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Protein

F-BAR domain only protein 1

Gene

FCHO1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors.1 Publication

GO - Molecular functioni

  • AP-2 adaptor complex binding Source: MGI
  • cytoskeletal protein binding Source: GO_Central
  • microtubule binding Source: GO_Central
  • phospholipid binding Source: GO_Central
  • tubulin binding Source: GO_Central

GO - Biological processi

  • clathrin coat assembly Source: UniProtKB
  • clathrin-dependent endocytosis Source: UniProtKB
  • membrane organization Source: Reactome
  • plasma membrane tubulation Source: GO_Central

Keywordsi

Biological processEndocytosis

Enzyme and pathway databases

ReactomeiR-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
F-BAR domain only protein 1
Gene namesi
Name:FCHO1
Synonyms:KIAA0290
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000130475.14
HGNCiHGNC:29002 FCHO1
MIMi613437 gene
neXtProtiNX_O14526

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Coated pit, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000130475
PharmGKBiPA134870625

Polymorphism and mutation databases

BioMutaiFCHO1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002717591 – 889F-BAR domain only protein 1Add BLAST889

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei295PhosphoserineCombined sources1
Modified residuei347PhosphoserineCombined sources1
Modified residuei372PhosphoserineCombined sources1
Modified residuei530PhosphoserineBy similarity1
Modified residuei616PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO14526
MaxQBiO14526
PaxDbiO14526
PeptideAtlasiO14526
PRIDEiO14526
ProteomicsDBi48073
48074 [O14526-2]

PTM databases

iPTMnetiO14526
PhosphoSitePlusiO14526

Expressioni

Gene expression databases

BgeeiENSG00000130475 Expressed in 141 organ(s), highest expression level in frontal cortex
CleanExiHS_FCHO1
ExpressionAtlasiO14526 baseline and differential
GenevisibleiO14526 HS

Organism-specific databases

HPAiHPA041653
HPA062981

Interactioni

Subunit structurei

May oligomerize and form homotetramer (By similarity). Interacts with AP2A2 and AP2B1; 2 subunits of the adaptor protein complex AP-2. Interacts with DAB2. Interacts with clathrin (CLTC or CLTCL1). Interacts with EPS15, EPS15R and ITSN1. Interacts with AGFG1 and CALM. May interact with ACVR1; linking this receptor to clathrin-mediated endocytosis.By similarity1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116764, 18 interactors
IntActiO14526, 7 interactors
MINTiO14526
STRINGi9606.ENSP00000252771

Structurei

3D structure databases

ProteinModelPortaliO14526
SMRiO14526
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 248F-BARPROSITE-ProRule annotationAdd BLAST248
Domaini625 – 888MHDPROSITE-ProRule annotationAdd BLAST264

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 275Mediates membrane-bindingAdd BLAST275
Regioni267 – 442Mediates interaction with the adaptor protein complex AP-2Add BLAST176
Regioni609 – 889Mediates interaction with AGFG1, CALM, DAB2, EPS15, EPS15R, ITSN1 and clathrin1 PublicationAdd BLAST281

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili156 – 195Sequence analysisAdd BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi375 – 378Poly-Ala4
Compositional biasi465 – 468Poly-Ser4
Compositional biasi480 – 561Pro-richAdd BLAST82
Compositional biasi671 – 674Poly-Pro4

Sequence similaritiesi

Belongs to the FCHO family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2398 Eukaryota
ENOG410Y7RY LUCA
GeneTreeiENSGT00930000150876
HOGENOMiHOG000231544
HOVERGENiHBG081524
InParanoidiO14526
KOiK20042
PhylomeDBiO14526
TreeFamiTF328986

