Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Rho GTPase-activating protein 33

Gene

ARHGAP33

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in several stages of intracellular trafficking. Could play an important role in the regulation of glucose transport by insulin. May act as a downstream effector of RHOQ/TC10 in the regulation of insulin-stimulated glucose transport (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • GTPase activator activity Source: GO_Central
  • phosphatidylinositol binding Source: InterPro
  • protein kinase binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation
Biological processProtein transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-194840 Rho GTPase cycle

SIGNOR Signaling Network Open Resource

More...
SIGNORi
O14559

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rho GTPase-activating protein 33
Alternative name(s):
Rho-type GTPase-activating protein 33
Sorting nexin-26
Tc10/CDC42 GTPase-activating protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ARHGAP33
Synonyms:SNX26, TCGAP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000004777.18

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23085 ARHGAP33

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
614902 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O14559

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
115703

Open Targets

More...
OpenTargetsi
ENSG00000004777

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165393003

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ARHGAP33

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000567211 – 1287Rho GTPase-activating protein 33Add BLAST1287

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei8PhosphoserineBy similarity1
Modified residuei570PhosphoserineBy similarity1
Modified residuei636PhosphoserineCombined sources1
Modified residuei727PhosphoserineBy similarity1
Modified residuei1169PhosphotyrosineBy similarity1
Modified residuei1244Omega-N-methylarginineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O14559

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O14559

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O14559

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O14559

PeptideAtlas

More...
PeptideAtlasi
O14559

PRoteomics IDEntifications database

More...
PRIDEi
O14559

ProteomicsDB human proteome resource

More...
ProteomicsDBi
48084
48085 [O14559-10]
48086 [O14559-11]
48087 [O14559-12]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O14559

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O14559

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000004777 Expressed in 192 organ(s), highest expression level in C1 segment of cervical spinal cord

CleanEx database of gene expression profiles

More...
CleanExi
HS_SNX26

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O14559 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O14559 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA030117
HPA030118

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Specifically interacts with CDC42 and RHOQ/TC10 through its Rho-GAP domain (By similarity). Interacts with NEK6.By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
FYNP062412EBI-1210010,EBI-515315

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
125448, 2 interactors

Protein interaction database and analysis system

More...
IntActi
O14559, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000320038

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O14559

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O14559

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini59 – 168PX; atypicalAdd BLAST110
Domaini186 – 248SH3PROSITE-ProRule annotationAdd BLAST63
Domaini315 – 510Rho-GAPPROSITE-ProRule annotationAdd BLAST196

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi126 – 129Poly-Pro4
Compositional biasi677 – 699Poly-SerAdd BLAST23
Compositional biasi874 – 879Poly-Pro6
Compositional biasi889 – 893Poly-Pro5
Compositional biasi1006 – 1009Poly-Gly4
Compositional biasi1183 – 1188Poly-Ser6
Compositional biasi1266 – 1273Poly-Pro8

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PX domain-containing GAP family.Curated

Keywords - Domaini

SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1449 Eukaryota
ENOG41112VR LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155110

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000154522

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG079688

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O14559

KEGG Orthology (KO)

More...
KOi
K17933

Identification of Orthologs from Complete Genome Data

More...
OMAi
CQQEICS

Database of Orthologous Groups

More...
OrthoDBi
1300981at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O14559

TreeFam database of animal gene trees

More...
TreeFami
TF351451

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.555.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035510 ARHGAP33
IPR036871 PX_dom_sf
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain

The PANTHER Classification System

More...
PANTHERi
PTHR15729:SF11 PTHR15729:SF11, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00620 RhoGAP, 1 hit
PF07653 SH3_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00324 RhoGAP, 1 hit
SM00326 SH3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48350 SSF48350, 1 hit
SSF50044 SSF50044, 1 hit
SSF64268 SSF64268, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50238 RHOGAP, 1 hit
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O14559-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVARSTDSLD GPGEGSVQPL PTAGGPSVKG KPGKRLSAPR GPFPRLADCA
60 70 80 90 100
HFHYENVDFG HIQLLLSPDR EGPSLSGENE LVFGVQVTCQ GRSWPVLRSY
110 120 130 140 150
DDFRSLDAHL HRCIFDRRFS CLPELPPPPE GARAAQMLVP LLLQYLETLS
160 170 180 190 200
GLVDSNLNCG PVLTWMELDN HGRRLLLSEE ASLNIPAVAA AHVIKRYTAQ
210 220 230 240 250
APDELSFEVG DIVSVIDMPP TEDRSWWRGK RGFQVGFFPS ECVELFTERP
260 270 280 290 300
GPGLKADADG PPCGIPAPQG ISSLTSAVPR PRGKLAGLLR TFMRSRPSRQ
310 320 330 340 350
RLRQRGILRQ RVFGCDLGEH LSNSGQDVPQ VLRCCSEFIE AHGVVDGIYR
360 370 380 390 400
LSGVSSNIQR LRHEFDSERI PELSGPAFLQ DIHSVSSLCK LYFRELPNPL
410 420 430 440 450
LTYQLYGKFS EAMSVPGEEE RLVRVHDVIQ QLPPPHYRTL EYLLRHLARM
460 470 480 490 500
ARHSANTSMH ARNLAIVWAP NLLRSMELES VGMGGAAAFR EVRVQSVVVE
510 520 530 540 550
FLLTHVDVLF SDTFTSAGLD PAGRCLLPRP KSLAGSCPST RLLTLEEAQA
560 570 580 590 600
RTQGRLGTPT EPTTPKAPAS PAERRKGERG EKQRKPGGSS WKTFFALGRG
610 620 630 640 650
PSVPRKKPLP WLGGTRAPPQ PSGSRPDTVT LRSAKSEESL SSQASGAGLQ
660 670 680 690 700
RLHRLRRPHS SSDAFPVGPA PAGSCESLSS SSSSESSSSE SSSSSSESSA
710 720 730 740 750
AGLGALSGSP SHRTSAWLDD GDELDFSPPR CLEGLRGLDF DPLTFRCSSP
760 770 780 790 800
TPGDPAPPAS PAPPAPASAF PPRVTPQAIS PRGPTSPASP AALDISEPLA
810 820 830 840 850
VSVPPAVLEL LGAGGAPASA TPTPALSPGR SLRPHLIPLL LRGAEAPLTD
860 870 880 890 900
ACQQEMCSKL RGAQGPLGPD MESPLPPPPL SLLRPGGAPP PPPKNPARLM
910 920 930 940 950
ALALAERAQQ VAEQQSQQEC GGTPPASQSP FHRSLSLEVG GEPLGTSGSG
960 970 980 990 1000
PPPNSLAHPG AWVPGPPPYL PRQQSDGSLL RSQRPMGTSR RGLRGPAQVS
1010 1020 1030 1040 1050
AQLRAGGGGR DAPEAAAQSP CSVPSQVPTP GFFSPAPREC LPPFLGVPKP
1060 1070 1080 1090 1100
GLYPLGPPSF QPSSPAPVWR SSLGPPAPLD RGENLYYEIG ASEGSPYSGP
1110 1120 1130 1140 1150
TRSWSPFRSM PPDRLNASYG MLGQSPPLHR SPDFLLSYPP APSCFPPDHL
1160 1170 1180 1190 1200
GYSAPQHPAR RPTPPEPLYV NLALGPRGPS PASSSSSSPP AHPRSRSDPG
1210 1220 1230 1240 1250
PPVPRLPQKQ RAPWGPRTPH RVPGPWGPPE PLLLYRAAPP AYGRGGELHR
1260 1270 1280
GSLYRNGGQR GEGAGPPPPY PTPSWSLHSE GQTRSYC
Note: No experimental confirmation available.
Length:1,287
Mass (Da):137,213
Last modified:July 5, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i802900F18B640DC0
GO
Isoform 2 (identifier: O14559-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-136: Missing.
     998-1025: Missing.

Show »
Length:1,123
Mass (Da):119,780
Checksum:i995F8936B26AF59F
GO
Isoform 3 (identifier: O14559-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     648-808: Missing.

Show »
Length:1,126
Mass (Da):121,066
Checksum:i53E7DA764B6C1919
GO
Isoform 4 (identifier: O14559-12) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2: MV → MLSLSLCSHLWGPLILSALQ
     168-228: LDNHGRRLLL...PPTEDRSWWR → VGLGRGLGDS...SLWVGESWDM
     229-1287: Missing.

Show »
Length:246
Mass (Da):26,858
Checksum:i88093F56B6055CEA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MQQ9A0A0A0MQQ9_HUMAN
Rho GTPase-activating protein 33
ARHGAP33
748Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EQI6K7EQI6_HUMAN
Rho GTPase-activating protein 33
ARHGAP33
662Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EMC2K7EMC2_HUMAN
Rho GTPase-activating protein 33
ARHGAP33
863Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EK14K7EK14_HUMAN
Rho GTPase-activating protein 33
ARHGAP33
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB81198 differs from that shown. Reason: Erroneous gene model prediction.Curated
Isoform 2 : The sequence BAC86902 differs from that shown. Reason: Frameshift at several positions.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti119F → S in AK096338 (PubMed:14702039).Curated1
Sequence conflicti1100P → L in CAB70821 (PubMed:17974005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0142871 – 136Missing in isoform 2. 1 PublicationAdd BLAST136
Alternative sequenceiVSP_0142881 – 2MV → MLSLSLCSHLWGPLILSALQ in isoform 4. 1 Publication2
Alternative sequenceiVSP_014289168 – 228LDNHG…RSWWR → VGLGRGLGDSEWVRGCVCHH AQHREILDGNRVASAVEDEG AEVDGEAFRWGSLWVGESWD M in isoform 4. 1 PublicationAdd BLAST61
Alternative sequenceiVSP_014290229 – 1287Missing in isoform 4. 1 PublicationAdd BLAST1059
Alternative sequenceiVSP_014291648 – 808Missing in isoform 3. 1 PublicationAdd BLAST161
Alternative sequenceiVSP_014292998 – 1025Missing in isoform 2. 1 PublicationAdd BLAST28

