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Protein

Cytochrome c oxidase subunit 7A-related protein, mitochondrial

Gene

COX7A2L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the regulation of oxidative phosphorylation and energy metabolism (By similarity). Necessary for the assembly of mitochondrial respiratory supercomplex (By similarity).By similarity

GO - Molecular functioni

  • cytochrome-c oxidase activity Source: ProtInc

GO - Biological processi

  • mitochondrial respiratory chain supercomplex assembly Source: GO_Central
  • regulation of oxidative phosphorylation Source: GO_Central

Enzyme and pathway databases

ReactomeiR-HSA-5628897 TP53 Regulates Metabolic Genes
R-HSA-611105 Respiratory electron transport

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 7A-related protein, mitochondrial
Alternative name(s):
COX7a-related protein
Cytochrome c oxidase subunit VIIa-related protein
EB1
Gene namesi
Name:COX7A2L
Synonyms:COX7AR, COX7RP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000115944.14
HGNCiHGNC:2289 COX7A2L
MIMi605771 gene
neXtProtiNX_O14548

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9167
OpenTargetsiENSG00000115944
PharmGKBiPA26807

Polymorphism and mutation databases

BioMutaiCOX7A2L

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 55MitochondrionSequence analysisAdd BLAST55
ChainiPRO_000000615456 – 114Cytochrome c oxidase subunit 7A-related protein, mitochondrialAdd BLAST59

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei69N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiO14548
PaxDbiO14548
PeptideAtlasiO14548
PRIDEiO14548
ProteomicsDBi48081
TopDownProteomicsiO14548

PTM databases

iPTMnetiO14548
PhosphoSitePlusiO14548

Expressioni

Inductioni

By estrogen.

Gene expression databases

BgeeiENSG00000115944 Expressed in 236 organ(s), highest expression level in female gonad
CleanExiHS_COX7A2L
ExpressionAtlasiO14548 baseline and differential
GenevisibleiO14548 HS

Organism-specific databases

HPAiCAB073545
HPA059124

Interactioni

Subunit structurei

Interacts with the mitochondrial respiratory supercomplex.By similarity

Protein-protein interaction databases

BioGridi114608, 19 interactors
IntActiO14548, 9 interactors
MINTiO14548
STRINGi9606.ENSP00000234301

Structurei

3D structure databases

ProteinModelPortaliO14548
SMRiO14548
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase VIIa family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410IYMH Eukaryota
ENOG41120Z9 LUCA
GeneTreeiENSGT00400000022054
HOGENOMiHOG000264231
HOVERGENiHBG051095
InParanoidiO14548
KOiK02270
OMAiKRGYPDR
OrthoDBiEOG091G12UD
PhylomeDBiO14548
TreeFamiTF105067

Family and domain databases

CDDicd00928 Cyt_c_Oxidase_VIIa, 1 hit
Gene3Di4.10.91.10, 1 hit
InterProiView protein in InterPro
IPR039297 COX7a
IPR017267 Cyt_c_oxidase_su7a-rel_mt
IPR036539 Cyt_c_oxidase_su7a_sf
IPR003177 Cytc_oxidase_su7a_met
PANTHERiPTHR10510 PTHR10510, 1 hit
PTHR10510:SF2 PTHR10510:SF2, 1 hit
PfamiView protein in Pfam
PF02238 COX7a, 1 hit
PIRSFiPIRSF037710 COX7A-rel_mt, 1 hit
SUPFAMiSSF81419 SSF81419, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

O14548-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYYKFSGFTQ KLAGAWASEA YSPQGLKPVV STEAPPIIFA TPTKLTSDST
60 70 80 90 100
VYDYAGKNKV PELQKFFQKA DGVPVYLKRG LPDQMLYRTT MALTVGGTIY
110
CLIALYMASQ PKNK
Length:114
Mass (Da):12,615
Last modified:April 3, 2002 - v2
Checksum:i67BCABEEAE0F552B
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YBD2H0YBD2_HUMAN
Cytochrome c oxidase subunit 7A-rel...
COX7A2L
95Annotation score:
E5RJZ1E5RJZ1_HUMAN
Cytochrome c oxidase subunit 7A-rel...
COX7A2L
79Annotation score:
E5RFH8E5RFH8_HUMAN
Cytochrome c oxidase subunit 7A-rel...
COX7A2L
39Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti107M → N in BAA22571 (PubMed:9418891).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007618 mRNA Translation: BAA22571.1
AF127788 mRNA Translation: AAF72746.1
AY007643 Genomic DNA Translation: AAG32129.1
BT007371 mRNA Translation: AAP36035.1
BC005251 mRNA Translation: AAH05251.1
BC007095 mRNA Translation: AAH07095.1
CCDSiCCDS1808.1
RefSeqiNP_001305965.1, NM_001319036.1
NP_001305969.1, NM_001319040.1
NP_004709.2, NM_004718.3
UniGeneiHs.339639
Hs.744101