Family and domain databases

Gene3Di1.20.1270.60, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR031160 F_BAR
IPR001060 FCH_dom
IPR030121 FCHo1
IPR028565 MHD
IPR018808 Muniscin_C
PANTHERiPTHR23065:SF6 PTHR23065:SF6, 1 hit
PfamiView protein in Pfam
PF00611 FCH, 1 hit
PF10291 muHD, 1 hit
SMARTiView protein in SMART
SM00055 FCH, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
PROSITEiView protein in PROSITE
PS51741 F_BAR, 1 hit
PS51072 MHD, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 19 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O14526-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSYFGEHFWG EKNHGFEVLY HSVKQGPIST KELADFIRER ATIEETYSKA
60 70 80 90 100
MAKLSKLASN GTPMGTFAPL WEVFRVSSDK LALCHLELTR KLQDLIKDVL
110 120 130 140 150
RYGEEQLKTH KKCKEEVVST LDAVQVLSGV SQLLPKSREN YLNRCMDQER
160 170 180 190 200
LRRESTSQKE MDKAETKTKK AAESLRRSVE KYNSARADFE QKMLDSALRF
210 220 230 240 250
QAMEETHLRH MKALLGSYAH SVEDTHVQIG QVHEEFKQNI ENVSVEMLLR
260 270 280 290 300
KFAESKGTGR EKPGPLDFEA YSAAALQEAM KRLRGAKAFR LPGLSRRERE
310 320 330 340 350
PEPPAAVDFL EPDSGTCPEV DEEGFTVRPD VTQNSTAEPS RFSSSDSDFD
360 370 380 390 400
DEEPRKFYVH IKPAPARAPA CSPEAAAAQL RATAGSLILP PGPGGTMKRH
410 420 430 440 450
SSRDAAGKPQ RPRSAPRTSS CAERLQSEEQ VSKNLFGPPL ESAFDHEDFT
460 470 480 490 500
GSSSLGFTSS PSPFSSSSPE NVEDSGLDSP SHAAPGPSPD SWVPRPGTPQ
510 520 530 540 550
SPPSCRAPPP EARGIRAPPL PDSPQPLASS PGPWGLEALA GGDLMPAPAD
560 570 580 590 600
PTAREGLAAP PRRLRSRKVS CPLTRSNGDL SRSLSPSPLG SSAASTALER
610 620 630 640 650
PSFLSQTGHG VSRGPSPVVL GSQDALPIAT AFTEYVHAYF RGHSPSCLAR
660 670 680 690 700
VTGELTMTFP AGIVRVFSGT PPPPVLSFRL VHTTAIEHFQ PNADLLFSDP
710 720 730 740 750
SQSDPETKDF WLNMAALTEA LQRQAEQNPT ASYYNVVLLR YQFSRPGPQS
760 770 780 790 800
VPLQLSAHWQ CGATLTQVSV EYGYRPGATA VPTPLTNVQI LLPVGEPVTN
810 820 830 840 850
VRLQPAATWN LEEKRLTWRL PDVSEAGGSG RLSASWEPLS GPSTPSPVAA
860 870 880
QFTSEGTTLS GVDLELVGSG YRMSLVKRRF ATGMYLVSC
Length:889
Mass (Da):96,861
Last modified:January 9, 2007 - v2
Checksum:i8CDA1F24F42256D2
GO
Isoform 2 (identifier: O14526-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     883-889: GMYLVSC → AAPPQG

Note: No experimental confirmation available.
Show »
Length:888
Mass (Da):96,629
Checksum:i27DB24B8191372A9
GO
Isoform 3 (identifier: O14526-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-50: Missing.

Note: No experimental confirmation available.
Show »
Length:839
Mass (Da):91,013
Checksum:i4CC94A2046D108CE
GO

Computationally mapped potential isoform sequencesi

There are 19 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C3SFZ9A0A0C3SFZ9_HUMAN
F-BAR domain only protein 1
FCHO1 hCG_2000568
891Annotation score:
M0QZI3M0QZI3_HUMAN
F-BAR domain only protein 1
FCHO1
896Annotation score:
M0R3E5M0R3E5_HUMAN
F-BAR domain only protein 1
FCHO1
218Annotation score:
M0R3E7M0R3E7_HUMAN
F-BAR domain only protein 1
FCHO1
185Annotation score:
M0R1K4M0R1K4_HUMAN
F-BAR domain only protein 1
FCHO1
264Annotation score:
M0QZI9M0QZI9_HUMAN
F-BAR domain only protein 1
FCHO1
235Annotation score:
M0QXW2M0QXW2_HUMAN
F-BAR domain only protein 1
FCHO1
111Annotation score:
M0R107M0R107_HUMAN
F-BAR domain only protein 1
FCHO1
101Annotation score:
M0R2J7M0R2J7_HUMAN
F-BAR domain only protein 1
FCHO1
97Annotation score:
M0QZF0M0QZF0_HUMAN
F-BAR domain only protein 1
FCHO1
92Annotation score:
There are more potential isoformsShow all

Sequence cautioni

The sequence BAA22959 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0469061 – 50Missing in isoform 3. 1 PublicationAdd BLAST50
Alternative sequenceiVSP_022338883 – 889GMYLVSC → AAPPQG in isoform 2. 1 Publication7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006628 mRNA Translation: BAA22959.1 Different initiation.
AK291410 mRNA Translation: BAF84099.1
AK303623 mRNA Translation: BAG64632.1
AC008761 Genomic DNA No translation available.
CH471106 Genomic DNA Translation: EAW84629.1
BC028021 mRNA Translation: AAH28021.1
BC041130 mRNA Translation: AAH41130.1
CCDSiCCDS32955.1 [O14526-1]
CCDS59366.1 [O14526-3]
PIRiT00039
RefSeqiNP_001154829.1, NM_001161357.1
NP_001154830.1, NM_001161358.1 [O14526-1]
NP_001154831.1, NM_001161359.1 [O14526-3]
NP_055937.1, NM_015122.2 [O14526-1]
XP_006722764.1, XM_006722701.3 [O14526-1]
XP_006722765.1, XM_006722702.3 [O14526-1]
XP_011526126.1, XM_011527824.2 [O14526-1]
XP_011526127.1, XM_011527825.2 [O14526-1]
XP_011526128.1, XM_011527826.2 [O14526-1]
XP_011526130.1, XM_011527828.2 [O14526-1]
XP_016882008.1, XM_017026519.1 [O14526-1]
XP_016882009.1, XM_017026520.1 [O14526-1]
XP_016882010.1, XM_017026521.1 [O14526-1]
UniGeneiHs.96485

