Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cytochrome b561 domain-containing protein 2

Gene

CYB561D2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cofactori

hemeBy similarityNote: Binds 2 heme groups non-covalently.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi48Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi86Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi120Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi159Iron (heme axial ligand)PROSITE-ProRule annotation1

GO - Molecular functioni

  • ferroxidase activity Source: UniProtKB
  • heme binding Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW

Keywordsi

Biological processElectron transport, Transport
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b561 domain-containing protein 2
Alternative name(s):
Putative tumor suppressor protein 101F6
Gene namesi
Name:CYB561D2
Synonyms:101F6
ORF Names:LUCA12.2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000114395.10
HGNCiHGNC:30253 CYB561D2
MIMi607068 gene
neXtProtiNX_O14569

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 17CytoplasmicSequence analysisAdd BLAST16
Transmembranei18 – 38HelicalSequence analysisAdd BLAST21
Transmembranei47 – 67HelicalSequence analysisAdd BLAST21
Transmembranei86 – 106HelicalSequence analysisAdd BLAST21
Transmembranei123 – 143HelicalSequence analysisAdd BLAST21
Transmembranei163 – 183HelicalSequence analysisAdd BLAST21
Transmembranei187 – 207HelicalSequence analysisAdd BLAST21
Topological domaini208 – 222CytoplasmicSequence analysisAdd BLAST15

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi11068
OpenTargetsiENSG00000114395
PharmGKBiPA134977950

Polymorphism and mutation databases

BioMutaiCYB561D2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001510362 – 222Cytochrome b561 domain-containing protein 2Add BLAST221

Proteomic databases

EPDiO14569
MaxQBiO14569
PaxDbiO14569
PeptideAtlasiO14569
PRIDEiO14569
ProteomicsDBi48090

PTM databases

iPTMnetiO14569
PhosphoSitePlusiO14569

Expressioni

Gene expression databases

BgeeiENSG00000114395 Expressed in 180 organ(s), highest expression level in right lobe of liver
CleanExiHS_CYB561D2
ExpressionAtlasiO14569 baseline and differential
GenevisibleiO14569 HS

Organism-specific databases

HPAiHPA042817

Interactioni

Protein-protein interaction databases

BioGridi116252, 4 interactors
IntActiO14569, 19 interactors
STRINGi9606.ENSP00000232508

Structurei

3D structure databases

ProteinModelPortaliO14569
SMRiO14569
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 217Cytochrome b561PROSITE-ProRule annotationAdd BLAST204

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVNX Eukaryota
ENOG4111KF1 LUCA
GeneTreeiENSGT00440000038072
HOGENOMiHOG000008685
HOVERGENiHBG050754
InParanoidiO14569
KOiK08371
OMAiAKLKRYH
OrthoDBiEOG091G0OYU
PhylomeDBiO14569
TreeFamiTF323584

Family and domain databases

InterProiView protein in InterPro
IPR006593 Cyt_b561/ferric_Rdtase_TM
PfamiView protein in Pfam
PF03188 Cytochrom_B561, 1 hit
SMARTiView protein in SMART
SM00665 B561, 1 hit
PROSITEiView protein in PROSITE
PS50939 CYTOCHROME_B561, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O14569-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALSAETESH IYRALRTASG AAAHLVALGF TIFVAVLARP GSSLFSWHPV
60 70 80 90 100
LMSLAFSFLM TEALLVFSPE SSLLHSLSRK GRARCHWVLQ LLALLCALLG
110 120 130 140 150
LGLVILHKEQ LGKAHLVTRH GQAGLLAVLW AGLQCSGGVG LLYPKLLPRW
160 170 180 190 200
PLAKLKLYHA TSGLVGYLLG SASLLLGMCS LWFTASVTGA AWYLAVLCPV
210 220
LTSLVIMNQV SNAYLYRKRI QP
Length:222
Mass (Da):23,974
Last modified:January 1, 1998 - v1
Checksum:i3AEEE64D8CB91A32
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF040704 mRNA Translation: AAC70911.1
AK291167 mRNA Translation: BAF83856.1
AC002481 Genomic DNA Translation: AAB67309.1
CH471055 Genomic DNA Translation: EAW65113.1
BC047691 mRNA Translation: AAH47691.1
CCDSiCCDS2827.1
RefSeqiNP_001278213.1, NM_001291284.1
NP_008953.1, NM_007022.4
UniGeneiHs.149443
Hs.669905

Genome annotation databases

EnsembliENST00000232508; ENSP00000232508; ENSG00000114395
ENST00000418577; ENSP00000391209; ENSG00000114395
ENST00000424512; ENSP00000410663; ENSG00000114395
ENST00000425346; ENSP00000400454; ENSG00000114395
GeneIDi11068
KEGGihsa:11068
UCSCiuc003dal.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF040704 mRNA Translation: AAC70911.1
AK291167 mRNA Translation: BAF83856.1
AC002481 Genomic DNA Translation: AAB67309.1
CH471055 Genomic DNA Translation: EAW65113.1
BC047691 mRNA Translation: AAH47691.1
CCDSiCCDS2827.1
RefSeqiNP_001278213.1, NM_001291284.1
NP_008953.1, NM_007022.4
UniGeneiHs.149443
Hs.669905

3D structure databases

ProteinModelPortaliO14569
SMRiO14569
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116252, 4 interactors
IntActiO14569, 19 interactors
STRINGi9606.ENSP00000232508

PTM databases

iPTMnetiO14569
PhosphoSitePlusiO14569

Polymorphism and mutation databases

BioMutaiCYB561D2

Proteomic databases

EPDiO14569
MaxQBiO14569
PaxDbiO14569
PeptideAtlasiO14569
PRIDEiO14569
ProteomicsDBi48090

Protocols and materials databases

DNASUi11068
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000232508; ENSP00000232508; ENSG00000114395
ENST00000418577; ENSP00000391209; ENSG00000114395
ENST00000424512; ENSP00000410663; ENSG00000114395
ENST00000425346; ENSP00000400454; ENSG00000114395
GeneIDi11068
KEGGihsa:11068
UCSCiuc003dal.4 human

Organism-specific databases

CTDi11068
DisGeNETi11068
EuPathDBiHostDB:ENSG00000114395.10
GeneCardsiCYB561D2
HGNCiHGNC:30253 CYB561D2
HPAiHPA042817
MIMi607068 gene
neXtProtiNX_O14569
OpenTargetsiENSG00000114395
PharmGKBiPA134977950
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVNX Eukaryota
ENOG4111KF1 LUCA
GeneTreeiENSGT00440000038072
HOGENOMiHOG000008685
HOVERGENiHBG050754
InParanoidiO14569
KOiK08371
OMAiAKLKRYH
OrthoDBiEOG091G0OYU
PhylomeDBiO14569
TreeFamiTF323584

Miscellaneous databases

ChiTaRSiCYB561D2 human
GenomeRNAii11068
PROiPR:O14569
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000114395 Expressed in 180 organ(s), highest expression level in right lobe of liver
CleanExiHS_CYB561D2
ExpressionAtlasiO14569 baseline and differential
GenevisibleiO14569 HS

Family and domain databases

InterProiView protein in InterPro
IPR006593 Cyt_b561/ferric_Rdtase_TM
PfamiView protein in Pfam
PF03188 Cytochrom_B561, 1 hit
SMARTiView protein in SMART
SM00665 B561, 1 hit
PROSITEiView protein in PROSITE
PS50939 CYTOCHROME_B561, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiC56D2_HUMAN
AccessioniPrimary (citable) accession number: O14569
Secondary accession number(s): A8K552
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: January 1, 1998
Last modified: November 7, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again