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Entry version 168 (08 May 2019)
Sequence version 3 (10 May 2005)
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Protein

Astrotactin-1

Gene

ASTN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Neuronal adhesion molecule that is required for normal migration of young postmitotic neuroblasts along glial fibers, especially in the cerebellum. Required for normal rate of migration of granule cells during brain development and for normal cerebellum development.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

Protein family/group databases

Transport Classification Database

More...
TCDBi
9.B.87.2.1 the selenoprotein p receptor (selp-receptor) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Astrotactin-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ASTN1
Synonyms:ASTN, KIAA0289
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:773 ASTN1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600904 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O14525

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini22 – 153ExtracellularCuratedAdd BLAST132
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei154 – 174HelicalSequence analysisAdd BLAST21
Topological domaini175 – 383CytoplasmicCuratedAdd BLAST209
Transmembranei384 – 402HelicalSequence analysisAdd BLAST19
Topological domaini403 – 1302ExtracellularBy similarityAdd BLAST900

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Endosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
460

Open Targets

More...
OpenTargetsi
ENSG00000152092

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162376961

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ASTN1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000748122 – 1302Astrotactin-1Add BLAST1281

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi115N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei227PhosphoserineBy similarity1
Modified residuei337Omega-N-methylarginineBy similarity1
Glycosylationi453N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi463 ↔ 475By similarity
Disulfide bondi471 ↔ 490By similarity
Disulfide bondi492 ↔ 506By similarity
Disulfide bondi612 ↔ 625By similarity
Disulfide bondi619 ↔ 636By similarity
Disulfide bondi638 ↔ 651By similarity
Disulfide bondi660 ↔ 672By similarity
Disulfide bondi668 ↔ 692By similarity
Disulfide bondi694 ↔ 707By similarity
Glycosylationi729N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi742N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi785 ↔ 951By similarity
Glycosylationi804N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi876 ↔ 941By similarity
Disulfide bondi947 ↔ 954By similarity
Glycosylationi984N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1000 ↔ 1011By similarity
Disulfide bondi1013 ↔ 1026By similarity
Disulfide bondi1101 ↔ 1121By similarity
Disulfide bondi1153 ↔ 1240By similarity
Disulfide bondi1261 ↔ 1284By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Methylation, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O14525

PeptideAtlas

More...
PeptideAtlasi
O14525

PRoteomics IDEntifications database

More...
PRIDEi
O14525

ProteomicsDB human proteome resource

More...
ProteomicsDBi
48071
48072 [O14525-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O14525

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O14525

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000152092 Expressed in 132 organ(s), highest expression level in entorhinal cortex

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O14525 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O14525 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA074112

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ASTN2; the interaction is not calcium-dependent.By similarity

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
O14525, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000354536

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O14525

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini459 – 507EGF-like 1Add BLAST49
Domaini608 – 652EGF-like 2Add BLAST45
Domaini656 – 708EGF-like 3Add BLAST53
Domaini1030 – 1145Fibronectin type-IIIAdd BLAST116

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the astrotactin family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IHIU Eukaryota
ENOG4110VB2 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000003140

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000034112

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O14525

Identification of Orthologs from Complete Genome Data

More...
OMAi
PEFLTGM

Database of Orthologous Groups

More...
OrthoDBi
39300at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O14525

TreeFam database of animal gene trees

More...
TreeFami
TF332034

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR040685 Annexin-like
IPR026995 Astrotactin
IPR000742 EGF-like_dom
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR020864 MACPF

