Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Suppressor of cytokine signaling 6

Gene

SOCS6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor.By similarity1 Publication

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

  • cytokine-mediated signaling pathway Source: GO_Central
  • defense response Source: ProtInc
  • JAK-STAT cascade Source: ProtInc
  • negative regulation of JAK-STAT cascade Source: GO_Central
  • negative regulation of protein kinase activity Source: GO_Central
  • negative regulation of T cell activation Source: Ensembl
  • post-translational protein modification Source: Reactome
  • proteasomal protein catabolic process Source: MGI
  • protein ubiquitination Source: UniProtKB-UniPathway
  • regulation of growth Source: UniProtKB-KW

Keywordsi

Molecular functionSignal transduction inhibitor
Biological processGrowth regulation, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-1433559 Regulation of KIT signaling
R-HSA-8951664 Neddylation
SignaLinkiO14544
SIGNORiO14544
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Suppressor of cytokine signaling 6
Short name:
SOCS-6
Alternative name(s):
Cytokine-inducible SH2 protein 4
Short name:
CIS-4
Suppressor of cytokine signaling 4
Short name:
SOCS-4
Gene namesi
Name:SOCS6
Synonyms:CIS4, SOCS4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000170677.5
HGNCiHGNC:16833 SOCS6
MIMi605118 gene
neXtProtiNX_O14544

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi9306
OpenTargetsiENSG00000170677
PharmGKBiPA134917653

Polymorphism and mutation databases

BioMutaiSOCS6

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001812511 – 535Suppressor of cytokine signaling 6Add BLAST535

Proteomic databases

EPDiO14544
MaxQBiO14544
PaxDbiO14544
PeptideAtlasiO14544
PRIDEiO14544
ProteomicsDBi48079

PTM databases

iPTMnetiO14544
PhosphoSitePlusiO14544

Expressioni

Gene expression databases

BgeeiENSG00000170677
CleanExiHS_SOCS4
HS_SOCS6
ExpressionAtlasiO14544 baseline and differential
GenevisibleiO14544 HS

Organism-specific databases

HPAiCAB010189

Interactioni

Subunit structurei

Interacts with RBCK1. Interacts with phosphorylated IRS4 (By similarity). Interacts with PIM3 (By similarity). Interacts with KIT (phosphorylated).By similarity1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi114719, 42 interactors
IntActiO14544, 23 interactors
MINTiO14544
STRINGi9606.ENSP00000381034

Structurei

Secondary structure

1535
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi372 – 382Combined sources11
Helixi391 – 397Combined sources7
Turni398 – 400Combined sources3
Beta strandi406 – 410Combined sources5
Beta strandi417 – 424Combined sources8
Beta strandi427 – 436Combined sources10
Beta strandi439 – 442Combined sources4
Beta strandi451 – 453Combined sources3
Helixi454 – 467Combined sources14
Beta strandi471 – 474Combined sources4

3D structure databases

ProteinModelPortaliO14544
SMRiO14544
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO14544

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini384 – 491SH2PROSITE-ProRule annotationAdd BLAST108
Domaini486 – 535SOCS boxPROSITE-ProRule annotationAdd BLAST50

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi105 – 108Poly-Ser4

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.By similarity

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiKOG4566 Eukaryota
ENOG4111V4J LUCA
GeneTreeiENSGT00760000119136
HOGENOMiHOG000027792
HOVERGENiHBG057479
InParanoidiO14544
KOiK04699
OMAiTRWEAEG
OrthoDBiEOG091G0EP6
PhylomeDBiO14544
TreeFamiTF321368

Family and domain databases

CDDicd10387 SH2_SOCS6, 1 hit
cd03740 SOCS_SOCS6, 1 hit
Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR028421 SOCS6
IPR035865 SOCS6_SH2
IPR037345 SOCS6_SOCS
IPR001496 SOCS_box
IPR036036 SOCS_box-like_dom_sf
PANTHERiPTHR44562 PTHR44562, 1 hit
PfamiView protein in Pfam
PF00017 SH2, 1 hit
PF07525 SOCS_box, 1 hit
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SM00253 SOCS, 1 hit
SM00969 SOCS_box, 1 hit
SUPFAMiSSF158235 SSF158235, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit
PS50225 SOCS, 1 hit

Sequencei

Sequence statusi: Complete.

O14544-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKISLKTLR KSFNLNKSKE ETDFMVVQQP SLASDFGKDD SLFGSCYGKD
60 70 80 90 100
MASCDINGED EKGGKNRSKS ESLMGTLKRR LSAKQKSKGK AGTPSGSSAD
110 120 130 140 150
EDTFSSSSAP IVFKDVRAQR PIRSTSLRSH HYSPAPWPLR PTNSEETCIK
160 170 180 190 200
MEVRVKALVH SSSPSPALNG VRKDFHDLQS ETTCQEQANS LKSSASHNGD
210 220 230 240 250
LHLHLDEHVP VVIGLMPQDY IQYTVPLDEG MYPLEGSRSY CLDSSSPMEV
260 270 280 290 300
SAVPPQVGGR AFPEDESQVD QDLVVAPEIF VDQSVNGLLI GTTGVMLQSP
310 320 330 340 350
RAGHDDVPPL SPLLPPMQNN QIQRNFSGLT GTEAHVAESM RCHLNFDPNS
360 370 380 390 400
APGVARVYDS VQSSGPMVVT SLTEELKKLA KQGWYWGPIT RWEAEGKLAN
410 420 430 440 450
VPDGSFLVRD SSDDRYLLSL SFRSHGKTLH TRIEHSNGRF SFYEQPDVEG
460 470 480 490 500
HTSIVDLIEH SIRDSENGAF CYSRSRLPGS ATYPVRLTNP VSRFMQVRSL
510 520 530
QYLCRFVIRQ YTRIDLIQKL PLPNKMKDYL QEKHY
Length:535
Mass (Da):59,528
Last modified:September 23, 2008 - v2
Checksum:iAE513312A999B763
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti74M → I in BAA22538 (PubMed:9344848).Curated1
Sequence conflicti161S → T in BAA22538 (PubMed:9344848).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006968 mRNA Translation: BAA22538.1
CH471117 Genomic DNA Translation: EAW66522.1
BC020082 mRNA Translation: AAH20082.1
CCDSiCCDS11998.1
PIRiJC5762
RefSeqiNP_004223.2, NM_004232.3
XP_005266840.1, XM_005266783.3
XP_016881575.1, XM_017026086.1
XP_016881576.1, XM_017026087.1
UniGeneiHs.44439

Genome annotation databases

EnsembliENST00000397942; ENSP00000381034; ENSG00000170677
ENST00000582322; ENSP00000463395; ENSG00000170677
GeneIDi9306
KEGGihsa:9306
UCSCiuc002lkr.2 human

Similar proteinsi

Entry informationi

Entry nameiSOCS6_HUMAN
AccessioniPrimary (citable) accession number: O14544
Secondary accession number(s): Q8WUM3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: September 23, 2008
Last modified: June 20, 2018
This is version 160 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health