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Protein

Citron Rho-interacting kinase

Gene

CIT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2.4 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei126ATPPROSITE-ProRule annotation1
Active sitei221Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi103 – 111ATPPROSITE-ProRule annotation9
Zinc fingeri1362 – 1411Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST50

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW
  • PDZ domain binding Source: UniProtKB
  • protein serine/threonine kinase activity Source: UniProtKB
  • Rho GTPase binding Source: Ensembl
  • scaffold protein binding Source: BHF-UCL
  • SH3 domain binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Kinase, Serine/threonine-protein kinase, Transferase
Biological processCell cycle, Cell division, Differentiation, Mitosis, Neurogenesis
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-5625900 RHO GTPases activate CIT
SignaLinkiO14578

Names & Taxonomyi

Protein namesi
Recommended name:
Citron Rho-interacting kinase (EC:2.7.11.1)
Short name:
CRIK
Alternative name(s):
Serine/threonine-protein kinase 21
Gene namesi
Name:CIT
Synonyms:CRIK, KIAA0949, STK21
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000122966.13
HGNCiHGNC:1985 CIT
MIMi605629 gene
neXtProtiNX_O14578

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Involvement in diseasei

Microcephaly 17, primary, autosomal recessive (MCPH17)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of microcephaly, a disease defined as a head circumference more than 3 standard deviations below the age, sex and ethnically matched mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. MCPH17 is a severe form characterized by lissencephaly, enlarged ventricles, agenesis of the corpus callosum, cerebellar hypoplasia, and brainstem hypoplasia. Patients manifest delayed psychomotor development, intellectual disability, spasticity, axial hypotonia, and dysmorphic features.
See also OMIM:617090
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_077442106G → V in MCPH17; impairs kinase activity; exhibits abnormal mitotic cytokinesis; exhibits multipolar spindles; increases the neurons apoptotic process. 1 PublicationCorresponds to variant dbSNP:rs886037892EnsemblClinVar.1
Natural variantiVAR_077443126K → Q in MCPH17; impairs kinase activity; exhibits abnormal mitotic cytokinesis; exhibits multipolar spindles; increases the neurons apoptotic process. 1 PublicationCorresponds to variant dbSNP:rs886037893Ensembl.1
Natural variantiVAR_077444230D → V in MCPH17; impairs kinase activity; exhibits abnormal mitotic cytokinesis; exhibits multipolar spindles; increases the neurons apoptotic process. 1 PublicationCorresponds to variant dbSNP:rs886037894EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Primary microcephaly

Organism-specific databases

DisGeNETi11113
MalaCardsiCIT
MIMi617090 phenotype
OpenTargetsiENSG00000122966
Orphaneti2512 Autosomal recessive primary microcephaly
PharmGKBiPA26522

Chemistry databases

ChEMBLiCHEMBL5579

Polymorphism and mutation databases

BioMutaiCIT

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000859081 – 2027Citron Rho-interacting kinaseAdd BLAST2027

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei433PhosphoserineCombined sources1
Modified residuei440PhosphoserineCombined sources1
Modified residuei480PhosphoserineCombined sources1
Modified residuei582PhosphoserineCombined sources1
Modified residuei1196PhosphotyrosineBy similarity1
Modified residuei1721N6-acetyllysineCombined sources1
Modified residuei1940PhosphoserineCombined sources1
Modified residuei1993PhosphoserineCombined sources1
Modified residuei2013PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO14578
MaxQBiO14578
PaxDbiO14578
PeptideAtlasiO14578
PRIDEiO14578
ProteomicsDBi48094
48095 [O14578-2]
48096 [O14578-3]
48097 [O14578-4]

PTM databases

iPTMnetiO14578
PhosphoSitePlusiO14578

Expressioni

Gene expression databases

BgeeiENSG00000122966 Expressed in 189 organ(s), highest expression level in anterior cingulate cortex
CleanExiHS_CIT
ExpressionAtlasiO14578 baseline and differential
GenevisibleiO14578 HS

Organism-specific databases

HPAiHPA019082
HPA048812
HPA075506

Interactioni

Subunit structurei

Directly interacts with KIF14 depending on the activation state (stronger interaction with the kinase-dead form). Homodimer (By similarity). Interacts with TTC3.By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116290, 46 interactors
IntActiO14578, 7 interactors
MINTiO14578
STRINGi9606.ENSP00000376306