The PANTHER Classification System

More...
PANTHERi
PTHR16592 PTHR16592, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF18411 Annexin_like, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 3 hits
SM00457 MACPF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265 SSF49265, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 2 (identifier: O14525-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALAGLCALL ACCWGPAAVL ATAAGDVDPS KELECKLKSI TVSALPFLRE
60 70 80 90 100
NDLSIMHSPS ASEPKLLFSV RNDFPGEMVV VDDLENTELP YFVLEISGNT
110 120 130 140 150
EDIPLVRWRQ QWLENGTLLF HIHHQDGAPS LPGQDPTEEP QHESAEEELR
160 170 180 190 200
ILHISVMGGM IALLLSILCL VMILYTRRRW CKRRRVPQPQ KSASAEAANE
210 220 230 240 250
IHYIPSVLIG GHGRESLRNA RVQGHNSSGT LSIRETPILD GYEYDITDLR
260 270 280 290 300
HHLQRECMNG GEDFASQVTR TLDSLQGCNE KSGMDLTPGS DNAKLSLMNK
310 320 330 340 350
YKDNIIATSP VDSNHQQATL LSHTSSSQRK RINNKARAGS AFLNPEGDSG
360 370 380 390 400
TEAENDPQLT FYTDPSRSRR RSRVGSPRSP VNKTTLTLIS ITSCVIGLVC
410 420 430 440 450
SSHVNCPLVV KITLHVPEHL IADGSRFILL EGSQLDASDW LNPAQVVLFS
460 470 480 490 500
QQNSSGPWAM DLCARRLLDP CEHQCDPETG RREHRAAGEC LCYEGYMKDP
510 520 530 540 550
VHKHLCIRNE WGTNQGPWPY TIFQRGFDLV LGEQPSDKIF RFTYTLGEGM
560 570 580 590 600
WLPLSKSFVI PPAELAINPS AKCKTDMTVM EDAVEVREEL MTSSSFDSLE
610 620 630 640 650
VLLDSFGPVR DCSKDNGGCS KNFRCISDRK LDSTGCVCPS GLSPMKDSSG
660 670 680 690 700
CYDRHIGVDC SDGFNGGCEQ LCLQQMAPFP DDPTLYNILM FCGCIEDYKL
710 720 730 740 750
GVDGRSCQLI TETCPEGSDC GESRELPMNQ TLFGEMFFGY NNHSKEVAAG
760 770 780 790 800
QVLKGTFRQN NFARGLDQQL PDGLVVATVP LENQCLEEIS EPTPDPDFLT
810 820 830 840 850
GMVNFSEVSG YPVLQHWKVR SVMYHIKLNQ VAISQALSNA LHSLDGATSR
860 870 880 890 900
ADFVALLDQF GNHYIQEAIY GFEESCSIWY PNKQVQRRLW LEYEDISKGN
910 920 930 940 950
SPSDESEERE RDPKVLTFPE YITSLSDSGT KHMAAGVRME CHSKGRCPSS
960 970 980 990 1000
CPLCHVTSSP DTPAEPVLLE VTKAAPIYEL VTNNQTQRLL QEATMSSLWC
1010 1020 1030 1040 1050
SGTGDVIEDW CRCDSTAFGA DGLPTCAPLP QPVLRLSTVH EPSSTLVVLE
1060 1070 1080 1090 1100
WEHSEPPIGV QIVDYLLRQE KVTDRMDHSK VETETVLSFV DDIISGAKSP
1110 1120 1130 1140 1150
CAMPSQVPDK QLTTISLIIR CLEPDTIYMF TLWGVDNTGR RSRPSDVIVK
1160 1170 1180 1190 1200
TPCPVVDDVK AQEIADKIYN LFNGYTSGKE QQTAYNTLLD LGSPTLHRVL
1210 1220 1230 1240 1250
YHYNQHYESF GEFTWRCEDE LGPRKAGLIL SQLGDLSSWC NGLLQEPKIS
1260 1270 1280 1290 1300
LRRSSLKYLG CRYSEIKPYG LDWAELSRDL RKTCEEQTLS IPYNDYGDSK

EI
Note: No experimental confirmation available.
Length:1,302
Mass (Da):144,913
Last modified:May 10, 2005 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCA9EDDA6621C4F3B
GO
Isoform 1 (identifier: O14525-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     480-487: Missing.

Show »
Length:1,294
Mass (Da):143,979
Checksum:iC38F3B239708FC9A
GO
Isoform 3 (identifier: O14525-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     480-487: Missing.
     1225-1302: Missing.

