UniProtKB - O14576 (DC1I1_HUMAN)
Cytoplasmic dynein 1 intermediate chain 1
DYNC1I1
Functioni
GO - Molecular functioni
- dynein heavy chain binding Source: GO_Central
- dynein light chain binding Source: GO_Central
- microtubule binding Source: HGNC-UCL
- microtubule motor activity Source: HGNC-UCL
- motor activity Source: ProtInc
- spectrin binding Source: MGI
GO - Biological processi
- antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
- endoplasmic reticulum to Golgi vesicle-mediated transport Source: Reactome
- microtubule-based movement Source: GO_Central
- transport along microtubule Source: GO_Central
- vesicle transport along microtubule Source: UniProtKB
Keywordsi
Molecular function | Motor protein |
Biological process | Transport |
Enzyme and pathway databases
PathwayCommonsi | O14576 |
Reactomei | R-HSA-141444, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-2132295, MHC class II antigen presentation R-HSA-2467813, Separation of Sister Chromatids R-HSA-2500257, Resolution of Sister Chromatid Cohesion R-HSA-3371497, HSP90 chaperone cycle for steroid hormone receptors (SHR) R-HSA-5663220, RHO GTPases Activate Formins R-HSA-6807878, COPI-mediated anterograde transport R-HSA-6811436, COPI-independent Golgi-to-ER retrograde traffic R-HSA-68877, Mitotic Prometaphase R-HSA-9609690, HCMV Early Events R-HSA-9646399, Aggrephagy R-HSA-9648025, EML4 and NUDC in mitotic spindle formation |
SignaLinki | O14576 |
Names & Taxonomyi
Protein namesi | Recommended name: Cytoplasmic dynein 1 intermediate chain 1Alternative name(s): Cytoplasmic dynein intermediate chain 1 Dynein intermediate chain 1, cytosolic Short name: DH IC-1 |
Gene namesi | Name:DYNC1I1 Synonyms:DNCI1, DNCIC1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000158560.14 |
HGNCi | HGNC:2963, DYNC1I1 |
MIMi | 603772, gene |
neXtProti | NX_O14576 |
Subcellular locationi
Cytoskeleton
- spindle pole 1 Publication
Other locations
- Cytoplasm By similarity
- kinetochore 1 Publication
Cytoskeleton
- cytoplasmic dynein complex Source: UniProtKB
- microtubule Source: UniProtKB-KW
- spindle pole Source: UniProtKB
Cytosol
- cytosol Source: Reactome
Endosome
- recycling endosome Source: UniProtKB
Nucleus
- nucleus Source: AgBase
Other locations
- condensed chromosome kinetochore Source: UniProtKB-SubCell
- cytoplasm Source: AgBase
- cytoplasmic ribonucleoprotein granule Source: ParkinsonsUK-UCL
- kinetochore Source: UniProtKB
- perinuclear region of cytoplasm Source: HGNC-UCL
- vesicle Source: UniProtKB
Keywords - Cellular componenti
Centromere, Chromosome, Cytoplasm, Cytoskeleton, Dynein, Kinetochore, MicrotubulePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 148 | L → G: Disrupts interaction with DYNLT1. 1 Publication | 1 | |
Mutagenesisi | 149 | G → E: No effect on interaction with DYNLT1. 1 Publication | 1 | |
Mutagenesisi | 150 | V → G: Disrupts interaction with DYNLT1. 1 Publication | 1 | |
Mutagenesisi | 150 | V → W: No effect on interaction with DYNLT1. 1 Publication | 1 | |
Mutagenesisi | 152 | K → A or Y: No effect on interaction with DYNLT1. 1 Publication | 1 | |
Mutagenesisi | 153 | V → G: Decreases interaction with DYNLT1. 1 Publication | 1 | |
Mutagenesisi | 155 | Q → H, R, T or Y: No effect on interaction with DYNLT1. 1 Publication | 1 | |
Mutagenesisi | 156 | V → G: Decreases interaction with DYNLT1. 1 Publication | 1 | |
Mutagenesisi | 157 | D → R: No effect on interaction with DYNLT1. 1 Publication | 1 | |
Mutagenesisi | 158 | F → G: Disrupts interaction with DYNLT1. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 1780 |
OpenTargetsi | ENSG00000158560 |
PharmGKBi | PA27434 |
Miscellaneous databases
Pharosi | O14576, Tbio |
Polymorphism and mutation databases
BioMutai | DYNC1I1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000114652 | 2 – 645 | Cytoplasmic dynein 1 intermediate chain 1Add BLAST | 644 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineBy similarity | 1 | |
Modified residuei | 50 | PhosphoserineBy similarity | 1 | |
Modified residuei | 100 | PhosphoserineBy similarity | 1 | |
Modified residuei | 105 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 107 | PhosphoserineBy similarity | 1 | |
Modified residuei | 111 | PhosphoserineBy similarity | 1 | |
Modified residuei | 114 | PhosphoserineBy similarity | 1 | |
Modified residuei | 176 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 179 | PhosphoserineBy similarity | 1 | |
Modified residuei | 197 | PhosphoserineBy similarity | 1 | |
Modified residuei | 635 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | O14576 |
jPOSTi | O14576 |
MassIVEi | O14576 |
MaxQBi | O14576 |
PaxDbi | O14576 |
PeptideAtlasi | O14576 |
PRIDEi | O14576 |
ProteomicsDBi | 25229 33962 48091 [O14576-1] 48092 [O14576-2] 48093 [O14576-3] |
TopDownProteomicsi | O14576-3 [O14576-3] |
PTM databases
iPTMneti | O14576 |
PhosphoSitePlusi | O14576 |
Expressioni
Gene expression databases
Bgeei | ENSG00000158560, Expressed in substantia nigra and 207 other tissues |
ExpressionAtlasi | O14576, baseline and differential |
Genevisiblei | O14576, HS |
Organism-specific databases
HPAi | ENSG00000158560, Tissue enhanced (brain) |
Interactioni
Subunit structurei
Homodimer (By similarity). The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer.
