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Entry version 172 (13 Feb 2019)
Sequence version 4 (30 Nov 2010)
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Protein

Homeobox protein cut-like 2

Gene

CUX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be a transcription factor involved in neural specification. Binds to DNA in a sequence-specific manner (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi544 – 631CUT 1PROSITE-ProRule annotationAdd BLAST88
DNA bindingi887 – 974CUT 2PROSITE-ProRule annotationAdd BLAST88
DNA bindingi1038 – 1125CUT 3PROSITE-ProRule annotationAdd BLAST88
DNA bindingi1168 – 1227HomeoboxPROSITE-ProRule annotationAdd BLAST60

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Homeobox protein cut-like 2
Alternative name(s):
Homeobox protein cux-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CUX2
Synonyms:CUTL2, KIAA0293
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000111249.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19347 CUX2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610648 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O14529

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
23316

Open Targets

More...
OpenTargetsi
ENSG00000111249

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
2382 Lennox-Gastaut syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162382977

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CUX2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002023961 – 1486Homeobox protein cut-like 2Add BLAST1486

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei143PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O14529

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O14529

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O14529

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O14529

PeptideAtlas

More...
PeptideAtlasi
O14529

PRoteomics IDEntifications database

More...
PRIDEi
O14529

ProteomicsDB human proteome resource

More...
ProteomicsDBi
48075

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O14529

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O14529

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000111249 Expressed in 101 organ(s), highest expression level in neocortex

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O14529 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O14529 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
O14529, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000261726

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11486
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WH6NMR-A887-974[»]
1WH8NMR-A1028-1125[»]
1X2LNMR-A544-631[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O14529

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O14529

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
O14529

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili195 – 374Sequence analysisAdd BLAST180
Coiled coili690 – 717Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi440 – 535Pro-richAdd BLAST96
Compositional biasi802 – 813Poly-SerAdd BLAST12
Compositional biasi1327 – 1437Pro-richAdd BLAST111

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CUT homeobox family.Curated

Keywords - Domaini

Coiled coil, Homeobox, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0963 Eukaryota
KOG2252 Eukaryota
ENOG410XPKP LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160241

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000143386

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG051268

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O14529

KEGG Orthology (KO)

More...
KOi
K09313

Identification of Orthologs from Complete Genome Data

More...
OMAi
FFPAQKF

Database of Orthologous Groups

More...
OrthoDBi
181575at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O14529

TreeFam database of animal gene trees

More...
TreeFami
TF318206

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00086 homeodomain, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003350 CUT_dom
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR010982 Lambda_DNA-bd_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02376 CUT, 3 hits
PF00046 Homeodomain, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01109 CUT, 3 hits
SM00389 HOX, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689 SSF46689, 1 hit
SSF47413 SSF47413, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51042 CUT, 3 hits
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O14529-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAANVGSMFQ YWKRFDLRRL QKELNSVASE LSARQEESEH SHKHLIELRR
60 70 80 90 100
EFKKNVPEEI REMVAPVLKS FQAEVVALSK RSQEAEAAFL SVYKQLIEAP
110 120 130 140 150
DPVPVFEAAR SLDDRLQPPS FDPSGQPRRD LHTSWKRNPE LLSPKEQREG
160 170 180 190 200
TSPAGPTLTE GSRLPGIPGK ALLTETLLQR NEAEKQKGLQ EVQITLAARL
210 220 230 240 250
GEAEEKIKVL HSALKATQAE LLELRRKYDE EAASKADEVG LIMTNLEKAN
260 270 280 290 300
QRAEAAQREV ESLREQLASV NSSIRLACCS PQGPSGDKVN FTLCSGPRLE
310 320 330 340 350
AALASKDREI LRLLKDVQHL QSSLQELEEA SANQIADLER QLTAKSEAIE
360 370 380 390 400
KLEEKLQAQS DYEEIKTELS ILKAMKLASS TCSLPQGMAK PEDSLLIAKE
410 420 430 440 450
AFFPTQKFLL EKPSLLASPE EDPSEDDSIK DSLGTEQSYP SPQQLPPPPG
460 470 480 490 500
PEDPLSPSPG QPLLGPSLGP DGTRTFSLSP FPSLASGERL MMPPAAFKGE
510 520 530 540 550
AGGLLVFPPA FYGAKPPTAP ATPAPGPEPL GGPEPADGGG GGAAGPGAEE
560 570 580 590 600
EQLDTAEIAF QVKEQLLKHN IGQRVFGHYV LGLSQGSVSE ILARPKPWRK
610 620 630 640 650
LTVKGKEPFI KMKQFLSDEQ NVLALRTIQV RQRGSITPRI RTPETGSDDA
660 670 680 690 700
IKSILEQAKK EIESQKGGEP KTSVAPLSIA NGTTPASTSE DAIKSILEQA
710 720 730 740 750
RREMQAQQQA LLEMEVAPRG RSVPPSPPER PSLATASQNG APALVKQEEG
760 770 780 790 800
SGGPAQAPLP VLSPAAFVQS IIRKVKSEIG DAGYFDHHWA SDRGLLSRPY
810 820 830 840 850
ASVSPSLSSS SSSGYSGQPN GRAWPRGDEA PVPPEDEAAA GAEDEPPRTG
860 870 880 890 900
ELKAEGATAE AGARLPYYPA YVPRTLKPTV PPLTPEQYEL YMYREVDTLE
910 920 930 940 950
LTRQVKEKLA KNGICQRIFG EKVLGLSQGS VSDMLSRPKP WSKLTQKGRE
960 970 980 990 1000
PFIRMQLWLS DQLGQAVGQQ PGASQASPTE PRSSPSPPPS PTEPEKSSQE
1010 1020 1030 1040 1050
PLSLSLESSK ENQQPEGRSS SSLSGKMYSG SQAPGGIQEI VAMSPELDTY
1060 1070 1080 1090 1100
SITKRVKEVL TDNNLGQRLF GESILGLTQG SVSDLLSRPK PWHKLSLKGR
1110 1120 1130 1140 1150
EPFVRMQLWL NDPHNVEKLR DMKKLEKKAY LKRRYGLIST GSDSESPATR
1160 1170 1180 1190 1200
SECPSPCLQP QDLSLLQIKK PRVVLAPEEK EALRKAYQLE PYPSQQTIEL
1210 1220 1230 1240 1250
LSFQLNLKTN TVINWFHNYR SRMRREMLVE GTQDEPDLDP SGGPGILPPG
1260 1270 1280 1290 1300
HSHPDPTPQS PDSETEDQKP TVKELELQEG PEENSTPLTT QDKAQVRIKQ
1310 1320 1330 1340 1350
EQMEEDAEEE AGSQPQDSGE LDKGQGPPKE EHPDPPGNDG LPKVAPGPLL
1360 1370 1380 1390 1400
PGGSTPDCPS LHPQQESEAG ERLHPDPLSF KSASESSRCS LEVSLNSPSA
1410 1420 1430 1440 1450
ASSPGLMMSV SPVPSSSAPI SPSPPGAPPA KVPSASPTAD MAGALHPSAK
1460 1470 1480
VNPNLQRRHE KMANLNNIIY RVERAANREE ALEWEF
Length:1,486
Mass (Da):161,677
Last modified:November 30, 2010 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i71782EF5214D0262
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5GWR6F5GWR6_HUMAN
Homeobox protein cut-like 2
CUX2
251Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA22962 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0650961472V → L2 PublicationsCorresponds to variant dbSNP:rs6490073Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB006631 mRNA Translation: BAA22962.2 Different initiation.
AC005805 Genomic DNA No translation available.
AC002979 Genomic DNA No translation available.
AC002352 Genomic DNA No translation available.
AC002978 Genomic DNA No translation available.
BC151245 mRNA Translation: AAI51246.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS41837.1

