UniProtKB - O14531 (DPYL4_HUMAN)
Protein
Dihydropyrimidinase-related protein 4
Gene
DPYSL4
Organism
Homo sapiens (Human)
Status
Functioni
Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity).By similarity
Caution
Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for dihydropyrimidinase activity. Its enzyme activity is therefore unsure.Curated
GO - Molecular functioni
- filamin binding Source: WormBase
- hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds Source: InterPro
GO - Biological processi
- nervous system development Source: ProtInc
- neuron death Source: InterPro
- neuron projection guidance Source: InterPro
Enzyme and pathway databases
PathwayCommonsi | O14531 |
Reactomei | R-HSA-399956, CRMPs in Sema3A signaling |
Protein family/group databases
MEROPSi | M38.977 |
Names & Taxonomyi
Protein namesi | Recommended name: Dihydropyrimidinase-related protein 4Short name: DRP-4 Alternative name(s): Collapsin response mediator protein 3 Short name: CRMP-3 UNC33-like phosphoprotein 4 Short name: ULIP-4 |
Gene namesi | Name:DPYSL4 Synonyms:CRMP3, ULIP4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3016, DPYSL4 |
MIMi | 608407, gene |
neXtProti | NX_O14531 |
VEuPathDBi | HostDB:ENSG00000151640.12 |
Subcellular locationi
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 10570 |
OpenTargetsi | ENSG00000151640 |
PharmGKBi | PA27474 |
Miscellaneous databases
Pharosi | O14531, Tbio |
Genetic variation databases
BioMutai | DPYSL4 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000165921 | 1 – 572 | Dihydropyrimidinase-related protein 4Add BLAST | 572 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 537 | PhosphoserineBy similarity | 1 | |
Modified residuei | 544 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | O14531 |
jPOSTi | O14531 |
MassIVEi | O14531 |
MaxQBi | O14531 |
PaxDbi | O14531 |
PeptideAtlasi | O14531 |
PRIDEi | O14531 |
ProteomicsDBi | 48077 |
TopDownProteomicsi | O14531 |
PTM databases
iPTMneti | O14531 |
PhosphoSitePlusi | O14531 |
Expressioni
Gene expression databases
Bgeei | ENSG00000151640, Expressed in apex of heart and 158 other tissues |
ExpressionAtlasi | O14531, baseline and differential |
Genevisiblei | O14531, HS |
Organism-specific databases
HPAi | ENSG00000151640, Tissue enhanced (brain, heart muscle) |
Interactioni
Subunit structurei
Homotetramer, and heterotetramer with CRMP1, DPYSL2, DPYSL3 or DPYSL5 (By similarity).
Interacts with PLEXA1 (By similarity).
Interacts with FLNA (PubMed:25358863).
By similarity1 PublicationBinary interactionsi
Hide detailsO14531
GO - Molecular functioni
- filamin binding Source: WormBase
Protein-protein interaction databases
BioGRIDi | 115821, 40 interactors |
IntActi | O14531, 25 interactors |
MINTi | O14531 |
STRINGi | 9606.ENSP00000339850 |
Miscellaneous databases
RNActi | O14531, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | O14531 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.Curated
Phylogenomic databases
eggNOGi | KOG2584, Eukaryota |
GeneTreei | ENSGT00990000203521 |
InParanoidi | O14531 |
OMAi | HCETAEI |
OrthoDBi | 719800at2759 |
PhylomeDBi | O14531 |
TreeFami | TF314706 |
Family and domain databases
CDDi | cd01314, D-HYD, 1 hit |
Gene3Di | 2.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR006680, Amidohydro-rel IPR030612, DRP4 IPR011778, Hydantoinase/dihydroPyrase IPR011059, Metal-dep_hydrolase_composite IPR032466, Metal_Hydrolase |
PANTHERi | PTHR11647:SF55, PTHR11647:SF55, 1 hit |
Pfami | View protein in Pfam PF01979, Amidohydro_1, 1 hit |
SUPFAMi | SSF51338, SSF51338, 2 hits SSF51556, SSF51556, 1 hit |
TIGRFAMsi | TIGR02033, D-hydantoinase, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
O14531-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSFQGKKSIP RITSDRLLIR GGRIVNDDQS FYADVHVEDG LIKQIGENLI
60 70 80 90 100
VPGGIKTIDA HGLMVLPGGV DVHTRLQMPV LGMTPADDFC QGTKAALAGG
110 120 130 140 150
TTMILDHVFP DTGVSLLAAY EQWRERADSA ACCDYSLHVD ITRWHESIKE
160 170 180 190 200
ELEALVKEKG VNSFLVFMAY KDRCQCSDSQ MYEIFSIIRD LGALAQVHAE
210 220 230 240 250
NGDIVEEEQK RLLELGITGP EGHVLSHPEE VEAEAVYRAV TIAKQANCPL
260 270 280 290 300
YVTKVMSKGA ADAIAQAKRR GVVVFGEPIT ASLGTDGSHY WSKNWAKAAA
310 320 330 340 350
FVTSPPVNPD PTTADHLTCL LSSGDLQVTG SAHCTFTTAQ KAVGKDNFAL
360 370 380 390 400
