UniProtKB - O14561 (ACPM_HUMAN)
Acyl carrier protein, mitochondrial
NDUFAB1
Functioni
Miscellaneous
GO - Molecular functioni
- acyl binding Source: GO_Central
- acyl carrier activity Source: GO_Central
- calcium ion binding Source: UniProtKB
- fatty acid binding Source: UniProtKB
- NADH dehydrogenase (ubiquinone) activity Source: UniProtKB
GO - Biological processi
- fatty acid biosynthetic process Source: UniProtKB
- mitochondrial electron transport, NADH to ubiquinone Source: Reactome
- mitochondrial respiratory chain complex I assembly Source: UniProtKB
- protein lipoylation Source: UniProtKB
Keywordsi
Biological process | Electron transport, Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Respiratory chain, Transport |
Enzyme and pathway databases
BioCyci | MetaCyc:ENSG00000004779-MONOMER |
PathwayCommonsi | O14561 |
Reactomei | R-HSA-389661, Glyoxylate metabolism and glycine degradation R-HSA-611105, Respiratory electron transport R-HSA-6799198, Complex I biogenesis R-HSA-77289, Mitochondrial Fatty Acid Beta-Oxidation |
Names & Taxonomyi
Protein namesi | Recommended name: Acyl carrier protein, mitochondrialShort name: ACP Alternative name(s): CI-SDAP NADH-ubiquinone oxidoreductase 9.6 kDa subunit |
Gene namesi | Name:NDUFAB1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7694, NDUFAB1 |
MIMi | 603836, gene |
neXtProti | NX_O14561 |
VEuPathDBi | HostDB:ENSG00000004779.9 |
Subcellular locationi
Mitochondrion
- Mitochondrion 2 Publications
Mitochondrion
- mitochondrial inner membrane Source: Reactome
- mitochondrial matrix Source: UniProtKB
- mitochondrial membrane Source: UniProtKB
- mitochondrial respiratory chain complex I Source: UniProtKB
- mitochondrion Source: HPA
Nucleus
- nucleoplasm Source: HPA
Keywords - Cellular componenti
MitochondrionPathology & Biotechi
Organism-specific databases
DisGeNETi | 4706 |
OpenTargetsi | ENSG00000004779 |
PharmGKBi | PA31500 |
Miscellaneous databases
Pharosi | O14561, Tclin |
Chemistry databases
ChEMBLi | CHEMBL2363065 |
DrugBanki | DB00157, NADH |
DrugCentrali | O14561 |
Genetic variation databases
BioMutai | NDUFAB1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 68 | MitochondrionCombined sources1 PublicationAdd BLAST | 68 | |
ChainiPRO_0000000561 | 69 – 156 | Acyl carrier protein, mitochondrialAdd BLAST | 88 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 88 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 112 | O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation | 1 |
Keywords - PTMi
Acetylation, Phosphopantetheine, PhosphoproteinProteomic databases
EPDi | O14561 |
jPOSTi | O14561 |
MassIVEi | O14561 |
MaxQBi | O14561 |
PaxDbi | O14561 |
PeptideAtlasi | O14561 |
PRIDEi | O14561 |
ProteomicsDBi | 48088 |
TopDownProteomicsi | O14561 |
PTM databases
iPTMneti | O14561 |
PhosphoSitePlusi | O14561 |
SwissPalmi | O14561 |
Expressioni
Gene expression databases
Bgeei | ENSG00000004779, Expressed in myocardium and 250 other tissues |
ExpressionAtlasi | O14561, baseline and differential |
Genevisiblei | O14561, HS |
Organism-specific databases
HPAi | ENSG00000004779, Tissue enhanced (heart muscle, skeletal muscle) |
Interactioni
Subunit structurei
Mammalian complex I is composed of 45 different subunits (PubMed:12611891).
Interacts with ETFRF1 (PubMed:27499296).
Identified in a complex composed of MALSU1, MIEF1 upstream open reading frame protein and NDUFAB1; within the trimeric complex, MIEF1 upstream open reading frame protein functions as a bridging scaffold that interacts with MALSU1 on one side, and with NDUFAB1 on the other side. The complex interacts with the mitochondrial large ribosomal subunit (PubMed:28892042, PubMed:30215512).
