UniProtKB - O14526 (FCHO1_HUMAN)
F-BAR domain only protein 1
FCHO1
Functioni
GO - Molecular functioni
- AP-2 adaptor complex binding Source: MGI
- cytoskeletal protein binding Source: GO_Central
GO - Biological processi
- clathrin coat assembly Source: UniProtKB
- clathrin-dependent endocytosis Source: UniProtKB
- membrane organization Source: Reactome
Keywordsi
Biological process | Endocytosis |
Enzyme and pathway databases
PathwayCommonsi | O14526 |
Reactomei | R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis R-HSA-8856828, Clathrin-mediated endocytosis |
SIGNORi | O14526 |
Names & Taxonomyi
Protein namesi | Recommended name: F-BAR domain only protein 1 |
Gene namesi | Name:FCHO1 Synonyms:KIAA0290 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:29002, FCHO1 |
MIMi | 613437, gene |
neXtProti | NX_O14526 |
VEuPathDBi | HostDB:ENSG00000130475.14 |
Subcellular locationi
Other locations
- clathrin-coated pit 2 Publications; Peripheral membrane protein 2 Publications; Cytoplasmic side 2 Publications
Note: Associated with forming but not mature clathrin-coated vesicles. The recruitment to coated-pits precede the one of clathrin and the adaptor protein complex AP-2. According to PubMed:17617719 it may also dynamically associate with Golgi/TGN membranes.
Cytoskeleton
- cytoskeleton Source: GO_Central
Cytosol
- cytosol Source: HPA
Nucleus
- nucleoplasm Source: HPA
Plasma Membrane
- clathrin-coated pit Source: ParkinsonsUK-UCL
- plasma membrane Source: UniProtKB
Other locations
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
Coated pit, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 23149 |
OpenTargetsi | ENSG00000130475 |
PharmGKBi | PA134870625 |
Miscellaneous databases
Pharosi | O14526, Tbio |
Genetic variation databases
BioMutai | FCHO1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000271759 | 1 – 889 | F-BAR domain only protein 1Add BLAST | 889 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 295 | PhosphoserineCombined sources | 1 | |
Modified residuei | 347 | PhosphoserineCombined sources | 1 | |
Modified residuei | 372 | PhosphoserineCombined sources | 1 | |
Modified residuei | 530 | PhosphoserineBy similarity | 1 | |
Modified residuei | 616 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | O14526 |
jPOSTi | O14526 |
MassIVEi | O14526 |
MaxQBi | O14526 |
PaxDbi | O14526 |
PeptideAtlasi | O14526 |
PRIDEi | O14526 |
ProteomicsDBi | 48073 [O14526-1] 48074 [O14526-2] |
PTM databases
iPTMneti | O14526 |
MetOSitei | O14526 |
PhosphoSitePlusi | O14526 |
Expressioni
Gene expression databases
Bgeei | ENSG00000130475, Expressed in frontal cortex and 163 other tissues |
ExpressionAtlasi | O14526, baseline and differential |
Genevisiblei | O14526, HS |
Organism-specific databases
HPAi | ENSG00000130475, Group enriched (blood, bone marrow, brain, lymphoid tissue, skin) |
Interactioni
Subunit structurei
May oligomerize and form homotetramer (By similarity).
Interacts with AP2A2 and AP2B1; 2 subunits of the adaptor protein complex AP-2.
Interacts with DAB2.
Interacts with clathrin (CLTC or CLTCL1).
Interacts with EPS15, EPS15R and ITSN1.
Interacts with AGFG1 and CALM. May interact with ACVR1; linking this receptor to clathrin-mediated endocytosis.