Genome annotation databases

EnsembliENST00000252771; ENSP00000252771; ENSG00000130475 [O14526-1]
ENST00000595033; ENSP00000472668; ENSG00000130475 [O14526-3]
ENST00000596536; ENSP00000470731; ENSG00000130475 [O14526-1]
ENST00000596951; ENSP00000472417; ENSG00000130475 [O14526-1]
ENST00000600676; ENSP00000470493; ENSG00000130475 [O14526-1]
GeneIDi23149
KEGGihsa:23149
UCSCiuc010ebb.3 human [O14526-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006628 mRNA Translation: BAA22959.1 Different initiation.
AK291410 mRNA Translation: BAF84099.1
AK303623 mRNA Translation: BAG64632.1
AC008761 Genomic DNA No translation available.
CH471106 Genomic DNA Translation: EAW84629.1
BC028021 mRNA Translation: AAH28021.1
BC041130 mRNA Translation: AAH41130.1
CCDSiCCDS32955.1 [O14526-1]
CCDS59366.1 [O14526-3]
PIRiT00039
RefSeqiNP_001154829.1, NM_001161357.1
NP_001154830.1, NM_001161358.1 [O14526-1]
NP_001154831.1, NM_001161359.1 [O14526-3]
NP_055937.1, NM_015122.2 [O14526-1]
XP_006722764.1, XM_006722701.3 [O14526-1]
XP_006722765.1, XM_006722702.3 [O14526-1]
XP_011526126.1, XM_011527824.2 [O14526-1]
XP_011526127.1, XM_011527825.2 [O14526-1]
XP_011526128.1, XM_011527826.2 [O14526-1]
XP_011526130.1, XM_011527828.2 [O14526-1]
XP_016882008.1, XM_017026519.1 [O14526-1]
XP_016882009.1, XM_017026520.1 [O14526-1]
XP_016882010.1, XM_017026521.1 [O14526-1]
UniGeneiHs.96485

3D structure databases

ProteinModelPortaliO14526
SMRiO14526
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116764, 18 interactors
IntActiO14526, 7 interactors
MINTiO14526
STRINGi9606.ENSP00000252771

PTM databases

iPTMnetiO14526
PhosphoSitePlusiO14526

Polymorphism and mutation databases

BioMutaiFCHO1

Proteomic databases

EPDiO14526
MaxQBiO14526
PaxDbiO14526
PeptideAtlasiO14526
PRIDEiO14526
ProteomicsDBi48073
48074 [O14526-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000252771; ENSP00000252771; ENSG00000130475 [O14526-1]
ENST00000595033; ENSP00000472668; ENSG00000130475 [O14526-3]
ENST00000596536; ENSP00000470731; ENSG00000130475 [O14526-1]
ENST00000596951; ENSP00000472417; ENSG00000130475 [O14526-1]
ENST00000600676; ENSP00000470493; ENSG00000130475 [O14526-1]
GeneIDi23149
KEGGihsa:23149
UCSCiuc010ebb.3 human [O14526-1]

Organism-specific databases

CTDi23149
EuPathDBiHostDB:ENSG00000130475.14
GeneCardsiFCHO1
HGNCiHGNC:29002 FCHO1
HPAiHPA041653
HPA062981
MIMi613437 gene
neXtProtiNX_O14526
OpenTargetsiENSG00000130475
PharmGKBiPA134870625
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2398 Eukaryota
ENOG410Y7RY LUCA
GeneTreeiENSGT00930000150876
HOGENOMiHOG000231544
HOVERGENiHBG081524
InParanoidiO14526
KOiK20042
PhylomeDBiO14526
TreeFamiTF328986

Enzyme and pathway databases

ReactomeiR-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis

Miscellaneous databases

ChiTaRSiFCHO1 human
GenomeRNAii23149
PROiPR:O14526
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000130475 Expressed in 141 organ(s), highest expression level in frontal cortex
CleanExiHS_FCHO1
ExpressionAtlasiO14526 baseline and differential
GenevisibleiO14526 HS

Family and domain databases

Gene3Di1.20.1270.60, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR031160 F_BAR
IPR001060 FCH_dom
IPR030121 FCHo1
IPR028565 MHD
IPR018808 Muniscin_C
PANTHERiPTHR23065:SF6 PTHR23065:SF6, 1 hit
PfamiView protein in Pfam
PF00611 FCH, 1 hit
PF10291 muHD, 1 hit
SMARTiView protein in SMART
SM00055 FCH, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
PROSITEiView protein in PROSITE
PS51741 F_BAR, 1 hit
PS51072 MHD, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFCHO1_HUMAN
AccessioniPrimary (citable) accession number: O14526
Secondary accession number(s): A6NHE6
, A8K5U5, B4E120, Q05C93, Q8IW22
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 9, 2007
Last modified: November 7, 2018
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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