Interacts with DYNC1H1.
Interacts with DYNLT1 and DYNLT3.
Interacts with DCTN1 (By similarity).
By similarity1 PublicationBinary interactionsi
Hide detailsO14576
With | #Exp. | IntAct |
---|---|---|
BICD2 [Q8TD16] | 2 | EBI-366267,EBI-2372628 |
Nde1 [Q9CZA6] from Mus musculus. | 2 | EBI-366267,EBI-309934 |
GO - Molecular functioni
- dynein heavy chain binding Source: GO_Central
- dynein light chain binding Source: GO_Central
- microtubule binding Source: HGNC-UCL
- spectrin binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 108118, 97 interactors |
CORUMi | O14576 |
ELMi | O14576 |
IntActi | O14576, 49 interactors |
MINTi | O14576 |
STRINGi | 9606.ENSP00000320130 |
Miscellaneous databases
RNActi | O14576, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 285 – 334 | WD 1Add BLAST | 50 | |
Repeati | 338 – 378 | WD 2Add BLAST | 41 | |
Repeati | 387 – 428 | WD 3Add BLAST | 42 | |
Repeati | 437 – 477 | WD 4Add BLAST | 41 | |
Repeati | 482 – 527 | WD 5Add BLAST | 46 | |
Repeati | 530 – 570 | WD 6Add BLAST | 41 | |
Repeati | 576 – 615 | WD 7Add BLAST | 40 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 2 – 123 | Interaction with DCTN1By similarityAdd BLAST | 122 | |
Regioni | 147 – 163 | Interaction with DYNLT11 PublicationAdd BLAST | 17 |
Sequence similaritiesi
Keywords - Domaini
Repeat, WD repeatPhylogenomic databases
eggNOGi | KOG1587, Eukaryota |
GeneTreei | ENSGT00940000156032 |
HOGENOMi | CLU_012999_1_1_1 |
InParanoidi | O14576 |
OMAi | VAHTDDW |
PhylomeDBi | O14576 |
TreeFami | TF300553 |
Family and domain databases
Gene3Di | 2.130.10.10, 2 hits |
InterProi | View protein in InterPro IPR025956, DYNC1I1/DYNC1I2 IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF11540, Dynein_IC2, 1 hit PF00400, WD40, 1 hit |
SMARTi | View protein in SMART SM00320, WD40, 5 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS50294, WD_REPEATS_REGION, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSDKSDLKAE LERKKQRLAQ IREEKKRKEE ERKKKEADMQ QKKEPVQDDS
60 70 80 90 100
DLDRKRRETE ALLQSIGISP EPPLVQPLHF LTWDTCYFHY LVPTPMSPSS
110 120 130 140 150
KSVSTPSEAG SQDSGDLGPL TRTLQWDTDP SVLQLQSDSE LGRRLHKLGV
160 170 180 190 200
SKVTQVDFLP REVVSYSKET QTPLATHQSE EDEEDEEMVE SKVGQDSELE
210 220 230 240 250
NQDKKQEVKE APPRELTEEE KQQILHSEEF LIFFDRTIRV IERALAEDSD
260 270 280 290 300
IFFDYSGREL EEKDGDVQAG ANLSFNRQFY DEHWSKHRVV TCMDWSLQYP
310 320 330 340 350
ELMVASYNNN EDAPHEPDGV ALVWNMKFKK TTPEYVFHCQ SSVMSVCFAR
360 370 380 390 400
FHPNLVVGGT YSGQIVLWDN RSHRRTPVQR TPLSAAAHTH PVYCVNVVGT
410 420 430 440 450
QNAHNLITVS TDGKMCSWSL DMLSTPQESM ELVYNKSKPV AVTGMAFPTG
460 470 480 490 500
DVNNFVVGSE EGTVYTACRH GSKAGIGEVF EGHQGPVTGI NCHMAVGPID
510 520 530 540 550
FSHLFVTSSF DWTVKLWTTK HNKPLYSFED NADYVYDVMW SPVHPALFAC
560 570 580 590 600
VDGMGRLDLW NLNNDTEVPT ASVAIEGASA LNRVRWAQAG KEVAVGDSEG
610 620 630 640
RIWVYDVGEL AVPHNDEWTR FARTLVEIRA NRADSEEEGT VELSA
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0A0MTG2 | A0A0A0MTG2_HUMAN | Cytoplasmic dynein 1 intermediate c... | DYNC1I1 | 544 | Annotation score: | ||
C9J3E7 | C9J3E7_HUMAN | Cytoplasmic dynein 1 intermediate c... | DYNC1I1 | 116 | Annotation score: | ||
E5RFE1 | E5RFE1_HUMAN | Cytoplasmic dynein 1 intermediate c... | DYNC1I1 | 85 | Annotation score: | ||
