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UniProtKB - O14526 (FCHO1_HUMAN)

Entry version 141 (22 Apr 2020)
Sequence version 2 (09 Jan 2007)
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Protein

F-BAR domain only protein 1

Gene

FCHO1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processEndocytosis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
F-BAR domain only protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FCHO1
Synonyms:KIAA0290
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:29002 FCHO1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		613437 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O14526

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Coated pit, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		23149

Open Targets

More...OpenTargetsi		ENSG00000130475

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134870625

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O14526 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		FCHO1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002717591 – 889F-BAR domain only protein 1Add BLAST889

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei295PhosphoserineCombined sources1
Modified residuei347PhosphoserineCombined sources1
Modified residuei372PhosphoserineCombined sources1
Modified residuei530PhosphoserineBy similarity1
Modified residuei616PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O14526

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O14526

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O14526

MaxQB - The MaxQuant DataBase

More...MaxQBi		O14526

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O14526

PeptideAtlas

More...PeptideAtlasi		O14526

PRoteomics IDEntifications database

More...PRIDEi		O14526

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		48073 [O14526-1]
48074 [O14526-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O14526

MetOSite database of methionine sulfoxide sites

More...MetOSitei		O14526

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O14526

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000130475 Expressed in frontal cortex and 140 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O14526 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O14526 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000130475 Group enriched (blood, bone marrow, brain, lymphoid tissue, skin)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May oligomerize and form homotetramer (By similarity).

Interacts with AP2A2 and AP2B1; 2 subunits of the adaptor protein complex AP-2.

Interacts with DAB2.

Interacts with clathrin (CLTC or CLTCL1).

Interacts with EPS15, EPS15R and ITSN1.

Interacts with AGFG1 and CALM. May interact with ACVR1; linking this receptor to clathrin-mediated endocytosis.

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		116764, 26 interactors

Protein interaction database and analysis system

More...IntActi		O14526, 17 interactors

Molecular INTeraction database

More...MINTi		O14526

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000473001

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O14526 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O14526

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 248F-BARPROSITE-ProRule annotationAdd BLAST248
Domaini625 – 888MHDPROSITE-ProRule annotationAdd BLAST264

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 275Mediates membrane-bindingAdd BLAST275
Regioni267 – 442Mediates interaction with the adaptor protein complex AP-2Add BLAST176
Regioni609 – 889Mediates interaction with AGFG1, CALM, DAB2, EPS15, EPS15R, ITSN1 and clathrin1 PublicationAdd BLAST281

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili156 – 195Sequence analysisAdd BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi375 – 378Poly-Ala4
Compositional biasi465 – 468Poly-Ser4
Compositional biasi480 – 561Pro-richAdd BLAST82
Compositional biasi671 – 674Poly-Pro4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FCHO family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2398 Eukaryota
ENOG410Y7RY LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160489

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_007107_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O14526

KEGG Orthology (KO)

More...KOi		K20042

Database of Orthologous Groups

More...OrthoDBi		638761at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O14526

TreeFam database of animal gene trees

More...TreeFami		TF328986

Family and domain databases

Conserved Domains Database

More...CDDi		cd07674 F-BAR_FCHO1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.1270.60, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR031160 F_BAR
IPR001060 FCH_dom
IPR030121 FCHo1
IPR042735 FCHo1_F-BAR
IPR028565 MHD
IPR018808 Muniscin_C

The PANTHER Classification System

More...PANTHERi		PTHR23065:SF6 PTHR23065:SF6, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00611 FCH, 1 hit
PF10291 muHD, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00055 FCH, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF103657 SSF103657, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51741 F_BAR, 1 hit
PS51072 MHD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 19 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O14526-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSYFGEHFWG EKNHGFEVLY HSVKQGPIST KELADFIRER ATIEETYSKA 
        60         70         80         90        100
MAKLSKLASN GTPMGTFAPL WEVFRVSSDK LALCHLELTR KLQDLIKDVL 
       110        120        130        140        150
RYGEEQLKTH KKCKEEVVST LDAVQVLSGV SQLLPKSREN YLNRCMDQER 
       160        170        180        190        200
LRRESTSQKE MDKAETKTKK AAESLRRSVE KYNSARADFE QKMLDSALRF 
       210        220        230        240        250
QAMEETHLRH MKALLGSYAH SVEDTHVQIG QVHEEFKQNI ENVSVEMLLR 
       260        270        280        290        300
KFAESKGTGR EKPGPLDFEA YSAAALQEAM KRLRGAKAFR LPGLSRRERE 
       310        320        330        340        350
PEPPAAVDFL EPDSGTCPEV DEEGFTVRPD VTQNSTAEPS RFSSSDSDFD 
       360        370        380        390        400
DEEPRKFYVH IKPAPARAPA CSPEAAAAQL RATAGSLILP PGPGGTMKRH 
       410        420        430        440        450
SSRDAAGKPQ RPRSAPRTSS CAERLQSEEQ VSKNLFGPPL ESAFDHEDFT 
       460        470        480        490        500
GSSSLGFTSS PSPFSSSSPE NVEDSGLDSP SHAAPGPSPD SWVPRPGTPQ 
       510        520        530        540        550
SPPSCRAPPP EARGIRAPPL PDSPQPLASS PGPWGLEALA GGDLMPAPAD 
       560        570        580        590        600
PTAREGLAAP PRRLRSRKVS CPLTRSNGDL SRSLSPSPLG SSAASTALER 
       610        620        630        640        650
PSFLSQTGHG VSRGPSPVVL GSQDALPIAT AFTEYVHAYF RGHSPSCLAR 
       660        670        680        690        700
VTGELTMTFP AGIVRVFSGT PPPPVLSFRL VHTTAIEHFQ PNADLLFSDP 
       710        720        730        740        750
SQSDPETKDF WLNMAALTEA LQRQAEQNPT ASYYNVVLLR YQFSRPGPQS 
       760        770        780        790        800
VPLQLSAHWQ CGATLTQVSV EYGYRPGATA VPTPLTNVQI LLPVGEPVTN 
       810        820        830        840        850
VRLQPAATWN LEEKRLTWRL PDVSEAGGSG RLSASWEPLS GPSTPSPVAA 
       860        870        880 
QFTSEGTTLS GVDLELVGSG YRMSLVKRRF ATGMYLVSC
Length:889
Mass (Da):96,861
Last modified:January 9, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8CDA1F24F42256D2
GO
Isoform 2 (identifier: O14526-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     883-889: GMYLVSC → AAPPQG

Show »
Length:888
Mass (Da):96,629
Checksum:i27DB24B8191372A9
GO
Isoform 3 (identifier: O14526-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-50: Missing.

Show »
Length:839
Mass (Da):91,013
Checksum:i4CC94A2046D108CE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 19 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C3SFZ9A0A0C3SFZ9_HUMAN
F-BAR domain only protein 1
FCHO1 hCG_2000568
891Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QZI3M0QZI3_HUMAN
F-BAR domain only protein 1
FCHO1
896Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R3E5M0R3E5_HUMAN
F-BAR domain only protein 1
FCHO1
218Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R1K4M0R1K4_HUMAN
F-BAR domain only protein 1
FCHO1
264Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QZI9M0QZI9_HUMAN
F-BAR domain only protein 1
FCHO1
235Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QXD1M0QXD1_HUMAN
F-BAR domain only protein 1
FCHO1
175Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R3E7M0R3E7_HUMAN
F-BAR domain only protein 1
FCHO1
185Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QZE1M0QZE1_HUMAN
F-BAR domain only protein 1
FCHO1
134Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R107M0R107_HUMAN
F-BAR domain only protein 1
FCHO1
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QXW2M0QXW2_HUMAN
F-BAR domain only protein 1
FCHO1
111Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA22959 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0469061 – 50Missing in isoform 3. 1 PublicationAdd BLAST50
Alternative sequenceiVSP_022338883 – 889GMYLVSC → AAPPQG in isoform 2. 1 Publication7

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB006628 mRNA Translation: BAA22959.1 Different initiation.
AK291410 mRNA Translation: BAF84099.1
AK303623 mRNA Translation: BAG64632.1
AC008761 Genomic DNA No translation available.
CH471106 Genomic DNA Translation: EAW84629.1
BC028021 mRNA Translation: AAH28021.1
BC041130 mRNA Translation: AAH41130.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS32955.1 [O14526-1]
CCDS59366.1 [O14526-3]

Protein sequence database of the Protein Information Resource

More...PIRi		T00039

NCBI Reference Sequences

More...RefSeqi		NP_001154829.1, NM_001161357.1
NP_001154830.1, NM_001161358.1 [O14526-1]
NP_001154831.1, NM_001161359.1 [O14526-3]
NP_055937.1, NM_015122.2 [O14526-1]
XP_006722764.1, XM_006722701.3 [O14526-1]
XP_006722765.1, XM_006722702.3 [O14526-1]
XP_011526126.1, XM_011527824.2 [O14526-1]
XP_011526127.1, XM_011527825.2 [O14526-1]
XP_011526128.1, XM_011527826.2 [O14526-1]
XP_011526130.1, XM_011527828.2 [O14526-1]
XP_016882008.1, XM_017026519.1 [O14526-1]
XP_016882009.1, XM_017026520.1 [O14526-1]
XP_016882010.1, XM_017026521.1 [O14526-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000252771; ENSP00000252771; ENSG00000130475 [O14526-1]
ENST00000595033; ENSP00000472668; ENSG00000130475 [O14526-3]
ENST00000596536; ENSP00000470731; ENSG00000130475 [O14526-1]
ENST00000596951; ENSP00000472417; ENSG00000130475 [O14526-1]
ENST00000600676; ENSP00000470493; ENSG00000130475 [O14526-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		23149

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:23149

UCSC genome browser

More...UCSCi		uc010ebb.3 human [O14526-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006628 mRNA Translation: BAA22959.1 Different initiation.
AK291410 mRNA Translation: BAF84099.1
AK303623 mRNA Translation: BAG64632.1
AC008761 Genomic DNA No translation available.
CH471106 Genomic DNA Translation: EAW84629.1
BC028021 mRNA Translation: AAH28021.1
BC041130 mRNA Translation: AAH41130.1
CCDSiCCDS32955.1 [O14526-1]
CCDS59366.1 [O14526-3]
PIRiT00039
RefSeqiNP_001154829.1, NM_001161357.1
NP_001154830.1, NM_001161358.1 [O14526-1]
NP_001154831.1, NM_001161359.1 [O14526-3]
NP_055937.1, NM_015122.2 [O14526-1]
XP_006722764.1, XM_006722701.3 [O14526-1]
XP_006722765.1, XM_006722702.3 [O14526-1]
XP_011526126.1, XM_011527824.2 [O14526-1]
XP_011526127.1, XM_011527825.2 [O14526-1]
XP_011526128.1, XM_011527826.2 [O14526-1]
XP_011526130.1, XM_011527828.2 [O14526-1]
XP_016882008.1, XM_017026519.1 [O14526-1]
XP_016882009.1, XM_017026520.1 [O14526-1]
XP_016882010.1, XM_017026521.1 [O14526-1]

3D structure databases

SMRiO14526
ModBaseiSearch...

Protein-protein interaction databases

BioGridi116764, 26 interactors
IntActiO14526, 17 interactors
MINTiO14526
STRINGi9606.ENSP00000473001

PTM databases

iPTMnetiO14526
MetOSiteiO14526
PhosphoSitePlusiO14526

Polymorphism and mutation databases

BioMutaiFCHO1

Proteomic databases

EPDiO14526
jPOSTiO14526
MassIVEiO14526
MaxQBiO14526
PaxDbiO14526
PeptideAtlasiO14526
PRIDEiO14526
ProteomicsDBi48073 [O14526-1]
48074 [O14526-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		27790 103 antibodies

Genome annotation databases

EnsembliENST00000252771; ENSP00000252771; ENSG00000130475 [O14526-1]
ENST00000595033; ENSP00000472668; ENSG00000130475 [O14526-3]
ENST00000596536; ENSP00000470731; ENSG00000130475 [O14526-1]
ENST00000596951; ENSP00000472417; ENSG00000130475 [O14526-1]
ENST00000600676; ENSP00000470493; ENSG00000130475 [O14526-1]
GeneIDi23149
KEGGihsa:23149
UCSCiuc010ebb.3 human [O14526-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		23149
DisGeNETi23149

GeneCards: human genes, protein and diseases

More...GeneCardsi		FCHO1
HGNCiHGNC:29002 FCHO1
HPAiENSG00000130475 Group enriched (blood, bone marrow, brain, lymphoid tissue, skin)
MIMi613437 gene
neXtProtiNX_O14526
OpenTargetsiENSG00000130475
PharmGKBiPA134870625

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2398 Eukaryota
ENOG410Y7RY LUCA
GeneTreeiENSGT00940000160489
HOGENOMiCLU_007107_0_0_1
InParanoidiO14526
KOiK20042
OrthoDBi638761at2759
PhylomeDBiO14526
TreeFamiTF328986

Enzyme and pathway databases

ReactomeiR-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		FCHO1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		23149
PharosiO14526 Tbio

Protein Ontology

More...PROi		PR:O14526
RNActiO14526 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000130475 Expressed in frontal cortex and 140 other tissues
ExpressionAtlasiO14526 baseline and differential
GenevisibleiO14526 HS

Family and domain databases

CDDicd07674 F-BAR_FCHO1, 1 hit
Gene3Di1.20.1270.60, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR031160 F_BAR
IPR001060 FCH_dom
IPR030121 FCHo1
IPR042735 FCHo1_F-BAR
IPR028565 MHD
IPR018808 Muniscin_C
PANTHERiPTHR23065:SF6 PTHR23065:SF6, 1 hit
PfamiView protein in Pfam
PF00611 FCH, 1 hit
PF10291 muHD, 1 hit
SMARTiView protein in SMART
SM00055 FCH, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
PROSITEiView protein in PROSITE
PS51741 F_BAR, 1 hit
PS51072 MHD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFCHO1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O14526
Secondary accession number(s): A6NHE6
, A8K5U5, B4E120, Q05C93, Q8IW22
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 9, 2007
Last modified: April 22, 2020
This is version 141 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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