4 PublicationsBinary interactionsi
Hide detailsO14561
Protein-protein interaction databases
BioGRIDi | 110786, 106 interactors |
ComplexPortali | CPX-577, Mitochondrial respiratory chain complex I |
CORUMi | O14561 |
IntActi | O14561, 68 interactors |
MINTi | O14561 |
STRINGi | 9606.ENSP00000458770 |
Chemistry databases
BindingDBi | O14561 |
Miscellaneous databases
RNActi | O14561, protein |
Structurei
Secondary structure
3D structure databases
SMRi | O14561 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O14561 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 77 – 152 | CarrierPROSITE-ProRule annotationAdd BLAST | 76 |
Sequence similaritiesi
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG1748, Eukaryota |
GeneTreei | ENSGT00390000002127 |
HOGENOMi | CLU_108696_0_1_1 |
InParanoidi | O14561 |
OMAi | QYCEAPP |
OrthoDBi | 1473625at2759 |
PhylomeDBi | O14561 |
TreeFami | TF314361 |
Family and domain databases
Gene3Di | 1.10.1200.10, 1 hit |
HAMAPi | MF_01217, Acyl_carrier, 1 hit |
InterProi | View protein in InterPro IPR036736, ACP-like_sf IPR003231, Acyl_carrier IPR009081, PP-bd_ACP IPR006162, Ppantetheine_attach_site |
Pfami | View protein in Pfam PF00550, PP-binding, 1 hit |
SUPFAMi | SSF47336, SSF47336, 1 hit |
TIGRFAMsi | TIGR00517, acyl_carrier, 1 hit |
PROSITEi | View protein in PROSITE PS50075, CARRIER, 1 hit PS00012, PHOSPHOPANTETHEINE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MASRVLSAYV SRLPAAFAPL PRVRMLAVAR PLSTALCSAG TQTRLGTLQP
60 70 80 90 100
ALVLAQVPGR VTQLCRQYSD MPPLTLEGIQ DRVLYVLKLY DKIDPEKLSV
110 120 130 140 150
NSHFMKDLGL DSLDQVEIIM AMEDEFGFEI PDIDAEKLMC PQEIVDYIAD
KKDVYE
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH3BNK3 | H3BNK3_HUMAN | Acyl carrier protein | NDUFAB1 | 111 | Annotation score: | ||
I3L505 | I3L505_HUMAN | Acyl carrier protein, mitochondrial | NDUFAB1 | 70 | Annotation score: | ||
H3BNE8 | H3BNE8_HUMAN | Acyl carrier protein, mitochondrial | NDUFAB1 | 74 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 132 | D → Y in AAH58920 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF087660 mRNA Translation: AAD23566.1 AK311877 mRNA Translation: BAG34818.1 AC002400 Genomic DNA Translation: AAC05814.1 Different initiation. CH471145 Genomic DNA Translation: EAW55816.1 BC058920 mRNA Translation: AAH58920.1 |
CCDSi | CCDS10614.1 |
PIRi | T00741 |
RefSeqi | NP_004994.1, NM_005003.2 |
Genome annotation databases
Ensembli | ENST00000007516; ENSP00000007516; ENSG00000004779 ENST00000570319; ENSP00000458770; ENSG00000004779 |
GeneIDi | 4706 |
KEGGi | hsa:4706 |
UCSCi | uc002dlw.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF087660 mRNA Translation: AAD23566.1 AK311877 mRNA Translation: BAG34818.1 AC002400 Genomic DNA Translation: AAC05814.1 Different initiation. CH471145 Genomic DNA Translation: EAW55816.1 BC058920 mRNA Translation: AAH58920.1 |
CCDSi | CCDS10614.1 |
PIRi | T00741 |
RefSeqi | NP_004994.1, NM_005003.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2DNW | NMR | - | A | 71-156 | [»] | |
5OOL | electron microscopy | 3.06 | w | 1-156 | [»] | |
5OOM | electron microscopy | 3.03 | w | 1-156 | [»] | |
5XTB | electron microscopy | 3.40 | G | 72-156 | [»] | |
5XTC | electron microscopy | 3.70 | X | 72-156 | [»] | |
5XTD | electron microscopy | 3.70 | G/X | 72-156 | [»] | |
5XTH | electron microscopy | 3.90 | G/X | 72-156 | [»] | |
5XTI | electron microscopy | 17.40 | BG/BX/G/X | 72-156 | [»] | |
6ODD | X-ray | 2.00 | A | 72-156 | [»] | |
SMRi | O14561 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 110786, 106 interactors |
ComplexPortali | CPX-577, Mitochondrial respiratory chain complex I |
CORUMi | O14561 |
IntActi | O14561, 68 interactors |
MINTi | O14561 |
STRINGi | 9606.ENSP00000458770 |
Chemistry databases
BindingDBi | O14561 |
ChEMBLi | CHEMBL2363065 |
DrugBanki | DB00157, NADH |
DrugCentrali | O14561 |
PTM databases
iPTMneti | O14561 |
PhosphoSitePlusi | O14561 |
SwissPalmi | O14561 |
Genetic variation databases
BioMutai | NDUFAB1 |
Proteomic databases
EPDi | O14561 |
jPOSTi | O14561 |
MassIVEi | O14561 |
MaxQBi | O14561 |
PaxDbi | O14561 |
PeptideAtlasi | O14561 |
PRIDEi | O14561 |
ProteomicsDBi | 48088 |
TopDownProteomicsi | O14561 |
Protocols and materials databases
Antibodypediai | 25997, 103 antibodies |
Genome annotation databases
Ensembli | ENST00000007516; ENSP00000007516; ENSG00000004779 ENST00000570319; ENSP00000458770; ENSG00000004779 |
GeneIDi | 4706 |
KEGGi | hsa:4706 |
UCSCi | uc002dlw.4, human |
Organism-specific databases
CTDi | 4706 |
DisGeNETi | 4706 |
GeneCardsi | NDUFAB1 |
HGNCi | HGNC:7694, NDUFAB1 |
HPAi | ENSG00000004779, Tissue enhanced (heart muscle, skeletal muscle) |
MIMi | 603836, gene |
neXtProti | NX_O14561 |
OpenTargetsi | ENSG00000004779 |
PharmGKBi | PA31500 |
VEuPathDBi | HostDB:ENSG00000004779.9 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1748, Eukaryota |
GeneTreei | ENSGT00390000002127 |
HOGENOMi | CLU_108696_0_1_1 |
InParanoidi | O14561 |
OMAi | QYCEAPP |
OrthoDBi | 1473625at2759 |
PhylomeDBi | O14561 |
TreeFami | TF314361 |
Enzyme and pathway databases
BioCyci | MetaCyc:ENSG00000004779-MONOMER |
PathwayCommonsi | O14561 |
Reactomei | R-HSA-389661, Glyoxylate metabolism and glycine degradation R-HSA-611105, Respiratory electron transport R-HSA-6799198, Complex I biogenesis R-HSA-77289, Mitochondrial Fatty Acid Beta-Oxidation |
Miscellaneous databases
BioGRID-ORCSi | 4706, 558 hits in 894 CRISPR screens |
ChiTaRSi | NDUFAB1, human |
EvolutionaryTracei | O14561 |
GenomeRNAii | 4706 |
Pharosi | O14561, Tclin |
PROi | PR:O14561 |
RNActi | O14561, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000004779, Expressed in myocardium and 250 other tissues |
ExpressionAtlasi | O14561, baseline and differential |
Genevisiblei | O14561, HS |
Family and domain databases
Gene3Di | 1.10.1200.10, 1 hit |
HAMAPi | MF_01217, Acyl_carrier, 1 hit |
InterProi | View protein in InterPro IPR036736, ACP-like_sf IPR003231, Acyl_carrier IPR009081, PP-bd_ACP IPR006162, Ppantetheine_attach_site |
Pfami | View protein in Pfam PF00550, PP-binding, 1 hit |
SUPFAMi | SSF47336, SSF47336, 1 hit |
TIGRFAMsi | TIGR00517, acyl_carrier, 1 hit |
PROSITEi | View protein in PROSITE PS50075, CARRIER, 1 hit PS00012, PHOSPHOPANTETHEINE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ACPM_HUMAN | |
Accessioni | O14561Primary (citable) accession number: O14561 Secondary accession number(s): B2R4M1, Q9UNV1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | July 11, 2002 | |
Last modified: | February 10, 2021 | |
This is version 195 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families