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY044864 mRNA Translation: AAK97795.1
AK096338 mRNA No translation available.
AK127255 mRNA Translation: BAC86902.1 Frameshift.
AC002398 Genomic DNA Translation: AAB81197.1
AC002398 Genomic DNA Translation: AAB81198.1 Sequence problems.
AL137579 mRNA Translation: CAB70821.1
BC014084 mRNA Translation: AAH14084.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12477.1 [O14559-11]
CCDS54254.1 [O14559-10]

Protein sequence database of the Protein Information Resource

More...
PIRi
T00704
T00705
T46289

NCBI Reference Sequences

More...
RefSeqi
NP_001166101.1, NM_001172630.1 [O14559-10]
NP_443180.2, NM_052948.3 [O14559-11]
XP_005258545.1, XM_005258488.1 [O14559-1]
XP_011524721.1, XM_011526419.1 [O14559-10]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.515364

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000314737; ENSP00000320038; ENSG00000004777 [O14559-11]
ENST00000378944; ENSP00000368227; ENSG00000004777 [O14559-10]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
115703

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:115703

UCSC genome browser

More...
UCSCi
uc002obs.3 human [O14559-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY044864 mRNA Translation: AAK97795.1
AK096338 mRNA No translation available.
AK127255 mRNA Translation: BAC86902.1 Frameshift.
AC002398 Genomic DNA Translation: AAB81197.1
AC002398 Genomic DNA Translation: AAB81198.1 Sequence problems.
AL137579 mRNA Translation: CAB70821.1
BC014084 mRNA Translation: AAH14084.2
CCDSiCCDS12477.1 [O14559-11]
CCDS54254.1 [O14559-10]
PIRiT00704
T00705
T46289
RefSeqiNP_001166101.1, NM_001172630.1 [O14559-10]
NP_443180.2, NM_052948.3 [O14559-11]
XP_005258545.1, XM_005258488.1 [O14559-1]
XP_011524721.1, XM_011526419.1 [O14559-10]
UniGeneiHs.515364

3D structure databases

ProteinModelPortaliO14559
SMRiO14559
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125448, 2 interactors
IntActiO14559, 2 interactors
STRINGi9606.ENSP00000320038

PTM databases

iPTMnetiO14559
PhosphoSitePlusiO14559

Polymorphism and mutation databases

BioMutaiARHGAP33

Proteomic databases

EPDiO14559
jPOSTiO14559
MaxQBiO14559
PaxDbiO14559
PeptideAtlasiO14559
PRIDEiO14559
ProteomicsDBi48084
48085 [O14559-10]
48086 [O14559-11]
48087 [O14559-12]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314737; ENSP00000320038; ENSG00000004777 [O14559-11]
ENST00000378944; ENSP00000368227; ENSG00000004777 [O14559-10]
GeneIDi115703
KEGGihsa:115703
UCSCiuc002obs.3 human [O14559-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
115703
DisGeNETi115703
EuPathDBiHostDB:ENSG00000004777.18

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ARHGAP33
HGNCiHGNC:23085 ARHGAP33
HPAiHPA030117
HPA030118
MIMi614902 gene
neXtProtiNX_O14559
OpenTargetsiENSG00000004777
PharmGKBiPA165393003

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1449 Eukaryota
ENOG41112VR LUCA
GeneTreeiENSGT00940000155110
HOGENOMiHOG000154522
HOVERGENiHBG079688
InParanoidiO14559
KOiK17933
OMAiCQQEICS
OrthoDBi1300981at2759
PhylomeDBiO14559
TreeFamiTF351451

Enzyme and pathway databases

ReactomeiR-HSA-194840 Rho GTPase cycle
SIGNORiO14559

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SNX26

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
115703

Protein Ontology

More...
PROi
PR:O14559

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000004777 Expressed in 192 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExiHS_SNX26
ExpressionAtlasiO14559 baseline and differential
GenevisibleiO14559 HS

Family and domain databases

Gene3Di1.10.555.10, 1 hit
InterProiView protein in InterPro
IPR035510 ARHGAP33
IPR036871 PX_dom_sf
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR15729:SF11 PTHR15729:SF11, 1 hit
PfamiView protein in Pfam
PF00620 RhoGAP, 1 hit
PF07653 SH3_2, 1 hit
SMARTiView protein in SMART
SM00324 RhoGAP, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF48350 SSF48350, 1 hit
SSF50044 SSF50044, 1 hit
SSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50238 RHOGAP, 1 hit
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRHG33_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O14559
Secondary accession number(s): O14552
, O14560, Q6ZSP6, Q96CP3, Q9NT23
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: July 5, 2005
Last modified: January 16, 2019
This is version 158 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again