Show »
Length:1,216
Mass (Da):135,083
Checksum:i91B51202F5EF4EC7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AJS1B1AJS1_HUMAN
Astrotactin-1
ASTN1
1,228Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA22958 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti439D → E in BAG58151 (PubMed:14702039).Curated1
Sequence conflicti994T → I in BAG58151 (PubMed:14702039).Curated1
Isoform 3 (identifier: O14525-3)
Sequence conflicti1216R → RYQ in BAG58151 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_069030932H → R3 PublicationsCorresponds to variant dbSNP:rs2228956Ensembl.1
Natural variantiVAR_069031942H → Q3 PublicationsCorresponds to variant dbSNP:rs2281180Ensembl.1
Natural variantiVAR_0367641270G → R. Corresponds to variant dbSNP:rs12118933Ensembl.1
Natural variantiVAR_0557131278R → G. Corresponds to variant dbSNP:rs12118933Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_001371480 – 487Missing in isoform 1 and isoform 3. 3 Publications8
Alternative sequenceiVSP_0450691225 – 1302Missing in isoform 3. 2 PublicationsAdd BLAST78

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB006627 mRNA Translation: BAA22958.1 Different initiation.
AK295126 mRNA Translation: BAG58151.1
AL021398 Genomic DNA No translation available.
AL022145 Genomic DNA No translation available.
AL031290 Genomic DNA No translation available.
AL136983 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW91007.1
BC142697 mRNA Translation: AAI42698.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1319.1 [O14525-2]
CCDS44280.1 [O14525-3]

Protein sequence database of the Protein Information Resource

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PIRi
T00038

NCBI Reference Sequences

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RefSeqi
NP_996991.1, NM_207108.2 [O14525-3]
XP_016856829.1, XM_017001340.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000361833; ENSP00000354536; ENSG00000152092 [O14525-2]
ENST00000424564; ENSP00000395041; ENSG00000152092 [O14525-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
460

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:460

UCSC genome browser

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UCSCi
uc001glc.5 human [O14525-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006627 mRNA Translation: BAA22958.1 Different initiation.
AK295126 mRNA Translation: BAG58151.1
AL021398 Genomic DNA No translation available.
AL022145 Genomic DNA No translation available.
AL031290 Genomic DNA No translation available.
AL136983 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW91007.1
BC142697 mRNA Translation: AAI42698.1
CCDSiCCDS1319.1 [O14525-2]
CCDS44280.1 [O14525-3]
PIRiT00038
RefSeqiNP_996991.1, NM_207108.2 [O14525-3]
XP_016856829.1, XM_017001340.1

3D structure databases

SMRiO14525
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO14525, 2 interactors
STRINGi9606.ENSP00000354536

Protein family/group databases

TCDBi9.B.87.2.1 the selenoprotein p receptor (selp-receptor) family

PTM databases

iPTMnetiO14525
PhosphoSitePlusiO14525

Polymorphism and mutation databases

BioMutaiASTN1

Proteomic databases

PaxDbiO14525
PeptideAtlasiO14525
PRIDEiO14525
ProteomicsDBi48071
48072 [O14525-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361833; ENSP00000354536; ENSG00000152092 [O14525-2]
ENST00000424564; ENSP00000395041; ENSG00000152092 [O14525-3]
GeneIDi460
KEGGihsa:460
UCSCiuc001glc.5 human [O14525-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
460
DisGeNETi460

GeneCards: human genes, protein and diseases

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GeneCardsi
ASTN1
HGNCiHGNC:773 ASTN1
HPAiHPA074112
MIMi600904 gene
neXtProtiNX_O14525
OpenTargetsiENSG00000152092
PharmGKBiPA162376961

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IHIU Eukaryota
ENOG4110VB2 LUCA
GeneTreeiENSGT00390000003140
HOGENOMiHOG000034112
InParanoidiO14525
OMAiPEFLTGM
OrthoDBi39300at2759
PhylomeDBiO14525
TreeFamiTF332034

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ASTN1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
460

Protein Ontology

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PROi
PR:O14525

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000152092 Expressed in 132 organ(s), highest expression level in entorhinal cortex
ExpressionAtlasiO14525 baseline and differential
GenevisibleiO14525 HS

Family and domain databases

CDDicd00063 FN3, 1 hit
InterProiView protein in InterPro
IPR040685 Annexin-like
IPR026995 Astrotactin
IPR000742 EGF-like_dom
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR020864 MACPF
PANTHERiPTHR16592 PTHR16592, 1 hit
PfamiView protein in Pfam
PF18411 Annexin_like, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 3 hits
SM00457 MACPF, 1 hit
SUPFAMiSSF49265 SSF49265, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiASTN1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O14525
Secondary accession number(s): A5PL12
, B4DHI9, E9PFR8, O60799, Q5W0V7, Q5W0V8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 10, 2005
Last modified: May 8, 2019
This is version 168 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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