Genome annotation databases

EnsembliENST00000234301; ENSP00000234301; ENSG00000115944
ENST00000378669; ENSP00000367938; ENSG00000115944
GeneIDi9167
KEGGihsa:9167

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007618 mRNA Translation: BAA22571.1
AF127788 mRNA Translation: AAF72746.1
AY007643 Genomic DNA Translation: AAG32129.1
BT007371 mRNA Translation: AAP36035.1
BC005251 mRNA Translation: AAH05251.1
BC007095 mRNA Translation: AAH07095.1
CCDSiCCDS1808.1
RefSeqiNP_001305965.1, NM_001319036.1
NP_001305969.1, NM_001319040.1
NP_004709.2, NM_004718.3
UniGeneiHs.339639
Hs.744101

3D structure databases

ProteinModelPortaliO14548
SMRiO14548
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114608, 19 interactors
IntActiO14548, 9 interactors
MINTiO14548
STRINGi9606.ENSP00000234301

PTM databases

iPTMnetiO14548
PhosphoSitePlusiO14548

Polymorphism and mutation databases

BioMutaiCOX7A2L

Proteomic databases

EPDiO14548
PaxDbiO14548
PeptideAtlasiO14548
PRIDEiO14548
ProteomicsDBi48081
TopDownProteomicsiO14548

Protocols and materials databases

DNASUi9167
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000234301; ENSP00000234301; ENSG00000115944
ENST00000378669; ENSP00000367938; ENSG00000115944
GeneIDi9167
KEGGihsa:9167

Organism-specific databases

CTDi9167
DisGeNETi9167
EuPathDBiHostDB:ENSG00000115944.14
GeneCardsiCOX7A2L
HGNCiHGNC:2289 COX7A2L
HPAiCAB073545
HPA059124
MIMi605771 gene
neXtProtiNX_O14548
OpenTargetsiENSG00000115944
PharmGKBiPA26807
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IYMH Eukaryota
ENOG41120Z9 LUCA
GeneTreeiENSGT00400000022054
HOGENOMiHOG000264231
HOVERGENiHBG051095
InParanoidiO14548
KOiK02270
OMAiKRGYPDR
OrthoDBiEOG091G12UD
PhylomeDBiO14548
TreeFamiTF105067

Enzyme and pathway databases

ReactomeiR-HSA-5628897 TP53 Regulates Metabolic Genes
R-HSA-611105 Respiratory electron transport

Miscellaneous databases

ChiTaRSiCOX7A2L human
GeneWikiiCOX7A2L
GenomeRNAii9167
PROiPR:O14548
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000115944 Expressed in 236 organ(s), highest expression level in female gonad
CleanExiHS_COX7A2L
ExpressionAtlasiO14548 baseline and differential
GenevisibleiO14548 HS

Family and domain databases

CDDicd00928 Cyt_c_Oxidase_VIIa, 1 hit
Gene3Di4.10.91.10, 1 hit
InterProiView protein in InterPro
IPR039297 COX7a
IPR017267 Cyt_c_oxidase_su7a-rel_mt
IPR036539 Cyt_c_oxidase_su7a_sf
IPR003177 Cytc_oxidase_su7a_met
PANTHERiPTHR10510 PTHR10510, 1 hit
PTHR10510:SF2 PTHR10510:SF2, 1 hit
PfamiView protein in Pfam
PF02238 COX7a, 1 hit
PIRSFiPIRSF037710 COX7A-rel_mt, 1 hit
SUPFAMiSSF81419 SSF81419, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCOX7R_HUMAN
AccessioniPrimary (citable) accession number: O14548
Secondary accession number(s): Q9P118
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: April 3, 2002
Last modified: November 7, 2018
This is version 164 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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