UniProtKB - O14524 (NEMP1_HUMAN)

BLAST

>sp|O14524|NEMP1_HUMAN Nuclear envelope integral membrane protein 1 OS=Homo sapiens OX=9606 GN=NEMP1 PE=1 SV=2
MAGGMKVAVSPAVGPGPWGSGVGGGGTVRLLLILSGCLVYGTAETDVNVVMLQESQVCEK
RASQQFCYTNVLIPKWHDIWTRIQIRVNSSRLVRVTQVENEEKLKELEQFSIWNFFSSFL
KEKLNDTYVNVGLYSTKTCLKVEIIEKDTKYSVIVIRRFDPKLFLVFLLGLMLFFCGDLL
SRSQIFYYSTGMTVGIVASLLIIIFILSKFMPKKSPIYVILVGGWSFSLYLIQLVFKNLQ
EIWRCYWQYLLSYVLTVGFMSFAVCYKYGPLENERSINLLTWTLQLMGLCFMYSGIQIPH
IALAIIIIALCTKNLEHPIQWLYITCRKVCKGAEKPVPPRLLTEEEYRIQGEVETRKALE
ELREFCNSPDCSAWKTVSRIQSPKRFADFVEGSSHLTPNEVSVHEQEYGLGSIIAQDEIY
EEASSEEEDSYSRCPAITQNNFLT

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History
Entry version 137 (10 Oct 2018)
Sequence version 2 (23 Nov 2004)
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Protein

Nuclear envelope integral membrane protein 1

Gene

NEMP1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Nuclear envelope integral membrane protein 1
Gene namesⁱ	Name:NEMP1 Synonyms:KIAA0286, TMEM194, TMEM194A
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000166881.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:29001 NEMP1
MIMⁱ	616496 gene
neXtProtⁱ	NX_O14524

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	161 – 181	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	186 – 206	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	216 – 236	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	245 – 265	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	289 – 309	HelicalSequence analysisAdd BLAST	21

Keywords - Cellular componentⁱ

Membrane, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000166881
PharmGKBⁱ	PA162406290

Polymorphism and mutation databases

BioMutaⁱ	TMEM194A

BioMutaⁱ

TMEM194A

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 43	Sequence analysisAdd BLAST		43
ChainⁱPRO_0000050744	44 – 444	Nuclear envelope integral membrane protein 1Add BLAST		401

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	125	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	368	PhosphoserineCombined sources	1
Modified residueⁱ	424	PhosphoserineCombined sources	1
Modified residueⁱ	425	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Phosphorylation may regulate its interaction with RAN-GTP.By similarity

Keywords - PTMⁱ

Glycoprotein, Phosphoprotein

Proteomic databases

EPDⁱ	O14524
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O14524
PaxDbⁱ	O14524
PeptideAtlas More...PeptideAtlasⁱ	O14524
PRIDEⁱ	O14524
ProteomicsDBⁱ	48069 48070 [O14524-2]

PTM databases

GlyConnectⁱ	1577
iPTMnetⁱ	O14524
PhosphoSitePlusⁱ	O14524

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000166881 Expressed in 180 organ(s), highest expression level in female gonad
CleanExⁱ	HS_TMEM194A
ExpressionAtlasⁱ	O14524 baseline and differential
Genevisibleⁱ	O14524 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA014394

HPAⁱ

HPA014394

Interactionⁱ

Subunit structureⁱ

Homooligomer. Interacts with RAN-GTP.By similarity

Protein-protein interaction databases

BioGridⁱ	116898, 31 interactors
IntActⁱ	O14524, 29 interactors
Molecular INTeraction database More...MINTⁱ	O14524
STRINGⁱ	9606.ENSP00000300128

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O14524
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	186 – 297	A; required for its colocalization with lamins at the nuclear envelopeBy similarityAdd BLAST	112
Regionⁱ	336 – 444	Required for nuclear localizationBy similarityAdd BLAST	109
Regionⁱ	336 – 405	B; required for interaction with RAN-GTPBy similarityAdd BLAST	70

Domainⁱ

The transmembrane domains are required and sufficient for its oligomerization.By similarity

Sequence similaritiesⁱ

Belongs to the NEMP family.Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3817 Eukaryota ENOG410ZZKM LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000002174
HOGENOMⁱ	HOG000122573
HOVERGENⁱ	HBG052180
InParanoidⁱ	O14524
OMAⁱ	HDIWTRI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G09L2
PhylomeDBⁱ	O14524
TreeFamⁱ	TF314831

