntActiO14579, 36 interactors
MINTiO14579
STRINGi9606.ENSP00000262812

PTM databases

iPTMnetiO14579
PhosphoSitePlusiO14579
SwissPalmiO14579

Polymorphism and mutation databases

BioMutaiCOPE

2D gel databases

OGPiO14579

Proteomic databases

EPDiO14579
MaxQBiO14579
PaxDbiO14579
PeptideAtlasiO14579
PRIDEiO14579
ProteomicsDBi48098
48099 [O14579-2]

Protocols and materials databases

DNASUi11316
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262812; ENSP00000262812; ENSG00000105669 [O14579-1]
ENST00000349893; ENSP00000343134; ENSG00000105669 [O14579-3]
ENST00000351079; ENSP00000345674; ENSG00000105669 [O14579-2]
GeneIDi11316
KEGGihsa:11316
UCSCiuc002nkk.4 human [O14579-1]

Organism-specific databases

CTDi11316
DisGeNETi11316
EuPathDBiHostDB:ENSG00000105669.12
GeneCardsiCOPE
HGNCiHGNC:2234 COPE
HPAiCAB034345
HPA041605
HPA043576
MIMi606942 gene
neXtProtiNX_O14579
OpenTargetsiENSG00000105669
PharmGKBiPA26750
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3081 Eukaryota
ENOG410XS5P LUCA
GeneTreeiENSGT00390000003478
HOGENOMiHOG000205825
HOVERGENiHBG002201
InParanoidiO14579
KOiK17268
PhylomeDBiO14579
TreeFamiTF313390

Enzyme and pathway databases

ReactomeiR-HSA-6807878 COPI-mediated anterograde transport
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Miscellaneous databases

ChiTaRSiCOPE human
GeneWikiiCOPE_(gene)
GenomeRNAii11316
PROiPR:O14579
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000105669 Expressed in 219 organ(s), highest expression level in right testis
CleanExiHS_COPE
ExpressionAtlasiO14579 baseline and differential
GenevisibleiO14579 HS

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR006822 Coatomer_esu
IPR011990 TPR-like_helical_dom_sf
PANTHERiPTHR10805 PTHR10805, 1 hit
PIRSFiPIRSF016478 Coatomer_esu, 1 hit
SUPFAMiSSF48452 SSF48452, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCOPE_HUMAN
AccessioniPrimary (citable) accession number: O14579
Secondary accession number(s): A6NE29
, A6NKA3, O76097, Q6IBB8, Q9UGP6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 165 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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