E5RJ75 | E5RJ75_HUMAN | Cytoplasmic dynein 1 intermediate c... | DYNC1I1 | 128 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 254 | D → G in BAG59855 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 517 | W → C in AAH22540 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_064709 | 373 | H → L Found in a renal cell carcinoma case; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_048905 | 582 | N → T. Corresponds to variant dbSNP:rs35077523Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_001332 | 74 – 90 | Missing in isoform 2, isoform 3 and isoform 4. 2 PublicationsAdd BLAST | 17 | |
Alternative sequenceiVSP_001333 | 123 – 142 | Missing in isoform 3, isoform 4 and isoform 5. 3 PublicationsAdd BLAST | 20 | |
Alternative sequenceiVSP_054766 | 610 – 645 | LAVPH…VELSA → GLAMLPGWSQNSWTQAILLC WPPKVLGLQT in isoform 4. 1 PublicationAdd BLAST | 36 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF063228 mRNA Translation: AAC33443.1 AF123074 mRNA Translation: AAD26852.1 AK091339 mRNA Translation: BAC03639.1 AK297427 mRNA Translation: BAG59855.1 AC022261 Genomic DNA No translation available. AC091779 Genomic DNA No translation available. AC002452 Genomic DNA Translation: AAB67047.2 AC002540 Genomic DNA Translation: AAB70113.1 CH471091 Genomic DNA Translation: EAW76753.1 BC022540 mRNA Translation: AAH22540.1 |
CCDSi | CCDS47645.1 [O14576-2] CCDS47646.1 [O14576-3] CCDS5644.1 [O14576-1] CCDS64718.1 [O14576-5] CCDS64719.1 [O14576-4] |
RefSeqi | NP_001129028.1, NM_001135556.1 [O14576-2] NP_001129029.1, NM_001135557.1 [O14576-3] NP_001265350.1, NM_001278421.1 [O14576-5] NP_001265351.1, NM_001278422.1 [O14576-4] NP_004402.1, NM_004411.4 [O14576-1] XP_011514163.1, XM_011515861.1 XP_011514164.1, XM_011515862.1 XP_016867293.1, XM_017011804.1 XP_016867294.1, XM_017011805.1 |
Genome annotation databases
Ensembli | ENST00000324972; ENSP00000320130; ENSG00000158560 [O14576-1] ENST00000359388; ENSP00000352348; ENSG00000158560 [O14576-3] ENST00000437599; ENSP00000398118; ENSG00000158560 [O14576-5] ENST00000447467; ENSP00000392337; ENSG00000158560 [O14576-2] ENST00000457059; ENSP00000412444; ENSG00000158560 [O14576-2] ENST00000630942; ENSP00000486363; ENSG00000158560 [O14576-4] |
GeneIDi | 1780 |
KEGGi | hsa:1780 |
UCSCi | uc003uob.4, human [O14576-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF063228 mRNA Translation: AAC33443.1 AF123074 mRNA Translation: AAD26852.1 AK091339 mRNA Translation: BAC03639.1 AK297427 mRNA Translation: BAG59855.1 AC022261 Genomic DNA No translation available. AC091779 Genomic DNA No translation available. AC002452 Genomic DNA Translation: AAB67047.2 AC002540 Genomic DNA Translation: AAB70113.1 CH471091 Genomic DNA Translation: EAW76753.1 BC022540 mRNA Translation: AAH22540.1 |
CCDSi | CCDS47645.1 [O14576-2] CCDS47646.1 [O14576-3] CCDS5644.1 [O14576-1] CCDS64718.1 [O14576-5] CCDS64719.1 [O14576-4] |
RefSeqi | NP_001129028.1, NM_001135556.1 [O14576-2] NP_001129029.1, NM_001135557.1 [O14576-3] NP_001265350.1, NM_001278421.1 [O14576-5] NP_001265351.1, NM_001278422.1 [O14576-4] NP_004402.1, NM_004411.4 [O14576-1] XP_011514163.1, XM_011515861.1 XP_011514164.1, XM_011515862.1 XP_016867293.1, XM_017011804.1 XP_016867294.1, XM_017011805.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 108118, 97 interactors |
CORUMi | O14576 |
ELMi | O14576 |
IntActi | O14576, 49 interactors |
MINTi | O14576 |