Family and domain databases

InterProⁱ	View protein in InterPro IPR019358 NEMP_fam
PANTHERⁱ	PTHR13598 PTHR13598, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF10225 NEMP, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: O14524-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGGMKVAVS PAVGPGPWGS GVGGGGTVRL LLILSGCLVY GTAETDVNVV 
        60         70         80         90        100
MLQESQVCEK RASQQFCYTN VLIPKWHDIW TRIQIRVNSS RLVRVTQVEN 
       110        120        130        140        150
EEKLKELEQF SIWNFFSSFL KEKLNDTYVN VGLYSTKTCL KVEIIEKDTK 
       160        170        180        190        200
YSVIVIRRFD PKLFLVFLLG LMLFFCGDLL SRSQIFYYST GMTVGIVASL 
       210        220        230        240        250
LIIIFILSKF MPKKSPIYVI LVGGWSFSLY LIQLVFKNLQ EIWRCYWQYL 
       260        270        280        290        300
LSYVLTVGFM SFAVCYKYGP LENERSINLL TWTLQLMGLC FMYSGIQIPH 
       310        320        330        340        350
IALAIIIIAL CTKNLEHPIQ WLYITCRKVC KGAEKPVPPR LLTEEEYRIQ 
       360        370        380        390        400
GEVETRKALE ELREFCNSPD CSAWKTVSRI QSPKRFADFV EGSSHLTPNE 
       410        420        430        440 
VSVHEQEYGL GSIIAQDEIY EEASSEEEDS YSRCPAITQN NFLT

Length:444

Mass (Da):50,640

Last modified:November 23, 2004 - v2

Checksum:ⁱF45D4D3F9B86C77B

Isoform 2 (identifier: O14524-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
110-182: Missing.

« Hide

        10         20         30         40         50
MAGGMKVAVS PAVGPGPWGS GVGGGGTVRL LLILSGCLVY GTAETDVNVV 
        60         70         80         90        100
MLQESQVCEK RASQQFCYTN VLIPKWHDIW TRIQIRVNSS RLVRVTQVEN 
       110        120        130        140        150
EEKLKELEQS QIFYYSTGMT VGIVASLLII IFILSKFMPK KSPIYVILVG 
       160        170        180        190        200
GWSFSLYLIQ LVFKNLQEIW RCYWQYLLSY VLTVGFMSFA VCYKYGPLEN 
       210        220        230        240        250
ERSINLLTWT LQLMGLCFMY SGIQIPHIAL AIIIIALCTK NLEHPIQWLY 
       260        270        280        290        300
ITCRKVCKGA EKPVPPRLLT EEEYRIQGEV ETRKALEELR EFCNSPDCSA 
       310        320        330        340        350
WKTVSRIQSP KRFADFVEGS SHLTPNEVSV HEQEYGLGSI IAQDEIYEEA 
       360        370 
SSEEEDSYSR CPAITQNNFL T

Note: No experimental confirmation available.

Show »

Length:371

Mass (Da):42,033

Checksum:ⁱBD222DDE1AB196A5

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	G3V5K2	G3V5K2_HUMAN		Nuclear envelope integral membrane ... Nuclear envelope integral membrane protein 1	NEMP1	110	Annotation score:

Sequence cautionⁱ

The sequence AAH71597 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence BAA22955 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	442	F → L in CAH18250 (PubMed:17974005).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_057817	217	I → V. Corresponds to variant dbSNP:rs17546579Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_011896	110 – 182	Missing in isoform 2. 3 PublicationsAdd BLAST		73

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB006624 mRNA Translation: BAA22955.2 Different initiation. CR749406 mRNA Translation: CAH18250.1 AK294566 mRNA Translation: BAG57761.1 BC071597 mRNA Translation: AAH71597.1 Different initiation. BC117436 mRNA Translation: AAI17437.1 BC126300 mRNA Translation: AAI26301.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31841.1 [O14524-2] CCDS44927.1 [O14524-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001124435.1, NM_001130963.1 [O14524-1] NP_056072.2, NM_015257.2 [O14524-2]
UniGeneⁱ	Hs.591040

Genome annotation databases

Ensemblⁱ	ENST00000300128; ENSP00000300128; ENSG00000166881 [O14524-1] ENST00000379391; ENSP00000368701; ENSG00000166881 [O14524-2]
GeneIDⁱ	23306
KEGGⁱ	hsa:23306
UCSC genome browser More...UCSCⁱ	uc001smx.4 human [O14524-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O14524	Nuclear envelope integral membrane protein 1		PONAB		444	UniRef90_O14524
Uncharacterized protein		AOTNA		444
Uncharacterized protein		NOMLE		444
Uncharacterized protein		Cebus capucinus imitator		444
NEMP1 isoform 2		PANTR		444
+18
O14524-2	NEMP1 isoform 3		PANTR		371	UniRef90_O14524-2
UPI0005CFF68B		HUMAN		419

Protein	Similar proteins		Species	Score	Length	Source
O14524	Nuclear envelope integral membrane protein 1		PONAB		444	UniRef50_O14524
Nuclear envelope integral membrane protein 1		BOVIN		445
Uncharacterized protein		NOMLE		444
NEMP1 isoform 2		PANTR		444
Uncharacterized protein		PANPA		444
+171
O14524-2	NEMP1 isoform 3		PANTR		371	UniRef50_O14524-2
transmembrane protein 194A		ODORO		368
Nuclear envelope integral membrane protein 1		FELCA		375
Uncharacterized protein		PROCO		371
Uncharacterized protein		MACMU		371
+31

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB006624 mRNA Translation: BAA22955.2 Different initiation. CR749406 mRNA Translation: CAH18250.1 AK294566 mRNA Translation: BAG57761.1 BC071597 mRNA Translation: AAH71597.1 Different initiation. BC117436 mRNA Translation: AAI17437.1 BC126300 mRNA Translation: AAI26301.1
CCDSⁱ	CCDS31841.1 [O14524-2] CCDS44927.1 [O14524-1]
RefSeqⁱ	NP_001124435.1, NM_001130963.1 [O14524-1] NP_056072.2, NM_015257.2 [O14524-2]
UniGeneⁱ	Hs.591040

3D structure databases

ProteinModelPortalⁱ	O14524
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	116898, 31 interactors
IntActⁱ	O14524, 29 interactors
MINTⁱ	O14524
STRINGⁱ	9606.ENSP00000300128

PTM databases

GlyConnectⁱ	1577
iPTMnetⁱ	O14524
PhosphoSitePlusⁱ	O14524

Polymorphism and mutation databases

BioMutaⁱ	TMEM194A

BioMutaⁱ

TMEM194A

Proteomic databases

EPDⁱ	O14524
MaxQBⁱ	O14524
PaxDbⁱ	O14524
PeptideAtlasⁱ	O14524
PRIDEⁱ	O14524
ProteomicsDBⁱ	48069 48070 [O14524-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	23306
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000300128; ENSP00000300128; ENSG00000166881 [O14524-1] ENST00000379391; ENSP00000368701; ENSG00000166881 [O14524-2]
GeneIDⁱ	23306
KEGGⁱ	hsa:23306
UCSCⁱ	uc001smx.4 human [O14524-1]

Organism-specific databases

CTDⁱ	23306
EuPathDBⁱ	HostDB:ENSG00000166881.9
GeneCardsⁱ	NEMP1
H-InvDBⁱ	HIX0010743
HGNCⁱ	HGNC:29001 NEMP1
HPAⁱ	HPA014394
MIMⁱ	616496 gene
neXtProtⁱ	NX_O14524
OpenTargetsⁱ	ENSG00000166881
PharmGKBⁱ	PA162406290
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3817 Eukaryota ENOG410ZZKM LUCA
GeneTreeⁱ	ENSGT00390000002174
HOGENOMⁱ	HOG000122573
HOVERGENⁱ	HBG052180
InParanoidⁱ	O14524
OMAⁱ	HDIWTRI
OrthoDBⁱ	EOG091G09L2
PhylomeDBⁱ	O14524
TreeFamⁱ	TF314831

Miscellaneous databases

GenomeRNAiⁱ	23306
Protein Ontology More...PROⁱ	PR:O14524
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000166881 Expressed in 180 organ(s), highest expression level in female gonad
CleanExⁱ	HS_TMEM194A
ExpressionAtlasⁱ	O14524 baseline and differential
Genevisibleⁱ	O14524 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR019358 NEMP_fam
PANTHERⁱ	PTHR13598 PTHR13598, 1 hit
Pfamⁱ	View protein in Pfam PF10225 NEMP, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NEMP1_HUMAN
Accessionⁱ	O14524Primary (citable) accession number: O14524 Secondary accession number(s): Q17R72, Q68DH0, Q6IQ25
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
	Last sequence update:	November 23, 2004
	Last modified:	October 10, 2018
	This is version 137 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O14524 (NEMP1_HUMAN)

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Nuclear envelope integral membrane protein 1

NEMP1

Select a section on the left to see content.

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