IPEGTNGIEE RMSMVWEKCV ASGKMDENEF VAVTSTNAAK IFNFYPRKGR
410 420 430 440 450
VAVGSDADLV IWNPKATKII SAKTHNLNVE YNIFEGVECR GAPAVVISQG
460 470 480 490 500
RVALEDGKMF VTPGAGRFVP RKTFPDFVYK RIKARNRLAE IHGVPRGLYD
510 520 530 540 550
GPVHEVMVPA KPGSGAPARA SCPGKISVPP VRNLHQSGFS LSGSQADDHI
560 570
ARRTAQKIMA PPGGRSNITS LS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ5T0Q6 | Q5T0Q6_HUMAN | Dihydropyrimidinase-related protein... | DPYSL4 | 412 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 122 | Q → R in BAA21886 (Ref. 1) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB006713 mRNA Translation: BAA21886.1 AL512622 Genomic DNA No translation available. CH471066 Genomic DNA Translation: EAW49132.1 CH471066 Genomic DNA Translation: EAW49134.1 CH471066 Genomic DNA Translation: EAW49135.1 BC136329 mRNA Translation: AAI36330.1 BC136330 mRNA Translation: AAI36331.1 Y10976 mRNA Translation: CAA71872.1 |
CCDSi | CCDS7665.1 |
RefSeqi | NP_006417.2, NM_006426.2 |
Genome annotation databases
Ensembli | ENST00000338492; ENSP00000339850; ENSG00000151640 |
GeneIDi | 10570 |
KEGGi | hsa:10570 |
UCSCi | uc009ybb.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB006713 mRNA Translation: BAA21886.1 AL512622 Genomic DNA No translation available. CH471066 Genomic DNA Translation: EAW49132.1 CH471066 Genomic DNA Translation: EAW49134.1 CH471066 Genomic DNA Translation: EAW49135.1 BC136329 mRNA Translation: AAI36330.1 BC136330 mRNA Translation: AAI36331.1 Y10976 mRNA Translation: CAA71872.1 |
CCDSi | CCDS7665.1 |
RefSeqi | NP_006417.2, NM_006426.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5NKS | X-ray | 1.80 | A | 1-572 | [»] | |
SMRi | O14531 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 115821, 40 interactors |
IntActi | O14531, 25 interactors |
MINTi | O14531 |
STRINGi | 9606.ENSP00000339850 |
Protein family/group databases
MEROPSi | M38.977 |
PTM databases
iPTMneti | O14531 |
PhosphoSitePlusi | O14531 |
Genetic variation databases
BioMutai | DPYSL4 |
Proteomic databases
EPDi | O14531 |
jPOSTi | O14531 |
MassIVEi | O14531 |
MaxQBi | O14531 |
PaxDbi | O14531 |
PeptideAtlasi | O14531 |
PRIDEi | O14531 |
ProteomicsDBi | 48077 |
TopDownProteomicsi | O14531 |
Protocols and materials databases
Antibodypediai | 32549, 201 antibodies |
Genome annotation databases
Ensembli | ENST00000338492; ENSP00000339850; ENSG00000151640 |
GeneIDi | 10570 |
KEGGi | hsa:10570 |
UCSCi | uc009ybb.4, human |
Organism-specific databases
CTDi | 10570 |
DisGeNETi | 10570 |
GeneCardsi | DPYSL4 |
HGNCi | HGNC:3016, DPYSL4 |
HPAi | ENSG00000151640, Tissue enhanced (brain, heart muscle) |
MIMi | 608407, gene |
neXtProti | NX_O14531 |
OpenTargetsi | ENSG00000151640 |
PharmGKBi | PA27474 |
VEuPathDBi | HostDB:ENSG00000151640.12 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2584, Eukaryota |
GeneTreei | ENSGT00990000203521 |
InParanoidi | O14531 |
OMAi | HCETAEI |
OrthoDBi | 719800at2759 |
PhylomeDBi | O14531 |
TreeFami | TF314706 |
Enzyme and pathway databases
PathwayCommonsi | O14531 |
Reactomei | R-HSA-399956, CRMPs in Sema3A signaling |
Miscellaneous databases
BioGRID-ORCSi | 10570, 5 hits in 874 CRISPR screens |
GeneWikii | DPYSL4 |
GenomeRNAii | 10570 |
Pharosi | O14531, Tbio |
PROi | PR:O14531 |
RNActi | O14531, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000151640, Expressed in apex of heart and 158 other tissues |
ExpressionAtlasi | O14531, baseline and differential |
Genevisiblei | O14531, HS |
Family and domain databases
CDDi | cd01314, D-HYD, 1 hit |
Gene3Di | 2.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR006680, Amidohydro-rel IPR030612, DRP4 IPR011778, Hydantoinase/dihydroPyrase IPR011059, Metal-dep_hydrolase_composite IPR032466, Metal_Hydrolase |
PANTHERi | PTHR11647:SF55, PTHR11647:SF55, 1 hit |
Pfami | View protein in Pfam PF01979, Amidohydro_1, 1 hit |
SUPFAMi | SSF51338, SSF51338, 2 hits SSF51556, SSF51556, 1 hit |
TIGRFAMsi | TIGR02033, D-hydantoinase, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DPYL4_HUMAN | |
Accessioni | O14531Primary (citable) accession number: O14531 Secondary accession number(s): B2RMQ1 Q5T0Q7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | June 21, 2005 | |
Last modified: | February 10, 2021 | |
This is version 178 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families