By similarity1 PublicationBinary interactionsi
Hide detailsO14526
With | #Exp. | IntAct |
---|---|---|
EXOSC5 [Q9NQT4] | 4 | EBI-719823,EBI-371876 |
LGALS14 [Q8TCE9] | 4 | EBI-719823,EBI-10274069 |
PTK6 [Q13882] | 4 | EBI-719823,EBI-1383632 |
A7BFV9 from Rattus norvegicus. | 2 | EBI-719823,EBI-6095043 |
GO - Molecular functioni
- cytoskeletal protein binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 116764, 61 interactors |
IntActi | O14526, 17 interactors |
MINTi | O14526 |
STRINGi | 9606.ENSP00000473001 |
Miscellaneous databases
RNActi | O14526, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 248 | F-BARPROSITE-ProRule annotationAdd BLAST | 248 | |
Domaini | 625 – 888 | MHDPROSITE-ProRule annotationAdd BLAST | 264 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 275 | Mediates membrane-bindingAdd BLAST | 275 | |
Regioni | 267 – 442 | Mediates interaction with the adaptor protein complex AP-2Add BLAST | 176 | |
Regioni | 609 – 889 | Mediates interaction with AGFG1, CALM, DAB2, EPS15, EPS15R, ITSN1 and clathrin1 PublicationAdd BLAST | 281 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 156 – 195 | Sequence analysisAdd BLAST | 40 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 375 – 378 | Poly-Ala | 4 | |
Compositional biasi | 465 – 468 | Poly-Ser | 4 | |
Compositional biasi | 480 – 561 | Pro-richAdd BLAST | 82 | |
Compositional biasi | 671 – 674 | Poly-Pro | 4 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG2398, Eukaryota |
GeneTreei | ENSGT00940000160489 |
HOGENOMi | CLU_007107_0_0_1 |
InParanoidi | O14526 |
OrthoDBi | 638761at2759 |
PhylomeDBi | O14526 |
TreeFami | TF328986 |
Family and domain databases
CDDi | cd07674, F-BAR_FCHO1, 1 hit |
Gene3Di | 1.20.1270.60, 1 hit |
InterProi | View protein in InterPro IPR027267, AH/BAR_dom_sf IPR031160, F_BAR IPR001060, FCH_dom IPR030121, FCHo1 IPR042735, FCHo1_F-BAR IPR028565, MHD IPR018808, Muniscin_C |
PANTHERi | PTHR23065:SF6, PTHR23065:SF6, 1 hit |
Pfami | View protein in Pfam PF00611, FCH, 1 hit PF10291, muHD, 1 hit |
SMARTi | View protein in SMART SM00055, FCH, 1 hit |
SUPFAMi | SSF103657, SSF103657, 1 hit |
PROSITEi | View protein in PROSITE PS51741, F_BAR, 1 hit PS51072, MHD, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 19 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSYFGEHFWG EKNHGFEVLY HSVKQGPIST KELADFIRER ATIEETYSKA
60 70 80 90 100
MAKLSKLASN GTPMGTFAPL WEVFRVSSDK LALCHLELTR KLQDLIKDVL
110 120 130 140 150
RYGEEQLKTH KKCKEEVVST LDAVQVLSGV SQLLPKSREN YLNRCMDQER
160 170 180 190 200
LRRESTSQKE MDKAETKTKK AAESLRRSVE KYNSARADFE QKMLDSALRF
210 220 230 240 250
QAMEETHLRH MKALLGSYAH SVEDTHVQIG QVHEEFKQNI ENVSVEMLLR
260 270 280 290 300
KFAESKGTGR EKPGPLDFEA YSAAALQEAM KRLRGAKAFR LPGLSRRERE
310 320 330 340 350
PEPPAAVDFL EPDSGTCPEV DEEGFTVRPD VTQNSTAEPS RFSSSDSDFD
360 370 380 390 400
DEEPRKFYVH IKPAPARAPA CSPEAAAAQL RATAGSLILP PGPGGTMKRH
410 420 430 440 450
SSRDAAGKPQ RPRSAPRTSS CAERLQSEEQ VSKNLFGPPL ESAFDHEDFT
460 470 480 490 500
GSSSLGFTSS PSPFSSSSPE NVEDSGLDSP SHAAPGPSPD SWVPRPGTPQ
510 520 530 540 550
SPPSCRAPPP EARGIRAPPL PDSPQPLASS PGPWGLEALA GGDLMPAPAD
560 570 580 590 600
PTAREGLAAP PRRLRSRKVS CPLTRSNGDL SRSLSPSPLG SSAASTALER
610 620 630 640 650
PSFLSQTGHG VSRGPSPVVL GSQDALPIAT AFTEYVHAYF RGHSPSCLAR
660 670 680 690 700
VTGELTMTFP AGIVRVFSGT PPPPVLSFRL VHTTAIEHFQ PNADLLFSDP
710 720 730 740 750
SQSDPETKDF WLNMAALTEA LQRQAEQNPT ASYYNVVLLR YQFSRPGPQS