Chemistry databases

BindingDBiO14578

Structurei

3D structure databases

ProteinModelPortaliO14578
SMRiO14578
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini97 – 360Protein kinasePROSITE-ProRule annotationAdd BLAST264
Domaini361 – 431AGC-kinase C-terminalAdd BLAST71
Domaini1443 – 1563PHPROSITE-ProRule annotationAdd BLAST121
Domaini1591 – 1881CNHPROSITE-ProRule annotationAdd BLAST291

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1091 – 1302Interaction with Rho/RacAdd BLAST212

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili453 – 1297Sequence analysisAdd BLAST845

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1953 – 1958SH3-bindingSequence analysis6

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1362 – 1411Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST50

Keywords - Domaini

Coiled coil, SH3-binding, Zinc-finger

Phylogenomic databases

eggNOGiKOG0612 Eukaryota
KOG0976 Eukaryota
ENOG410XR1Q LUCA
GeneTreeiENSGT00760000118994
HOGENOMiHOG000015347
HOVERGENiHBG071093
InParanoidiO14578
KOiK16308
OMAiDVSCDYW
OrthoDBiEOG091G00DT
PhylomeDBiO14578
TreeFamiTF101140

Family and domain databases

CDDicd00029 C1, 1 hit
cd05601 STKc_CRIK, 1 hit
Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR000961 AGC-kinase_C
IPR017405 Citron_Rho-interacting_kinase
IPR001180 CNH_dom
IPR037708 CRIK_dom
IPR011009 Kinase-like_dom_sf
IPR002219 PE/DAG-bd
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PANTHERiPTHR22988:SF26 PTHR22988:SF26, 3 hits
PfamiView protein in Pfam
PF00780 CNH, 1 hit
PF00169 PH, 1 hit
PF00069 Pkinase, 1 hit
PIRSFiPIRSF038145 Citron_Rho-interacting_kinase, 1 hit
SMARTiView protein in SMART
SM00109 C1, 1 hit
SM00036 CNH, 1 hit
SM00233 PH, 1 hit
SM00133 S_TK_X, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS50219 CNH, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS00479 ZF_DAG_PE_1, 1 hit
PS50081 ZF_DAG_PE_2, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O14578-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLKFKYGARN PLDAGAAEPI ASRASRLNLF FQGKPPFMTQ QQMSPLSREG
60 70 80 90 100
ILDALFVLFE ECSQPALMKI KHVSNFVRKY SDTIAELQEL QPSAKDFEVR
110 120 130 140 150
SLVGCGHFAE VQVVREKATG DIYAMKVMKK KALLAQEQVS FFEEERNILS
160 170 180 190 200
RSTSPWIPQL QYAFQDKNHL YLVMEYQPGG DLLSLLNRYE DQLDENLIQF
210 220 230 240 250
YLAELILAVH SVHLMGYVHR DIKPENILVD RTGHIKLVDF GSAAKMNSNK
260 270 280 290 300
MVNAKLPIGT PDYMAPEVLT VMNGDGKGTY GLDCDWWSVG VIAYEMIYGR
310 320 330 340 350
SPFAEGTSAR TFNNIMNFQR FLKFPDDPKV SSDFLDLIQS LLCGQKERLK
360 370 380 390 400
FEGLCCHPFF SKIDWNNIRN SPPPFVPTLK SDDDTSNFDE PEKNSWVSSS
410 420 430 440 450
PCQLSPSGFS GEELPFVGFS YSKALGILGR SESVVSGLDS PAKTSSMEKK
460 470 480 490 500
LLIKSKELQD SQDKCHKMEQ EMTRLHRRVS EVEAVLSQKE VELKASETQR
510 520 530 540 550
SLLEQDLATY ITECSSLKRS LEQARMEVSQ EDDKALQLLH DIREQSRKLQ
560 570 580 590 600
EIKEQEYQAQ VEEMRLMMNQ LEEDLVSARR RSDLYESELR ESRLAAEEFK
610 620 630 640 650
RKATECQHKL LKAKDQGKPE VGEYAKLEKI NAEQQLKIQE LQEKLEKAVK
660 670 680 690 700
ASTEATELLQ NIRQAKERAE RELEKLQNRE DSSEGIRKKL VEAEELEEKH
710 720 730 740 750
REAQVSAQHL EVHLKQKEQH YEEKIKVLDN QIKKDLADKE TLENMMQRHE
760 770 780 790 800
EEAHEKGKIL SEQKAMINAM DSKIRSLEQR IVELSEANKL AANSSLFTQR
810 820 830 840 850
NMKAQEEMIS ELRQQKFYLE TQAGKLEAQN RKLEEQLEKI SHQDHSDKNR
860 870 880 890 900
LLELETRLRE VSLEHEEQKL ELKRQLTELQ LSLQERESQL TALQAARAAL
910 920 930 940 950
ESQLRQAKTE LEETTAEAEE EIQALTAHRD EIQRKFDALR NSCTVITDLE
960 970 980 990 1000
EQLNQLTEDN AELNNQNFYL SKQLDEASGA NDEIVQLRSE VDHLRREITE
1010 1020 1030 1040 1050
REMQLTSQKQ TMEALKTTCT MLEEQVMDLE ALNDELLEKE RQWEAWRSVL
1060 1070 1080 1090 1100
GDEKSQFECR VRELQRMLDT EKQSRARADQ RITESRQVVE LAVKEHKAEI
1110 1120 1130 1140 1150
LALQQALKEQ KLKAESLSDK LNDLEKKHAM LEMNARSLQQ KLETERELKQ
1160 1170 1180 1190 1200
RLLEEQAKLQ QQMDLQKNHI FRLTQGLQEA LDRADLLKTE RSDLEYQLEN
1210 1220 1230 1240 1250
IQVLYSHEKV KMEGTISQQT KLIDFLQAKM DQPAKKKKGL FSRRKEDPAL
1260 1270 1280 1290 1300
PTQVPLQYNE LKLALEKEKA RCAELEEALQ KTRIELRSAR EEAAHRKATD
1310 1320 1330 1340 1350
HPHPSTPATA RQQIAMSAIV RSPEHQPSAM SLLAPPSSRR KESSTPEEFS
1360 1370 1380 1390 1400
RRLKERMHHN IPHRFNVGLN MRATKCAVCL DTVHFGRQAS KCLECQVMCH
1410 1420 1430 1440 1450
PKCSTCLPAT CGLPAEYATH FTEAFCRDKM NSPGLQTKEP SSSLHLEGWM
1460 1470 1480 1490 1500
KVPRNNKRGQ QGWDRKYIVL EGSKVLIYDN EAREAGQRPV EEFELCLPDG
1510 1520 1530 1540 1550
DVSIHGAVGA SELANTAKAD VPYILKMESH PHTTCWPGRT LYLLAPSFPD
1560 1570 1580 1590 1600
KQRWVTALES VVAGGRVSRE KAEADAKLLG NSLLKLEGDD RLDMNCTLPF
1610 1620 1630 1640 1650
SDQVVLVGTE EGLYALNVLK NSLTHVPGIG AVFQIYIIKD LEKLLMIAGE
1660 1670 1680 1690 1700
ERALCLVDVK KVKQSLAQSH LPAQPDISPN IFEAVKGCHL FGAGKIENGL
1710 1720 1730 1740 1750
CICAAMPSKV VILRYNENLS KYCIRKEIET SEPCSCIHFT NYSILIGTNK
1760 1770 1780 1790 1800
FYEIDMKQYT LEEFLDKNDH SLAPAVFAAS SNSFPVSIVQ VNSAGQREEY
1810 1820 1830 1840 1850
LLCFHEFGVF VDSYGRRSRT DDLKWSRLPL AFAYREPYLF VTHFNSLEVI
1860 1870 1880 1890 1900
EIQARSSAGT PARAYLDIPN PRYLGPAISS GAIYLASSYQ DKLRVICCKG
1910 1920 1930 1940 1950
NLVKESGTEH HRGPSTSRSS PNKRGPPTYN EHITKRVASS PAPPEGPSHP
1960 1970 1980 1990 2000
REPSTPHRYR EGRTELRRDK SPGRPLEREK SPGRMLSTRR ERSPGRLFED
2010 2020
SSRGRLPAGA VRTPLSQVNK VWDQSSV
Length:2,027
Mass (Da):231,431
Last modified:January 4, 2005 - v2
Checksum:i6B1D8C3F661F357B
GO
Isoform 2 (identifier: O14578-2) [UniParc]FASTAAdd to basket
Also known as: Short, CRIK-SK

The sequence of this isoform differs from the canonical sequence as follows:
     481-482: EV → GG
     483-2027: Missing.

Show »
Length:482
Mass (Da):54,399
Checksum:i7F23D62DD30DC0CE
GO
Isoform 3 (identifier: O14578-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-467: Missing.
     1239-1253: Missing.
     1919-1919: Missing.

Note: No experimental confirmation available.
Show »
Length:1,544
Mass (Da):177,035
Checksum:i309A4BA63CB1419D
GO
Isoform 4 (identifier: O14578-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     694-694: E → EERRHSLENKVKRLETMERRENRLKDDIQTKSQQIQQMADKIL

Show »
Length:2,069
Mass (Da):236,607
Checksum:iA491E1437044643D
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BYJ3H7BYJ3_HUMAN
Citron Rho-interacting kinase
CIT
1,640Annotation score:
H0YGG8H0YGG8_HUMAN
Citron Rho-interacting kinase
CIT
109Annotation score:
F5H4K4F5H4K4_HUMAN
Citron Rho-interacting kinase
CIT
162Annotation score:

Sequence cautioni

The sequence BAA76793 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12L → S in AAP43922 (Ref. 2) Curated1
Sequence conflicti56F → L in AAP43922 (Ref. 2) Curated1
Sequence conflicti218V → L in AAP43922 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0404177G → E1 PublicationCorresponds to variant dbSNP:rs36054900Ensembl.1
Natural variantiVAR_0404189R → Q1 PublicationCorresponds to variant dbSNP:rs56193743Ensembl.1
Natural variantiVAR_077442106G → V in MCPH17; impairs kinase activity; exhibits abnormal mitotic cytokinesis; exhibits multipolar spindles; increases the neurons apoptotic process. 1 PublicationCorresponds to variant dbSNP:rs886037892EnsemblClinVar.1
Natural variantiVAR_077443126K → Q in MCPH17; impairs kinase activity; exhibits abnormal mitotic cytokinesis; exhibits multipolar spindles; increases the neurons apoptotic process. 1 PublicationCorresponds to variant dbSNP:rs886037893Ensembl.1
Natural variantiVAR_040419183L → F1 Publication1
Natural variantiVAR_077444230D → V in MCPH17; impairs kinase activity; exhibits abnormal mitotic cytokinesis; exhibits multipolar spindles; increases the neurons apoptotic process. 1 PublicationCorresponds to variant dbSNP:rs886037894EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0145071 – 467Missing in isoform 3. 1 PublicationAdd BLAST467
Alternative sequenceiVSP_012434481 – 482EV → GG in isoform 2. 1 Publication2
Alternative sequenceiVSP_012435483 – 2027Missing in isoform 2. 1 PublicationAdd BLAST1545
Alternative sequenceiVSP_043301694E → EERRHSLENKVKRLETMERR ENRLKDDIQTKSQQIQQMAD KIL in isoform 4. 1 Publication1
Alternative sequenceiVSP_0145081239 – 1253Missing in isoform 3. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_0145091919Missing in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY257469 mRNA Translation: AAP13528.1
AY209000 mRNA Translation: AAP43922.1
AY681966 mRNA Translation: AAV87216.1
AB023166 mRNA Translation: BAA76793.2 Different initiation.
AC002563 Genomic DNA Translation: AAB71327.1
AC079317 Genomic DNA No translation available.
AC004813 Genomic DNA No translation available.
CCDSiCCDS55891.1 [O14578-4]
CCDS9192.1 [O14578-1]
RefSeqiNP_001193928.1, NM_001206999.1 [O14578-4]
NP_009105.1, NM_007174.2 [O14578-1]
UniGeneiHs.119594

Genome annotation databases

EnsembliENST00000261833; ENSP00000261833; ENSG00000122966 [O14578-1]
ENST00000392521; ENSP00000376306; ENSG00000122966 [O14578-4]
ENST00000612548; ENSP00000482318; ENSG00000122966 [O14578-2]
GeneIDi11113
KEGGihsa:11113
UCSCiuc001txi.3 human [O14578-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY257469 mRNA Translation: AAP13528.1
AY209000 mRNA Translation: AAP43922.1
AY681966 mRNA Translation: AAV87216.1
AB023166 mRNA Translation: BAA76793.2 Different initiation.
AC002563 Genomic DNA Translation: AAB71327.1
AC079317 Genomic DNA No translation available.
AC004813 Genomic DNA No translation available.
CCDSiCCDS55891.1 [O14578-4]
CCDS9192.1 [O14578-1]
RefSeqiNP_001193928.1, NM_001206999.1 [O14578-4]
NP_009105.1, NM_007174.2 [O14578-1]
UniGeneiHs.119594

3D structure databases

ProteinModelPortaliO14578
SMRiO14578
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116290, 46 interactors
IntActiO14578, 7 interactors
MINTiO14578
STRINGi9606.ENSP00000376306

Chemistry databases

BindingDBiO14578
ChEMBLiCHEMBL5579

PTM databases

iPTMnetiO14578
PhosphoSitePlusiO14578

Polymorphism and mutation databases

BioMutaiCIT

Proteomic databases

EPDiO14578
MaxQBiO14578
PaxDbiO14578
PeptideAtlasiO14578
PRIDEiO14578
ProteomicsDBi48094
48095 [O14578-2]
48096 [O14578-3]
48097 [O14578-4]

Protocols and materials databases

DNASUi11113
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261833; ENSP00000261833; ENSG00000122966 [O14578-1]
ENST00000392521; ENSP00000376306; ENSG00000122966 [O14578-4]
ENST00000612548; ENSP00000482318; ENSG00000122966 [O14578-2]
GeneIDi11113
KEGGihsa:11113
UCSCiuc001txi.3 human [O14578-1]

Organism-specific databases

CTDi11113
DisGeNETi11113
EuPathDBiHostDB:ENSG00000122966.13
GeneCardsiCIT
HGNCiHGNC:1985 CIT
HPAiHPA019082
HPA048812
HPA075506
MalaCardsiCIT
MIMi605629 gene
617090 phenotype
neXtProtiNX_O14578
OpenTargetsiENSG00000122966
Orphaneti2512 Autosomal recessive primary microcephaly
PharmGKBiPA26522
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0612 Eukaryota
KOG0976 Eukaryota
ENOG410XR1Q LUCA
GeneTreeiENSGT00760000118994
HOGENOMiHOG000015347
HOVERGENiHBG071093
InParanoidiO14578
KOiK16308
OMAiDVSCDYW
OrthoDBiEOG091G00DT
PhylomeDBiO14578
TreeFamiTF101140

Enzyme and pathway databases

ReactomeiR-HSA-5625900 RHO GTPases activate CIT
SignaLinkiO14578

Miscellaneous databases

ChiTaRSiCIT human
GeneWikiiCIT_(gene)
GenomeRNAii11113
PROiPR:O14578
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000122966 Expressed in 189 organ(s), highest expression level in anterior cingulate cortex
CleanExiHS_CIT
ExpressionAtlasiO14578 baseline and differential
GenevisibleiO14578 HS

Family and domain databases

CDDicd00029 C1, 1 hit
cd05601 STKc_CRIK, 1 hit
Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR000961 AGC-kinase_C
IPR017405 Citron_Rho-interacting_kinase
IPR001180 CNH_dom
IPR037708 CRIK_dom
IPR011009 Kinase-like_dom_sf
IPR002219 PE/DAG-bd
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PANTHERiPTHR22988:SF26 PTHR22988:SF26, 3 hits
PfamiView protein in Pfam
PF00780 CNH, 1 hit
PF00169 PH, 1 hit
PF00069 Pkinase, 1 hit
PIRSFiPIRSF038145 Citron_Rho-interacting_kinase, 1 hit
SMARTiView protein in SMART
SM00109 C1, 1 hit
SM00036 CNH, 1 hit
SM00233 PH, 1 hit
SM00133 S_TK_X, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS50219 CNH, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS00479 ZF_DAG_PE_1, 1 hit
PS50081 ZF_DAG_PE_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCTRO_HUMAN
AccessioniPrimary (citable) accession number: O14578
Secondary accession number(s): Q2M5E1
, Q6XUH8, Q86UQ9, Q9UPZ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 4, 2005
Last modified: November 7, 2018
This is version 178 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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