NCBI Reference Sequences

More...
RefSeqi
NP_056082.2, NM_015267.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.124953

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000261726; ENSP00000261726; ENSG00000111249

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
23316

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:23316

UCSC genome browser

More...
UCSCi
uc001tsa.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006631 mRNA Translation: BAA22962.2 Different initiation.
AC005805 Genomic DNA No translation available.
AC002979 Genomic DNA No translation available.
AC002352 Genomic DNA No translation available.
AC002978 Genomic DNA No translation available.
BC151245 mRNA Translation: AAI51246.1
CCDSiCCDS41837.1
RefSeqiNP_056082.2, NM_015267.3
UniGeneiHs.124953

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WH6NMR-A887-974[»]
1WH8NMR-A1028-1125[»]
1X2LNMR-A544-631[»]
ProteinModelPortaliO14529
SMRiO14529
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO14529, 1 interactor
STRINGi9606.ENSP00000261726

PTM databases

iPTMnetiO14529
PhosphoSitePlusiO14529

Polymorphism and mutation databases

BioMutaiCUX2

Proteomic databases

EPDiO14529
jPOSTiO14529
MaxQBiO14529
PaxDbiO14529
PeptideAtlasiO14529
PRIDEiO14529
ProteomicsDBi48075

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
23316
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261726; ENSP00000261726; ENSG00000111249
GeneIDi23316
KEGGihsa:23316
UCSCiuc001tsa.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23316
DisGeNETi23316
EuPathDBiHostDB:ENSG00000111249.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CUX2
HGNCiHGNC:19347 CUX2
MIMi610648 gene
neXtProtiNX_O14529
OpenTargetsiENSG00000111249
Orphaneti2382 Lennox-Gastaut syndrome
PharmGKBiPA162382977

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0963 Eukaryota
KOG2252 Eukaryota
ENOG410XPKP LUCA
GeneTreeiENSGT00940000160241
HOGENOMiHOG000143386
HOVERGENiHBG051268
InParanoidiO14529
KOiK09313
OMAiFFPAQKF
OrthoDBi181575at2759
PhylomeDBiO14529
TreeFamiTF318206

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CUX2 human
EvolutionaryTraceiO14529

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
23316

Protein Ontology

More...
PROi
PR:O14529

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000111249 Expressed in 101 organ(s), highest expression level in neocortex
ExpressionAtlasiO14529 baseline and differential
GenevisibleiO14529 HS

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR003350 CUT_dom
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR010982 Lambda_DNA-bd_dom_sf
PfamiView protein in Pfam
PF02376 CUT, 3 hits
PF00046 Homeodomain, 1 hit
SMARTiView protein in SMART
SM01109 CUT, 3 hits
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
SSF47413 SSF47413, 3 hits
PROSITEiView protein in PROSITE
PS51042 CUT, 3 hits
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCUX2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O14529
Secondary accession number(s): A7E2Y4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 30, 2010
Last modified: February 13, 2019
This is version 172 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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