760 770 780 790 800
VPLQLSAHWQ CGATLTQVSV EYGYRPGATA VPTPLTNVQI LLPVGEPVTN
810 820 830 840 850
VRLQPAATWN LEEKRLTWRL PDVSEAGGSG RLSASWEPLS GPSTPSPVAA
860 870 880
QFTSEGTTLS GVDLELVGSG YRMSLVKRRF ATGMYLVSC
Computationally mapped potential isoform sequencesi
There are 19 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0C3SFZ9 | A0A0C3SFZ9_HUMAN | F-BAR domain only protein 1 | FCHO1 hCG_2000568 | 891 | Annotation score: | ||
M0QZI3 | M0QZI3_HUMAN | F-BAR domain only protein 1 | FCHO1 | 896 | Annotation score: | ||
M0R3E5 | M0R3E5_HUMAN | F-BAR domain only protein 1 | FCHO1 | 218 | Annotation score: | ||
M0QZI9 | M0QZI9_HUMAN | F-BAR domain only protein 1 | FCHO1 | 235 | Annotation score: | ||
M0R1K4 | M0R1K4_HUMAN | F-BAR domain only protein 1 | FCHO1 | 264 | Annotation score: | ||
M0QXD1 | M0QXD1_HUMAN | F-BAR domain only protein 1 | FCHO1 | 175 | Annotation score: | ||
M0R3E7 | M0R3E7_HUMAN | F-BAR domain only protein 1 | FCHO1 | 185 | Annotation score: | ||
M0QZE1 | M0QZE1_HUMAN | F-BAR domain only protein 1 | FCHO1 | 134 | Annotation score: | ||
M0R107 | M0R107_HUMAN | F-BAR domain only protein 1 | FCHO1 | 101 | Annotation score: | ||
M0QXW2 | M0QXW2_HUMAN | F-BAR domain only protein 1 | FCHO1 | 111 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence cautioni
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_046906 | 1 – 50 | Missing in isoform 3. 1 PublicationAdd BLAST | 50 | |
Alternative sequenceiVSP_022338 | 883 – 889 | GMYLVSC → AAPPQG in isoform 2. 1 Publication | 7 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB006628 mRNA Translation: BAA22959.1 Different initiation. AK291410 mRNA Translation: BAF84099.1 AK303623 mRNA Translation: BAG64632.1 AC008761 Genomic DNA No translation available. CH471106 Genomic DNA Translation: EAW84629.1 BC028021 mRNA Translation: AAH28021.1 BC041130 mRNA Translation: AAH41130.1 |
CCDSi | CCDS32955.1 [O14526-1] CCDS59366.1 [O14526-3] |
PIRi | T00039 |
RefSeqi | NP_001154829.1, NM_001161357.1 NP_001154830.1, NM_001161358.1 [O14526-1] NP_001154831.1, NM_001161359.1 [O14526-3] NP_055937.1, NM_015122.2 [O14526-1] XP_006722764.1, XM_006722701.3 XP_006722765.1, XM_006722702.3 XP_011526126.1, XM_011527824.2 XP_011526127.1, XM_011527825.2 [O14526-1] XP_011526128.1, XM_011527826.2 XP_011526130.1, XM_011527828.2 XP_016882008.1, XM_017026519.1 XP_016882009.1, XM_017026520.1 XP_016882010.1, XM_017026521.1 |
Genome annotation databases
Ensembli | ENST00000252771; ENSP00000252771; ENSG00000130475 [O14526-1] ENST00000595033; ENSP00000472668; ENSG00000130475 [O14526-3] ENST00000596536; ENSP00000470731; ENSG00000130475 [O14526-1] ENST00000596951; ENSP00000472417; ENSG00000130475 [O14526-1] ENST00000600676; ENSP00000470493; ENSG00000130475 [O14526-1] |
GeneIDi | 23149 |
KEGGi | hsa:23149 |
UCSCi | uc010ebb.3, human [O14526-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB006628 mRNA Translation: BAA22959.1 Different initiation. AK291410 mRNA Translation: BAF84099.1 AK303623 mRNA Translation: BAG64632.1 AC008761 Genomic DNA No translation available. CH471106 Genomic DNA Translation: EAW84629.1 BC028021 mRNA Translation: AAH28021.1 BC041130 mRNA Translation: AAH41130.1 |
CCDSi | CCDS32955.1 [O14526-1] CCDS59366.1 [O14526-3] |
PIRi | T00039 |
RefSeqi | NP_001154829.1, NM_001161357.1 NP_001154830.1, NM_001161358.1 [O14526-1] NP_001154831.1, NM_001161359.1 [O14526-3] NP_055937.1, NM_015122.2 [O14526-1] XP_006722764.1, XM_006722701.3 XP_006722765.1, XM_006722702.3 XP_011526126.1, XM_011527824.2 XP_011526127.1, XM_011527825.2 [O14526-1] XP_011526128.1, XM_011527826.2 XP_011526130.1, XM_011527828.2 XP_016882008.1, XM_017026519.1 XP_016882009.1, XM_017026520.1 XP_016882010.1, XM_017026521.1 |
3D structure databases
SMRi | O14526 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 116764, 61 interactors |
IntActi | O14526, 17 interactors |
MINTi | O14526 |
STRINGi | 9606.ENSP00000473001 |
PTM databases
iPTMneti | O14526 |
MetOSitei | O14526 |
PhosphoSitePlusi | O14526 |
Genetic variation databases
BioMutai | FCHO1 |
Proteomic databases
EPDi | O14526 |
jPOSTi | O14526 |
MassIVEi | O14526 |
MaxQBi | O14526 |
PaxDbi | O14526 |
PeptideAtlasi | O14526 |
PRIDEi | O14526 |
ProteomicsDBi | 48073 [O14526-1] 48074 [O14526-2] |
Protocols and materials databases
Antibodypediai | 27790, 106 antibodies |
Genome annotation databases
Ensembli | ENST00000252771; ENSP00000252771; ENSG00000130475 [O14526-1] ENST00000595033; ENSP00000472668; ENSG00000130475 [O14526-3] ENST00000596536; ENSP00000470731; ENSG00000130475 [O14526-1] ENST00000596951; ENSP00000472417; ENSG00000130475 [O14526-1] ENST00000600676; ENSP00000470493; ENSG00000130475 [O14526-1] |
GeneIDi | 23149 |
KEGGi | hsa:23149 |
UCSCi | uc010ebb.3, human [O14526-1] |
Organism-specific databases
CTDi | 23149 |
DisGeNETi | 23149 |
GeneCardsi | FCHO1 |
HGNCi | HGNC:29002, FCHO1 |
HPAi | ENSG00000130475, Group enriched (blood, bone marrow, brain, lymphoid tissue, skin) |
MIMi | 613437, gene |
neXtProti | NX_O14526 |
OpenTargetsi | ENSG00000130475 |
PharmGKBi | PA134870625 |
VEuPathDBi | HostDB:ENSG00000130475.14 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2398, Eukaryota |
GeneTreei | ENSGT00940000160489 |
HOGENOMi | CLU_007107_0_0_1 |
InParanoidi | O14526 |
OrthoDBi | 638761at2759 |
PhylomeDBi | O14526 |
TreeFami | TF328986 |
Enzyme and pathway databases
PathwayCommonsi | O14526 |
Reactomei | R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis R-HSA-8856828, Clathrin-mediated endocytosis |
SIGNORi | O14526 |
Miscellaneous databases
BioGRID-ORCSi | 23149, 11 hits in 872 CRISPR screens |
ChiTaRSi | FCHO1, human |
GenomeRNAii | 23149 |
Pharosi | O14526, Tbio |
PROi | PR:O14526 |
RNActi | O14526, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000130475, Expressed in frontal cortex and 163 other tissues |
ExpressionAtlasi | O14526, baseline and differential |
Genevisiblei | O14526, HS |
Family and domain databases
CDDi | cd07674, F-BAR_FCHO1, 1 hit |
Gene3Di | 1.20.1270.60, 1 hit |
InterProi | View protein in InterPro IPR027267, AH/BAR_dom_sf IPR031160, F_BAR IPR001060, FCH_dom IPR030121, FCHo1 IPR042735, FCHo1_F-BAR IPR028565, MHD IPR018808, Muniscin_C |
PANTHERi | PTHR23065:SF6, PTHR23065:SF6, 1 hit |
Pfami | View protein in Pfam PF00611, FCH, 1 hit PF10291, muHD, 1 hit |
SMARTi | View protein in SMART SM00055, FCH, 1 hit |
SUPFAMi | SSF103657, SSF103657, 1 hit |
PROSITEi | View protein in PROSITE PS51741, F_BAR, 1 hit PS51072, MHD, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FCHO1_HUMAN | |
Accessioni | O14526Primary (citable) accession number: O14526 Secondary accession number(s): A6NHE6 Q8IW22 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 9, 2007 |
Last sequence update: | January 9, 2007 | |
Last modified: | February 10, 2021 | |
This is version 146 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families