STRINGi | 9606.ENSP00000320130 |
PTM databases
iPTMneti | O14576 |
PhosphoSitePlusi | O14576 |
Polymorphism and mutation databases
BioMutai | DYNC1I1 |
Proteomic databases
EPDi | O14576 |
jPOSTi | O14576 |
MassIVEi | O14576 |
MaxQBi | O14576 |
PaxDbi | O14576 |
PeptideAtlasi | O14576 |
PRIDEi | O14576 |
ProteomicsDBi | 25229 33962 48091 [O14576-1] 48092 [O14576-2] 48093 [O14576-3] |
TopDownProteomicsi | O14576-3 [O14576-3] |
Protocols and materials databases
Antibodypediai | 15905, 148 antibodies |
Genome annotation databases
Ensembli | ENST00000324972; ENSP00000320130; ENSG00000158560 [O14576-1] ENST00000359388; ENSP00000352348; ENSG00000158560 [O14576-3] ENST00000437599; ENSP00000398118; ENSG00000158560 [O14576-5] ENST00000447467; ENSP00000392337; ENSG00000158560 [O14576-2] ENST00000457059; ENSP00000412444; ENSG00000158560 [O14576-2] ENST00000630942; ENSP00000486363; ENSG00000158560 [O14576-4] |
GeneIDi | 1780 |
KEGGi | hsa:1780 |
UCSCi | uc003uob.4, human [O14576-1] |
Organism-specific databases
CTDi | 1780 |
DisGeNETi | 1780 |
EuPathDBi | HostDB:ENSG00000158560.14 |
GeneCardsi | DYNC1I1 |
HGNCi | HGNC:2963, DYNC1I1 |
HPAi | ENSG00000158560, Tissue enhanced (brain) |
MIMi | 603772, gene |
neXtProti | NX_O14576 |
OpenTargetsi | ENSG00000158560 |
PharmGKBi | PA27434 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1587, Eukaryota |
GeneTreei | ENSGT00940000156032 |
HOGENOMi | CLU_012999_1_1_1 |
InParanoidi | O14576 |
OMAi | VAHTDDW |
PhylomeDBi | O14576 |
TreeFami | TF300553 |
Enzyme and pathway databases
PathwayCommonsi | O14576 |
Reactomei | R-HSA-141444, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-2132295, MHC class II antigen presentation R-HSA-2467813, Separation of Sister Chromatids R-HSA-2500257, Resolution of Sister Chromatid Cohesion R-HSA-3371497, HSP90 chaperone cycle for steroid hormone receptors (SHR) R-HSA-5663220, RHO GTPases Activate Formins R-HSA-6807878, COPI-mediated anterograde transport R-HSA-6811436, COPI-independent Golgi-to-ER retrograde traffic R-HSA-68877, Mitotic Prometaphase R-HSA-9609690, HCMV Early Events R-HSA-9646399, Aggrephagy R-HSA-9648025, EML4 and NUDC in mitotic spindle formation |
SignaLinki | O14576 |
Miscellaneous databases
BioGRID-ORCSi | 1780, 3 hits in 840 CRISPR screens |
ChiTaRSi | DYNC1I1, human |
GeneWikii | DYNC1I1 |
GenomeRNAii | 1780 |
Pharosi | O14576, Tbio |
PROi | PR:O14576 |
RNActi | O14576, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000158560, Expressed in substantia nigra and 207 other tissues |
ExpressionAtlasi | O14576, baseline and differential |
Genevisiblei | O14576, HS |
Family and domain databases
Gene3Di | 2.130.10.10, 2 hits |
InterProi | View protein in InterPro IPR025956, DYNC1I1/DYNC1I2 IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF11540, Dynein_IC2, 1 hit PF00400, WD40, 1 hit |
SMARTi | View protein in SMART SM00320, WD40, 5 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS50294, WD_REPEATS_REGION, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DC1I1_HUMAN | |
Accessioni | O14576Primary (citable) accession number: O14576 Secondary accession number(s): B4DME3 Q9Y2X1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | May 1, 1999 | |
Last modified: | December 2, 2020 | |
This is version 185 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations